H. Hamada

K. Houkin, J. Kocsis, H. Hamada, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia

K. Houkin, J. Kocsis, H. Hamada, 2009, Experimental Neurology.

Gene therapy for α‐fetoprotein‐producing human hepatoma cells by adenovirus‐mediated transfer of the herpes simplex virus thymidine kinase gene

Keng, H. Wakimoto, Y. Shiratori, 1996, Hepatology.

De novo follicular regeneration of the skin by wingless int 3 and bone morphogenetic protein 2 genes introduced into dermal fibroblasts and fibroblast growth factor‐2 protein

T. Yamashita, H. Hamada, I. Ono, 2009, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Involvement of the SKP2–p27KIP1 pathway in suppression of cancer cell proliferation by RECK

Y. Yoshida, H. Hamada, M. Noda, 2012, Oncogene.

In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.

H. Wakimoto, Y. Shiratori, T. Tanaka, 1997, Cancer research.

Characteristics of resistance to adriamycin in human myelogenous leukemia K562 resistant to adriamycin and in isolated clones.

T. Tsuruo, H. Hamada, T. Oh‐hara, 1986, Japanese journal of cancer research : Gann.

Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID-ß2m -/- repopulating cells. Short title for running head: Stem cell expansion by Indian hedgehog

R. Takimoto, H. Hamada, Y. Niitsu, 2017 .

Mesenchymal stem cells (MSC) as therapeutic cytoreagents for gene therapy

K. Houkin, H. Hamada, Y. Niitsu, 2005, Cancer science.

Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells.

H. Hamada, Y. Niitsu, Yoshinori Ito, 2004, Experimental hematology.

Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID-beta2m-/- repopulating cells.

R. Takimoto, H. Hamada, Y. Niitsu, 2004, Blood.

Optimal dose of plasmid vascular endothelial growth factor for enhancement of angiogenesis in the rat brain ischemia model.

I. Date, H. Hamada, K. Sugiu, 2010, Neurologia medico-chirurgica.

Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma

I. Date, H. Hamada, K. Nakamura, 2012, Cancer Gene Therapy.

Pre‐administration of angiopoietin‐1 followed by VEGF induces functional and mature vascular formation in a rabbit ischemic model

H. Hamada, Y. Niitsu, Yoshinori Ito, 2003, The journal of gene medicine.

Sendai viral vector mediated angiopoietin-1 gene transfer for experimental ischemic limb disease

H. Hamada, M. Hasegawa, Toshihiro Tanaka, 2009, Angiogenesis.

Myocardial injection of CA promoter‐based plasmid mediates efficient transgene expression in rat heart

H. Hamada, Kazunori Kato, Yoshinori Ito, 2003, The journal of gene medicine.

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

T. Tsuruo, H. Hamada, Hirofumi Hamada, 1988, The Journal of biological chemistry.

cancer Pancreas cancer Renal cancer Malignant lymphoma Gastric cancer Neuroblastoma Malignant fibrous histiocytoma Osteogenic sarcoma Lung cancer Ovarian cancer Uterine cervical cancer Smooth muscle sarcoma of the uterus Breast cancer Thymoma

T. Tsuruo, S. Mori, H. Hamada, 2006 .

Growth Inhibition of Multidrug-Resistant Cells by Monoclonal Antibodies against P-Glycoprotein

T. Tsuruo, H. Hamada, 1991 .

Therapeutic Implication of Monoclonal Antibodies against Multidrug-Resistant Tumor Cells

T. Tsuruo, H. Hamada, 1990 .

A Novel Multidrug Resistance in Cultured Leukemia and Lymphoma Cells Detected by a Monoclonal Antibody to 85‐kDa Protein, MRK20

T. Tsuruo, H. Hamada, K. Tobinai, 1989, Japanese journal of cancer research : Gann.

Elimination of drug-resistant myeloma tumor cell lines by monoclonal anti-P-glycoprotein antibody and rabbit complement.

T. Tsuruo, H. Hamada, G. Spitzer, 1989, Blood.

Mr 85,000 membrane protein specifically expressed in adriamycin-resistant human tumor cells.

T. Tsuruo, H. Hamada, Y. Sugimoto, 1988, Cancer research.

Cellular and Tissue Distribution of MRK20 Murine Monoclonal Antibody‐defined 85‐kDa Protein in Adriamycin‐resistant Cancer Cell Lines*1

T. Tsuruo, S. Mori, H. Hamada, 1988, Japanese journal of cancer research : Gann.

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.

T. Tsuruo, H. Hamada, Hirofumi Hamada, 1988, Cancer research.

Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies.

T. Tsuruo, H. Hamada, T. Oh‐hara, 1988, Cancer research.

ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.

T. Tsuruo, M. Naito, H. Hamada, 1988, The Journal of biological chemistry.

Comparison of glutathione S-transferase activity between drug-resistant and-sensitive human tumor cells: Is glutathione S-transferase associated with multidrug resistance?

T. Tsuruo, H. Hamada, K. Yusa, 1988, Cancer Chemotherapy and Pharmacology.

E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer

I. Hyodo, H. Hamada, K. Yokoyama, 2009, Cancer Gene Therapy.

Overexpression of Basic Fibroblast Growth Factor and Bcl-xL with Adenoviral Vectors Protects Primarily Cultured Neurons against Glutamate Insult

M. Akimoto, N. Hashimoto, S. Miyatake, 2002, Neurosurgery.

Bcl-xL Gene Transfer Inhibits Bax Translocation and Prolongs Cardiac Cold Preservation Time in Rats

H. Hamada, Kazunori Kato, Yoshinori Ito, 2005, Circulation.

In vivo efficacy and toxicity of 5-fluorocytosine/cytosine deaminase gene therapy for malignant gliomas mediated by adenovirus

T. Tamiya, H. Hamada, T. Ohmoto, 2000, Cancer Gene Therapy.

Apoptosis by retrovirus- and adenovirus-mediated gene transfer of Fas ligand to glioma cells: implications for gene therapy.

S. Yamamoto, A. Asai, T. Kirino, 1998, Human gene therapy.

Construction, propagation, and titer estimation of recombinant adenoviruses carrying proapoptotic genes.

A. Asai, T. Kirino, H. Hamada, 1998, Human gene therapy.

Changes in N-glycosylation of human stromal cells by telomerase expression.

H. Hamada, Y. Niitsu, I. Kuwahara, 2003, Biochemical and biophysical research communications.

Functional analysis of CD82 in the early phase of T cell activation: roles in cell adhesion and signal transduction

H. Hamada, H. Yamashita, N. Shibagaki, 1998, European journal of immunology.

Reduced transduction efficiency of adenoviral vectors expressing human p53 gene by repeated transduction into glioma cells in vitro.

M. Aoyagi, K. Ohno, H. Hamada, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax

A. Asai, T. Kirino, H. Hamada, 1999, Oncogene.

Augmented antitumor effects of killer cells induced by tumor necrosis factor gene-transduced autologous tumor cells from gastrointestinal cancer patients.

H. Wakimoto, H. Hamada, M. Hirayama, 1996, Human gene therapy.

Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas.

A. Asai, T. Kirino, H. Hamada, 1999, Cancer research.

Carcinoembryonic Antigen–Targeted Selective Gene Therapy for Gastric Cancer through FZ33 Fiber-Modified Adenovirus Vectors

M. Kuroki, N. Watanabe, H. Hamada, 2006, Clinical Cancer Research.

Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber-mutant adenoviral vector.

H. Tsuda, T. Yamashita, H. Hamada, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Targeting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury

M. Makuuchi, J. Abe, H. Hamada, 1999, Gene Therapy.

Successful adoptive immunotherapy of murine poorly immunogenic tumor with specific effector cells generated from gene-modified tumor-primed lymph node cells.

H. Hamada, F. Gejyo, M. Arakawa, 1999, Journal of immunology.

Gene-Modified Tumor-Primed Lymph Node Specific Effector Cells Generated from Tumor with Poorly Immunogenic Murine Successful Adoptive Immunotherapy

H. Hamada, F. Gejyo, E. Suzuki, 1999 .

Molecular Cloning and Characterization of the Complementary DNA for the Mr 85,000 Protein Overexpressed in Adriamycin-resistant Human Tumor Cells

T. Tsuruo, K. Noguchi, K. Yamaguchi, 1993 .

Multidrug Resistance in Cultured Human Leukemia and Lymphoma Cell Lines Detected by a Monoclonal Antibody, MRK16

T. Tsuruo, H. Hamada, Y. Sugimoto, 1989, Japanese journal of cancer research : Gann.

Adenovirus-mediated transfer of caspase-3 with Fas ligand induces drastic apoptosis in U-373MG glioma cells.

A. Asai, T. Kirino, H. Hamada, 2000, Experimental cell research.

CD40 Ligand Promotes Priming of Fully Potent Antitumor CD4+ T Cells in Draining Lymph Nodes in the Presence of Apoptotic Tumor Cells

H. Hamada, F. Gejyo, E. Suzuki, 2001, The Journal of Immunology.

Tumor Cells Lymph Nodes in the Presence of Apoptotic T Cells in Draining + Potent Antitumor CD4 CD40 Ligand Promotes Priming of Fully

H. Hamada, F. Gejyo, E. Suzuki, 2001 .

Cytokine-gene-modified tumor vaccination intensified by a streptococcal preparation OK-432

H. Wakimoto, M. Aoyagi, H. Hamada, 1995, Cancer Immunology, Immunotherapy.

Antitumor effect induced by granulocyte/macrophage-colony-stimulating factor gene-modified tumor vaccination: Comparison of adenovirus- and retrovirus-mediated genetic transduction

H. Wakimoto, M. Aoyagi, H. Hamada, 2005, Journal of Cancer Research and Clinical Oncology.

Ex vivo expansion of G-CSF-mobilized peripheral blood CD133+ progenitor cells on coculture with human stromal cells.

R. Takimoto, H. Hamada, Y. Niitsu, 2006, Experimental hematology.

An E1B-deleted Adenovirus Selectively Kills p53-Deficient Lung Cancer Cells.

Y. Okita, K. Kiyooka, M. Kanki, 1999 .

Adenovirus-mediated transfer of caspase-8 in combination with superrepressor of NF-kappaB drastically induced apoptosis in gliomas.

N. Yamamoto, A. Asai, T. Kirino, 2000, Biochemical and biophysical research communications.

Adenovirus‐mediated Gene Transduction of IkB or IkB Plus Bax Gene Drastically Enhances Tumor Necrosis Factor (TNF)‐induced Apoptosis in Human Gliomas

N. Yamamoto, A. Asai, T. Kirino, 2000, Japanese journal of cancer research : Gann.

Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis

H. Hamada, Bing Liu, H. Shiku, 2012, British journal of haematology.

Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: potential utility for adoptive immunotherapy.

R. Ono, H. Hamada, Bing Liu, 2013, Experimental hematology.

Gene Transfer of Noncleavable Cell Surface Mutants of Human CD154 Induces the Immune Response and Diminishes Systemic Inflammatory Reactions

H. Hamada, Kazunori Kato, Y. Masuta, 2007, Journal of immunotherapy.

Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas

F. Shibasaki, A. Asai, T. Kirino, 2002, British Journal of Cancer.

In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma.

Y. Shiratori, T. Tanaka, K. Lan, 1997, Cancer research.

Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules.

H. Hamada, K. Hara, H. Moriyama, 2008, Diabetes research and clinical practice.

Antitumor Immunity for Peptide Delivery to Induce Specific Dendritic Cells Act as More Potent Adjuvants Lymphotactin Gene-Modified Bone Marrow

H. Hamada, Xuetao Cao, Zhifang Xie, 1998 .

Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity.

S. Ma, H. Hamada, L. He, 1998, Journal of immunology.

Mouse‐Human Chimeric Antibody MH171 against the Multidrug Transporter P‐Glycoprotein

T. Tsuruo, M. Naito, H. Seimiya, 1992, Japanese journal of cancer research : Gann.

Mouse-human chimeric antibody against the multidrug transporter P-glycoprotein.

Y. Kurosawa, T. Tsuruo, S. Sato, 1990, Cancer research.

Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells.

M. Yamaguchi, H. Hamada, Y. Sakuma, 2014, Biochemical and Biophysical Research Communications - BBRC.

Oncolytic Virotherapy as a Novel Strategy for Pancreatic Cancer

F. Motoi, H. Hamada, N. Omura, 2004, Pancreas.

ATP / Mg 2 +-dependent Binding of Vincristine to the Plasma Membrane of Multidrug-resistant K 562 Cells *

H. Hamada, M. Naito, Takashi TsuruoS, 2001 .

Adoptive immunotherapy with murine tumor-specific T lymphocytes engineered to secrete interleukin 2.

H. Wakimoto, M. Aoyagi, H. Hamada, 1994, Cancer research.

Caspase-8 gene transduction augments radiation-induced apoptosis in DLD-1 cells.

H. Nagawa, H. Hamada, N. Shinoura, 2002, Biochemical and biophysical research communications.

Adenovirus-mediated transfection of caspase-8 augments anoikis and inhibits peritoneal dissemination of human gastric carcinoma cells.

K. Imai, H. Hamada, M. Adachi, 2001, Cancer research.

Advances in Brief Adenovirus-mediated Transfection of Caspase-8 Augments Anoikis and Inhibits Peritoneal Dissemination of Human Gastric Carcinoma Cells 1

K. Imai, H. Hamada, M. Adachi, 2001 .

Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas: implication for gene therapy.

A. Asai, T. Kirino, H. Hamada, 2000, Human gene therapy.

Differential regulation of Fas-mediated apoptosis of rheumatoid synoviocytes by tumor necrosis factor alpha and basic fibroblast growth factor is associated with the expression of apoptosis-related molecules.

H. Hamada, K. Nishioka, T. Kato, 2000, Arthritis and rheumatism.

Novel gene therapy for rheumatoid arthritis by FADD gene transfer: induction of apoptosis of rheumatoid synoviocytes but not chondrocytes

H. Hamada, K. Nishioka, T. Kato, 2000, Gene Therapy.

Effect of CTLA4-Ig gene transfer using adenoviral vector in organ and cell transplantation.

H. Hamada, T. Kobayashi, I. Saito, 1997, Transplantation proceedings.

Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.

F. Motoi, L. Ding, H. Hamada, 2000, Human gene therapy.

Detection of 300-kilodalton membrane protein in adriamycin-resistant human tumor cells by a monoclonal antibody MRK18.

T. Tsuruo, H. Hamada, Y. Sugimoto, 1990, Biochemical and biophysical research communications.

Inhibition of Multidrug‐resistant Human Tumor Growth in Athymic Mice by Anti‐P‐glycoprotein Monoclonal Antibodies

T. Tsuruo, Shigeo Sato, H. Hamada, 1989, Japanese journal of cancer research : Gann.

E1A, E1B Double-Restricted Adenovirus with RGD-Fiber Modification Exhibits Enhanced Oncolysis for CAR–Deficient Biliary Cancers

I. Hyodo, N. Tanaka, H. Hamada, 2007, Clinical Cancer Research.

Effective gene therapy of biliary tract cancers by a conditionally replicative adenovirus expressing uracil phosphoribosyltransferase: significance of timing of 5-fluorouracil administration.

N. Tanaka, Y. Matsuzaki, H. Hamada, 2005, Cancer research.

5-Fluorouracil Administration Phosphoribosyltransferase : Significance of Timing of Conditionally Replicative Adenovirus Expressing Uracil Effective Gene Therapy of Biliary Tract Cancers by a

N. Tanaka, Y. Matsuzaki, H. Hamada, 2005 .

E1A, E1B double-restricted adenovirus for oncolytic gene therapy of gallbladder cancer.

N. Tanaka, H. Hamada, K. Yokoyama, 2003, Cancer research.

Upregulation of p21WAF1/CIP1 leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1

N. Yamamoto, H. Hamada, K. Takeda, 2001, Oncogene.

EpCAM‐ and EGFR‐targeted selective gene therapy for biliary cancers using Z33‐fiber‐modified adenovirus

I. Hyodo, H. Mizuguchi, Y. Obata, 2011, International journal of cancer.

The Antiangiogenesis Effect of Interleukin 12 During Early Growth of Human Pancreatic Cancer in SCID Mice

H. Hamada, L. Sun, D. Duda, 2000, Pancreas.

Adjuvant immunotherapy using fibroblasts genetically engineered to secrete interleukin 12 prevents recurrence after surgical resection of established tumors in a murine adenocarcinoma model.

K. Kato, H. Hamada, K. Takeda, 1999, Surgery.

IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells.

R. Ono, T. Kitamura, H. Hamada, 2011, International journal of oncology.

Vaccine effect of granulocyte–macrophage colony-stimulating factor or CD80 gene-transduced murine hematopoietic tumor cells and their cooperative enhancement of antitumor immunity

S. Asano, H. Hamada, H. Hase, 1998, Gene Therapy.

Antibody Screening System Using a Herpes Simplex Virus (HSV)-Based Probe To Identify a Novel Target for Receptor-Retargeted Oncolytic HSVs

M. Yamaguchi, H. Hamada, Masato Tanaka, 2021, Journal of Virology.

Development of an oncolytic HSV vector fully retargeted specifically to cellular EpCAM for virus entry and cell-to-cell spread

M. Yamaguchi, J. B. Cohen, H. Hamada, 2016, Gene Therapy.

Generation of a Considerable Number of Functional Mast Cells with a High Basal Level of FcɛRI Expression from Cord Blood CD34+ Cells by Co‐culturing Them with Bone Marrow Stromal Cell Line Under Serum‐free Conditions

M. Yamaguchi, H. Hamada, M. Fujihara, 2007, Scandinavian journal of immunology.

Biocompatibility Study of Hemoglobin Vesicles, Cellular-Type Artificial Oxygen Carriers, with Human Umbilical Cord Hematopoietic Stem/Progenitor Cells Using an In Vitro Expansion System

M. Yamaguchi, S. Takeoka, H. Hamada, 2009, ASAIO journal.

Oncolytic viral therapy by bladder instillation using an E1A, E1B double-restricted adenovirus in an orthotopic bladder cancer model.

H. Hamada, S. Ishidoya, M. Satoh, 2006, Urology.

Transduction of a Fiber‐mutant Adenovirus for the HSVtk Gene Highly Augments the Cytopathic Effect towards Gliomas

A. Asai, T. Kirino, H. Hamada, 2000, Japanese journal of cancer research : Gann.

Generation of reactive oxygen species and activation of NF‐κB by non‐Aβ component of Alzheimer's disease amyloid

E. Masliah, S. Futaki, Tomoki Suzuki, 2002, Journal of neurochemistry.

Gene therapy for intraperitoneally disseminated pancreatic cancers by Escherichia coli uracil phosphoribosiltransferase (UPRT) gene mediated by restricted replication‐competent adenoviral vectors

F. Motoi, H. Hamada, S. Egawa, 2002, International journal of cancer.

Inhibition of the antigen‐induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI‐P131 and WHI‐P154 in a Janus kinase 3‐independent manner

H. Hamada, Takashi Saito, N. Hirasawa, 2005, British journal of pharmacology.

Human beta-defensin-2 induction in Helicobacter pylori-infected gastric mucosal tissues: antimicrobial effect of overexpression.

N. Tsuji, A. Yagihashi, H. Hamada, 2003, Journal of medical microbiology.

Inhibition of type I procollagen production by tRNAVal CTE‐HSP47 ribozyme

T. Takayama, K. Taira, H. Hamada, 2003, The journal of gene medicine.

High Level Calcineurin Activity Predisposes Neuronal Cells to Apoptosis*

A. Asai, Y. Kuchino, T. Kirino, 1999, The Journal of Biological Chemistry.

Modulation of Motility and Proliferation of Glioma Cells by Hepatocyte Growth Factor

H. Wakimoto, M. Aoyagi, H. Hamada, 1997, Japanese journal of cancer research : Gann.

Telomerized human bone marrow-derived cell clones maintain the phenotype of hematopoietic-supporting osteoblastic and myofibroblastic stromal cells after long-term culture.

R. Takimoto, H. Hamada, Y. Niitsu, 2005, Experimental hematology.

Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1+ T helper 1 cells by a contact-dependent mechanism.

M. Mochizuki, Juan Ma, H. Hamada, 2009, Investigative ophthalmology & visual science.

Immunocytochemical Identification and Localization of the Mr 22,000 Calcium‐binding Protein (Sorcin) in an Adriamycin‐resistant Myelogenous Leukemia Cell Line

T. Tsuruo, K. Mizumoto, S. Mori, 1989, Japanese journal of cancer research : Gann.

Dual effects of adenovirus-mediated thrombopoietin gene transfer on hepatic oval cell proliferation and platelet counts.

A. Kurimasa, H. Hamada, N. Miura, 2005, Biochemical and biophysical research communications.

Over‐expression of APAF‐1 and caspase‐9 augments radiation‐induced apoptosis in U‐373MG glioma cells

A. Asai, T. Kirino, H. Hamada, 2001, International journal of cancer.

Adoptive Immunotherapy with Cytokine Gene-modified Cytotoxic T Lymphocytes

H. Wakimoto, S. Okabe, M. Aoyagi, 1996 .

Exploration of target molecules for prostate cancer gene therapy

H. Hamada, Kazunori Kato, Kazuhiro Suzuki, 2007, The Prostate.

Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5‐fluorouracil in mice

T. Takayama, R. Takimoto, H. Hamada, 2008, Hepatology.

Adenovirus-mediated gene transfer of CTLA4Ig gene results in prolonged survival of heart allograft.

H. Hamada, I. Yokoyama, S. Hayashi, 1998, Transplant international : official journal of the European Society for Organ Transplantation.

Adenovirus‐mediated Transfer of Fas Ligand Gene Augments Radiation‐induced Apoptosis in U‐373MG Glioma Cells

N. Yamamoto, A. Asai, T. Kirino, 2000, Japanese journal of cancer research : Gann.

Enhanced growth suppression in esophageal carcinoma cells using adenovirus-mediated fusion gene transfer (uracil phosphoribosyl transferase and herpes simplex virus thymidine kinase)

H. Shimada, H. Hamada, T. Ochiai, 2001, Cancer Gene Therapy.

Adenovirus-mediated drug-sensitivity gene therapy for hepatocellular carcinoma.

Y. Shiratori, M. Omata, P. Marignani, 2000, Methods in molecular medicine.

Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy

H. Hamada, Kazunori Kato, R. Nakano, 2011, Cancer science.

Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome

K. Houkin, J. Kocsis, H. Hamada, 2010, Brain Research.

Specialized Localization of P‐Glycoprotein Recognized by MRK 16 Monoclonal Antibody in Endothelial Cells of the Brain and the Spinal Cord

T. Tsuruo, S. Mori, H. Hamada, 1990, Japanese journal of cancer research : Gann.

Oncolytic gene therapy combined with double suicide genes for human bile duct cancer in nude mouse models.

H. Hamada, K. Honda, Nobuaki Kobayashi, 2009, The Journal of surgical research.

Tumor-specific gene expression in carcinoembryonic antigen--producing gastric cancer cells using adenovirus vectors.

H. Wakimoto, Y. Shiratori, S. Okabe, 1996, Gastroenterology.

Local tumor irradiation augments the antitumor effect of cytokine-producing autologous cancer cell vaccines in a murine glioma model

B. Szende, H. Hamada, L. Mangel, 2002, Cancer Gene Therapy.

In situ generation of pseudotyped retroviral progeny by adenovirus‐mediated transduction of tumor cells enhances the killing effect of HSV‐tk suicide gene therapy in vitro and in vivo

N. Caplen, K. Ozawa, H. Hamada, 2004, The journal of gene medicine.

Effects of immunization with tumor cells double transfected with interleukin-2 (IL-2) and interleukin-12 (IL-12) genes on artificial metastasis of colon26 cells in BALB/c mice

H. Hamada, Kazunori Kato, K. Okumura, 1999, Clinical & Experimental Metastasis.

Bone Marrow Stromal Cell Line Promotes the Proliferation of Mast Cell Progenitors Derived from Cord Blood CD34+ Cells under Serum-free Conditions with a Combination of Both Cell-cell Interaction and Soluble Factors

M. Yamaguchi, H. Hamada, M. Fujihara, 2011, Artificial cells, blood substitutes, and immobilization biotechnology.

Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas.

T. Furukawa, A. Asai, T. Kirino, 1999, Cancer research.

Adenovirus-mediated Transfer of p 33 ING 1 with p 53 Drastically Augments Apoptosis in Gliomas 1

T. Furukawa, A. Asai, T. Kirino, 1999 .

Induction of potent antitumor response by vaccination with tumor lysate-pulsed macrophages engineered to secrete macrophage colony-stimulating factor and interferon-γ

H. Hamada, X. Cao, S. Gu, 2000, Gene Therapy.

Effect of antisense ribozyme to alpha (1,3)galactosyl transferase gene on the expression of Gal alpha (1,3)Gal epitope.

H. Hamada, T. Kobayashi, I. Saito, 1997, Transplantation proceedings.

Anti-tumor effect of murine renal cell carcinoma cells genetically modified to express B7-1 combined with cytokine secreting fibroblasts.

H. Hamada, J. Wang, T. Nakamoto, 2000, Hiroshima journal of medical sciences.

Purification of infectious adenovirus in two hours by ultracentrifugation and tangential flow filtration.

M. Kimura, Y. Obata, H. Hamada, 2005, Biochemical and biophysical research communications.

Monoclonal Anti‐P‐glycoprotein Antibody‐dependent Killing of Multidrug‐resistant Tumor Cells by Human Mononuclear Cells

T. Tsuruo, S. Sone, H. Hamada, 1990, Japanese journal of cancer research : Gann.

Determination of membrane antigens by a covalent crosslinking method with monoclonal antibodies.

T. Tsuruo, H. Hamada, 1987, Analytical biochemistry.

Metalloprotease inhibitors block release of soluble CD27 and enhance the immune stimulatory activity of chronic lymphocytic leukemia cells.

T. Kipps, H. Hamada, Kazunori Kato, 2007, Experimental Hematology.

Recombinant human soluble thrombomodulin for the treatment of hepatic sinusoidal obstructive syndrome post allogeneic hematopoietic SCT

S. Suzuki, H. Hamada, S. Fujino, 2012, Bone Marrow Transplantation.

Intensified antitumor immunity by a cancer vaccine that produces granulocyte-macrophage colony-stimulating factor plus interleukin 4.

H. Wakimoto, M. Aoyagi, H. Hamada, 1996, Cancer research.

Activated dendritic cells from bone marrow cells of mice receiving cytokine-expressing tumor cells are associated with the enhanced survival of mice bearing syngeneic tumors.

H. Hamada, M. Kawakita, S. Fujii, 1999, Blood.

Enhanced osteoinduction by mesenchymal stem cells transfected with a fiber‐mutant adenoviral BMP2 gene

H. Tsuda, T. Yamashita, H. Hamada, 2005, The journal of gene medicine.

Changes in Markers, Receptors and Adhesion Molecules Expressed on Murine Hemopoietic Stem Cells After a Single Injection of 5‐Fluorouracil

H. Hamada, S. Ikehara, M. Inaba, 1996, Stem Cells.

Construction and expression of the replication-deficient adenonirus vector of human GM-CSF

H. Hamada, Xuetao Cao, Q. Tao, 1997 .

Inhibitory effect of α(1,2) fucosyltransferase recombinant adenoviral vector on αGal expression

Takeshi Kobayashi, H. Hamada, D. Liu, 1998 .

Effective gene transfer to human melanomas via integrin-targeted adenoviral vectors.

H. Hamada, Takafumi Nakamura, Kenzo Sato, 2002, Human gene therapy.

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

M C Willingham, I. Pastan, M. Willingham, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion

T. Takayama, R. Takimoto, H. Hamada, 2005 .

Liver retransplantation in children.

H. Hamada, F. Gauthier, J. Valayer, 1995, Journal of pediatric surgery.

Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice.

M. Kasuga, H. Hamada, H. Moriyama, 1998, The Journal of clinical investigation.

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

E. Jaffee, G. Dranoff, D. Pardoll, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro.

H. Wakimoto, Y. Shiratori, S. Okabe, 1996, Cancer research.

Transduction of the human deoxycytidine kinase gene in rodent tumor cells induces in vivo growth retardation in syngeneic hosts.

M. Tagawa, H. Namba, S. Sakiyama, 2000, Cancer letters.

Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte-macrophage colony-stimulating factor gene transfer

H. Hamada, Xuetao Cao, Jianli Wang, 2000, Cancer Gene Therapy.

Adenovirus mediated p53 tumour suppressor gene therapy for human gastric cancer cells in vitro and in vivo

Y. Shiratori, H. Ueno, T. Tanaka, 1999, Gut.

Adenovirus mediated p 53 tumour suppressor gene therapy for human gastric cancer cells in vitro and in vivo

Y. Shiratori, H. Ueno, T. Tanaka, 1999 .

Dose of Adenoviral Vectors Expressing Interleukin‐2 Plays an Important Role in Combined Gene Therapy with Cytosine Deaminase/5–Fluorocytosine: Preclinical Consideration

H. Hamada, H. Yamaue, T. Tsunoda, 2002, Japanese journal of cancer research : Gann.

Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma

H. Hamada, X. Cao, D. Cheng, 2000, Gene Therapy.

Adenovirus-mediated GM-CSF gene and cytosine deaminase gene transfer followed by 5-fluorocytosine administration elicit more potent antitumor response in tumor-bearing mice

H. Hamada, T. Wan, X. Cao, 1998, Gene Therapy.

Adenovirus-mediated tissue-specific cytosine deaminase gene therapy for human hepatocellular carcinoma with different AFP expression levels.

H. Wakimoto, H. Hamada, Xuetao Cao, 2002, Journal of experimental therapeutics & oncology.

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

T. Tsuruo, H. Hamada, I. Sugawara, 1988, Cancer research.

Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.

T. Tsuruo, I. Roninson, H. Hamada, 1987, Japanese journal of cancer research : Gann.

Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity.

Y. Maniwa, H. Hamada, K. Hara, 2007, Human gene therapy.

Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide.

T. Kurabayashi, I. Aoki, Y. Minemoto, 2012, Journal of controlled release : official journal of the Controlled Release Society.

A new delivery system for 5-fluorouracil using prodrug and converting enzyme

M. Akimoto, H. Hamada, N. Yoshimura, 2002, The British journal of ophthalmology.

Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo.

K. Taira, M. Miyagishi, H. Hamada, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells.

A. Masamune, T. Shimosegawa, K. Kikuta, 2012, Biochemical and biophysical research communications.

Adenovirus-mediated transfer of Bax with caspase-8 controlled by myelin basic protein promoter exerts an enhanced cytotoxic effect in gliomas

A. Asai, T. Kirino, H. Hamada, 2000, Cancer Gene Therapy.

Adenovirus-mediated transfer of p53 and Fas ligand drastically enhances apoptosis in gliomas

A. Asai, T. Kirino, H. Hamada, 2000, Cancer Gene Therapy.

Expression level of Bcl-2 determines anti- or proapoptotic function.

A. Asai, T. Kirino, H. Hamada, 1999, Cancer research.

Adenovirus-mediated overexpression of Fas induces apoptosis of gliomas

A. Asai, T. Kirino, H. Hamada, 2000, Cancer Gene Therapy.

Intravenous administration of glial cell line‐derived neurotrophic factor gene‐modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat

K. Houkin, J. Kocsis, H. Hamada, 2006, Journal of neuroscience research.

Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia.

K. Houkin, J. Kocsis, H. Hamada, 2006, Brain : a journal of neurology.

Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33ING1 in T.Tn human esophageal carcinoma cells

M. Oka, Y. Haupt, H. Shimada, 2002, Oncogene.

A speedy method to detect inserted DNA fragment in cell lines transfected with retroviral vectors

H. Hamada, K. Saijo, T. Ohno, 2000, Cytotechnology.

Efficient Retrovirus‐mediated Cytokine‐gene Transduction of Primary‐cultured Human Glioma Cells for Tumor Vaccination Therapy

H. Wakimoto, M. Aoyagi, H. Hamada, 1997, Japanese journal of cancer research : Gann.

Adenoviral-delivered angiopoietin-1 reduces the infarction and attenuates the progression of cardiac dysfunction in the rat model of acute myocardial infarction.

Sachie Hirai, Jianhua Huang, Katsunori Sasaki, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lung‐cancer cells in natural killer cell–depleted SCID mice

S. Sone, H. Hamada, N. Nishimura, 2001, International journal of cancer.

Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia

K. Houkin, J. Kocsis, H. Hamada, 2010, Brain Research.

Adenovirus-mediated transfer of tissuetype plasminogen activator gene to human endothelial cells

M. Makuuchi, Y. Sakata, H. Hamada, 1997 .

Adenovirus-Mediated Bcl-Xl Gene Therapy Combined with Pronase Treatment Protects the Small Intestine from Radiation-Induced Enteritis in Mouse Model

H. Hamada, K. Ohashi, Y. Nakajima, 2014 .

Adenovirus-mediated inducible gene expression through tetracycline-controllable transactivator with nuclear localization signal.

H. Hamada, Y. Yoshida, 1997, Biochemical and biophysical research communications.

VSV-G-pseudotyped retroviral packaging through adenovirus-mediated inducible gene expression.

H. Hamada, Y. Yoshida, N. Emi, 1997, Biochemical and biophysical research communications.

Effect of Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells on Mice Infected with Prions

H. Furuoka, M. Horiuchi, H. Hamada, 2009, Journal of Virology.

Neurorescue effects of VEGF on a rat model of Parkinson's disease

M. Kameda, T. Yasuhara, T. Agari, 2005, Brain Research.

Adenovirus-mediated transfer of Bcl-X(L) protects neuronal cells from Bax-induced apoptosis.

A. Asai, T. Kirino, H. Hamada, 2000, Experimental cell research.

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

M C Willingham, I. Pastan, M. Willingham, 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr 170,000-180,000 P-glycoprotein.

T. Tsuruo, H. Hamada, I. Sugawara, 1988, Cancer research.

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

M C Willingham, I H Pastan, I. Pastan, 1987, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Adenovirus-mediated gene transfer of Bcl-xL prevents cell death in primary neuronal culture of the rat

M. Akimoto, S. Miyatake, H. Hamada, 1999, Neuroscience Letters.

A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload.

K Takada, T. Takayama, R. Takimoto, 2001, American journal of human genetics.

Gene therapy for murine renal cell carcinoma using genetically engineered tumor cells to secrete interleukin-12.

H. Hamada, J. Wang, T. Nakamoto, 2000, Hiroshima journal of medical sciences.

Adeno-retroviral chimeric viruses as in vivo transducing agents

N. Caplen, J. Scheel, H. Hamada, 1999, Gene Therapy.

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

I. Komuro, T. Minamino, Y. Zou, 2007, Nature.

Mutated focal adhesion kinase induces apoptosis in a human glioma cell line, T98G.

H. Hamada, N. Shinoura, T. Kasahara, 2002, Biochemical and biophysical research communications.

Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings.

M. Noguchi, H. Akaza, R. Mulligan, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

In vivo Adenovirus‐mediated Prodrug Gene Therapy for Carcinoembryonic Antigen‐producing Pancreatic Cancer

Y. Shiratori, K. Lan, T. Kawabe, 1998, Japanese journal of cancer research : Gann.

Polyadenylation signal facilitates the expression of foreign gene that is driven by an internal promoter located in the reverse orientation to long terminal repeat of retrovirus.

M. Tagawa, S. Sakiyama, H. Hamada, 2000, Anticancer research.

Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate and integrate after intracerebral transplantation in rats with transient forebrain ischemia

T. Matsui, M. Kameda, T. Yasuhara, 2007, European Journal of Neuroscience.

Transduction of Soluble Flt-1 Gene to Peritoneal Mesothelial Cells Can Effectively Suppress Peritoneal Metastasis of Gastric Cancer

H. Ueno, H. Nagawa, H. Hamada, 2004, Cancer Research.

Gene Therapy for Pancreatic Cancer Using an Adenovirus Vector Encoding Soluble flt-1 Vascular Endothelial Growth Factor Receptor

H. Hamada, S. Egawa, H. Ohtani, 2002, Pancreas.

Further Characterization of the Human Adrenal‐derived P‐GIycoprotein Recognized by Monoclonal Antibody MRK 16 Reacting with Only Human P‐Glycoprotein

T. Tsuruo, S. Mori, H. Hamada, 1989, Japanese journal of cancer research : Gann.

Enhancement of voltage-gated Na+ channel current associated with multidrug resistance in human leukemia cells.

T. Tsuruo, E. Ogata, H. Hamada, 1987, Cancer research.

BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model.

K. Houkin, T. Tamiya, I. Date, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

I. Pastan, M. Willingham, M. Gottesman, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Enhanced brain angiogenesis in chronic cerebral hypoperfusion after administration of plasmid human vascular endothelial growth factor in combination with indirect vasoreconstructive surgery.

I. Date, H. Hamada, K. Sugiu, 2005, Journal of neurosurgery.

Successful allo-HSCT with a minimal myeloablative conditioning regimen in an adult patient with Fanconi’s anemia

S. Suzuki, S. Hanada, H. Hamada, 2012, Bone Marrow Transplantation.

Syncytial Mutations Do Not Impair the Specificity of Entry and Spread of a Glycoprotein D Receptor-Retargeted Herpes Simplex Virus

M. Yamaguchi, H. Hamada, M. Tagaya, 2016, Journal of Virology.

Short-fiber protein of ad40 confers enteric tropism and protection against acidic gastrointestinal conditions.

H. Hamada, J. C. Perales, M. Chillón, 2013, Human gene therapy methods.

Circumvention of 5‐Fluorouracil Resistance in Human Stomach Cancer Cells by Uracil Phosphoribosyltransferase Gene Transduction

H. Hamada, M. Inaba, A. Sadata, 1999, Japanese journal of cancer research : Gann.

Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease

T. Yasuhara, I. Date, H. Hamada, 2004, The European journal of neuroscience.

Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism

T. Takayama, R. Takimoto, H. Hamada, 2007, Molecular Cancer Therapeutics.

Gene transfer of CD40-ligand to dendritic cells stimulates interferon-γ production to induce growth arrest and apoptosis of tumor cells

K. Kato, H. Hamada, H. Hiratsuka, 2008, Gene Therapy.

Gene transfer of the CD40‐ligand to human dendritic cells induces NK‐mediated antitumor effects against human carcinoma cells

H. Hamada, H. Hiratsuka, Kazunori Kato, 2007, International journal of cancer.

Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID– cells.

R. Takimoto, H. Hamada, Y. Niitsu, 2004 .

Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma

S. Ishikawa, D. Komura, M. Fukayama, 2019, Scientific Reports.

Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages

T. Takayama, R. Takimoto, H. Hamada, 2008, International journal of hematology.

GM‐CSF and B7‐1 (CD80) co‐stimulatory signals co‐operate in the induction of effective anti‐tumor immunity in syngeneic mice

S. Asano, H. Hamada, M. Azuma, 1997, International journal of cancer.

Enhanced therapeutic efficacy of tumor RNA-pulsed dendritic cells after genetic modification with lymphotactin.

H. Hamada, X. Cao, Z. Xie, 1999, Human gene therapy.

Lymphotactin cotransfection enhances the therapeutic efficacy of dendritic cells genetically modified with melanoma antigen gp100

H. Hamada, S. Zheng, X. Cao, 2002, Gene Therapy.

Targeting the replication of adenovirus to p53-defective thyroid carcinoma with a p53-regulated Cre/loxP system

H. Mizuguchi, T. Hayakawa, H. Namba, 2001, Cancer Gene Therapy.

Enhanced antitumor effect of RGD fiber-modified adenovirus for gene therapy of oral cancer

H. Hamada, Yoshinori Ito, Takafumi Nakamura, 2003, Cancer Gene Therapy.

Accumulation of infectious mutants in stocks during the propagation of fiber-modified recombinant adenoviruses.

Y. Obata, H. Hamada, K. Yokoyama, 2005, Biochemical and biophysical research communications.

Co-transduction of p27Kip1 strongly augments Fas ligand- and caspase-8-mediated apoptosis in U-373MG glioma cells.

A. Asai, T. Kirino, H. Hamada, 2001, Anticancer research.

Caspase-9 transduction overrides the resistance mechanism against p53-mediated apoptosis in U-87MG glioma cells. Commentaries

M. Israel, A. Asai, T. Kirino, 2001 .

Adenovirus-mediated gene therapy for mucopolysaccharidosis VII: involvement of cross-correction in wide-spread distribution of the gene products and long-term effects of CTLA-4Ig coexpression.

H. Hamada, M. Fujino, T. Okuyama, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

Selective gene delivery into target cells by fiber-modified adenovirus

H. Hamada, Kazunori Kato, 2007 .

Amelioration of murine dextran sulfate sodium‐induced colitis by ex vivo extracellular superoxide dismutase gene transfer

T. Takayama, H. Hamada, Y. Niitsu, 2006, Inflammatory bowel diseases.

Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region

F. Motoi, Y. Saito, H. Hamada, 2006, Cancer Gene Therapy.

High-level expression of MRK 16 and MRK 20 murine monoclonal antibody-define proteins (170,000-180,000 P-glycoprotein and 85,000 protein) in leukaemias and malignant lymphomas.

T. Tsuruo, H. Hamada, I. Sugawara, 1989, British Journal of Cancer.

Selective gene transfer into neurons via Na,K‐ATPase β1. Targeting gene transfer with monoclonal antibody and adenovirus vector

T. Yamashita, H. Hamada, Kazunori Kato, 2008, The journal of gene medicine.

Superiority of interleukin-12-transduced murine lung cancer cells to GM-CSF or B7-1 (CD80) transfectants for therapeutic antitumor immunity in syngeneic immunocompetent mice.

S. Asano, H. Hamada, K. Tani, 1998, Cancer gene therapy.

Mesenchymal stem cells derived from peripheral blood protects against ischemia.

K. Houkin, J. Kocsis, H. Hamada, 2007, Journal of neurotrauma.

Bystander effect in uracil phosphoribosyltransferase/5-fluorouracil-mediated suicide gene therapy is correlated with the level of intercellular communication.

M. Tagawa, H. Namba, S. Sakiyama, 2001, International journal of oncology.

Biliary atresia: results of long-term conservative treatment and of liver transplantation.

H. Hamada, F. Gauthier, J. Valayer, 1993, Transplantation proceedings.

Generation of reactive oxygen species and activation of NF-kappaB by non-Abeta component of Alzheimer's disease amyloid.

E. Masliah, S. Futaki, Tomoki Suzuki, 2002, Journal of neurochemistry.

Spontaneous mutations in the human gene for p53 in recombinant adenovirus during multiple passages in human embryonic kidney 293 cells.

E. Suzuki, H. Hamada, K. Yokoyama, 2003, Biochemical and biophysical research communications.

Cancer-targeting gene therapy using tropism-modified adenovirus.

Kazunori Kato, M. Kuroki, H. Hamada, 2007, Anticancer research.

Proteasome Inhibitors Induce Cytochrome c–Caspase-3-Like Protease-Mediated Apoptosis in Cultured Cortical Neurons

A. Asai, T. Kirino, H. Hamada, 2000, The Journal of Neuroscience.

Oncolytic virotherapy for prostate cancer by E1A, E1B mutant adenovirus.

H. Hamada, S. Ishidoya, M. Satoh, 2007, Urology.

Targeting vectors for cancer gene therapy.

H. Hamada, Kazunori Kato, Toshihiro Tanaka, 2009, Frontiers in bioscience.

Brain tumor treatment with IL-2 and IL-12 producing autologous cancer cell vaccines.

H. Hamada, K. Lumniczky, G. Sáfrány, 2001, Advances in Experimental Medicine and Biology.

Gene therapy using an adenovirus vector for apoptosis-related genes is a highly effective therapeutic modality for killing glioma cells.

H. Hamada, N. Shinoura, 2003, Current gene therapy.

An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives

S. Futaki, K. Nagayama, R. Danev, 2008, Analytical and bioanalytical chemistry.

Adenoviral-mediated transfer of Escherichia coli uracil phosphoribosyltransferase (UPRT) gene to modulate the sensitivity of the human colon cancer cells to 5-fluorouracil.

H. Hamada, T. Hirao, H. Fujii, 2000, European journal of cancer.

Adenovirus-mediated gene therapy of gastric carcinoma using cancer-specific gene expression in vivo.

Y. Shiratori, K. Lan, M. Omata, 1997, Biochemical and biophysical research communications.

Effector Cell Analysis of Human Multidrug‐resistant Cell Killing by Mouse‐Human Chimeric Antibody against P‐Glycoprotein

T. Tsuruo, S. Sone, H. Hamada, 1992, Japanese journal of cancer research : Gann.

Keratinocyte growth factor regulates proliferation and differentiation of hematopoietic cells expressing the receptor gene K-sam.

M. Kizaki, Y. Ikeda, T. Kamata, 2002, Experimental hematology.

In vivo retention of endothelial cells adenovirally transduced with tissue-type plasminogen activator and seeded onto expanded polytetrafluoroethylene.

M. Makuuchi, Y. Sakata, H. Hamada, 2000, Journal of vascular surgery.

In vivo antitumor effect of cytotoxic T lymphocytes engineered to produce interferon-gamma by adenovirus-mediated genetic transduction.

H. Wakimoto, S. Okabe, M. Aoyagi, 1996, Biochemical and biophysical research communications.

Encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia.

T. Yasuhara, I. Date, H. Hamada, 2005, Journal of neurosurgery.

In vivo transfer of hepatocyte growth factor gene accelerates proliferation of hepatic oval cells in a 2‐acetylaminofluorene/partial hepatectomy model in rats

T. Nakamura, H. Kawasaki, S. Sell, 2000, FEBS letters.

Effectiveness of adenovirus-mediated gene transfer with CTLA4Ig in allo and xeno-transplantation.

H. Hamada, T. Kato, T. Kobayashi, 2000, Transplantation proceedings.

Effect of adenovirus-mediated gene transfer with CTLA4-Ig gene in organ transplantation.

H. Hamada, T. Kobayashi, I. Yokoyama, 1999, Transplantation proceedings.

Prolonged survival of mice with multiple liver metastases of human colon cancer by intravenous administration of replicable E1B-55K-deleted adenovirus with E1A expressed by CEA promoter.

T. Takayama, H. Hamada, Y. Niitsu, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Epigenetic Modulation Enhances the Therapeutic Effect of Anti–IL-13Rα2 Antibody in Human Mesothelioma Xenografts

H. Hamada, Kazunori Kato, H. Yagita, 2011, Clinical Cancer Research.

Ex Vivo Large Scale Generation of Human Platelets from Cord Blood CD34+ Cells.

H. Hamada, Y. Niitsu, T. Matsunaga, 2005 .

Functional analysis of CD82 in the early phase of T cell activation: roles in cell adhesion and signal transduction

H. Hamada, N. Shibagaki, S. Shimada, 1998, European journal of immunology.

Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53.

N. Mukaida, S. Sone, H. Hamada, 2001, Cancer research.

Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat

K. Houkin, J. Kocsis, H. Hamada, 2006, Experimental Neurology.

E1A, E1B double-restricted adenovirus enhances the cytotoxicity and antitumor activity of gemcitabine to renal cell carcinoma.

H. Hamada, M. Satoh, Y. Arai, 2011, Chinese medical journal.

I.v. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat

K. Houkin, T. Nomura, J. Kocsis, 2005, Neuroscience.

Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells.

A. Asai, T. Kirino, H. Hamada, 2000, Cancer letters.

[Expression and function of proteins associated with multidrug resistance].

T. Tsuruo, H. Hamada, 1989, Gan to kagaku ryoho. Cancer & chemotherapy.

Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro.

Hiroaki, Hamada, Yasushi, 1996, Cancer research.

Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.

A. Sakurada, T. Furukawa, S. Sato, 1999, International journal of oncology.

Modulation of Hepatic Sinusoidal Cell Function by Transduction of Genes in the Liver: Gene Therapy for Hepatic Micro-Metastasis

Y. Shiratori, M. Omata, H. Hamada, 1999 .

IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells.

R. Ono, T. Kitamura, H. Hamada, 2011, International Journal of Oncology.

Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5‐fluorouracil in mice

T. Takayama, R. Takimoto, H. Hamada, 2008, Hepatology.

Transplantation of sendai viral angiopoietin-1-modified mesenchymal stem cells for ischemic limb disease

H. Hamada, M. Hasegawa, Huishan Wang, 2010, Angiogenesis.

Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia

K. Houkin, J. Kocsis, H. Hamada, 2010, Brain Research.

Adenovirus-mediated gene transfer of CTLA4Ig gene results in prolonged survival of heart allograft

H. Hamada, I. Yokoyama, S. Hayashi, 2000 .

Adenovirus‐mediated gene transfer of CTLA4lg gene results in prolonged survival of heart allograft

H. Hamada, I. Yokoyama, S. Hayashi, 2000, Transplantation proceedings.

Erratum to “BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model” [Molecular Therapy 9: 189–197 (2004), doi:10.1016/j.ymthe.2003.10.012]

K. Houkin, T. Tamiya, I. Date, 2004 .