H. Flad

H. Flad, A. Ludwig, F. Petersen, 2002, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Platelet-Derived Chemokines CXC Chemokine Ligand (CXCL)7, Connective Tissue-Activating Peptide III, and CXCL4 Differentially Affect and Cross-Regulate Neutrophil Adhesion and Transendothelial Migration1

H. Flad, F. Petersen, E. Brandt, 2002, The Journal of Immunology.

Identification of Distinct Surface-Expressed and Intracellular CXC-Chemokine Receptor 2 Glycoforms in Neutrophils: N-Glycosylation Is Essential for Maintenance of Receptor Surface Expression1

H. Flad, A. Ludwig, E. Brandt, 2000, The Journal of Immunology.

Surface Expression Is Essential for Maintenance of Receptor -Glycosylation N 2 Glycoforms in Neutrophils: and Intracellular CXC-Chemokine Receptor Identification of Distinct Surface-Expressed

H. Flad, J. Ehlert, Brandt Andreas Ludwig, 2000 .

Platelet‐derived CXC chemokines: old players in new games

H. Flad, F. Petersen, E. Brandt, 2000, Immunological reviews.

Platelet factor 4-induced neutrophil-endothelial cell interaction: involvement of mechanisms and functional consequences different from those elicited by interleukin-8.

H. Flad, F. Petersen, E. Brandt, 1999, Blood.

CHEMOKINES Platelet Factor 4-Induced Neutrophil-Endothelial Cell Interaction : Involvement of Mechanisms and Functional Consequences Different From Those Elicited by Interleukin-8 By

H. Flad, F. Petersen, E. Brandt, 1999 .

Novel C-terminally truncated isoforms of the CXC chemokine beta-thromboglobulin and their impact on neutrophil functions.

J. Gerdes, H. Flad, E. Brandt, 1998, Journal of immunology.

Characterization of a platelet derived factor modulating phagocyte functions and cooperating with interleukin 1.

M. Ernst, H. Flad, H. Loppnow, 1989, Lymphokine research.

Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III.

H. Flad, J. Van Damme, E. Brandt, 1991, Cytokine.

Recombinant tumor necrosis factor-alpha potentiates neutrophil degranulation in response to host defense cytokines neutrophil-activating peptide 2 and IL-8 by modulating intracellular cyclic AMP levels.

H. Flad, F. Petersen, E. Brandt, 1992, Journal of immunology.

Neutrophil-activating peptides NAP-2 and IL-8 bind to the same sites on neutrophils but interact in different ways. Discrepancies in binding affinities, receptor densities, and biologic effects.

H. Flad, F. Petersen, E. Brandt, 1994, Journal of immunology.

Connective tissue-activating peptide III desensitizes chemokine receptors on neutrophils. Requirement for proteolytic formation of the neutrophil-activating peptide 2.

H. Flad, F. Petersen, L. Härter, 1994, Journal of immunology.

TNF-alpha renders human neutrophils responsive to platelet factor 4. Comparison of PF-4 and IL-8 reveals different activity profiles of the two chemokines.

H. Flad, A. Ludwig, F. Petersen, 1996, Journal of immunology.

Discontinuous density gradient separation of human mononuclear leucocytes using Percoll as gradient medium.

H. Flad, A. Ulmer, Artur J. Ulmer, 1979, Journal of immunological methods.

Low In Vitro Production of Interferon-γ and Tumor Necrosis Factor-α in HIV-Seronegative Patients with Pulmonary Disease Caused by Nontuberculous Mycobacteria

M. Ernst, M. Schlaak, H. Flad, 2000, Journal of Clinical Immunology.

Low in vitro production of interferon-gamma and tumor necrosis factor-alpha in HIV-seronegative patients with pulmonary disease caused by nontuberculous mycobacteria.

M. Ernst, M. Schlaak, S. Rüsch-Gerdes, 2000, Journal of clinical immunology.

Fas (CD95)-Fas Ligand Interactions Are Responsible for Monocyte Apoptosis Occurring as a Result of Phagocytosis and Killing of Staphylococcus aureus

M. Ernst, K. Węglarczyk, H. Flad, 2001, Infection and Immunity.

Species-specific assessment of Mycobacterium leprae in skin biopsies by in situ hybridization and polymerase chain reaction.

J. Gerdes, M. Ernst, M. Duchrow, 1992, Laboratory investigation; a journal of technical methods and pathology.

Effects of local bacillus Calmette-Guerin therapy in patients with bladder carcinoma on immunocompetent cells of the bladder wall.

J. Gerdes, H. Flad, A. Ulmer, 1990, The Journal of urology.

New Ki-67-equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair repetitive elements encoding for the Ki-67 epitope.

J. Gerdes, M. Duchrow, H. Flad, 1993, Laboratory investigation; a journal of technical methods and pathology.

Bacillus-Calmette-Guérin (BCG) and 3D tumors: an in vitro model for the study of adhesion and invasion.

H. Flad, A. Ulmer, A. Böhle, 1999, The Journal of urology.

Detection of interleukin 1 with human dermal fibroblasts.

H. Flad, A. Ulmer, H. Loppnow, 1989, Immunobiology.

Induction of tumor necrosis factor-alpha release by lipopolysaccharide and defined lipopolysaccharide partial structures.

H. Flad, A. Ulmer, H. Brade, 1989, Immunobiology.

Glycosphingolipids from Sphingomonas paucimobilis induce monokine production in human mononuclear cells

H. Flad, A. Ulmer, E. Rietschel, 1995, Infection and immunity.

Effect of in vitro infection of human monocytes with low numbers of Mycobacterium tuberculosis bacteria on monocyte apoptosis

M. Ernst, H. Flad, J. Gercken, 1996, Infection and immunity.

The interleukin-1 and interleukin-1 converting enzyme families in the cardiovascular system.

K. Werdan, H. Flad, H. Loppnow, 1999, European cytokine network.

Immunotherapy of leukaemias: Present status and future prospects

H. Flad, 1978, Blut.

A CASE OF IMPAIRED CHEMOTAXIS AND LYMPHOCYTE TRANSFORMATION

H. Flad, D. Niethammer, E. Kleihauer, 1976, Acta paediatrica Scandinavica.

Lipopolysaccharide‐binding protein mediates CD14‐independent intercalation of lipopolysaccharide into phospholipid membranes

H. Flad, E. Rietschel, K. Brandenburg, 1996, FEBS letters.

Biochemistry and cell biology of bacterial endotoxins.

H. Flad, O. Holst, A. Ulmer, 1996, FEMS immunology and medical microbiology.

Biochemistry and cell biology of bacterial endotoxins MiniReview

H. Flad, O. Holst, A. Ulmer, 1996 .

Ligation of CD 40 Activates Interleukin 1 b-converting Enzyme ( Caspase-1 ) Activity in Vascular Smooth Muscle and Endothelial Cells and Promotes Elaboration of Active Interleukin 1 b *

P. Libby, F. Mach, H. Flad, 1997 .

S-form LPS induces leukocyte adhesion to human vascular endothelial cells as potent as IL-1: lipid A precursor Ia antagonizes induction of adhesion by LPS

H. Flad, E. Rietschel, H. Loppnow, 1994 .

Bone marrow transplantation for aplastic anaemia from a HL-A and MLC-identical unrelated donor

H. Heimpel, H. Flad, S. Goldmann, 1975, Blut.

An examination of the immune system of the duck (Anas platyrhynchos) for factors resembling some defined mammalian cytokines.

J. Gerdes, G. Srivastava, H. Flad, 1993, Developmental and comparative immunology.

The role of fetal calf serum in the primary immune response in vitro

H. Flad, H. Lemke, W. Schreml, 1977, The Journal of experimental medicine.

Enhancement of monocyte antimycobacterial activity by diethyldithiocarbamate (DTC).

M. Ernst, H. Flad, S. Schwander, 1991, International journal of immunopharmacology.

CD26 Antigen is a Surface Dipeptidyl Peptidase IV (DPPIV) as Characterized by Monoclonal Antibodies Clone Til‐19‐4‐7 and 4EL1C7

A. Feller, H. Flad, A. Ulmer, 1990, Scandinavian journal of immunology.

The role of cytokines in monocyte apoptosis.

M. Ernst, J. Fleischer, H. Flad, 1998, Research in immunology.

Immunohistologic assessment of cytokine production of infiltrating cells in various forms of leprosy.

J. Gerdes, H. Flad, J. Arnoldi, 1990, The American journal of pathology.

CD34+ Hematopoietic Stem Cells Exert Accessory Function in Lipopolysaccharide-induced T Cell Stimulation and CD80 Expression on Monocytes

H. Flad, A. Ulmer, E. Rietschel, 1999, The Journal of experimental medicine.

Stimulation of human T lymphocytes by LPS is MHC unrestricted, but strongly dependent on B7 interactions.

H. Flad, A. Ulmer, E. Rietschel, 1998, Journal of immunology.

The involvement of CD14 in the activation of human monocytes by peptidoglycan monomers.

H. Flad, D. Muhvić, V. El-Samalouti, 2001, Mediators of inflammation.

Identification of the 80-kDa LPS-binding protein (LMP80) as decay-accelerating factor (DAF, CD55).

H. Flad, A. Ulmer, L. Brade, 1999, FEMS immunology and medical microbiology.

Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes

H. Flad, A. Ulmer, E. Rietschel, 1997, Infection and immunity.

Binding of lipopolysaccharide (LPS) to an 80-kilodalton membrane protein of human cells is mediated by soluble CD14 and LPS-binding protein

H. Flad, A. Ulmer, E. Rietschel, 1995, Infection and immunity.

Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures

H. Flad, A. Ulmer, E. Rietschel, 1994, Infection and immunity.

Induction of proliferation and cytokine production in human T lymphocytes by lipopolysaccharide (LPS).

H. Flad, A. Ulmer, T. Mattern, 2000, Toxicology.

Components of gut bacteria as immunomodulators.

H. Flad, A. Ulmer, E. Rietschel, 1998, International journal of food microbiology.

Lipopolysaccharide-induced change of phosphorylation of two cytosolic proteins in human monocytes is prevented by inhibitors of ADP-ribosylation.

H. Flad, H. Heine, S. Hauschildt, 1995, Journal of immunology.

IL-8 specifically binds to endothelial but not to smooth muscle cells.

H. Flad, H. Loppnow, U. Schönbeck, 1995, Journal of immunology.

Neutrophil-activating polypeptides IL-8 and NAP-2 induce identical signal transduction pathways in the regulation of lysosomal enzyme release.

H. Flad, J. Van Damme, F. Petersen, 1991, Lymphokine and cytokine research.

Anti-CD26 monoclonal antibodies can reversibly arrest human T lymphocytes in the late G1 phase of the cell cycle.

H. Flad, A. Ulmer, S. Ansorge, 1993, Immunobiology.

Staining pattern of seven monoclonal anti-CD26 antibodies in leprosy: implications for the use of CD26 as a surrogate marker of a human Th1-like reaction

J. Gerdes, H. Flad, D. Scheel-Toellner, 1998, Virchows Archiv.

Tumor necrosis factor alpha and lymphotoxin production in Hodgkin's disease.

D. Jones, H. Flad, A. Ulmer, 1990, The American journal of pathology.

Tumor Necrosis Factor α and Lymphotoxin Production in Hodgkin's Disease

J. Gerdes, D. Jones, H. Flad, 1990 .

Nitric oxide synthase: MRNA expression of different isoforms in human monocytes/macrophages

M. Ernst, M. Duchrow, N. Reiling, 1994, European journal of immunology.

TNF-alpha and HLA-DR genotyping as potential prognostic markers in pulmonary sarcoidosis.

J. Gerdes, H. Flad, K. Bogunia-Kubik, 1999, European cytokine network.

Tumour necrosis factor alpha promoter gene polymorphism in sarcoidosis.

J. Gerdes, P. Zabel, F. Stüber, 1997, Cytokine.

Expression of CD26 (Dipeptidyl Peptidase IV) on Resting and Activated Human T‐Lymphocytes

A. Feller, H. Flad, A. Ulmer, 1991, Scandinavian journal of immunology.

Antibody-induced modulation of CD26 surface expression.

M. Duchrow, H. Flad, A. Ulmer, 1995, Immunology.

Follicular dendritic cells productively infected with immunodeficiency viruses transmit infection to T cells

J. Gerdes, K. Toellner, M. Ernst, 1995, Medical Microbiology and Immunology.

Isolation of normal human follicular dendritic cells and CD4‐independent in vitro infection by human immunodeficiency virus (HIV‐1)

J. Gerdes, M. Ernst, H. Flad, 1991, European journal of immunology.

Detection of intracellular interleukin 2: evidence for novel immunologically related forms of the lymphokine.

H. Flad, S. Kloth, E. Brandt, 1994, Cytokine.

Follicular dendritic cells and their role in HIV infection.

J. Gerdes, H. Flad, Johannes Gerdes, 1992, Immunology today.

Reduced T‐cell receptor CD3ζ‐chain protein and sustained CD3ε expression at the site of mycobacterial infection

K. Kayser, J. Gerdes, P. Entzian, 2001 .

Elevations of cytokines interleukin-1, interleukin-2 and tumor necrosis factor in the urine of patients after intravesical bacillus Calmette-Guerin immunotherapy.

J. Gerdes, H. Flad, A. Ulmer, 1990, The Journal of urology.

Impaired recirculation of b lymphocytes in chronic lymphocytic leukemia

H. Flad, C. Huber, H. Huber, 1973, European journal of immunology.

Dipeptidyl peptidase IV as a new surface marker for a subpopulation of human T-lymphocytes.

A. Feller, H. Flad, W. Scholz, 1984, Cellular immunology.

Establishment and characterization of an Epstein-Barr virus transformed cell line with strong phagocytic activity.

H. Flad, R. Bhardwaj, H. Pielken, 1989, Blood.

Agonists and antagonists for lipopolysaccharide-induced cytokines.

H. Flad, A. Ulmer, E. Rietschel, 1993, Immunobiology.

Split chimerism in three patients suffering from severe combined immunodeficiency (SCID).

P. Wernet, H. Flad, S. Goldmann, 1980, Haematology and blood transfusion.

The Internalization Time Course of a Given Lipopolysaccharide Chemotype Does Not Correspond to Its Activation Kinetics in Monocytes

J. Gerdes, M. Ernst, H. Flad, 1999, Infection and Immunity.

Human MO subsets as defined by expression of CD64 and CD16 differ in phagocytic activity and generation of oxygen intermediates.

M. Ernst, H. Flad, J. Pryjma, 2000, Immunobiology.

Association of IL-2 Production with the Expression of Dipeptidyl Peptidase IV (DPIV) on Human T Lymphocytes

A. Feller, H. Flad, A. Ulmer, 1986 .

Isolation and subfractionation of human peripheral blood mononuclear cells (PBMC) by density gradient centrifugation on Percoll.

M. Ernst, H. Flad, A. Ulmer, 1984, Immunobiology.

Functional Relationship of Human T Lymphocytes, Monocytes and Interleukins

H. Flad, A. Ulmer, H.‐D. FLAD, 1983, Scandinavian journal of immunology.

Nitric oxide synthase: expression of the endothelial, Ca2+/calmodulin‐dependent isoform in human B and T lymphocytes

J. Gerdes, N. Reiling, H. Flad, 1996, European journal of immunology.

induces monocyte differentiation into macrophages The CXC-chemokine platelet factor 4 promotes monocyte survival and

M. Ernst, J. Fleischer, H. Flad, 2013 .

Regulation of neutrophil activation by proteolytic processing of platelet-derived alpha-chemokines.

H. Flad, A. Ludwig, F. Petersen, 1997, Advances in experimental medicine and biology.

Molecular Aspects of the Chemistry and Biology of Endotoxin

T. Kirikae, P. Zabel, M. Schlaak, 1991 .

Inhibition of HIV progression by dithiocarb

M. Dietrich, H. Flad, E. Reisinger, 1990, The Lancet.

Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells.

K. Werdan, H. Flad, E. Rietschel, 1998, Blood.

An Fcγ receptor I (CD64)‐negative subpopulation of human peripheral blood monocytes is resistant to killing by antigen‐activated CD4‐positive cytotoxic T cells

M. Ernst, H. Flad, H. Loppnow, 1997 .

Expression of CD26 (Dipeptidyl Peptidase IV) on Memory and Naive T Lymphocytes

H. Flad, A. Ulmer, T. Mattern, 1992, Scandinavian journal of immunology.

Factor 4 and Is Involved in Cell ActivationPlatelet Human Neutrophils Specifically Binds A Chondroitin Sulfate Proteoglycan on

H. Flad, F. Petersen, E. Brandt, 1998 .

The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2.

O. Götze, H. Flad, A. Ludwig, 1997, Blood.

Lipopolysaccharide and peptidoglycan: CD14-dependent bacterial inducers of inflammation.

H. Flad, A. Ulmer, E. Rietschel, 1998, Microbial drug resistance.

Inhibition of LPS binding on human monocytes by phosphonooxyethyl analogs of lipid A

H. Flad, H. Heine, A. Ulmer, 1994 .

Chemical structure and biologic activity of bacterial and synthetic lipid A.

H. Flad, B. Lindner, E. Rietschel, 1987, Reviews of infectious diseases.

An Fc gamma receptor I (CD64)-negative subpopulation of human peripheral blood monocytes is resistant to killing by antigen-activated CD4-positive cytotoxic T cells.

M. Ernst, H. Flad, H. Loppnow, 1997, European journal of immunology.

Platelet Factor 4 Inhibits Proliferation and Cytokine Release of Activated Human T Cells1

M. Ernst, J. Fleischer, H. Flad, 2002, The Journal of Immunology.

CellsCytokine Release of Activated Human T Platelet Factor 4 Inhibits Proliferation and and

M. Ernst, J. Fleischer, H. Flad, 2002 .

Mycobacterial nucleic acids in sarcoid lesions.

H. Magnussen, J. Gerdes, M. Schlaak, 1992, Lancet.

Effects of systemicin vivo interleukin-2 (IL-2) reconstitution in patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC) on phenotypes and functions of peripheral blood mononuclear cells (PBMC)

M. Ernst, H. Flad, A. Ulmer, 1986, Journal of Clinical Immunology.

Histocompatibility testing in dogs. II. Leukocyte typing in relation to the mixed lymphocyte culture (MLC) reactivity.

H. Flad, S. Goldmann, K. Krumbacher, 2008, Tissue antigens.

On the mode of action of intravesical bacillus Calmette-Guérin: in vitro characterization of BCG-activated killer cells

M. Ernst, H. Flad, A. Ulmer, 2004, Urological Research.

CD26 (dipeptidyl peptidase i.v.) on human T lymphocytes does not mediate adhesion of these cells to endothelial cells or fibroblasts.

H. Flad, A. Ulmer, H. Loppnow, 1998, Immunobiology.

Differential expression and function of CD80 (B7‐1) and CD86 (B7‐2) on human peripheral blood monocytes

M. Ernst, J. Fleischer, N. Reiling, 1996, Immunology.

HIV‐1 envelope protein gp120 affects phenotype and function of monocytes in vitro

M. Ernst, H. Flad, I. Dürrbaum-Landmann, 1994, Journal of leukocyte biology.

Induction of cytokines in mononuclear and vascular cells by endotoxin and other bacterial products.

H. Flad, E. Rietschel, H. Brade, 1994, Methods in enzymology.

Specific Activation of Human Peripheral Blood γ/δ+ T Lymphocytes by Sonicated Antigens of Mycobacterium tuberculosis: Role In Vitro in Killing Human Bladder Carcinoma Cell Lines

M. Ernst, H. Flad, A. Ulmer, 1993, Scandinavian journal of immunology.

Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells, and IL-2 and IL-6 production.

H. Flad, A. Ulmer, F. Bühling, 1993, Immunobiology.

Inhibition of interleukin-6 release and T-cell proliferation by synthetic mirror pseudo cord factor analogues in human peripheral blood mononuclear cells.

H. Flad, A. Ulmer, W. Feist, 1993, FEMS immunology and medical microbiology.

Inhibition of endotoxin-induced interleukin-6 production by synthetic lipid A partial structures in human peripheral blood mononuclear cells

H. Flad, A. Ulmer, E. Rietschel, 1991, Infection and immunity.

Suppressive effect of lipid A partial structures on lipopolysaccharide or lipid A-induced release of interleukin 1 by human monocytes.

H. Flad, A. Ulmer, E. Rietschel, 1990, FEMS microbiology immunology.

The effect of interleukin 2 on Fc-gamma receptor function of human monocytes requires specific intercellular interaction.

M. Ernst, H. Flad, J. Ennen, 1989, Immunobiology.

Functional relationships of human T-lymphocytes and interleukins: I. Different accessory cell requirements of human T-lymphocyte subpopulations for generation of interleukin-2.

H. Flad, A. Ulmer, 1982, Immunobiology.

IL-1 induction-capacity of defined lipopolysaccharide partial structures.

H. Flad, C. Dinarello, E. Rietschel, 1989, Journal of immunology.

Specific binding of bacillus Calmette-Guérin to urothelial tumor cells in vitro

E. Vollmer, H. Flad, A. Ulmer, 2004, World Journal of Urology.

Perforin-mediated lysis of tumor cells by Mycobacterium bovis Bacillus Calmette-Guérin-activated killer cells.

H. Flad, A. Böhle, D. Jocham, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Cell proliferation-associated nuclear antigen defined by antibody Ki-67: a new kind of cell cycle-maintaining proteins.

M. Kubbutat, J. Gerdes, M. Duchrow, 1995, Archivum immunologiae et therapiae experimentalis.

Presence of mRNA for interferon‐gamma (IFN‐γ) in blood mononuclear cells is associated with an active stage I sarcoidosis

J. Gerdes, H. Flad, A. Lange, 1995, Clinical and experimental immunology.

Stimulation of human T lymphocytes by lipopolysaccaride (LPS) in the presence of autologous and heterologous monocytes.

H. Flad, A. Ulmer, T. Mattern, 1998, Progress in clinical and biological research.

Dissociation of responses measured by natural cytotoxicity and chemiluminescence

M. Ernst, H. Flad, A. Ulmer, 1984, European journal of immunology.

Interleukin 2 induces appearance of LGL/Leu11+/K562 lytic cells in Leu11- low density peripheral blood mononuclear cell population.

M. Ernst, H. Flad, A. Ulmer, 1987, Immunology letters.

The repopulation of lymph nodes of dogs after 1200 R whole-body x-irradiation and intravenous administration of mononuclear blood leukocytes.

H. Flad, E. Herbst, T. Fliedner, 1976, The American journal of pathology.

Disseminated mycobacterial histiocytosis due to M. fortuitum associated with helper T-lymphocyte immune deficiency

H. Müller-Hermelink, H. Heimpel, H. Flad, 2004, Virchows Archiv A.

Bacterial Endotoxins: Relationships Between Chemical Structure and Biological Activity

H. Flad, E. Rietschel, U. Zähringer, 1989 .

Effects of colony-stimulating factors on cellular cytotoxicity

Ingmar B. Schäfer, M. Ernst, H. Flad, 1997, Cancer Immunology, Immunotherapy.

Apoptosis of monocytes and prolonged survival of granulocytes as a result of phagocytosis of bacteria

M. Ernst, H. Flad, J. Pryjma, 1996, Infection and immunity.

The human germinal centre cells, follicular dendritic cells and germinal centre T cells produce B cell-stimulating cytokines.

J. Gerdes, K. Toellner, M. Ernst, 1995, Cytokine.

Biochemical characterization of a factor released by macrophages.

R. Jackson, H. Flad, H. Lemke, 1975, Cellular immunology.

Immunoenzymatic assessment of interferon-γ in hodgkin and sternberg-reed cells

J. Gerdes, M. Ernst, D. Jones, 1990 .

Transforming growth factor-β1 (TGF-β1) inhibits DNA synthesis of PWM-stimulated PBMC via suppression of IL-2 and IL-6 production

H. Flad, A. Ulmer, U. Lendeckel, 1994 .

Corticosteroid-interleukin 2 interactions: inhibition of binding of interleukin 2 to interleukin 2 receptors.

H. Flad, H. Horst, 1987, Clinical and experimental immunology.

Influence of human T lymphocytes identified by antibodies to dipeptidyl peptidase IV on differentiation of human B lymphocytes stimulated with Staphylococcus aureus Cowan I and pokeweed mitogen.

H. Flad, W. Scholz, M. Gruber, 1988, Cellular immunology.

Treatment of aplastic anemia by blood stem cell transfusion: a canine model.

W. Ross, W. Nothdurft, H. Flad, 1976, Haematologica.

Stimulation of human and murine adherent cells by bacterial lipoprotein and synthetic lipopeptide analogues.

W. Bessler, H. Flad, A. Ulmer, 1988, Immunobiology.

Comparative study of CD26 as a Th1-like and CD30 as a potential Th2-like operational marker in leprosy.

J. Gerdes, H. Flad, D. Scheel-Toellner, 1997, Advances in experimental medicine and biology.

Human follicular dendritic cells and vascular cells produce interleukin‐7: a potential role for interleukin‐7 in the germinal center reaction

J. Gerdes, H. Flad, H. Loppnow, 1996, European journal of immunology.

Monocyte‐T‐Cell Interactions in the Regulation of Polyclonal B‐Cell Response

M. Ernst, H. Flad, J. Pryjma, 1986, Scandinavian journal of immunology.

Heterogeneity of human peripheral blood monocyte subsets

M. Ernst, H. Flad, E. Grage‐griebenow, 2001, Journal of leukocyte biology.

Identification of a novel dendritic cell‐like subset of CD64+ / CD16+ blood monocytes

M. Ernst, R. Zawatzky, H. Flad, 2001, European journal of immunology.

Joint report of 1st International Workshop on Canine Immunogenetics.

H. Flad, L. Bernini, R. Saison, 1973, Tissue antigens.

Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.

R R Schumann, U Seydel, H. Flad, 1996, Current topics in microbiology and immunology.

The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins

J. Gerdes, M. Duchrow, H. Flad, 1993, The Journal of cell biology.

Assessment of mycobacterial DNA in cells and tissues of mycobacterial and sarcoid lesions.

H. Magnussen, J. Gerdes, M. Schlaak, 1996, American journal of respiratory and critical care medicine.

Phase I evaluation of bestatin in patients bearing advanced solid tumors

M. Beltzer, H. Flad, G. Mathé, 1980 .

Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67.

J. Gerdes, M. Duchrow, H. Flad, 1991, The American journal of pathology.

Interleukin 1 and related cytokines.

K. Resch, H. Flad, H. Kirchner, 1989, Lymphokine research.

Correlation between cytokinetically resting lymphocytes and bone marrow restoration: experiments using a discontinuous albumin gradient.

H. Flad, T. Fliedner, R. Haas, 1973, Blood.

Immunodiagnosis and Immunotherapy of Malignant Tumors

C. Herfarth, H. Flad, M. Betzler, 1979, Springer Berlin Heidelberg.

Alterations in structure and cellular localization of molecular forms of DP IV/CD26 during T cell activation.

H. Flad, A. Ulmer, T. Kähne, 1996, Cellular immunology.

Humoral primary immune response in vitro in a homologous mouse system: replacement of fetal calf serum by a 2-mercaptoethanol or macrophage-activated fraction of mouse serum.

H. Flad, H. Lemke, U. Opitz, 1977, Journal of immunology.

Phenotypical and functional characterization of Fey receptor I (CD64)‐negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity

Dirk Lorenzen, M. Ernst, H. Flad, 1993, European journal of immunology.

Biological activity of synthetic phosphonooxyethyl analogs of lipid A and lipid A partial structures

H. Flad, H. Heine, A. Ulmer, 1992, Infection and immunity.

Induction of human interleukin 1 by bacterial and synthetic lipid A

H. Flad, H. Brade, S. Kusumoto, 1986, European journal of immunology.

CFU-C populations in blood and bone marrow of dogs after lethal irradiation and allogeneic transfusion with cryopreserved blood mononuclear cells.

W. Ross, W. Nothdurft, H. Flad, 2009, Scandinavian journal of haematology.

Detection of urinary TNF, IL 1, and IL 2 after local BCG immunotherapy for bladder carcinoma.

J. Gerdes, H. Flad, A. Ulmer, 1990, Cytokine.

Induction of bacillus-Calmette-Guérin-activated killer cells from human peripheral blood mononuclear cells against human bladder carcinoma cell lines in vitro

M. Ernst, H. Flad, A. Ulmer, 1993, Cancer Immunology, Immunotherapy.

The induction of bacillus-Calmette-Guérin-activated killer cells requires the presence of monocytes and T-helper type-1 cells

M. Ernst, N. Reiling, H. Flad, 1995, Cancer Immunology, Immunotherapy.

Cellular cytotoxicity of human natural killer cells and lymphokine-activated killer cells against bladder carcinoma cell lines.

H. Flad, A. Ulmer, M. H. Wang, 1991, Immunology letters.

Autologous Regulation of rIL-2-Activated Natural Killer Cells

M. Ernst, H. Flad, B. Jaźwiec, 1990 .

Binding characteristics of a monoclonal antibody against human IL-2 and its application for IL-2 measurement.

H. Flad, A. Ulmer, E. Brandt, 1986, Lymphokine research.

In vitro generation of bacillus Calmette-Guérin-activated killer cells.

M. Ernst, H. Flad, A. Ulmer, 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Dissecting the immunobiological effects of Bacillus Calmette-Guérin (BCG) in vitro: evidence of a distinct BCG-activated killer (BAK) cell phenomenon.

M. Ernst, H. Flad, A. Ulmer, 1993, The Journal of urology.

Reduction of side effects of intravesical therapy with bacille Calmette-Guérin by pentoxifylline?--an in vitro approach.

M. Ernst, S. Rüsch-Gerdes, H. Flad, 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Graft-versus-host reaction after blood transfusion in a patient with cellular immunodeficiency: The role of histocompatibility testing

U. Töllner, H. Flad, S. Goldmann, 1979, European Journal of Pediatrics.

The effect of vitamin A on experimental immune thyroiditis.

H. Flad, D. Koffler, P. Miescher, 1967, International Archives of Allergy and Applied Immunology.

In Vitro Cellular Cytotoxicity Against Human Bladder Carcinoma Cell Lines

H. Flad, A. Ulmer, A. Böhle, 1991 .

Inhibition of 3H-thymidine incorporation of lymphocytes by a soluble factor from macrophages.

H. Flad, H. Lemke, D. Niethammer, 1975, Cellular immunology.

Long-term immunobiological effects of intravesical bacillus Calmette-Guérin against bladder carcinoma recurrences.

J. Gerdes, H. Flad, A. Ulmer, 1992, Developments in biological standardization.

Interleukin 2 as an inducer of proliferation in Klebsiella-stimulated human B cells.

M. Ernst, F. Stüber, H. Flad, 1989, Clinical immunology and immunopathology.

A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation.

H. Flad, F. Petersen, E. Brandt, 1998, Journal of immunology.

Adjuvant and suppressor activity of the polycation protamine hydrochloride in the primary immune response of mice.

H. Flad, H. Opitz, R. Huget, 1976, Zeitschrift fur Immunitatsforschung. Immunobiology.

PRODUCTION OF CYTOKINES (TNF‐ALPHA, IL‐1‐BETA) AND ENDOTHELIAL CELL ACTIVATION IN HUMAN LIVER ALLOGRAFT REJECTION1

H. Flad, Prof. Dr. med. Gustav Steinhoff, H. Herzbeck, 1993, Transplantation.

Bone marrow transplanation for severe combined immunodeficiency with the HL-A-incompatible but MLC-identical mother as a donor.

H. Flad, S. Goldmann, T. Fliedner, 1976, Transplantation proceedings.

Expression and specificity of FcIgG receptor sites on neoplastic lymphocytes

H. Flad, C. Huber, H. Wigzell, 1978 .

The Role of Cytokines in Monocyte Apoptosis

M. Ernst, H. Flad, J. Pryjma, 2000, Pathobiology.

Nature of reconstitution with histoincompatible maternal marrow in a case of severe combined immunodeficiency with graft-versus-host disease following maternofetal transfusion.

H. Flad, S. Goldmann, B. Belohradsky, 1981, Clinical immunology and immunopathology.

Proliferation-associated Ki-67 protein is a target for autoantibodies in the human autoimmune disease systemic lupus erythematosus.

M. Kubbutat, J. Gerdes, H. Flad, 1998, Laboratory investigation; a journal of technical methods and pathology.

Bithermic Complement Activation in Cryoglobulinaemic Serum

H. Flad, U. Rother, P. Miescher, 1972, European journal of clinical investigation.

Mycobacterial nucleic acids in sarcoid lesions

J. Gerdes, M. Schlaak, S. Rüsch-Gerdes, 1992, The Lancet.

Definition of MLC specificities in the dog.

H. Flad, S. Goldmann, K. Krumbacher, 1975, Transplantation proceedings.

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages.

M. Ernst, J. Fleischer, H. Flad, 2000, Blood.

The β‐thromboglobulins and platelet factor 4: blood platelet‐derived CXC chemokines with divergent roles in early neutrophil regulation

H. Flad, A. Ludwig, F. Petersen, 2000, Journal of leukocyte biology.

Control of Mycobacterial Replication in Human Macrophages: Roles of Extracellular Signal-Regulated Kinases 1 and 2 and p38 Mitogen-Activated Protein Kinase Pathways

M. Ernst, N. Reiling, A. Blumenthal, 2002, Infection and Immunity.

Hemopoietic and lymphopoietic split chimerism in severe combined immunodeficiency disease (SCID).

U. Töllner, E. Gelfand, H. Flad, 1979, Transplantation proceedings.

Functional and molecular characterization of a monoclonal antibody against human interleukin 2.

H. Flad, A. Ulmer, E. Brandt, 1986, Immunobiology.

B and T lymphocyte colony formation in agar: 2-mercaptoethanol-activated albumin can substitute for 2-mercaptoethanol.

H. Flad, M. H. Claësson, H. Opitz, 1979, Cellular immunology.

Membrane dynamics of HL-A-anti-HL-A complexes of human normal and leukaemic lymphocytes.

H. Flad, H. D. Menne, H. Menne, 1973, Clinical and experimental immunology.

Interleukin 2 production by human T lymphocytes identified by antibodies to dipeptidyl peptidase IV.

A. Feller, H. Flad, A. Ulmer, 1985, Cellular immunology.

FcR+ and FcR- monocytes differentially secrete monokines during pokeweed mitogen-induced T-cell-monocyte interactions.

M. Ernst, H. Flad, H. Loppnow, 1992, Immunology.

Immunoglobulin production of human lymphocytes stimulated by Staphylococcus aureus Cowan I and pokeweed mitogen: differential effects of recombinant interleukin-2.

M. Ernst, H. Flad, A. Ulmer, 1986, Immunology.

Pokeweed mitogen activated suppressor T-cells preferentially reduce immunoglobulin secretion by differentiated B-lymphocytes.

M. Ernst, H. Flad, J. Pryjma, 1986, Immunology letters.

Augmentation of interleukin 2-activated cytotoxicity after treatment of cells with inhibitors of interferon production.

M. Ernst, H. Flad, B. Jaźwiec, 1991, Cellular immunology.

Effect of human recombinant interleukin 2 on natural killing of low density Percoll fraction cells.

M. Ernst, H. Flad, A. Ulmer, 1986, Immunology letters.

Cell-mediated lympholysis in dogs: studies of the cytotoxic mechanism.

H. Flad, S. Goldmann, K. Krumbacher, 1975, Transplantation proceedings.

Response of human T lymphocytes to phytohemagglutinin (PHA) after sequential depletion of monocytes, HLA-DR+, Leu11a+, and Leu7+ cells.

M. Ernst, H. Flad, A. Ulmer, 1985, Immunobiology.

Application of a new ultra-microculture system. II. Stimulation of human B lymphocytes.

H. Flad, A. Ulmer, M. Gruber, 1988, Journal of immunological methods.

Pentoxifylline: a potent inhibitor of IL-2 and IFN-gamma biosynthesis and BCG-induced cytotoxicity.

K. Toellner, M. Ernst, M. Duchrow, 1993, Immunology.

Apoptosis in monocytes.

M. Ernst, H. Flad, H. Loppnow, 1999, European cytokine network.

Cytokine production and proliferative capacity of infiltrating cells in various forms of leprosy.

J. Gerdes, H. Flad, J. Arnoldi, 1990, Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit.

Mycobacterium leprae DNA content, cellular and cytokine patterns in skin lesions of leprosy patients undergoing multidrug therapy (MDT).

J. Gerdes, M. Duchrow, H. Flad, 1994, Immunobiology.

Inhibition of endotoxin or lipid A-induced tumor necrosis factor production by synthetic lipid A partial structures in human peripheral blood mononuclear cells.

J. Gerdes, H. Flad, A. Ulmer, 1992, Lymphokine and cytokine research.

Bacterial endotoxin: molecular relationships between structure and activity.

H. Flad, A. Ulmer, E. Rietschel, 1991, Infectious disease clinics of North America.

Detection of Mycobacterium leprae by three-primer PCR.

J. Gerdes, M. Duchrow, H. Flad, 1994, Immunobiology.

CD26 is not required for infection of the lymphoma cell line C8166 with HIV-1.

R. Kurth, H. Flad, A. Ulmer, 1994, AIDS.

Interleukin 1 and tumor necrosis factor: studies on the induction by lipopolysaccharide partial structures.

H. Flad, A. Ulmer, E. Rietschel, 1989, Lymphokine research.

Book reviews

H. Heimpel, H. Flad, F. Porzsolt, 2004, Blut.

Lissencephaly, abnormal lymph nodes, and T-cell deficiency in one patient.

M. Ernst, H. Flad, A. Ulmer, 1989, American journal of medical genetics.

A new ultra-microculture system. I. Stimulation of human T lymphocytes by phytohemagglutinin (PHA).

H. Flad, A. Ulmer, W. Scholz, 1984, Journal of immunological methods.

One-stage stimulation of human T-lymphocyte colony-forming units (TL-CFU) in a micro agar culture in glass capillaries.

H. Flad, A. Ulmer, 1979, Immunology.

CD26 expression in leprosy and other granulomatous diseases correlates with the production of interferon-gamma.

J. Gerdes, K. Toellner, H. Wacker, 1995, Laboratory investigation; a journal of technical methods and pathology.

Actin: a target of lipopolysaccharide-induced phosphorylation in human monocytes.

M. Mann, M. Mann, O. Jensen, 1997, Biochemical and biophysical research communications.

Promotion of L1210 tumour growth by macrophages.

H. Flad, H. Opitz, R. Huget, 1978, Zeitschrift fur Immunitatsforschung. Immunobiology.

Altered antigen-presenting capacity of human monocytes after phagocytosis of bacteria

M. Ernst, H. Flad, J. Pryjma, 1994, Infection and immunity.

The role of monocytes in the induction and regulation of IFN-gamma production by lectin-activated human T lymphocytes.

M. Ernst, H. Flad, J. Pryjma, 1991, European cytokine network.

Monocyte-T-cell interactions in pokeweed mitogen-activated cultures.

M. Ernst, H. Flad, J. Pryjma, 1990, Immunology.

T-lymphocyte colony formation of murine spleen cells in a one-stage micro agar culture.

H. Flad, A. Ulmer, H. Opitz, 1981, Journal of immunological methods.

Separation of human lymphocytes by free-flow electrophoresis.

H. Flad, R. Pabst, F. Trepel, 1973, Biomedicine / [publiee pour l'A.A.I.C.I.G.].

Epitope analysis of antibodies recognising the cell proliferation associated nuclear antigen previously defined by the antibody Ki-67 (Ki-67 protein).

M. Kubbutat, J. Gerdes, M. Duchrow, 1994, Journal of clinical pathology.

In vitro effects of phytohemagglutinin and brain antigen on cell transfer of experimental autoimmune encephalomyelitis in Lewis rats.

H. Flad, P. Y. Paterson, P. Mischer, 1968, Journal of immunology.

Expression and specificity of FcIgG receptor sites on neoplastic lymphocytes.

H. Flad, C. Huber, H. Wigzell, 1978, Blood.

Adjuvant intermittent chemoimmunotherapy for primary breast cancer: a prospective study with immunologic follow-up.

H. Heimpel, P. Schlag, C. Herfarth, 1982, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Quantitative and Functional Studies of Lymphocyte Subpopulations During Adjuvant Chemo(immuno)therapy in Patients with Breast Cancer

H. Heimpel, C. Herfarth, H. Flad, 1979 .

K cell activity of normal and chronic lymphocytic leukaemia lymphocytes: association with lymphocytes bearing receptors for human C3b.

H. Flad, M. Dierich, U. Fink, 1977, Haematology and blood transfusion.

Polyclonal stimulation of lymphocytes by macrophages

H. Flad, H. Lemke, U. Opitz, 1976, European journal of immunology.

Molecular characterization of the gene locus of the human cell proliferation‐associated nuclear protein defined by monoclonal antibody Ki‐67

J. Gerdes, M. Duchrow, H. Flad, 1996, Cell proliferation.

Functional and Molecular Characterization of a Monoclonal Antibody against the 165–186 Peptide of Human 1β

W. Roenspeck, H. Flad, A. Ulmer, 1989, Scandinavian journal of immunology.

The use of reverse transcription polymerase chain reaction to analyse large numbers of mRNA species from a single cell.

J. Gerdes, K. Toellner, L. Trümper, 1996, Journal of immunological methods.

Immunoenzymatic assessment of interferon-gamma in Hodgkin and Sternberg-Reed cells.

J. Gerdes, M. Ernst, D. Jones, 1990, Cytokine.

An improved method for the species‐specific assessment of mycobacteria in routinely formalin‐fixed and paraffin‐embedded tissues

J. Gerdes, S. Rüsch-Gerdes, M. Duchrow, 1995, The Journal of pathology.

The interaction of human peripheral blood eosinophils with bacterial lipopolysaccharide is CD14 dependent.

H. Behrendt, H. Flad, A. Ulmer, 2001, Blood.

The Interaction of Human Peripheral Blood Eosinophils with Bacterial

H. Behrendt, H. Flad, A. Ulmer, 2001 .

Limited and Defined Truncation at the C Terminus Enhances Receptor Binding and Degranulation Activity of the Neutrophil-activating Peptide 2 (NAP-2)

M. Kubbutat, J. Gerdes, H. Flad, 1995, The Journal of Biological Chemistry.

A novel molecular variant of the neutrophil-activating peptide NAP-2 with enhanced biological activity is truncated at the C-terminus: identification by antibodies with defined epitope specificity.

H. Flad, F. Petersen, E. Brandt, 1993, Molecular immunology.

Expression and functional role of dipeptidyl peptidase IV (CD26) on human natural killer cells.

M. Ernst, H. Flad, A. Ulmer, 1994, Natural immunity.

Macrophages/monocytes require cell-to-cell contact in order to regulate the growth of a murine lymphoma cell line.

H. Flad, G. Hewlett, H. Schlumberger, 1979, Journal of Immunology.

Fcγ receptor I (CD64)‐negative human monocytes are potent accessory cells in viral antigen‐induced T cell activation and exhibit high IFN‐α‐producing capacity

M. Ernst, H. Flad, E. Grage‐griebenow, 1996, Journal of leukocyte biology.

Reduced T-cell receptor CD3zeta-chain protein and sustained CD3epsilon expression at the site of mycobacterial infection.

K. Kayser, J. Gerdes, P. Entzian, 2001, Immunology.

Modulation of lipopolysaccharide-induced production of tumor necrosis factor, interleukin 1, and interleukin 6 by synthetic precursor Ia of lipid A.

J. Gerdes, H. Flad, Ming-Hai Wang, 1992, FEMS microbiology immunology.

Binding of lipopolysaccharide (LPS) to CHO cells does not correlate with LPS‐induced NF‐κB activation

H. Flad, A. Ulmer, E. Rietschel, 2000, European journal of immunology.

Activation of human monocytes by interleukin 2: role of T lymphocytes.

M. Ernst, H. Flad, J. Ennen, 1991, Journal of bioluminescence and chemiluminescence (Print).

The involvement of CD14 in the activation of human monocytes by peptidoglycan monomers.

H. Flad, D. Muhvić, V. El-Samalouti, 2001, Mediators of inflammation.

Role of ADP-ribosylation in activated monocytes/macrophages.

H. Flad, S. Hauschildt, P. Scheipers, 1997, Advances in experimental medicine and biology.

Mitogen-Activated Protein Kinase Activity Differentially Regulated at the Level of Formation by Human Macrophages Is and IL-10 a Mycobacteria-Induced TNF-Ernst

N. Reiling, H. Flad, Ernst, 2022 .

Elimination of monocytes from cultures activated with recall antigens.

M. Ernst, H. Flad, J. Pryjma, 1995, Immunology letters.

CD14, An Innate Immune Receptor for Various Bacterial Cell Wall Components

H. Flad, A. Ulmer, E. Rietschel, 2020 .

Suppression of in vitro primary immune response by L1210 cells and their culture supernatant: evidence for cytotoxic effects.

H. Flad, H. Opitz, R. Huget, 1977, Cellular immunology.

Down-regulation of neutrophil functions by the ELR(+) CXC chemokine platelet basic protein.

H. Flad, B. Lindner, A. Ludwig, 2000, Blood.

Zeitschrift Für Immunitätsforschung Editors Editor-in-chief Gustav Fischer Verlag @bullet Stuttgart @bullet New York @bullet 1993 Tumor-induced Macrophage Tumor Necrosis Factor-oc Production Suppresses Autoreactive T Cell Proliferation 430 Induction of Ige and Iggl in Human B Cell Cultures with Stap

R. Brezinschek, G. Vanham, S. Euvrard, 2011 .

Possible Bithermic Pathomechanism in Cryoglobulinemic Vasculitis

H. Flad, U. Rother, P. Miescher, 1969 .

Effect of dexamethasone on mechanisms responsible for regulation of polyclonal B-cell response.

M. Ernst, H. Flad, J. Pryjma, 1989, International journal of immunopharmacology.

The biology of endotoxin.

H. Flad, H. Heine, A. Ulmer, 2001, Molecular biotechnology.

[Circulating immune complexes and NK activity in systemic lupus erythematosus].

M. Schlaak, H. Flad, W. Gross, 1984, Immunitat und Infektion.

Within the spectral forms of leprosy cellbound CD30 cannot be regarded as an operational marker for the Th2‐like reaction

J. Gerdes, H. Flad, U. Seitzer, 1996, Journal of leukocyte biology.

PROPERTIES OF MULTINUCLEATED GIANT CELLS IN A NEW IN VITRO MODEL FOR HUMAN GRANULOMA FORMATION

J. Gerdes, K. Toellner, N. Reiling, 1997, The Journal of pathology.

Adjuvant intermittent chemo-immunotherapy of breast cancer. A prospective study.

H. Heimpel, P. Schlag, C. Herfarth, 1980, European journal of cancer.