J. Stone

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Mitogen-Activated Protein Kinase in T Cells: and -Independent Activation of Evidence for Protein Kinase C-Dependent

Ostergaard, L. Puente, J. Stone, 2000 .

Evidence for Protein Kinase C-Dependent and -Independent Activation of Mitogen-Activated Protein Kinase in T Cells: Potential Role of Additional Diacylglycerol Binding Proteins1

James C. Stone, L. Puente, J. Stone, 2000, The Journal of Immunology.

Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts.

A. Gomez-Muñoz, J. Stone, A. Martín, 1993, The Journal of biological chemistry.

Rap1a Null Mice Have Altered Myeloid Cell Functions Suggesting Distinct Roles for the Closely Related Rap1a and 1b Proteins1

Pradip De, Akira Yamauchi, Mark H. Kaplan, 2007, The Journal of Immunology.

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α

J. Stone, T. Gajewski, Y. Zha, 2006, Nature Immunology.

RasGRPs Are Targets of the Anti-Cancer Agent Ingenol-3-Angelate

P. Blumberg, J. Stone, A. Lopez-Campistrous, 2013, PloS one.

Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.

I. Enyedy, P. Blumberg, J. Stone, 2001, Journal of medicinal chemistry.

Sos1 regulates sustained TCR‐mediated Erk activation

B. Schraven, J. Stone, M. Poltorak, 2014, European journal of immunology.

RasGRP 1 Regulates Antigen-Induced Developmental Programming by Naive CD 8 T Cells

J. Stone, Xiaoxi Chen, L. Zenewicz, 2009 .

A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1

J C Stone, D. Lowy, J. Declue, 1991, Molecular and cellular biology.

ras effector loop mutations that dissociate p120GAP and neurofibromin interactions

J. Stone, D. Bottorff, S. Stang, 1996, Molecular carcinogenesis.

Genetic definition of ras effector elements

J. Stone, R. A. Blanchard, 1991 .

Synthetic bryostatin analogues activate the RasGRP1 signaling pathway.

J. Stone, P. Wender, J. Baryza, 2004, Journal of medicinal chemistry.

RasGRP1 Is Essential for Ras Activation by the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate in Epidermal Keratinocytes

J. Stone, N. Dower, P. Lorenzo, 2010, The Journal of Biological Chemistry.

Potential Role of Granulocyte Colony-Stimulating Factor

J. Stone, J. Cline, N. Dower, 2009 .

RasGRP1 transgenic mice develop cutaneous squamous cell carcinomas in response to skin wounding: potential role of granulocyte colony-stimulating factor.

J. Stone, J. Cline, N. Dower, 2009, The American journal of pathology.

RasGRP1 Represents a Novel Non-protein Kinase C Phorbol Ester Signaling Pathway in Mouse Epidermal Keratinocytes*

P. Blumberg, J. Stone, P. Lorenzo, 2003, Journal of Biological Chemistry.

Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts

A. Gomez-Muñoz, J. Stone, D. Brindley, 1997, Oncogene.

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

J. Stone, H. Ostergaard, D. Bottorff, 2000, Nature Immunology.

RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.

J. Stone, J. Priatel, H. Teh, 2002, Immunity.

RasGRP links T-cell receptor signaling to Ras.

P. Blumberg, J. Stone, H. Ostergaard, 2000, Blood.

Alkali lability of bacteriophage phi W-14 DNA

J. Stone, R. Miller, R. Warren, 1975, Journal of virology.

p21-ras effector domain mutants constructed by "cassette" mutagenesis

D. Lowy, W. Vass, J. Stone, 1988, Molecular and cellular biology.

RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions

J. Stone, D. Bottorff, J. Ebinu, 1999, Mammalian Genome.

Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction

J. Stone, D. Bottorff, M. Colleton, 1993, Molecular and cellular biology.

Functional links between diacylglycerol and phosphatidylinositol signaling systems in human leukocyte-derived cell lines.

J. Stone, H. Poon, 2009, Biochemical and biophysical research communications.

A Novel Pathway for Tumor Necrosis Factor-α and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, p21 ras , and Phosphatidylinositol 3-Kinase*

J. Stone, James Xu, D. Brindley, 1999, The Journal of Biological Chemistry.

Targeted deletion of RasGRP1 impairs skin tumorigenesis.

Junfang Ji, J. Ramos, J. Stone, 2014, Carcinogenesis.

Construction and expression of linker insertion and site-directed mutants of v-fps protein-tyrosine kinase.

M. Moran, T. Pawson, J. Stone, 1991, Methods in enzymology.

Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis

T. Pawson, Michael B. Smith, J. Stone, 1984, Cell.

RasGRP 1 and RasGRP 3 Regulate B Cell Proliferation by Facilitating B Cell Receptor-Ras Signaling 1

J. Stone, N. Dower, S. Stang, 2005 .

T Cell Activation In Vivo Targets Diacylglycerol Kinase α to the Membrane: A Novel Mechanism for Ras Attenuation1

C. Martínez-A, I. Mérida, David R. Jones, 2003, The Journal of Immunology.

T Cells Developmental Programming by Naive CD8 RasGRP1 Regulates Antigen-Induced

Chow, J. Stone, Xiaoxi Chen, 2009 .

Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

B. Lim, T. Chevassut, Xiaoyu Li, 2012, Immunity.

Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis*

S. Grinstein, M. Gold, R. Harrison, 2009, The Journal of Biological Chemistry.

Expression of a catalytically inactive form of diacylglycerol kinase α induces sustained signaling through RasGRP

I. Mérida, David R. Jones, J. Stone, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Differential Requirement of RasGRP1 for γδ T Cell Development and Activation

P. Pereira, B. Gorentla, X. Zhong, 2012, The Journal of Immunology.

Isolation and phenotypic analysis of conditional-lethal, linker-insertion mutations in the gene encoding the largest subunit of RNA polymerase II in Saccharomyces cerevisme

M. Drebot, J. Friesen, J. Stone, 1992, Molecular and General Genetics MGG.

Critical Roles of RasGRP1 for Invariant NKT Cell Development

B. Gorentla, X. Zhong, J. Stone, 2011, The Journal of Immunology.

Cell Development Critical Roles of RasGRP1 for Invariant

B. Gorentla, X. Zhong, J. Stone, 2011 .

Effects of inhibition of myocardial extracellular-responsive kinase and P38 mitogen-activated protein kinase on mechanical function of rat hearts after prolonged hypothermic ischemia

J. Stone, D. Bottorff, B. Finegan, 2003, Transplantation.

RasGRP1, but Not RasGRP3, Is Required for Efficient Thymic β-Selection and ERK Activation Downstream of CXCR4

J. Stone, N. Dower, T. Baldwin, 2013, PloS one.

Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3.

J. Stone, S. Stang, Yong Zheng, 2003, Blood.

Receptor-Ras Signaling Proliferation by Facilitating B Cell RasGRP1 and RasGRP3 Regulate B Cell

J. Stone, N. Dower, S. Stang, 2005 .

T Cell Development and Activation Δ Γ Differential Requirement of Rasgrp1 For

P. Pereira, B. Gorentla, X. Zhong, 2022 .

A Mutational Analysis of ras Function

D. Lowy, Ke Zhang, F. McCormick, 1989 .

A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells.

P. Blumberg, J. Stone, A. Lopez-Campistrous, 2009, Experimental hematology.

Recombinant Genetic Approaches to Functional Mapping of Thrombin a

R. MacGillivray, J. Stone, D. Irwin, 1986, Annals of the New York Academy of Sciences.

The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters.

P. Blumberg, J. Stone, M. Beheshti, 2000, Molecular pharmacology.

Delineation of functional determinants in the transforming protein of Fujinami sarcoma virus

J. Stone, K. Johnson, 1990, Journal of virology.

Genetic definition of ras effector elements

J. Stone, R. A. Blanchard, 1991, Molecular and cellular biology.

PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.

T. Hyman, P. Blumberg, H. Rubinfeld, 2004, Molecular pharmacology.

TCR‐mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells

B. Kowtharapu, B. Schraven, J. Stone, 2012, EMBO reports.

The role of RasGRPs in regulation of lymphocyte proliferation.

J. Stone, N. Dower, S. Stang, 2006, Immunology letters.

Phorbol esters modulate the Ras exchange factor RasGRP3.

P. Blumberg, J. Stone, D. Bottorff, 2001, Cancer research.

Correspondence between immunological and functional domains in the transforming protein of Fujinami sarcoma virus

T. Pawson, J. Stone, 1985, Journal of virology.

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

T. Pawson, I. Sadowski, J. Stone, 1986, Molecular and Cellular Biology.

Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines.

J. Stone, A. Lopez-Campistrous, P. Wender, 2012, Experimental Hematology.

Organization and chromosomal locations of Rap1a/Krev sequences in the mouse

M. Seldin, J. Stone, N. Dower, 2004, Mammalian Genome.

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling.

S. Lowe, M. Serrano, L. Van Aelst, 1998, Genes & development.

to constitutive MEK / MAPK mitogenic signaling Premature senescence involving p 53 and p 16 is activated in response

S. Lowe, M. Serrano, M. Barradas, 1998 .

Structural basis of RasGRP binding to high-affinity PKC ligands.

I. Enyedy, Shaomeng Wang, P. Blumberg, 2002, Journal of medicinal chemistry.

RasGRP1 and RasGRP3 Regulate B Cell Proliferation by Facilitating B Cell Receptor-Ras Signaling1

James C. Stone, J. Stone, N. Dower, 2005, The Journal of Immunology.

Insertion mutations of the RIIA Na+ channel reveal novel features of voltage gating and protein kinase A modulation

P. Drapeau, J. Stone, T. Hébert, 1994, Pflügers Archiv.

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

T Pawson, J C Stone, T. Pawson, 1986, Molecular and cellular biology.

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.

J. Stone, D. Bottorff, R. Dunn, 1998, Science.

Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain

J. Stone, S. Sullivan, Weiguo Zhang, 2012, PloS one.

Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells

J. Stone, D. Bottorff, S. Stang, 1997, Molecular and cellular biology.

RAS signalling is abnormal in a c-raf1 MEK1 double mutant

J. Stone, D. Bottorff, S. Stang, 1995, Molecular and cellular biology.

Mutations in conserved regions 1, 2, and 3 of Raf‐1 that activate transforming activity

J. Stone, D. Bottorff, S. Stang, 2002, Molecular carcinogenesis.

Stability of retrovirally transduced markers in a rat cell line

L. Siminovitch, J. Stone, N. Dower, 1986, Somatic cell and molecular genetics.

RasGRP1 Regulates Antigen-Induced Developmental Programming by Naive CD8 T Cells

Hao Shen, James C. Stone, J. Stone, 2009, The Journal of Immunology.

A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation upon Antigen Receptor Stimulation of T Cells

Arthur Weiss, A. Weiss, J. Stone, 2005, Molecular and Cellular Biology.

Hypothermic stress leads to activation of Ras-Erk signaling.

J. Stone, D. Bottorff, S. Stang, 1999, The Journal of clinical investigation.

Distribution of ras guanyl releasing protein (RasGRP) mRNA in the adult rat central nervous system

J. Stone, R. Dunn, P. Richardson, 2000, Journal of neurocytology.

Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells.

J. Stone, 2011, Genes & cancer.

The murine leukemia inhibition factor gene (Lif) is located on proximal Chromosome 11, not Chromosome 13

J. Stone, D. Bottorff, 2004, Mammalian Genome.

Stimulation of ras GTPase activity by an anti‐ras monoclonal antibody

J. Stone, S. Agellon, Sherry Agellon, 1996, Molecular carcinogenesis.

A Novel Diacylglycerol-lactone Shows Marked Selectivity in Vitro among C1 Domains of Protein Kinase C (PKC) Isoforms α and δ as Well as Selectivity for RasGRP Compared with PKCα*

P. Blumberg, J. Stone, Y. Pu, 2005, Journal of Biological Chemistry.

Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells.

J. Stone, Jing Zheng, Liang Li, 2005, Blood.

Alkali lability of a bacteriophage W-14 DNA.

J. Stone, R. Miller, R. Warren, 1975 .

A recombinant DNA plasmid which inhibits bacteriophage T7 reproduction in escherichia coli.

J. Stone, R. Miller, R. D. Smith, 1983, The Journal of general virology.

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

M. Kaplan, M. Dinauer, P. De, 2008, The Journal of Immunology.

The murine retinoblastoma homolog maps to chromosome 14 near Es-10.

J. Nadeau, C. Kozak, J. Stone, 1989, Genomics.

Filicidal ring-Y chromosomes in D. melanogaster.

J. Stone, 1982, Genetics.

Regulation of Ras in lymphocytes: get a GRP.

J. Stone, 2006, Biochemical Society transactions.

Spontaneous temperature-sensitive mutations in bacteriophage T7

J. Stone, R. Miller, 1985, Journal of virology.

Plasmid-phage recombination in T7 infected Escherichia coli.

J. Stone, R. Miller, 1984, Virology.

Retraction. Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

B. Lim, T. Chevassut, Xiaoyu Li, 2003, Immunity.

The characterization of a mutant affecting DNA metabolism in the development of D. melanogaster.

R. Sederoff, J. Stone, N. Dower, 1983, Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie.

Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines.

J. Stone, A. Lopez-Campistrous, P. Wender, 2012, Experimental hematology.