G. Takaesu

发表

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

K. Irie, K. Matsumoto, J. Ninomiya-Tsuji, 2000, Molecular cell.

GRIM‐19 is a target of mycobacterial Zn2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation

G. Takaesu, Tomomi Kurane, Tetsuro Matsunaga, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.

Y. Maehara, H. Ogata, A. Yoshimura, 2006, Gastroenterology.

A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2006, Biochemical and biophysical research communications.

Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes.

A. Yoshimura, G. Takaesu, H. Mori, 2007, Biochemical and biophysical research communications.

Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved.

H. Ogata, A. Yoshimura, G. Takaesu, 2006, Gastroenterology.

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.

R. Surabhi, R. Gaynor, Kyu-Jin Park, 2003, Journal of molecular biology.

Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.

N. Sakurai, J. Ninomiya-Tsuji, Kunihiro Matsumoto, 2002, Molecular and cellular biology.

Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway

G. Stark, J. Ninomiya-Tsuji, Kunihiro Matsumoto, 2001, Molecular and Cellular Biology.

Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production

Takafumi Yoshida, H. Ogata, A. Yoshimura, 2006, Oncogene.

Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels.

A. Yoshimura, D. Yoshiga, G. Takaesu, 2007, Molecular endocrinology.

Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2009, Immunity.

An RNA-binding protein αCP-1 is involved in the STAT3-mediated suppression of NF-κB transcriptional activity

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2007 .

Suppressor of cytokine signaling 1 protects mice against concanavalin A–induced hepatitis by inhibiting apoptosis

A. Yoshimura, H. Yoshida, G. Takaesu, 2008, Hepatology.

A Major Lipid Raft Protein Raftlin Modulates T Cell Receptor Signaling and Enhances Th17-Mediated Autoimmune Responses1

A. Yoshimura, S. Fukuyama, G. Takaesu, 2009, The Journal of Immunology.

Lose the battle to win the war: bacterial strategies for evading host inflammasome activation.

G. Takaesu, N. Nakasone, Toshihiko Suzuki, 2013, Trends in microbiology.

Sprouty4 negatively regulates protein kinase C activation by inhibiting phosphatidylinositol 4,5-biphosphate hydrolysis

S. Komune, R. Kato, K. Taniguchi, 2009, Oncogene.

Mal-function of TLRs by SOCS

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2006, Nature Immunology.

An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2007, International immunology.

Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells

A. Yoshimura, H. Yoshida, T. Inaba, 2008, Genes to cells : devoted to molecular & cellular mechanisms.

TGF‐β1 suppresses IFN‐γ‐induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2006 .

TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

A Drosophila MAPKKK, D‐MEKK1, mediates stress responses through activation of p38 MAPK

K. Irie, J. Ninomiya-Tsuji, Kunihiro Matsumoto, 2001, The EMBO journal.

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1

Satoru Fukuyama, Hiromasa Inoue, A. Yoshimura, 2006, The Journal of experimental medicine.

Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads1

A. Yoshimura, H. Yoshida, Y. Nakanishi, 2008, The Journal of Immunology.

STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor*

A. Yoshimura, S. Kato, G. Takaesu, 2008, Journal of Biological Chemistry.

Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*♦

A. Yoshimura, H. Yoshida, G. Takaesu, 2008, Journal of Biological Chemistry.

A Cdo–Bnip-2–Cdc42 signaling pathway regulates p38α/β MAPK activity and myogenic differentiation

Jong-Sun Kang, G. Bae, G. Takaesu, 2008, The Journal of cell biology.

Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway

Y. Watanabe, K. Irie, K. Matsumoto, 1997, Molecular and cellular biology.

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy

G. Takaesu, T. Otomo, Chinatsu Otomo, 2012, Nature Structural &Molecular Biology.

Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12

G. Takaesu, T. Otomo, Chinatsu Otomo, 2013, Proceedings of the National Academy of Sciences.

Role of the TAB2‐related protein TAB3 in IL‐1 and TNF signaling

R. Gaynor, J. Ninomiya-Tsuji, Kunihiro Matsumoto, 2003, The EMBO journal.

TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway

R. Surabhi, R. Gaynor, Kyu-Jin Park, 2003 .

Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells.

A. Yoshimura, H. Yoshida, G. Takaesu, 2008, International immunology.

HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein.

A. Yoshimura, H. Yoshida, G. Takaesu, 2008, Biochemical and biophysical research communications.

Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact

Jong-Sun Kang, G. Takaesu, F. Cole, 2005, Journal of Cell Science.

FLN29 Deficiency Reveals Its Negative Regulatory Role in the Toll-like Receptor (TLR) and Retinoic Acid-inducible Gene I (RIG-I)-like Helicase Signaling Pathway*

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2008, Journal of Biological Chemistry.

An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.

A. Yoshimura, H. Sakurai, G. Takaesu, 2009, Biochemical and biophysical research communications.

STAT 3 and Smads γ Effects of IFN-Differentiation by Enhancing Antagonistic Helper T Cells Leads to Defective Th 17 Loss of Suppressor of Cytokine Signaling 1 in

A. Yoshimura, H. Yoshida, Y. Nakanishi, 2008 .

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

J. Ninomiya-Tsuji, Kunihiro Matsumoto, G. Takaesu, 2014, The Journal of cell biology.

TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway*

S. Akira, A. Yoshimura, T. Kawai, 2008, Journal of Biological Chemistry.

Activated Macrophage Survival Is Coordinated by TAK1 Binding Proteins

J. Ninomiya-Tsuji, G. Takaesu, S. Morioka, 2014, PloS one.

TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2012, Journal of biochemistry.

Activation of p38α/β MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo

E. Reddy, Jong-Sun Kang, G. Bae, 2006, The Journal of cell biology.

Corrigendum to “A novel zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling” [Biochem. Biophys. Res. Commun. 344 (2006) 1023–1030]

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2007 .

SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage.

A. Yoshimura, W. McBride, G. Takaesu, 2008, Cellular signalling.

Effects of Psidium guajava leaf extract on secretion systems of gram‐negative enteropathogenic bacteria

Y. Ogura, G. Takaesu, T. Yamashiro, 2018, Microbiology and immunology.

TAK1 regulates resident macrophages by protecting lysosomal integrity

J. Ninomiya-Tsuji, M. Fessler, J. Foley, 2017, Cell Death & Disease.

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus

H. T. Ghashghaei, J. Ninomiya-Tsuji, Kunihiro Matsumoto, 2016, Journal of Cell Science.

TAK 1 determines susceptibility to endoplasmic reticulum stress and hypothalamic leptin resistance Authors / Affiliations

H. T. Ghashghaei, J. Ninomiya-Tsuji, Kunihiro Matsumoto, 2016 .

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

A. Yoshimura, J. Ninomiya-Tsuji, Kunihiro Matsumoto, 2012, PloS one.

Structural insights into E2–E3 interaction for LC3 lipidation

G. Takaesu, T. Otomo, Chinatsu Otomo, 2014, Autophagy.

Loss of SOCS3 Gene Expression Converts STAT3 Function from Anti-apoptotic to Pro-apoptotic*

A. Yoshimura, S. Fukuyama, G. Takaesu, 2006, Journal of Biological Chemistry.

miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A)

G. Takaesu, G. Matsuzaki, M. Umikawa, 2020, AntiCancer Research.

Application of unstable Gfp variants to the kinetic study of Legionella pneumophila icm gene expression during infection.

G. Takaesu, S. Yoshida, J. Fujii, 2008, Microbiology.

A Cdo–Bnip-2–Cdc42 signaling pathway regulates p38α/β MAPK activity and myogenic differentiation

Jong-Sun Kang, G. Bae, G. Takaesu, 2008, The Journal of cell biology.

Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2009, Immunity.