J. Lacal

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Signal Transduction in Xenopus laevis Oocytes by Ras Oncoproteins and Lipid Metabolites

A. Carnero, J. Lacal, 1999 .

Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.

M. A. García-Cabezas, E. Bandrés, J. García-Foncillas, 2008, International journal of oncology.

Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers.

R. Rosell, A. Ramírez de Molina, J. Lacal, 2002, Biochemical and biophysical research communications.

Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy

Jose M. Silva, J. Lacal, J. Sánchez, 2002, Oncogene.

Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells

J. Lacal, J. Campos, M. C. Núñez, 2003, Oncogene.

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models.

J. Griffiths, M. Leach, P. Workman, 2006, Cancer research.

Sensitization of (colon) cancer cells to death receptor related therapies

B. Zhivotovsky, P. Workman, J. Martinou, 2012, Cancer biology & therapy.

Choline kinase inhibitors synergize with TRAIL in the treatment of colorectal tumors and overcomes TRAIL resistance

L. Andĕra, J. Lacal, L. Andera, 2016 .

Microinjection of ras p21 induces a rapid rise in intracellular pH

S. Aaronson, J. Lacal, M. Graber, 1987, Molecular and cellular biology.

Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid‐dependent signaling

J. Lacal, 1997, FEBS letters.

Ras protein is involved in the physiological regulation of phospholipase D by platelet derived growth factor

L. Peso, J. Lacal, L. Lucas, 2000, Oncogene.

Combined 5-FU and ChoKα Inhibitors as a New Alternative Therapy of Colorectal Cancer: Evidence in Human Tumor-Derived Cell Lines and Mouse Xenografts

A. Cebrián, A. Ramírez de Molina, J. Lacal, 2013, PloS one.

Xenopus laevis Oocytes as a Model for Studying the Activation of Intracellular Kinases

A. Carnero, J. Lacal, 1999 .

Microinjection of Xenopus laevis Oocytes: A Model System

J. Lacal, 1999 .

Progesterone but not ras requires MPF for in vivo activation of MAPK and S6 KII: MAPK is an essential conexion point of both signaling pathways

A. Carnero, J. Lacal, B. Jiménez, 1994, Journal of cellular biochemistry.

Micro‐injection of recombinant lysyl oxidase blocks oncogenic p21‐Ha‐Ras and progesterone effects on Xenopus laevis oocyte maturation

G. Ghiggeri, J. Lacal, A. Di Donato, 1997, FEBS letters.

H-ras mutants lacking the epitope for the neutralizing monoclonal antibody Y13-259 show decreased biological activity and are deficient in GTPase-activating protein interaction

S. Srivastava, J. Lacal, A. Di Donato, 1989, Molecular and cellular biology.

Analysis of the Biochemical and Biological Activities of Deletion Mutants of the H-Ras P21 Protein Suggest That Gap is an Essential Component of Its Effector Function

S. Srivastava, J. Lacal, A. Donato, 1989 .

Conformational alterations detected by circular dichroism induced in the normal ras p21 protein by activating point mutations at position 12, 59, or 61.

L. Serrano, P. Anderson, J. Lacal, 1988, European journal of biochemistry.

Activation of ras p21 transforming properties associated with an increase in the release rate of bound guanine nucleotide

S. Aaronson, J. Lacal, 1986 .

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH 3T3 cells

S. Srivastava, P. Anderson, S. Aaronson, 1986, Cell.

ras p21 deletion mutants and monoclonal antibodies as tools for localization of regions relevant to p21 function.

S. Aaronson, J. Lacal, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Antibody of predetermined specificity to a carboxy-terminal region of H-ras gene products inhibits their guanine nucleotide-binding function

S. Srivastava, S. Aaronson, J. Lacal, 1985, Molecular and cellular biology.

Microinjection of acylphosphatase blocks Xenopus laevis oocytes maturation induced by ras‐p21

G. Ramponi, A. Carnero, J. Lacal, 1993, FEBS letters.

Biological Function of Aplysia californica rho Gene

R. Perona, J. Lacal, R. P. Ballestero, 1991 .

Intelligent drug design come of age: STI571 as the start a of a new era in cancer research and treatment

J. Lacal, 2001, Revista de Oncología.

Protein chimerism: Novel source of protein diversity in humans adds complexity to bottom‐up proteomics

J. Lacal, J. Casado-Vela, F. Elortza, 2013, Proteomics.

Tumorigenic activity of rho genes from Aplysia californica.

S. Y. Cajal, S. Ramón y. Cajal, R. Perona, 1993, Oncogene.

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production.

R. Terkeltaub, M. Karin, R. Liu-Bryan, 2019, Cell metabolism.

Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer.

A. Ramírez de Molina, J. Lacal, P. Cejas, 2006, International journal of oncology.

Permeabilization of cells during animal virus infection.

Luis Carrasco, J. Lacal, 1983, Pharmacology & therapeutics.

Deletion mutants of Harvey ras p21 protein reveal the absolute requirement of at least two distant regions for GTP‐binding and transforming activities.

P. Anderson, S. Aaronson, J. Lacal, 1986, The EMBO journal.

Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21.

P. Anderson, S. Aaronson, J. Moscat, 1988, Science.

Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability.

R. Perona, J. Lacal, S. Benitah, 2002, Molecular biology of the cell.

Activation of ras p21 transforming properties associated with an increase in the release rate of bound guanine nucleotide

S. Aaronson, J. Lacal, 1986, Molecular and cellular biology.

The Phosphoinositide 3-Kinase Inhibitor PI-103 Downregulates Choline Kinase α Leading to Phosphocholine and Total Choline Decrease Detected by Magnetic Resonance Spectroscopy

M. Leach, P. Workman, P. Clarke, 2010 .

Differential Role of Human Choline Kinase α and β Enzymes in Lipid Metabolism: Implications in Cancer Onset and Treatment

A. Ramírez de Molina, J. Lacal, D. Gallego-Ortega, 2009, PloS one.

Choline kinase: a novel target for antitumor drugs.

J. Lacal, 2001, IDrugs : the investigational drugs journal.

Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism

J. Lacal, 1990, Molecular and cellular biology.

Rho GTPase Rac1: Molecular Switch within the Galectin Network and for N-Glycan α2,6-Sialylation/O-Glycan Core 1 Sialylation in Colon Cancer in Vitro (apoptosis/cancer/glycosylation/invasion/lectin/migration)

J. Lacal, K. Smetana, H. Gabius, 2014 .

J. Lacal, T. Pulgar, 2011 .

rap1B, a cAMP-dependent protein kinase substrate, associates with the platelet cytoskeleton.

T. Fischer, J. Lacal, G. White, 1990, The Journal of biological chemistry.

Agonist-induced phosphorylation of an immunologically ras-related protein in human erythroleukemia cells.

E. Lapetina, J. Lacal, E. Lazarowski, 1989, Biochemical and biophysical research communications.

E. Lapetina, J. Lacal, L. M. Molina y Vedia, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Signaling from G Protein-coupled Receptors to the c-jun Promoter Involves the MEF2 Transcription Factor

J. Gutkind, J. Lacal, R. Prywes, 1997, The Journal of Biological Chemistry.

Identification of rho as a substrate for botulinum toxin C3‐catalyzed ADP‐ribosylation

G. Bokoch, J. Lacal, L. Quilliam, 1989, FEBS letters.

Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides.

J. Lacal, J. Campos, A. Conejo-García, 2003, European journal of medicinal chemistry.

Wortmannin, an inhibitor of phosphatidyl‐inositol 3‐kinase, induces oocyte maturation through a MPF‐MAPK‐dependent pathway

A. Carnero, J. Lacal, 1998, FEBS letters.

Potentiation of oncogenic N‐ras‐induced neurite outgrowth and ornithine decarboxylase activity by phorbol dibutyrate and protein kinase inhibitor H‐8

D. Burstein, A. Pellicer, J. Lacal, 1990, Journal of cellular physiology.

Acylphosphatase synergizes with progesterone during maturation of Xenopus laevis oocytes

G. Ramponi, A. Cuadrado, A. Carnero, 1993, FEBS letters.

CHKA (choline kinase alpha)

J. Lacal, D. M. A. Ramirez, M. Alvarez-Miranda, 2011 .

Thrombolamban, the 22-kDa platelet substrate of cyclic AMP-dependent protein kinase, is immunologically homologous with the Ras family of GTP-binding proteins.

T. Fischer, E. Lapetina, J. Lacal, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Identification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae

J. Lacal, S. Ibrahim, T. Zimmerman, 2020, Scientific Reports.

Delft University of Technology Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

Jeffrey M. Spraggins, T. Muley, M. Meister, 2016 .

Targeting new anticancer drugs within signalling pathways regulated by the Ras GTPase superfamily (Review).

A. Ramírez de Molina, J. Lacal, A. Rodríguez-González, 2001, International journal of oncology.

Modulation of phospholipase D by Ras proteins mediated by its effectors Ral-GDS, PI3K and Raf-1.

L. del Peso, A. Ramírez de Molina, J. Lacal, 2002, International journal of oncology.

Modulation of cellular chemoresistance in keratinocytes by activation of different oncogenes

S. Y. Cajal, A. Carnero, R. Sánchez-Prieto, 2006, International journal of cancer.

ras‐p21 Activates phospholipase D and A2, but not phospholipase C or PKC, in Xenopus laevis Oocytes

A. Carnero, J. Lacal, F. Dolfi, 1994, Journal of cellular biochemistry.

Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells

A. Cuadrado, D. Burstein, A. Pellicer, 1990, Molecular and cellular biology.

Choline Kinase α Inhibitors MN58b and RSM932A Enhances the Antitumor Response to Cisplatin in Lung Tumor Cells

A. Cebrián, R. Perona, J. Lacal, 2022, Pharmaceutics.

Involvement ofFunctional Protein Kinase C intheMitogenic Response totheH-rasOncogene Product

J. Lacal, 1987 .

Modification of membrane permeability in poliovirus-infected HeLa cells: effect of guanidine.

Luis Carrasco, J. Lacal, 1983, The Journal of general virology.

Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism.

A. Ramírez de Molina, D. Megías, J. Lacal, 2005, International journal of oncology.

Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of rho-p21, a GTPase protein of the ras superfamily.

A. Wyllie, M. Arends, S. Ramón y. Cajal, 1995, Oncogene.

phosphatidylcholine metabolism. is a consequence of activation of oocytes after microinjection of p21ras proteins Diacylglycerol production in Xenopus laevis

J. Lacal, 2013 .

Diacylglycerol Production inXenopus laevis Oocytes after Microinjection ofp2lras Proteins Isa Consequence ofActivation of Phosphatidylcholine

J. Lacal, A. Duperier, 1990 .

Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins.

M. Barbacid, H. Kung, J. Lacal, 1984, Proceedings of the National Academy of Sciences of the United States of America.

A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products

Á. Ravelo, J. Lacal, A. Estévez-Braun, 2014, Clinical and Translational Oncology.

Symmetrical bis-quinolinium compounds: new human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line.

J. Lacal, J. Campos, A. Conejo-García, 2005, Journal of medicinal chemistry.

Quantitative structure-activity relationships for a series of symmetrical bisquaternary anticancer compounds.

J. Lacal, J. Campos, J. A. Gómez-Vidal, 2002, Bioorganic & medicinal chemistry.

New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.

J. Lacal, Mónica Báñez-Coronel, M. Braña, 2004, Journal of medicinal chemistry.

Development of an enzyme-linked immunosorbent assay for equine infectious anemia virus detection using recombinant Pr55gag

J. Lacal, D. Archambault, S. Tronick, 1989, Journal of clinical microbiology.

Monoclonal antibody Y13-259 recognizes an epitope of the p21 ras molecule not directly involved in the GTP-binding activity of the protein

S. Aaronson, J. Lacal, 1986, Molecular and cellular biology.

Tumorigenesis and Neoplastic Progression Orthotopic Microinjection of Human Colon Cancer Cells in Nude Mice Induces Tumor Foci in All Clinically Relevant Metastatic Sites

Ramon Mangues, R. Mangues, J. Lacal, 2007 .

Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells

Luis Carrasco, J. Lacal, 1983, Antimicrobial Agents and Chemotherapy.

Relationship between membrane integrity and the inhibition of host translation in virus-infected mammalian cells. Comparative studies between encephalomyocarditis virus and poliovirus.

Luis Carrasco, J. Lacal, 1982, European journal of biochemistry.

Antibiotics that specifically block translation in virus-infected cells.

Luis Carrasco, J. Lacal, D. Vazquez, 1980, The Journal of antibiotics.

Screening for new compounds with antiherpes activity.

Luis Carrasco, J. Lacal, J. Fernández-Sousa, 1984, Antiviral research.

Tumorigenesis and Neoplastic Progression A Critical Role for Rac1 in Tumor Progression of Human Colorectal Adenocarcinoma Cells malignant phenotype

R. Mangues, J. Lacal, P. Cejas, 2008 .

A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells.

R. Mangues, J. Lacal, P. Cejas, 2008, The American journal of pathology.

Differential expression of Rac1 identifies its target genes and its contribution to progression of colorectal cancer.

E. Bandrés, J. García-Foncillas, J. Lacal, 2007, The international journal of biochemistry & cell biology.

Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors.

J. Lacal, S. Aznar, 2001, Progress in nucleic acid research and molecular biology.

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

R. Bravo, R. Perona, J. Lacal, 1997, Genes & development.

Rho GTPase expression in tumourigenesis: Evidence for a significant link

J. Lacal, S. Benitah, T. G. del Pulgar, 2005, BioEssays : news and reviews in molecular, cellular and developmental biology.

Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production.

J. Lacal, E. López-Collazo, N. Embade, 2000, Molecular biology of the cell.

Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis.

David Gallego-Ortega, A. Ramírez de Molina, J. Lacal, 2005, Cancer research.

CDC 42 ( cell division cycle 42 ( GTP binding protein , 25 kDa ) )

J. Lacal, F. Valdés-Mora, T. Pulgar, 2022 .

Rho GTPases: potential candidates for anticancer therapy.

J. Lacal, C. Espina, S. Aznar, 2004, Cancer letters.

Rho signals to cell growth and apoptosis.

J. Lacal, S. Aznar, Salvador Aznar, 2001, Cancer letters.

Rho proteins induce metastatic properties in vivo

L. Peso, A. Carnero, J. Lacal, 1997, Oncogene.

A critical role for choline kinase-α in the aggressiveness of bladder carcinomas

C. Cordon-Cardo, B. Bochner, J. Koutcher, 2009, Oncogene.

TWIST1 Overexpression is Associated with Nodal Invasion and Male Sex in Primary Colorectal Cancer

E. Bandrés, J. García-Foncillas, A. Ramírez de Molina, 2008, Annals of Surgical Oncology.

Activation of the nuclear factor-KB by Rho , CDC 42 , and Rac1 proteins

J. Lacal, ̂. Isabel Sanchez-Perez Rodrigo Bravo, 2007 .

Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics

A. Cebrián, J. Lacal, J. Casado-Vela, 2011, Clinical and Translational Oncology.

Clinical Investigation : Gastrointestinal Cancer Upregulation of Trefoil Factor 3 ( TFF 3 ) After Rectal Cancer Chemoradiotherapy Is an Adverse Prognostic Factor and a Potential Therapeutic Target

J. Lacal, J. Feliu, J. Maurel, 2022 .

From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design.

A. Ramírez de Molina, J. Lacal, A. Rodríguez-González, 2004, Cancer letters.

Choline kinase alpha depletion selectively kills tumoral cells.

A. Ramírez de Molina, J. Lacal, Mónica Báñez-Coronel, 2008, Current cancer drug targets.

Human urine proteomics: building a list of human urine cancer biomarkers

A. Cebrián, J. Lacal, J. Casado-Vela, 2011, Expert review of proteomics.

Analysis of the rasH oncogene and its p21 product in chemically induced skin tumors and tumor-derived cell lines.

S. Yuspa, J. Lacal, S. Reynolds, 1987, Carcinogenesis.

Regulation of choline kinase activity by Ras proteins involves Ral–GDS and PI3K

J. Lacal, A. Molina, L. Lucas, 2002, Oncogene.

Localization of rap1 and rap2 proteins in the gelatinase‐containing granules of human neutrophils

F. Mollinedo, C. Gajate, J. Lacal, 1993, FEBS letters.

The Ras family of GTPases in cancer cell invasion

L. Peso, L. del Peso, J. Lacal, 2000, Cellular and Molecular Life Sciences CMLS.

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

H. Dienemann, R. Caprioli, Michael Thomas, 2016, Oncotarget.

Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors

F. Real, W. Greenhalf, Eithne Costello, 2016, Molecular Cancer Therapeutics.

Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells

A. Ullrich, J. Downward, J. Lacal, 2009, Molecular Cancer.

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product

T. Fleming, S. Aaronson, P. Blumberg, 1987, Molecular and cellular biology.

Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21

P. Anderson, S. Aaronson, J. Moscat, 1987 .

CHOLINE KINASE AS A PRECISION MEDICINE TARGET FOR THERAPY IN CANCER, AUTOIMMUNE DISEASES AND MALARIA

J. Lacal, 2015 .

In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery.

J. Lacal, F. Fernández, R. Hernández-Alcoceba, 1999, Cancer research.

Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases

J. Lacal, J. Campos, T. Zimmerman, 2021, Pharmaceutics.

Changing the course of oncogenesis: The development of tyrosine kinase inhibitors

J. Lacal, 2006 .

Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation.

C. Marshall, L. Van Aelst, J. Lacal, 2004, Biochimica et biophysica acta.

Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases*

R. Perona, J. Lacal, S. Montaner, 1998, The Journal of Biological Chemistry.

Expression of the Aplysia californica rho gene in Escherichia coli: purification and characterization of its encoded p21 product

P. Anderson, J. Lacal, 1987, Molecular and cellular biology.

Activation of Serum Response Factor by RhoA Is Mediated by the Nuclear Factor-κB and C/EBP Transcription Factors*

R. Perona, J. Lacal, S. Montaner, 1999, The Journal of Biological Chemistry.

Activation of intracellular kinases in Xenopus oocytes by p21ras and phospholipases: a comparative study

A. Carnero, J. Lacal, 1995, Molecular and cellular biology.

LUMO energy of model compounds of bispyridinium compounds as an index for the inhibition of choline kinase.

J. Lacal, V. Rodríguez, F. Fernández, 2001, European journal of medicinal chemistry.

Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation.

R. Perona, J. Lacal, L. Perez, 2001, Molecular biology of the cell.

Signal transduction and apoptosis pathways as therapeutic targets.

J. Lacal, P. F. Valerón, S. Aznar-Benitah, 2004, Progress in molecular and subcellular biology.

Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study.

Marcin Skrzypski, Enrique Casado, Paloma Cejas, 2007, The Lancet. Oncology.

Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action

J. Lacal, A. Rodríguez-González, A. Molina, 2004, Oncogene.

Choline Kinase Emerges as a Promising Drug Target in Gram-Positive Bacteria

J. Lacal, S. Ibrahim, T. Zimmerman, 2019, Front. Microbiol..

A dual choline/phosphocholine colorimetric method for measuring the relative strength of inhibitors of choline kinases of Gram-positive pathogens

J. Lacal, S. Ibrahim, T. Zimmerman, 2018, Food Science and Applied Biotechnology.

Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway

L. Peso, M. Arends, R. Perona, 1998, Oncogene.

New Approaches to Antiviral Agents

Luis Carrasco, J. Lacal, M. A. Alonso, 1981 .

Needle Microinjection: A Brief History

J. Feramisco, R. Perona, J. C. Lacal, 1999 .

18F-Choline Images Murine Atherosclerotic Plaques Ex Vivo

B. Weber, A. Buck, G. V. von Schulthess, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity

J. Lacal, R. Hernández-Alcoceba, L. Lucas, 2001, Oncogene.

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

S. Aaronson, J. Moscat, J. Lacal, 1987, Nature.

Phospholipase‐induced maturation of Xenopus laevis oocytes: Mitogenic activity of generated metabolites

A. Carnero, J. Lacal, 1993, Journal of cellular biochemistry.

Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.

A. Ramírez de Molina, J. Lacal, A. Rodríguez-González, 2001, Biochemical and biophysical research communications.

Ras Proteins as Potential Activators of Protein Kinase C Function

J. Lacal, Janet E. Jones, 1989 .

Loss of mouse fibroblast cell response to phorbol esters restored by microinjected protein kinase C

S. Aaronson, P. Blumberg, J. Lacal, 1986, Nature.

Choline kinase inhibitors as a novel approach for antiproliferative drug design

J. Lacal, J. Campos, M. Gallo, 1997, Oncogene.

Generation of phosphorylcholine as an essential event in the activation of Raf‐1 and MAP‐kinases in growth factors‐induced mitogenic stimulation

L. del Peso, J. Lacal, S. Montaner, 1995, Journal of cellular biochemistry.

Antiplasmodial Activity and Mechanism of Action of RSM-932A, a Promising Synergistic Inhibitor of Plasmodium falciparum Choline Kinase

A. Cebrián, J. Lacal, J. Bautista, 2013, Antimicrobial Agents and Chemotherapy.

STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA.

H. Rui, J. Lacal, S. Benitah, 2003, Molecular biology of the cell.

Preclinical Characterization of RSM-932A, a Novel Anticancer Drug Targeting the Human Choline Kinase Alpha, an Enzyme Involved in Increased Lipid Metabolism of Cancer Cells

J. Lacal, J. Campos, 2014, Molecular Cancer Therapeutics.

Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions.

A. Cebrián, J. Lacal, D. Gallego-Ortega, 2011, Advances in enzyme regulation.

Phospholipase D and choline kinase: their role in cancer development and their potential as drug targets.

A. Ramírez de Molina, J. Lacal, A. Rodríguez-González, 2003, Progress in cell cycle research.

Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors.

A. Cuadrado, A. Carnero, J. Lacal, 1993, Oncogene.

Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.

David Gallego-Ortega, E. Bandrés, J. García-Foncillas, 2008, The international journal of biochemistry & cell biology.

QSAR-derived choline kinase inhibitors: how rational can antiproliferative drug design be?

J. Lacal, A. Conejo-García, R. Sánchez-Martín, 2003, Current medicinal chemistry.

Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility

A. Cebrián, M. Taron, J. Lacal, 2013, Clinical and Translational Oncology.

Activation of phospholipase D by ras proteins is independent of protein kinase C

L. del Peso, R. Hernández, J. Lacal, 1996, Journal of cellular biochemistry.

Choline Kinase Activation Is a Critical Requirement for the Proliferation of Primary Human Mammary Epithelial Cells and Breast Tumor Progression

D. Megías, J. Lacal, Mónica Báñez-Coronel, 2004, Cancer Research.

Influence of the linker in bispyridium compounds on the inhibition of human choline kinase.

A. Ramírez de Molina, J. Lacal, J. Campos, 2004, Journal of medicinal chemistry.

Rho GTPases in human carcinogenesis: a tale of excess

J. Lacal, S. Benitah, C. Espina, 2003, Revista de Oncología.

The ras Superfamily of GTPases

F. McCormick, J. Lacal, 1993 .

Choline kinase inhibition in rheumatoid arthritis

G. Firestein, J. Lacal, M. Karin, 2014, Annals of the rheumatic diseases.

Differential effects of phorbol ester on the in vitro invasiveness of malignant and non‐malignant human fibroblast cells

J. Lacal, R. Reich, C. Ahn, 1990, Journal of cellular physiology.

Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product.

P. Lacal, J. Lacal, C. Y. Pennington, 1988, Oncogene.

Phosphorylation of ras oncogene product by protein kinase C.

S. Srivastava, P. Blumberg, J. Lacal, 1987, Biochemical and biophysical research communications.

Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells.

A. Cuadrado, L. del Peso, A. Carnero, 1994, Oncogene.

Evidence for different signalling pathways of PKC zeta and ras-p21 in Xenopus oocytes.

A. Carnero, J. Lacal, M. Liyanage, 1995, Oncogene.

The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.

M. Leach, P. Workman, P. Clarke, 2010, Cancer research.

Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer

E. Bandrés, J. Lacal, J. Feliu, 2017, Oncotarget.

Overexpression of PKC zeta in NIH3T3 cells does not induce cell transformation nor tumorigenicity and does not alter NF kappa B activity.

A. Carnero, R. Perona, J. Lacal, 1995, Oncogene.

Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways.

L. del Peso, J. Lacal, P. Esteve, 1997, The Biochemical journal.

ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences.

J. Lacal, S. Benitah, P. F. Valerón, 2003, Molecular biology of the cell.

Regulation of ras proteins and their involvement in signal-transduction pathways (review).

A. Carnero, J. Lacal, 1994, Oncology reports.

Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells

A. Cebrián, E. Medico, J. Lacal, 2024, British journal of cancer.

Rho GTPase Rac1: molecular switch within the galectin network and for N-glycan α2,6-sialylation/O-glycan core 1 sialylation in colon cancer in vitro.

J. Lacal, Sabine André, Karel Smetana, 2014, Folia biologica.

GTPase-Activating Protein

M. Moran, T. Pawson, F. McCormick, 2020, Definitions.