M. Kohno

M. Kohno, N. Sugiyama, T. Yokoyama, 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

A New Approach to the Detection of Autoantibodies Against Insulin Receptors that Inhibit the Internalization of Insulin into Human Cells

H. Imura, M. Kohno, M. Okamoto, 1984, Diabetes.

Synthesis and structure-activity relationships of thioflavone derivatives as specific inhibitors of the ERK-MAP kinase signaling pathway.

M. Kohno, Eiji Mori, T. Kataoka, 2004, Bioorganic & medicinal chemistry.

Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive guanosine triphosphate-binding protein and of protein kinase C.

Y. Nozawa, M. Kohno, Y. Chatani, 1990, Cell regulation.

Targeting the extracellular signal-regulated kinase pathway in cancer therapy.

M. Kohno, S. Tanimura, K. Ozaki, 2011, Biological & pharmaceutical bulletin.

Tyrosine phosphorylation and activation of mitogen-activated protein kinases by thrombin in human platelets: possible involvement in late arachidonic acid release.

S. Nakashima, Y. Nozawa, M. Kohno, 1994, Biochemical and biophysical research communications.

Chapter 12 Na+-H+ Exchange and Growth Control in Fibroblasts: A Genetic Approach

J. Pouysségur, M. Kohno, G. l'Allemain, 1986 .

Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes.

M. Kohno, Aya Harada, M. Awazu, 2016, American journal of physiology. Endocrinology and metabolism.

Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner.

M. Kohno, S. Tanimura, D. Takano, 2006, Biochemical and biophysical research communications.

Tumor necrosis factor is markedly synergistic with interleukin 1 and interferon‐γ in stimulating the production of nerve growth factor in fibroblasts

M. Kohno, M. Tsujimoto, Masahiro Sato, 1994, FEBS letters.

Hepatocyte growth factor rapidly induces the tyrosine phosphorylation of 41-kDa and 43-kDa proteins in mouse keratinocytes.

T. Nakamura, M. Kohno, Y. Chatani, 1992, Biochemical and biophysical research communications.

Interleukin 2 induces rapid phosphorylation of cellular proteins in murine T‐lymphocytes

M. Kohno, Y. Namba, M. Hanaoka, 1986, FEBS letters.

Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44.

M. Kohno, S. Tanimura, Shuh-hei Fujishiro, 2003, Biochemical and biophysical research communications.

Blockade of the Extracellular Signal-regulated Kinase Pathway Induces Marked G1 Cell Cycle Arrest and Apoptosis in Tumor Cells in Which the Pathway Is Constitutively Activated

M. Kohno, R. Hoshino, Kazushi Watanabe, 2001, The Journal of Biological Chemistry.

Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells.

M. Kohno, 1985, The Journal of biological chemistry.

Specific Activation of the p38 Mitogen-activated Protein Kinase Signaling Pathway and Induction of Neurite Outgrowth in PC12 Cells by Bone Morphogenetic Protein-2*

M. Kohno, R. Hoshino, Kazushi Watanabe, 1999, The Journal of Biological Chemistry.

Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross‐resistance to a wide range of DNA‐damaging drugs

M. Kohno, Masashi Tanaka, S. Tanimura, 2008, Cancer science.

Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms

S. Miyazaki, M. Kohno, S. Tanimura, 2005, Journal of Cell Science.

ERK pathway positively regulates the expression of Sprouty genes.

M. Kohno, S. Tanimura, K. Ozaki, 2001, Biochemical and biophysical research communications.

Targeting the ERK signaling pathway in cancer therapy

J. Pouysségur, M. Kohno, 2006, Annals of medicine.

Characterization of interleukin 2-stimulated phosphorylation of 67 and 63 kDa proteins in human T-cells.

K. Sugamura, M. Kohno, M. Nakamura, 1987, The Biochemical journal.

Characterization of the Bone Morphogenetic Protein-2 as a Neurotrophic Factor

M. Kohno, M. Tsujimoto, M. Sato, 1996, The Journal of Biological Chemistry.

Cell Type-specific Modulation of Cell Growth by Transforming Growth Factor β1 Does Not Correlate with Mitogen-activated Protein Kinase Activation (*)

M. Kohno, Y. Chatani, Masahiro Sato, 1995, The Journal of Biological Chemistry.

65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites.

E. Nishida, K. Shigesada, M. Kohno, 1990, Biochemistry.

GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.

M. Kohno, O. Rotstein, E. Kakiashvili, 2009, The Journal of biological chemistry.

Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.

Yazaki, Y. Yazaki, M. Kasuga, 1992, The Journal of biological chemistry.

Inhibition of MAP kinase by sphingosine and its methylated derivative, N,N-dimethylsphingosine.

S. Hakomori, Y. Igarashi, E. Fischer, 1997, International journal of oncology.

Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease.

Hisahide Takahashi, M. Kohno, Hisayo Fujita, 2006, Journal of the American Society of Nephrology : JASN.

Activation of protein phosphatase causes alternative splicing of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): potential effect on immune surveillance.

K. Eguchi, M. Kohno, M. Kamachi, 2007, Biochemical and biophysical research communications.

Target Therapy for Cancer : Anti-cancer Drugs Targeting Growth-Factor Signaling Molecules

M. Kohno, S. Tanimura, Kei-ichi, 2011 .

Prolonged Nuclear Retention of Activated Extracellular Signal-regulated Kinase 1/2 Is Required for Hepatocyte Growth Factor-induced Cell Motility*

M. Kohno, M. Tsujimoto, T. Kondo, 2002, The Journal of Biological Chemistry.

Tumor necrosis factor (TNF) stimulates the production of nerve growth factor in fibroblasts via the 55‐kDa type 1 TNF receptor

M. Kohno, A. Hattori, K. Hayashi, 1996, FEBS letters.

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA.

M. Kohno, Kazushi Watanabe, S. Tanimura, 2008, Biochemical and biophysical research communications.

ERK Regulates Renal Cell Proliferation and Renal Cyst Expansion in inv Mutant Mice

M. Kohno, N. Sugiyama, K. Hamaoka, 2009, Acta histochemica et cytochemica.

Constitutive activation of the 41‐ and 43‐kDa mitogen‐activated protein (MAP) kinases in the progression of prostate cancer to an androgen‐independent state

O. Ogawa, M. Kohno, H. Oka, 2005, International journal of urology : official journal of the Japanese Urological Association.

Enantioselective total synthesis of (+)-ottelione A, (-)-ottelione B, (+)-3-epi-ottelione A and preliminary evaluation of their antitumor activity.

H. Araki, M. Kohno, T. Yamori, 2007, Chemistry.

Synthesis of extremely simplified compounds possessing the key pharmacophore units of taxol, phenylisoserine and oxetane moieties.

M. Kohno, Y. Hamajima, K. Fuji, 1999, Chemical & pharmaceutical bulletin.

Dissociation of c-fos induction and mitogen-activated-protein kinase activation from the hepatocyte-growth-factor-induced motility response in human gastric carcinoma cells.

K. Miyazawa, K. Nagamine, K. Takeuchi, 1996, European journal of biochemistry.

Nature of Adult T‐Cell Leukemia‐Associated Membrane Antigen on the Surface of Adult T‐Cell Leukemia Virus‐Carrying Cells as Revealed by Membrane Immunofluorescence

N. Yamamoto, M. Kohno, Y. Koyanagi, 1984, Microbiology and immunology.

Blockade of the Extracellular Signal-Regulated Kinase Pathway Enhances the Therapeutic Efficacy of Microtubule-Destabilizing Agents in Human Tumor Xenograft Models

M. Kohno, Kazushi Watanabe, A. Uchiyama, 2010, Clinical Cancer Research.

Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilizing agents in tumor cells.

M. Kohno, Kazushi Watanabe, M. Yasunaga, 2009, Biochemical and biophysical research communications.

Requirement for ERK MAP kinase in mouse preimplantation development

E. Nishida, M. Takeichi, M. Maekawa, 2007, Development.

Blockade of the ERK pathway enhances the therapeutic efficacy of the histone deacetylase inhibitor MS-275 in human tumor xenograft models.

T. Koji, M. Kohno, Kazushi Watanabe, 2013, Biochemical and biophysical research communications.

ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips

M. Kohno, K. Takeda, Kazushi Watanabe, 2016, The Journal of cell biology.

SH3P2 is a negative regulator of cell motility whose function is inhibited by ribosomal S6 kinase‐mediated phosphorylation

Michihiro Kawano, M. Kohno, Kazushi Watanabe, 2011, Genes to cells : devoted to molecular & cellular mechanisms.

KGFR as a possible therapeutic target in middle ear cholesteatoma

T. Koji, M. Kohno, Y. Shibata, 2014, Acta oto-laryngologica.

Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins. Potential role in integrating multiple mitogenic signalling pathways.

M. Kohno, Y. Chatani, A. Hattori, 1992, The Biochemical journal.

[Heat shock protein 70 binding protein 1 induces enhanced apoptotic response against anticancer drugs in tumor cells].

M. Kohno, S. Tanimura, 2004, Nihon rinsho. Japanese journal of clinical medicine.

Anticancer Drugs Upregulate HspBP 1 and Thereby Antagonize the Prosurvival Function of Hsp 70 in Tumor Cells *

M. Kohno, Junya Hashizume, M. Yasunaga, 2007 .

Blockade of the ERK or PI3K-Akt signaling pathway enhances the cytotoxicity of histone deacetylase inhibitors in tumor cells resistant to gefitinib or imatinib.

S. Kimura, M. Kohno, S. Tanimura, 2010, Biochemical and biophysical research communications.

Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma.

M. Kawaichi, Osamu Ogawa, O. Yoshida, 1995, Cancer research.

Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes.

M. Kohno, Aya Harada, M. Awazu, 2016, American journal of physiology. Endocrinology and metabolism.

GEF-H1 Mediates Tumor Necrosis Factor-α-induced Rho Activation and Myosin Phosphorylation

M. Kohno, O. Rotstein, E. Kakiashvili, 2009, Journal of Biological Chemistry.

Up-regulation of Pro-apoptotic Protein Bim and Down-regulation of Anti-apoptotic Protein Mcl-1 Cooperatively Mediate Enhanced Tumor Cell Death Induced by the Combination of ERK Kinase (MEK) Inhibitor and Microtubule Inhibitor*

M. Kohno, R. Kawasaki, S. Tanimura, 2012, The Journal of Biological Chemistry.