Gaochao Zhou

发表

Components of a New Human Protein Kinase Signal Transduction Pathway (*)

Gaochao Zhou, Z. Bao, J. Dixon, 1995, The Journal of Biological Chemistry.

A Novel Liver X Receptor Agonist Establishes Species Differences in the Regulation of Cholesterol 7α-Hydroxylase (CYP7a).

Y. Chao, D. Moller, Gaochao Zhou, 2002, Endocrinology.

A Novel Liver X Receptor Agonist Establishes Species Differences in the Regulation of Cholesterol 7α-Hydroxylase (CYP7a).

Y. Chao, D. Moller, Gaochao Zhou, 2002, Endocrinology.

27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells*

Gaochao Zhou, S. Wright, J. Menke, 2001, The Journal of Biological Chemistry.

The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression*

J. Dixon, M. David, Gaochao Zhou, 1996, The Journal of Biological Chemistry.

Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

Michael E. Lassman, N. Thornberry, Gaochao Zhou, 2009, Diabetes.

A Common Requirement for the Catalytic Activity and Both SH2 Domains of SHP-2 in Mitogen-activated Protein (MAP) Kinase Activation by the ErbB Family of Receptors

J. Dixon, D. Salomon, J. Gutkind, 1998, The Journal of Biological Chemistry.

Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects.

G. Pavlovic, Gaochao Zhou, T. Rosahl, 2018, American journal of physiology. Endocrinology and metabolism.

A Potent Synthetic LXR Agonist Is More Effective than Cholesterol Loading at Inducing ABCA1 mRNA and Stimulating Cholesterol Efflux*

D. Moller, Gaochao Zhou, S. Wright, 2002, The Journal of Biological Chemistry.

O-Arylmandelic acids as highly selective human PPAR α/γ agonists

J. Berger, D. Moller, Gaochao Zhou, 2003 .

Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.

Olle Ljunqvist, D. Moller, L. Goodyear, 2002, Diabetes.

Differential Gene Regulation in Human Versus Rodent Hepatocytes by Peroxisome Proliferator-activated Receptor (PPAR) α

J. Berger, D. Moller, Gaochao Zhou, 2001, The Journal of Biological Chemistry.

Discovery of novel non-steroidal reverse indole mineralocorticoid receptor antagonists.

J. Lisnock, A. Crespo, Gaochao Zhou, 2016, Bioorganic & medicinal chemistry letters.

Insulin- and Mitogen-activated Protein Kinase-mediated Phosphorylation and Activation of Peroxisome Proliferator-activated Receptor γ*

G. Zhou, J. Berger, D. Moller, 1996, The Journal of Biological Chemistry.

Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists.

J. Lisnock, A. Crespo, Gaochao Zhou, 2013, Bioorganic & medicinal chemistry letters.

A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Bei B. Zhang, 2009, Bioorganic & medicinal chemistry letters.

Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Bei B. Zhang, 2009, Bioorganic & medicinal chemistry letters.

GLP-1/GCGR dual agonism reverses obesity in mice Short-running title: Dual GLP-1/GCGR agonist for the treatment of obesity

Michael E. Lassman, N. Thornberry, Gaochao Zhou, 2009 .

Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity

Y. Chao, J. Berger, D. Moller, 2005 .

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Journal of medicinal chemistry.

In Vivo Phosphorylation of Insulin Receptor Substrate 1 at Serine 789 by a Novel Serine Kinase in Insulin-resistant Rodents*

R. Zhande, Gaochao Zhou, T. Jetton, 2002, The Journal of Biological Chemistry.

Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.

J. Berger, D. Moller, Gaochao Zhou, 2005, Journal of medicinal chemistry.

(2R)-2-Ethylchromane-2-carboxylic Acids: Discovery of Novel PPARα/γ Dual Agonists as Antihyperglycemic and Hypolipidemic Agents

Margaret S. Wu, Y. Chao, J. Berger, 2004 .

Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.

Margaret S. Wu, J. Berger, Gaochao Zhou, 2011, Journal of medicinal chemistry.

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

M. Erion, D. Kemp, S. Prahalada, 2017, Science.

p300 Interacts with the N- and C-terminal Part of PPARγ2 in a Ligand-independent and -dependent Manner, Respectively*

J. Auwerx, Gaochao Zhou, E. Raspé, 1999, The Journal of Biological Chemistry.

MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activities

Margaret S. Wu, Y. Chao, J. Berger, 2004 .

Both Coactivator LXXLL Motif-dependent and -independent Interactions Are Required for Peroxisome Proliferator-activated Receptor γ (PPARγ) Function*

Bruce A. Johnson, D. Moller, Gaochao Zhou, 2000, The Journal of Biological Chemistry.

Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.

Bruce A. Johnson, J. Berger, D. Moller, 2003, Molecular endocrinology.

Activation of PPARα or γ Reduces Secretion of Matrix Metalloproteinase 9 but Not Interleukin 8 from Human Monocytic THP-1 Cells

J. Berger, Gaochao Zhou, S. Wright, 2000 .

L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor γ

J. Berger, D. Moller, Gaochao Zhou, 1999, The Journal of Biological Chemistry.

The Purification and Characterization of a Human Dual-specific Protein Tyrosine Phosphatase (*)

J. Dixon, J. Denu, Gaochao Zhou, 1995, The Journal of Biological Chemistry.

Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells (*)

G. Zhou, J. Dixon, K. Guan, 1996, The Journal of Biological Chemistry.

AMPK: an emerging drug target for diabetes and the metabolic syndrome.

Gaochao Zhou, Bei B. Zhang, Cai Li, 2009, Cell metabolism.

Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonists.

Margaret S. Wu, J. Berger, D. Moller, 2002, Diabetes.

Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.

Y. Chao, J. Berger, D. Moller, 2005, Journal of medicinal chemistry.

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Bioorganic & medicinal chemistry letters.

Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.

J. Lisnock, A. Crespo, Gaochao Zhou, 2015, ACS medicinal chemistry letters.

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase.

D. Kemp, Gaochao Zhou, F. A. Romero, 2018, ACS medicinal chemistry letters.

Dual Mechanisms of ABCA1 Regulation by Geranylgeranyl Pyrophosphate*

Gaochao Zhou, S. Wright, J. Menke, 2001, The Journal of Biological Chemistry.

Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase.

Margaret S. Wu, Q. Dang, D. Mackenna, 2017, Journal of medicinal chemistry.

A Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist Demonstrates Favorable Effects on Lipid Homeostasis

Margaret S. Wu, Y. Chao, J. Berger, 2004 .

Homogeneous assays for adenosine 5'-monophosphate-activated protein kinase.

Ying Li, Gaochao Zhou, R. Cummings, 2003, Analytical biochemistry.

Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.

M. Struthers, D. Macneil, D. Cully, 2017, Bioorganic & medicinal chemistry letters.

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Michael E. Lassman, M. Struthers, Qingzhong Hu, 2015, ACS medicinal chemistry letters.

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Michael E. Lassman, Jeffrey T. Kuethe, M. Struthers, 2015, ACS medicinal chemistry letters.

Role of AMP-activated protein kinase in mechanism of metformin action.

Margaret S. Wu, G. Zhou, N. Fujii, 2001, The Journal of clinical investigation.

The catalytic role of Cys124 in the dual specificity phosphatase VHR.

G. Zhou, J. Dixon, J. Denu, 1994, The Journal of biological chemistry.

Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.

M. Struthers, D. Macneil, D. Cully, 2017, ACS medicinal chemistry letters.

Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe.

P. Russell, G. Zhou, J. Denu, 1995, Biochemistry.

Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series.

J. Lisnock, A. Crespo, Gaochao Zhou, 2014, Bioorganic & medicinal chemistry letters.

Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation.

R G Smith, Y. Li, G. Zhou, 2000, Journal of molecular biology.

Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer.

G. Zhou, H. Wilkinson, J. Hermes, 1998, Molecular endocrinology.

Role of AMP-activated protein kinase in mechanism of metformin action.

Margaret S. Wu, N. Fujii, D. Moller, 2001, The Journal of clinical investigation.