Hung‐wen Liu

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Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.

C. Thibodeaux, Hung‐wen Liu, 2011, Biochemistry.

Membrane Environment Can Enhance the Interaction of Glycan Binding Protein to Cell Surface Glycan Receptors

Hung‐wen Liu, Lei Shen, Yini Wang, 2014, ACS chemical biology.

Current development in isoprenoid precursor biosynthesis and regulation.

Hung‐wen Liu, Wei‐chen Chang, Heng Song, 2013, Current opinion in chemical biology.

Biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of permethylated rhamnose and characterization of the functions of SpnH, SpnI, and SpnK.

Hung‐wen Liu, Hak Joong Kim, J. White-Phillip, 2010, Journal of the American Chemical Society.

Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes.

Hung‐wen Liu, Mark W. Ruszczycky, Aoshu Zhong, 2018, Natural product reports.

Mechanistic Enzymology of the Radical SAM Enzyme DesII.

Hung‐wen Liu, Mark W. Ruszczycky, M. Ruszczycky, 2015, Israel journal of chemistry.

Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis.

G. Petsko, D. Ringe, Hung‐wen Liu, 2004, Biochemistry.

Developmental programming in skeletal muscle in response to overnourishment in the immediate postnatal life in rats.

D. Smiraglia, Hung‐wen Liu, Mulchand S Patel, 2013, The Journal of nutritional biochemistry.

Studies of 1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid: Mechanism of Decomposition and Inhibition of 1-Aminocyclopropane-1-carboxylic Acid Deaminase.

Hung‐wen Liu, Mark W. Ruszczycky, Huawei Chen, 2015, Organic letters.

Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses.

J. Thorson, Hung‐wen Liu, Changsheng Zhang, 2006, Angewandte Chemie.

Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998, Chemistry & biology.

The Structure of SpnF, a Standalone Enzyme that Catalyzes [4+2] Cycloaddition

Hung‐wen Liu, E. A. Isiorho, A. Keatinge-Clay, 2015, Nature chemical biology.

Resveratrol protects muscle cells against palmitate-induced cellular senescence and insulin resistance through ameliorating autophagic flux

Yun-Ching Chang, Hung‐wen Liu, Sue-Joan Chang, 2018, Journal of food and drug analysis.

Inactivation of general acyl-coa dehydrogenase by enantiomerically pure (Methylenecyclopropyl)acetyl-coa and its implication for this enzyme-catalyzed reaction

M. Lai, Hung‐wen Liu, 1990 .

An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis

Hung‐wen Liu, C. Drennan, J. Bridwell-Rabb, 2016, Proceedings of the National Academy of Sciences.

Natural-product sugar biosynthesis and enzymatic glycodiversification.

C. Thibodeaux, Hung‐wen Liu, C. Melançon, 2008, Angewandte Chemie.

The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.

Hung‐wen Liu, Chia-I Lin, R. McCarty, 2013, Chemical Society reviews.

Nucleophilic Participation of Reduced Flavin Coenzyme in Mechanism of UDP-galactopyranose Mutase*

C. Thibodeaux, Hung‐wen Liu, Wei‐chen Chang, 2011, The Journal of Biological Chemistry.

Stereoselective synthesis of beta-1-C-substituted 1,4-dideoxy-1,4-imino-D-galactitols and evaluation as UDP-galactopyranose mutase inhibitors.

S. Py, Hung‐wen Liu, K. Itoh, 2007, Bioorganic & medicinal chemistry.

An alternative model for studying age-associated metabolic complications: Senescence-accelerated mouse prone 8

Hung‐wen Liu, Ming-Fu Wang, Y. Chan, 2017, Experimental Gerontology.

Adult-onset obesity induced by early life overnutrition could be reversed by moderate caloric restriction.

D. Smiraglia, Hung‐wen Liu, Mulchand S Patel, 2013, American journal of physiology. Endocrinology and metabolism.

Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme

L. J. Higgins, Hung‐wen Liu, C. Drennan, 2005, Nature.

Conformational Activation of Poly(ADP-ribose) Polymerase-1 upon DNA Binding Revealed by Small-Angle X-ray Scattering

Hung‐wen Liu, Liang Guo, S. O. Mansoorabadi, 2014, Biochemistry.

The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics.

M. Nishiyama, K. Shin‐ya, Hung‐wen Liu, 2019, Journal of the American Chemical Society.

A B12-dependent radical SAM enzyme involved in Oxetanocin-A biosynthesis

Hung‐wen Liu, C. Drennan, J. Bridwell-Rabb, 2017, Nature.

Structural Studies of the Spinosyn Forosaminyltransferase, SpnP

Hung‐wen Liu, Nam-Ho Kim, E. A. Isiorho, 2014, Biochemistry.

Unusual sugar biosynthesis and natural product glycodiversification

C. Thibodeaux, Hung‐wen Liu, C. Melançon, 2007, Nature.

Evidence for radical-mediated catalysis by HppE: a study using cyclopropyl and methylenecyclopropyl substrate analogues.

Hung‐wen Liu, D. Russell, Wei‐chen Chang, 2012, Journal of the American Chemical Society.

Biosynthesis of fosfomycin, re-examination and re-confirmation of a unique Fe(II)- and NAD(P)H-dependent epoxidation reaction.

Hung‐wen Liu, Pinghua Liu, F. Yan, 2006, Biochemistry.

Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase.

J. Lipscomb, Hung‐wen Liu, Aimin Liu, 2005, Archives of biochemistry and biophysics.

Mechanistic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: single turnover reaction

L. Que, J. Lipscomb, Hung‐wen Liu, 2004, JBIC Journal of Biological Inorganic Chemistry.

Probing the unfolding of myoglobin and domain C of PARP-1 with covalent labeling and top-down ultraviolet photodissociation mass spectrometry.

J. Brodbelt, Hung‐wen Liu, J. Pruet, 2014, Analytical chemistry.

A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.

Hung‐wen Liu, E. Sasaki, Yasushi Ogasawara, 2010, Journal of the American Chemical Society.

Structural studies of the spinosyn rhamnosyltransferase, SpnG.

Hung‐wen Liu, E. A. Isiorho, A. Keatinge-Clay, 2012, Biochemistry.

Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice

Yun-Ching Chang, Hung‐wen Liu, Y. Chan, 2020, Biogerontology.

The branching point in the petasaccharides viridopentaoses A, B and C

K. Nakanishi, Hung‐wen Liu, M. Dinovi, 1982 .

Biosynthesis of 3,6-dideoxyhexoses: new mechanistic reflections upon 2,6-dideoxy, 4,6-dideoxy, and amino sugar construction

J. Thorson, Hung‐wen Liu, C. Hutchinson, 1993 .

Structure and mutagenic conversion of E1 dehydrase: at the crossroads of dehydration, amino transfer, and epimerization.

Hung‐wen Liu, S. Tsai, Peter W. Smith, 2008, Biochemistry.

Moderate Exercise Suppresses NF-κB Signaling and Activates the SIRT1-AMPK-PGC1α Axis to Attenuate Muscle Loss in Diabetic db/db Mice

Hung‐wen Liu, Sue-Joan Chang, 2018, Front. Physiol..

Pathway and Enzyme Engineering and Applications for Glycodiversification

Hung‐wen Liu, Lishan Zhao, 2011 .

Stereospecificity of hydride transfer for the catalytically recycled NAD+ in CDP-d-glucose 4,6-dehydratase

Hung‐wen Liu, T. Hallis, 1998 .

Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine.

Hung‐wen Liu, F. Yan, M. Ruszczycky, 2009, Journal of the American Chemical Society.

Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality.

Yun-Ching Chang, Hung‐wen Liu, Ming-Fu Wang, 2019, Molecular nutrition & food research.

Biochemistry: The surprising history of an antioxidant

Hung‐wen Liu, M. Ruszczycky, 2017, Nature.

Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice

Hung‐wen Liu, Hao-Han Kao, Chi-Hang Wu, 2019, Nutrition & Metabolism.

Dietary (-)-Epigallocatechin-3-gallate Supplementation Counteracts Aging-Associated Skeletal Muscle Insulin Resistance and Fatty Liver in Senescence-Accelerated Mouse.

Hung‐wen Liu, Ming-Fu Wang, Y. Chan, 2015, Journal of agricultural and food chemistry.

Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle.

Hung‐wen Liu, Sue-Joan Chang, Yun-An Chen, 2016, Molecular nutrition & food research.

Reaction of 1-amino-2-methylenecyclopropane-1-carboxylate with 1-aminocyclopropane-1-carboxylate deaminase: analysis and mechanistic implications.

Hung‐wen Liu, Z. Zhao, Huawei Chen, 2003, Biochemistry.

Mechanistic Studies of 1-Aminocyclopropane-1-carboxylate Deaminase: Unique Covalent Catalysis by Coenzyme B6

Hung‐wen Liu, Keqiang Li, N. Que, 1996 .

Stereochemical Studies on the Reactions Catalyzed by the PLP-Dependent Enzyme 1-Aminocyclopropane-1-carboxylate Deaminase

C. Walsh, Hung‐wen Liu, R. Auchus, 1984 .

Structural analysis of 1-aminocyclopropane-1-carboxylate deaminase: observation of an aminyl intermediate and identification of Tyr 294 as the active-site nucleophile.

Hung‐wen Liu, Z. Zhao, S. Karthikeyan, 2004, Angewandte Chemie.

Biosynthesis of Oxetanocin-A Includes a B12-Dependent Radical SAM Enzyme That Can Catalyze both Oxidative Ring Contraction and the Demethylation of SAM.

Hung‐wen Liu, Aoshu Zhong, Yung-nan Liu, 2021, Biochemistry.

Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1

Yun-Ching Chang, Hung‐wen Liu, Sue-Joan Chang, 2017, Nutrients.

Characterisation of a sugar epimerase enzyme involved in the biosynthesis of a vancomycin-group antibiotic

Dudley H. Williams, Hung‐wen Liu, W. Scaife, 2000 .

A retro-evolution study of CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) from Yersinia pseudotuberculosis: implications for C-3 deoxygenation in the biosynthesis of 3,6-dideoxyhexoses.

Hung‐wen Liu, Huawei Chen, Yung-nan Liu, 2007, Biochemistry.

Mechanistic Studies of 1-Aminocyclopropane-1-carboxylate Deaminase (ACCD): Characterization of an Unusual PLP-dependent Reaction

C. Thibodeaux, Hung‐wen Liu, 2011 .

Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis.

C. Thibodeaux, Hung‐wen Liu, Wei‐chen Chang, 2012, Chemical reviews.

Effect of Progressive Resistance Training on Circulating Adipogenesis-, Myogenesis-, and Inflammation-Related microRNAs in Healthy Older Adults: An Exploratory Study

Hung‐wen Liu, Hao-Chien Cheng, S. Tsai, 2020, Gerontology.

A fluoro analogue of UDP-α-D-glucuronic acid is an inhibitor of UDP-α-D-apiose/UDP-α-D-xylose synthase.

Hung‐wen Liu, Hua Zhang, M. Ruszczycky, 2011, Chemical communications.

A revised mechanism for the inactivation of bovine liver enoyl-CoA hydratase by (methylenecyclopropyl)formyl-CoA based on unexpected results with the C114A mutant.

S. Withers, Hung‐wen Liu, S. Dakoji, 2002, Biochemistry.

Flavin-enabled reductive and oxidative epoxide ring opening reactions

Hung‐wen Liu, A. Mándi, T. Kurtán, 2022, Nature Communications.

Analysis of UDP-D-apiose/UDP-D-xylose synthase-catalyzed conversion of UDP-D-apiose phosphonate to UDP-D-xylose phosphonate: implications for a retroaldol-aldol mechanism.

Hung‐wen Liu, Tun-Cheng Chien, S. O. Mansoorabadi, 2012, Journal of the American Chemical Society.

DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1.

T. Paull, Hung‐wen Liu, Wei He, 2022, Cell reports.

Mechanistic Implications of the Deamination of TDP-4-amino-4-deoxy-d-fucose Catalyzed by the Radical SAM Enzyme DesII.

Hung‐wen Liu, Geng-min Lin, M. Ruszczycky, 2018, Biochemistry.

Study of Uridine 5'-Diphosphate (UDP)-Galactopyranose Mutase Using UDP-5-Fluorogalactopyranose as a Probe: Incubation Results and Mechanistic Implications.

Hung‐wen Liu, Geng-min Lin, H. Sun, 2016, Organic letters.

Synthesis of TDP-3-amino-3,4,6-trideoxy-α-d-xylo-hexopyranose—The immediate precursor of TDP-α-d-desosamine

Hung‐wen Liu, C. Chang, 2002 .

Chemical synthesis of UDP-β-l-arabinofuranose and its turnover to UDP-β-l-arabinopyranose by UDP-galactopyranose mutase

Hung‐wen Liu, Qibo Zhang, 2001 .

Expression, Purification, and Characterization of TylM1, an N,N-Dimethyltransferase Involved in the Biosynthesis of Mycaminose

Zhihong Guo, Hung‐wen Liu, Huawei Chen, 1998 .

Linear aglycones are the substrates for glycosyltransferase DesVII in methymycin biosynthesis: analysis and implications.

Hung‐wen Liu, Hak Joong Kim, S. Borisova, 2006, Journal of the American Chemical Society.

A two-stage one-pot enzymatic synthesis of TDP-L-mycarose from thymidine and glucose-1-phosphate.

Hung‐wen Liu, Haruko Takahashi, Yung-nan Liu, 2006, Journal of the American Chemical Society.

Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway.

Hung‐wen Liu, Huawei Chen, Haruko Takahashi, 2005, Journal of the American Chemical Society.

Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.

Hung‐wen Liu, Lishan Zhao, S. Borisova, 2004, Journal of the American Chemical Society.

Engineering a methymycin/pikromycin-calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety [6]

D. Sherman, J. Thorson, Hung‐wen Liu, 1999 .

Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety.

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1999, Organic letters.

Mechanistic studies of desosamine biosynthesis: C-4 deoxygenation precedes C-3 transamination [18]

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998 .

Biosynthesis of Desosamine: Construction of a New Methymycin/Neomethymycin Analogue by Deletion of a Desosamine Biosynthetic Gene

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998 .

Mechanistic studies of the biosynthesis of 2-thiosugar: evidence for the formation of an enzyme-bound 2-ketohexose intermediate in BexX-catalyzed reaction.

Hung‐wen Liu, E. Sasaki, 2010, Journal of the American Chemical Society.

Studies of GenK and OxsB, two B12-dependent radical SAM enzymes involved in natural product biosynthesis.

Hung‐wen Liu, Yu-Hsuan Lee, 2022, Methods in enzymology.

C3'-Deoxygenation of Paromamine Catalyzed by a Radical S-Adenosylmethionine Enzyme: Characterization of the Enzyme AprD4 and Its Reductase Partner AprD3.

Hung‐wen Liu, Hak Joong Kim, Y. Yeh, 2016, Angewandte Chemie.

Reaction Catalyzed by GenK, a Cobalamin-Dependent Radical S-Adenosyl-l-methionine Methyltransferase in the Biosynthetic Pathway of Gentamicin, Proceeds with Retention of Configuration.

Hung‐wen Liu, Hak Joong Kim, Yung-nan Liu, 2017, Journal of the American Chemical Society.

Identification of the Early Steps in Herbicidin Biosynthesis Reveals an Atypical Mechanism of C-Glycosylation.

Hung‐wen Liu, Shusuke Sato, Yujie Geng, 2022, Journal of the American Chemical Society.

Characterization of the Oxazinomycin Biosynthetic Pathway Revealing the Key Role of a Nonheme Iron-Dependent Mono-oxygenase.

Hung‐wen Liu, Shao‐An Wang, Daan Ren, 2022, Journal of the American Chemical Society.

Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin.

Hung‐wen Liu, Yasushi Ogasawara, Shao‐An Wang, 2019, Angewandte Chemie.

Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de Novo Purine Biosynthesis.

Hung‐wen Liu, Yasushi Ogasawara, Y. Zhang, 2019, Journal of the American Chemical Society.

Theory and Application of the Relationship Between Steady-State Isotope Effects on Enzyme Intermediate Concentrations and Net Rate Constants.

Hung‐wen Liu, M. Ruszczycky, 2017, Methods in enzymology.

Mechanistic studies of the radical S-adenosylmethionine enzyme DesII with TDP-D-fucose.

Hung‐wen Liu, M. Ruszczycky, Sei-hyun Choi, 2015, Angewandte Chemie.

GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme.

Hung‐wen Liu, Hak Joong Kim, Yasushi Ogasawara, 2013, Journal of the American Chemical Society.

Spiropentylacetyl-CoA, A Mechanism-Based Inactivator of Acyl-CoA Dehydrogenases

Hung‐wen Liu, I. Shin, S. Dakoji, 1998 .

Inactivation of medium-chain acyl-CoA dehydrogenase by a metabolite of hypoglycin: characterization of the major turnover product and evidence suggesting an alternative flavin modification pathway

M. Lai, Hung‐wen Liu, Ding Li, 1993 .

New evidence supporting a radical mechanism of the inactivation of general acyl-CoA dehydrogenase by a metabolite of hypoglycin

M. Lai, Hung‐wen Liu, 1992 .

Stoichiometry of the redox neutral deamination and oxidative dehydrogenation reactions catalyzed by the radical SAM enzyme DesII.

Hung‐wen Liu, M. Ruszczycky, Sei-hyun Choi, 2010, Journal of the American Chemical Society.

In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.

Hung‐wen Liu, Z. Zhao, C. Melançon, 2008, Journal of the American Chemical Society.

Characterization and mechanistic studies of type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Staphylococcus aureus.

C. Thibodeaux, Hung‐wen Liu, Hua Zhang, 2007, Biochemistry.

Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies.

Hung‐wen Liu, C. Melançon, Yung-nan Liu, 2007, Biochemistry.

Vi antigen biosynthesis in Salmonella typhi: characterization of UDP-N-acetylglucosamine C-6 dehydrogenase (TviB) and UDP-N-acetylglucosaminuronic acid C-4 epimerase (TviC).

Hung‐wen Liu, Ying Zhou, Hua Zhang, 2006, Biochemistry.

Studies of UDP-Galactopyranose Mutase from Escherichia coli: An Unusual Role of Reduced FAD in Its Catalysis

Hung‐wen Liu, Qibo Zhang, 2000 .

Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif.

Hung‐wen Liu, D. Hoffman, Z. Tao, 2008, Biochemistry.

Cyclopropane Fatty Acid Synthase from Escherichia coli: Enzyme Purification and Inhibition by Vinylfluorine and Epoxide‐Containing Substrate Analogues

Hung‐wen Liu, E. Molitor, Beth M. Paschal, 2003, Chembiochem : a European journal of chemical biology.

Biosynthesis of colitose: expression, purification, and mechanistic characterization of GDP-4-keto-6-deoxy-D-mannose-3-dehydrase (ColD) and GDP-L-colitose synthase (ColC).

Hung‐wen Liu, Jenefer Alam, N. Beyer, 2004, Biochemistry.

Mechanisms of enzymatic CbondO bond cleavages in deoxyhexose biosynthesis.

Hung‐wen Liu, Xuemei M He, 2002, Current opinion in chemical biology.

Characterization of a unique coenzyme B6 radical in the ascarylose biosynthetic pathway [14]

G. H. Reed, Hung‐wen Liu, V. Bandarian, 2000 .

Characterization of the first PMP-dependent iron-sulfur-containing enzyme which is essential for the biosynthesis of 3,6-dideoxyhexoses

J. Thorson, Hung‐wen Liu, 1993 .

Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway.

Hung‐wen Liu, S. Borisova, 2010, Biochemistry.

Glycosylation of Acyclic and Cyclic Aglycone Substrates by Macrolide Glycosyltransferase DesVII/DesVIII: Analysis and Implications

Hung‐wen Liu, Hak Joong Kim, S. Borisova, 2008, Chembiochem : a European journal of chemical biology.

Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis.

Hung‐wen Liu, C. Melançon, Haruko Takahashi, 2004, Journal of the American Chemical Society.

Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.

Hung‐wen Liu, Z. Zhao, Lishan Zhao, 2002, Biochemistry.

Engineering a hybrid sugar biosynthetic pathway: Production of L-rhamnose and its implication on dihydrostreptose biosynthesis

Hung‐wen Liu, Lishan Zhao, H. Yamase, 2000 .

New Insights into the Mechanism of CDP-d-Tyvelose 2-Epimerase: An Enzyme-Catalyzing Epimerization at an Unactivated Stereocenter

Hung‐wen Liu, T. Hallis, And Z. Zhao, 2000 .

Enzymatic synthesis of TDP-deoxysugars.

C. Thibodeaux, Hung‐wen Liu, J. White-Phillip, 2009, Methods in enzymology.

Mechanistic studies of an IspH-catalyzed reaction: implications for substrate binding and protonation in the biosynthesis of isoprenoids.

Hung‐wen Liu, Youli Xiao, Wei‐chen Chang, 2011, Angewandte Chemie.

Toona sinensis leaf extract inhibits lipid accumulation through up-regulation of genes involved in lipolysis and fatty acid oxidation in adipocytes.

Hung‐wen Liu, Sue-Joan Chang, Y. Tsai, 2014, Journal of agricultural and food chemistry.

Learning Nature's Strategies for Making Deoxy Sugars: Pathways, Mechanisms, and Combinatorial Applications

Hung‐wen Liu, T. Hallis, 1999 .

Low-molecular-weight polyphenols protect kidney damage through suppressing NF-κB and modulating mitochondrial biogenesis in diabetic db/db mice.

Hung‐wen Liu, Sue-Joan Chang, Chu-Chun Wei, 2016, Food & function.

Synthesis of β-difluorine-containing amino acids

Hung‐wen Liu, C. Leriche, Keqiang Li, 1998 .

Reaction of HppE with substrate analogues: evidence for carbon-phosphorus bond cleavage by a carbocation rearrangement.

Hung‐wen Liu, Wei‐chen Chang, S. O. Mansoorabadi, 2013, Journal of the American Chemical Society.

Dynamically Complex [6+4] and [4+2] Cycloadditions in the Biosynthesis of Spinosyn A.

Hung‐wen Liu, Zhuo Chen, K. Houk, 2016, Journal of the American Chemical Society.

Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A.

Hung‐wen Liu, Yasushi Ogasawara, Shao‐An Wang, 2017, Organic letters.

Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis.

L. Que, Hung‐wen Liu, Z. Zhao, 2004, Journal of the American Chemical Society.

The type II isopentenyl Diphosphate:Dimethylallyl diphosphate isomerase (IDI-2): A model for acid/base chemistry in flavoenzyme catalysis.

C. Thibodeaux, Hung‐wen Liu, 2017, Archives of biochemistry and biophysics.

Biosynthesis of 3,6-dideoxyhexoses: stereochemical analysis of the deprotonation catalyzed by the pyridoxamine 5'-phosphate dependent enzyme CDP-4-keto-6-deoxy-D-glucose-3-dehydrase isolated from Yersinia pseudotuberculosis

Ding-Yah Yang, Hung‐wen Liu, T. M. Weigel, 1990 .

3-DEOXY-3-FLUOROPYRIDOXAMINE 5'-PHOSPHATE: SYNTHESIS AND CHEMICAL AND BIOLOGICAL PROPERTIES OF A COENZYME B6 ANALOG

Ding-Yah Yang, Hung‐wen Liu, Hui-qiang Zhou, 1997 .

Elucidation of enzyme mechanisms using fluorinated substrate analogues.

Hung‐wen Liu, R. Pongdee, 2004, Bioorganic chemistry.

Mechanisms and structures of vitamin B(6)-dependent enzymes involved in deoxy sugar biosynthesis.

Hung‐wen Liu, A. Romo, 2011, Biochimica et biophysica acta.

Biosynthesis of a 3,6-dideoxyhexose: crystallization and X-ray diffraction of CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase (E1) for ascarylose biosynthesis.

Hung‐wen Liu, S. Tsai, Peter W. Smith, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Biosynthesis of mycarose: Isolation and characterization of enzymes involved in the C-2 deoxygenation

Zhihong Guo, Hung‐wen Liu, Huawei Chen, 1999 .

Mechanistic studies of the biosynthesis of 3,6-dideoxy sugars: Stereochemical analysis of C-3 deoxygenation

Zhihong Guo, Hung‐wen Liu, P. A. Pieper, 1995 .

Coenzyme B6 as a Redox Cofactor: A New Role for an Old Coenzyme?

J. Thorson, Hung‐wen Liu, 1993 .

Molecular basis of 3,6-dideoxyhexose biosynthesis elucidation of CDP-ascarylose biosynthetic genes and their relationship to other 3,6-dideoxyhexose pathways

J. Thorson, Hung‐wen Liu, S. Lo, 1993 .

Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity

Hung‐wen Liu, Xueting Liu, Lixin Zhang, 2016, Applied Microbiology and Biotechnology.

An Enzyme-Catalyzed [4+2] Cycloaddition is a Key Step in the Biosynthesis of Spinosyn A

Hung‐wen Liu, Mark W. Ruszczycky, Hak Joong Kim, 2011, Nature.

On the mechanism of sodium cyanoborohydride reduction of tosylhydrazones

Hung‐wen Liu, Leroy F. Liu, O. Han, 1988 .

Studies of the mechanistic diversity of sodium cyanoborohydride reduction of tosylhydrazones

Ding-Yah Yang, Hung‐wen Liu, O. Han, 1989 .

The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems.

Hung‐wen Liu, Chia-I Lin, R. McCarty, 2017, Angewandte Chemie.

Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis.

Hung‐wen Liu, Z. Zheng, Binju Wang, 2022, ACS catalysis.

Measurement of Net Rate Constants from Enzyme Progress Curves without Curve Fitting.

Hung‐wen Liu, M. Ruszczycky, 2019, Biochemistry.

Changes in Regioselectivity of H Atom Abstraction during the Hydroxylation and Cyclization Reactions Catalyzed by Hyoscyamine 6β-Hydroxylase.

Hung‐wen Liu, Richiro Ushimaru, M. Ruszczycky, 2018, Journal of the American Chemical Society.

Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.

Charles E Melançon, Hung‐wen Liu, H. Kwon, 2007, Journal of the American Chemical Society.

A Mechanistic Analysis of C—O Bond Cleavage Events with a Comparison to 3,6-Dideoxysugar Formation

Hung‐wen Liu, David A. Johnson, 2000 .

Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity.

X. Zhai, Hung‐wen Liu, Geng-min Lin, 2019, Organic letters.

Evidence for an Enzyme-Catalyzed Rauhut-Currier Reaction during the Biosynthesis of Spinosyn A.

M. Tsai, T. Ko, Hung‐wen Liu, 2021, Journal of the American Chemical Society.

Synthesis of labeled 1-amino-2-methylenecyclopropane-1-carboxylic acid, an inactivator of 1-aminocyclopropane-1-carboxylate deaminase.

Hung‐wen Liu, Z. Zhao, 2002, The Journal of organic chemistry.

Chemoenzymatic synthesis of spinosyn A.

Hung‐wen Liu, Hak Joong Kim, Byung-sun Jeon, 2014, Angewandte Chemie.

Enantioselective intermolecular aldehyde-ketone cross-coupling through an enzymatic carboligation reaction.

M. Richter, Michael Müller, Hung‐wen Liu, 2010, Angewandte Chemie.

Mechanistic Studies of the Biosynthesis of 3,6‐Dideoxysugars in Bacteria: Exploration of a Novel C‐O Bond Cleavage Event

Ding-Yah Yang, J. Thorson, Hung‐wen Liu, 1995 .

A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity.

Hung‐wen Liu, J. Penn, G. O'Doherty, 2010, Organic letters.

Recent Progress in Unusual Carbohydrate-Containing Natural Products Biosynthesis

Hung‐wen Liu, Geng-min Lin, Wei‐chen Chang, 2019 .

Radical SAM enzymes in the biosynthesis of sugar-containing natural products.

Hung‐wen Liu, Yasushi Ogasawara, M. Ruszczycky, 2012, Biochimica et biophysica acta.

Synthesis of cytidine diphosphate-d-quinovose

Hung‐wen Liu, L. Liu, 1989 .

Synthesis of stereospecifically labeled carbohydrates: Preparation of (3S)− and (3R)-[3-2H1]ascarylose

R. N. Russell, Hung‐wen Liu, 1987 .

Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction.

Hung‐wen Liu, Z. Zhao, Hong Zhang, 2004, Biochemistry.

A secondary kinetic isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangement.

Hung‐wen Liu, Hak Joong Kim, S. O. Mansoorabadi, 2009, Journal of the American Chemical Society.

Biosynthetic studies of aziridine formation in azicemicins.

Hung‐wen Liu, Yasushi Ogasawara, 2009, Journal of the American Chemical Society.

Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: a novel mononuclear non-heme iron enzyme.

J. Lipscomb, Hung‐wen Liu, Pinghua Liu, 2003, Biochemistry.

Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions.

Hung‐wen Liu, Wei‐chen Chang, Yung-nan Liu, 2018, Journal of the American Chemical Society.

Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae.

Hung‐wen Liu, Weichen Chang, S. O. Mansoorabadi, 2008, Biochemistry.

Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues.

J. Lipscomb, Hung‐wen Liu, Z. Zhao, 2007, Biochemistry.

Mechanistic Consequences of Chiral Radical Clock Probes: Analysis of the Mononuclear Non-Heme Iron Enzyme HppE with 2-Hydroxy-3-methylenecyclopropyl Radical Clock Substrates

Hung‐wen Liu, D. Russell, Geng-min Lin, 2014, Journal of the American Chemical Society.

Evidence that the Fosfomycin-Producing Epoxidase, HppE, Is a Non–Heme-Iron Peroxidase

C. Krebs, J. Bollinger, Hung‐wen Liu, 2013, Science.

Mechanistic studies of an unprecedented enzyme-catalyzed 1,2-phosphono migration reaction

Hung‐wen Liu, Z. Zhao, C. Drennan, 2013, Nature.

Structural Basis of Regiospecificity of a Mononuclear Iron Enzyme in Antibiotic Fosfomycin Biosynthesis

L. J. Higgins, Hung‐wen Liu, C. Drennan, 2011, Journal of the American Chemical Society.

Byproduct formation during the biosynthesis of spinosyn A and evidence for an enzymatic interplay to prevent its formation.

S. Hung, Hung‐wen Liu, Teng-Yi Huang, 2021, Tetrahedron.

Natural [4 + 2]-Cyclases.

Hung‐wen Liu, Shao‐An Wang, Byung-sun Jeon, 2017, Chemical reviews.

Biosynthesis of Versipelostatin: Identification of an Enzyme-Catalyzed [4+2]-Cycloaddition Required for Macrocyclization of Spirotetronate-Containing Polyketides

M. Nishiyama, T. Hashimoto, J. Hashimoto, 2014, Journal of the American Chemical Society.

The biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of the cross-bridging precursor and identification of the function of SpnJ.

Hung‐wen Liu, Hak Joong Kim, Lin Hong, 2007, Journal of the American Chemical Society.

Cyclobutaneacetyl-CoA: A Janus-Faced Substrate for Acyl-CoA Dehydrogenases

Hung‐wen Liu, D. Becker, I. Shin, 1994 .

The structures of balanitins, potent molluscicides isolated from Balanites aegyptiaca

K. Nakanishi, Hung‐wen Liu, 1982 .

Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships.

C. Thibodeaux, Hung‐wen Liu, Wei‐chen Chang, 2019, Methods in enzymology.

Characterization of methyl glycosides at the pico- to nano-gram level

K. Nakanishi, Hung‐wen Liu, M. Dinovi, 1983 .

Additivity relation found in the amplitudes of exciton-split circular dichroism curves of pyranose benzoates

K. Nakanishi, Hung‐wen Liu, 1981 .

A Southern Army-Worm Antifeedant, 12b-Acetoxyharrisonin from an African Shrub Harrisonia Abyssinica

K. Nakanishi, Hung‐wen Liu, I. Kubo, 1982 .

Methylerythritol phosphate pathway of isoprenoid biosynthesis.

Hung‐wen Liu, Lishan Zhao, Youli Xiao, 2013, Annual review of biochemistry.

Toona Sinensis ameliorates insulin resistance via AMPK and PPARγ pathways.

Hung‐wen Liu, Wenlan Yu, Sue-Joan Chang, 2015, Food & function.

Formation of unusual sugars: mechanistic studies and biosynthetic applications.

Hung‐wen Liu, Xuemei M He, 2002, Annual review of biochemistry.

Insights into the Branched-Chain Formation of Mycarose: Methylation Catalyzed by an (S)-Adenosylmethionine-Dependent Methyltransferase.

Zhihong Guo, Hung‐wen Liu, Z. Zhao, 2001, Angewandte Chemie.

Characterization of Enzymes Catalyzing Transformations of Cysteine S‐Conjugated Intermediates in the Lincosamide Biosynthetic Pathway

Hung‐wen Liu, E. Sasaki, Chia-I Lin, 2016, Chembiochem : a European journal of chemical biology.

Biological activity of (3R,5S,6R)- and (3S,5R,6S)-3,5-dimethyl-6-(methylethyl)-3,4,5,6-tetrahydropyran-2-one, a pheromone ofMacrocentrus grandii (Goidanich) (Hymenoptera: Braconidae)

Hung‐wen Liu, I. Shin, Richard L. Jones, 1994, Journal of Chemical Ecology.

Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

Hung‐wen Liu, Yiguang Zhu, Qingbo Zhang, 2018, Nature Communications.

The diverse roles of flavin coenzymes--nature's most versatile thespians.

C. Thibodeaux, Hung‐wen Liu, S. O. Mansoorabadi, 2007, The Journal of organic chemistry.

Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus.

C. Thibodeaux, Hung‐wen Liu, Wei‐chen Chang, 2008, Biochemistry.

Reconstitution of UDP-galactopyranose mutase with 1-deaza-FAD and 5-deaza-FAD: analysis and mechanistic implications.

Hung‐wen Liu, Qibo Zhang, Zhi-Yun Huang, 2003, Bioorganic chemistry.

Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A

Hung‐wen Liu, E. Sasaki, Chia-I Lin, 2020, Proceedings of the National Academy of Sciences.

In vitro characterization of LmbK and LmbO: identification of GDP-D-erythro-α-D-gluco-octose as a key intermediate in lincomycin A biosynthesis.

Hung‐wen Liu, E. Sasaki, Chia-I Lin, 2014, Journal of the American Chemical Society.

Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN.

Hung‐wen Liu, E. Sasaki, Chia-I Lin, 2012, Journal of the American Chemical Society.

3.12 – Deoxysugars: Occurrence, Genetics, and Mechanisms of Biosynthesis

Hung‐wen Liu, David A. Johnson, 1999 .

Stereochemical and Mechanistic Studies of CDP-D-glucose Oxidoreductase Isolated from Yersinia pseudotuberculosis

R. N. Russell, Hung‐wen Liu, 1991 .

Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues.

Hung‐wen Liu, Youli Xiao, Wei‐chen Chang, 2011, Organic letters.

Stereochemical analysis of isopentenyl diphosphate isomerase type II from Staphylococcus aureus using chemically synthesized (S)- and (R)-[2-2H]isopentenyl diphosphates.

Hung‐wen Liu, H. Seto, Hua Zhang, 2005, Organic letters.

Stereochemistry of the enzymatic ring opening of 1-aminocyclopropanecarboxylic acid

C. Walsh, Hung‐wen Liu, D. Arigoni, 1984 .

Convergent and stereoselective synthesis of iminosugar-containing Galf and UDP-Galf mimicks: evaluation as inhibitors of UDP-Gal mutase.

Hung‐wen Liu, K. Itoh, O. Martin, 2008, The Journal of organic chemistry.

Mechanistic Investigation of the Radical S-Adenosyl-L-methionine Enzyme DesII Using Fluorinated Analogues.

Hung‐wen Liu, Geng-min Lin, M. Ruszczycky, 2015, Journal of the American Chemical Society.

Radical S-Adenosyl Methionine Enzyme BlsE Catalyzes a Radical-Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S.

Hung‐wen Liu, Jin-Ming Gao, Binju Wang, 2022, Journal of the American Chemical Society.

The Radical SAM Enzyme BlsE Catalyzes a Radical Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S

Hung‐wen Liu, Binju Wang, Jiahai Zhou, 2022 .

Mechanistic Investigation of 1,2-Diol Dehydration of Paromamine Catalyzed by the Radical S-Adenosyl-l-methionine Enzyme AprD4.

Hung‐wen Liu, Hak Joong Kim, Y. Yeh, 2021, Journal of the American Chemical Society.

EPR-kinetic isotope effect study of the mechanism of radical-mediated dehydrogenation of an alcohol by the radical SAM enzyme DesII

Hung‐wen Liu, M. Ruszczycky, Sei-hyun Choi, 2013, Proceedings of the National Academy of Sciences.

Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose.

Hung‐wen Liu, S. O. Mansoorabadi, M. Ruszczycky, 2011, Journal of the American Chemical Society.

Biosynthesis of TDP-D-desosamine: identification of a strategy for C4 deoxygenation.

Hung‐wen Liu, Lishan Zhao, Xuemei M He, 2005, Angewandte Chemie.

Pyranose benzoates: an additivity relation in the amplitudes of exciton-split CD curves

K. Nakanishi, Hung‐wen Liu, 1982 .

TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene.

Hung‐wen Liu, C. Melançon, Wei-luen Yu, 2005, Journal of the American Chemical Society.

Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification† †Electronic supplementary information (ESI) available: The experimental procedures, materials, and characterization of compounds. See DOI: 10.1039/c7sc01182b Click here for additiona

Hung‐wen Liu, Yuemao Shen, C. Tian, 2017, Chemical science.

Biosynthetic Origin of the Atypical Stereochemistry in the Thioheptose Core of Albomycin Nucleoside Antibiotics.

Hung‐wen Liu, Richiro Ushimaru, 2019, Journal of the American Chemical Society.

The Biosynthesis of Nitrogen‐, Sulfur‐, and High‐Carbon Chain‐Containing Sugars

Hung‐wen Liu, Chia-I Lin, R. McCarty, 2013 .

Characterization of SpnQ from the spinosyn biosynthetic pathway of Saccharopolyspora spinosa: mechanistic and evolutionary implications for C-3 deoxygenation in deoxysugar biosynthesis.

Hung‐wen Liu, Z. Zhao, Lin Hong, 2006, Journal of the American Chemical Society.

Biosynthesis of desosamine: Molecular evidence suggesting β- glucosylation as a self-resistance mechanism in methymycin/neomethymycin producing strain, Streptomyces venezuelae [7]

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998 .

Study of 1-deoxy-D-xylulose-5-phosphate reductoisomerase: synthesis and evaluation of fluorinated substrate analogues.

Hung‐wen Liu, A. Wong, J. Munos, 2004, Organic letters.

Complete reconstitution of the diverse pathways of gentamicin B biosynthesis.

Hung‐wen Liu, S. Cha, Y. Yoon, 2019 .

Complete reconstitution of the diverse pathways of gentamicin B biosynthesis

Hung‐wen Liu, S. Cha, Y. Yoon, 2018, Nature Chemical Biology.

Synthesis of Enantiomerically Pure [(Methylenecyclopropyl)acetyl]-CoA: The Causative Agent of Jamaican Vomiting Sickness

M. Lai, Hung‐wen Liu, E. Oh, 1992 .

A Sex Pheromone Isolated from Macrocentrus grandii. Absolute Stereochemistry Determination and Implications

Hung‐wen Liu, I. Shin, Richard L. Jones, 1993 .

Mechanistic Study on the Inactivation of General Acyl‐CoA Dehydrogenase by a Metabolite of Hypoglycin A

M. Lai, Hung‐wen Liu, L. Liu, 1991 .

Mechanistic study on the inactivation of general acyl-CoA dehydrogenase by a metabolite of hypoglycin A

M. Lai, Hung‐wen Liu, L. Liu, 1991 .

Studies of the inactivation of general acyl-coa dehydrogenase by (1R)- and (1S)-(methylenecyclopropyl)acetyl-coa

M. Lai, Hung‐wen Liu, E. Oh, 1992 .

Highly regioselective and rapid ring opening of the (methylenecyclopropyl)methyl radical

M. Lai, Hung‐wen Liu, M. Newcomb, 1994 .

Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis.

Hung‐wen Liu, B. Bachmann, Ahmad H Al-Mestarihi, 2013, Journal of the American Chemical Society.

Biochemistry of the Cyclopropyl Group

C. Walsh, Hung‐wen Liu, 2005 .

Synthesis and analysis of substrate analogues for UDP-galactopyranose mutase: implication for an oxocarbenium ion intermediate in the catalytic mechanism.

Hung‐wen Liu, K. Itoh, Zhi-Yun Huang, 2007, Organic letters.

(3R*,5S*,6R*)-3,5-dimethyl-6-(methylethyl)-3,4,5,6-tetrahydropyran-2-one, a third sex pheromone component forMacrocentrus grandii (goidanich) (Hymenoptera: Braconidae) and evidence for its utility at eclosion

Hung‐wen Liu, T. Krick, Richard L. Jones, 1993, Journal of Chemical Ecology.

Studies of acyl-CoA dehydrogenase catalyzed allylic isomerization: A one-base or two-base mechanism?

Hung‐wen Liu, D. Becker, I. Shin, 1996 .

Biochemical Basis of Vosevi, a New Treatment for Hepatitis CPublished as part of the Biochemistry series "Biochemistry to Bedside".

Hung‐wen Liu, Ronald Besandre, 2017, Biochemistry.

Enoyl-CoA hydratase. reaction, mechanism, and inhibition.

Hung‐wen Liu, G. Agnihotri, 2003, Bioorganic & medicinal chemistry.

The toxicity of methylenecyclopropylglycine: Studies of the inhibitory effects of (methylenecyclopropyl)formyl-CoA on enzymes involved in fatty acid metabolism and the molecular basis of its inactivation of enoyl-CoA hydratases

Hung‐wen Liu, S. Dakoji, Ding Li, 1999 .

Dinoflagellate neurotoxins related to saxitoxin: Structures of toxins C3 and C4, and confirmation of the structure of neosaxitoxin ☆

Hung‐wen Liu, P. Reichardt, S. Hall, 1984 .

The green tea polyphenol epigallocatechin-3-gallate attenuates age-associated muscle loss via regulation of miR-486-5p and myostatin.

Yun-Ching Chang, Hung‐wen Liu, Y. Chan, 2020, Archives of biochemistry and biophysics.

PARP-1–dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability

Hung‐wen Liu, Jung-Kuei Chen, Wen-Ling Lin, 2018, Proceedings of the National Academy of Sciences.

S-Adenosylmethionine: more than just a methyl donor

Hung‐wen Liu, Daan Ren, Yu-Hsuan Lee, 2023, Natural product reports.

Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications.

Hung‐wen Liu, Zhihua Tao, Peng Gao, 2009, Journal of the American Chemical Society.

Investigation of the mechanism of the SpnF-catalyzed [4+2]-cycloaddition reaction in the biosynthesis of spinosyn A

J. Patrick, Hung‐wen Liu, D. Russell, 2017, Proceedings of the National Academy of Sciences.

Reversal of the apparent regiospecificity of NAD(P)H-dependent hydride transfer: the properties of the difluoromethylene group, a carbonyl mimic.

Hung‐wen Liu, Xuemei M He, C. Leriche, 2003, Journal of the American Chemical Society.

Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE.

J. Rohr, Hung‐wen Liu, E. Sasaki, 2016, ACS chemical biology.

Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases

Hung‐wen Liu, E. Sasaki, Avinash B. Patel, 2015, Proceedings of the National Academy of Sciences.

Influence of water and enzyme SpnF on the dynamics and energetics of the ambimodal [6+4]/[4+2] cycloaddition

K. Houk, C. Doubleday, Song Yang, 2018, Proceedings of the National Academy of Sciences.

Mapping Protein Surface Accessibility via an Electron Transfer Dissociation Selectively Cleavable Hydrazone Probe*

J. Brodbelt, Hung‐wen Liu, K. Browning, 2012, Molecular & Cellular Proteomics.

Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice

Yun-Ching Chang, Hung‐wen Liu, Y. Chan, 2020, Biogerontology.

Supervised high-load resistance training for improving muscle strength and quality in prediabetic older adults: A pilot randomized controlled trial.

Hung‐wen Liu, Hao-Chien Cheng, Shun-Hsi Tsai, 2022, Geriatric nursing.

A micromethod for determining the branching points in oligosaccharides based on circular dichroism

K. Nakanishi, Hung‐wen Liu, 1981 .

Exploiting sulphur-carrier proteins from primary metabolism for 2-thiosugar biosynthesis

Hung‐wen Liu, E. Sasaki, S. Ealick, 2014, Nature.

Enantioselective Intermolecular Aldehyde—Ketone Cross‐Coupling Through an Enzymatic Carboligation Reaction.

M. Richter, Hung‐wen Liu, C. Roehr, 2010 .

Biosynthesis of yersiniose: Attachment of the two-carbon branched-chain is catalyzed by a thiamine pyrophosphate-dependent flavoprotein

Zhihong Guo, Hung‐wen Liu, Huawei Chen, 1998 .

Current developments and challenges in the search for a naturally selected Diels-Alderase.

Hung‐wen Liu, Hak Joong Kim, M. Ruszczycky, 2012, Current opinion in chemical biology.

Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase.

C. Thibodeaux, Hung‐wen Liu, Wei‐chen Chang, 2010, Journal of the American Chemical Society.

Stereochemical Studies of the Type II Isopentenyl Diphosphate–Dimethylallyl Diphosphate Isomerase Implicate the FMN Coenzyme in Substrate Protonation

C. Thibodeaux, Hung‐wen Liu, J. Calveras, 2012, Chembiochem : a European journal of chemical biology.

Unraveling the mechanisms of isoprenoid biosynthetic enzymes: mechanistic studies of the early stage enzymes

C. Thibodeaux, Hung‐wen Liu, 2009 .

Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

Hung‐wen Liu, X. Pu, J. Munos, 2008, Bioorganic & medicinal chemistry letters.

Characterization of the coformycin biosynthetic gene cluster in Streptomyces kaniharaensis

Hung‐wen Liu, Yasushi Ogasawara, Shao‐An Wang, 2020, Proceedings of the National Academy of Sciences.

Identification of a Pyrrole Intermediate Which Undergoes C-Glycosidation and Autoxidation to Yield the Final Product in Showdomycin Biosynthesis.

Hung‐wen Liu, Shao‐An Wang, Daan Ren, 2021, Angewandte Chemie.

18O kinetic isotope effects in non-heme iron enzymes: probing the nature of Fe/O2 intermediates.

J. Klinman, Hung‐wen Liu, Liviu M. Mirica, 2008, Journal of the American Chemical Society.

HygY Is a Twitch Radical SAM Epimerase with Latent Dehydrogenase Activity Revealed upon Mutation of a Single Cysteine Residue.

Hung‐wen Liu, Aimin Liu, I. Davis, 2021, Journal of the American Chemical Society.

Investigation of binding of UDP-Galf and UDP-[3-F]Galf to UDP-galactopyranose mutase by STD-NMR spectroscopy, molecular dynamics, and CORCEMA-ST calculations.

B. M. Pinto, Hung‐wen Liu, D. Sanders, 2008, Journal of the American Chemical Society.

Mechanistic studies of the biosynthesis of tyvelose: Purification and characterization of CDP-D-tyvelose 2-epimerase [10]

Hung‐wen Liu, T. Hallis, 1999 .

Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

Hung‐wen Liu, Yiguang Zhu, Qingbo Zhang, 2018, Nature Communications.

Glycoscience: Chemistry and Chemical Biology. Volumes I−III Edited by Bertram Fraser-Reid (Natural Products & Glycotechnology Research Institute, Durham, NC), Kuniaki Tatsuta (Waseda University, Japan), and Joachim Thiem (University of Hamburg, Germany). Springer-Verlag: Berlin, Heidelberg, New York

Hung‐wen Liu, 2003 .

Identification of a Pyrrole Intermediate Which Undergoes C‐Glycosidation and Autoxidation to Yield the Final Product in Showdomycin Biosynthesis

Hung‐wen Liu, Shao‐An Wang, Daan Ren, 2021, Angewandte Chemie.

AN EFFICIENT SYNTHESIS OF UNSYMMETRICAL OPTICALLY ACTIVE PHOSPHATIDYL GLYCEROL

Hung‐wen Liu, K. Murakami, E. Molitor, 1999 .

Effects of volume-matched resistance training with different loads on glycemic control, inflammation, and body composition in prediabetic older adults.

Hung‐wen Liu, Hao-Chien Cheng, Shun-Hsi Tsai, 2021, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Effects of acute resistance exercise with different loads on appetite, appetite hormones and autonomic nervous system responses in healthy young men

Hung‐wen Liu, Hao-Chien Cheng, Shun-Hsi Tsai, 2022, Appetite.

Studies of the inactivation of general acyl-CoA dehydrogenase by racemic (methylenecyclopropyl)acetyl-CoA: new evidence suggesting a radical mechanism of this enzyme-catalyzed reaction

Hung‐wen Liu, M. Stankovich, N. D. Lenn, 1989 .

Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S-Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase.

Hung‐wen Liu, Jiahai Zhou, M. Ruszczycky, 2022, Journal of the American Chemical Society.

The Enzymes Mediating Maturation of the Seryl-tRNA Synthetase Inhibitor SB-217452 during Biosynthesis of Albomycins.

Hung‐wen Liu, Richiro Ushimaru, Zhang Chen, 2019, Angewandte Chemie.

Identification of the Enzymes Mediating the Maturation of the Seryl‐tRNA Synthetase Inhibitor SB‐217452 during the Biosynthesis of Albomycins

Hung‐wen Liu, Richiro Ushimaru, Zhang Chen, 2019 .

Changing Fates of the Substrate Radicals Generated in the Active Sites of the B12-Dependent Radical SAM Enzymes OxsB and AlsB.

Hung‐wen Liu, Aoshu Zhong, Y. Yeh, 2023, Journal of the American Chemical Society.

Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity

Hung‐wen Liu, Xiaolin Li, Xueting Liu, 2016, Applied Microbiology and Biotechnology.

Formation of cyanide from carbon 1 of 1-aminocyclopropane-1-carboxylic acid during its conversion to ethylene.

C. Walsh, N. Hoffman, Hung‐wen Liu, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Studies of the expression of human poly(ADP-ribose) polymerase-1 in Saccharomyces cerevisiae and identification of PARP-1 substrates by yeast proteome microarray screening.

Hung‐wen Liu, Z. Tao, P. Gao, 2009, Biochemistry.

The biosynthesis of GDP-L-colitose: C-3 deoxygenation is catalyzed by a unique coenzyme B6-dependent enzyme.

Zhihong Guo, Hung‐wen Liu, Jenefer Alam, 2003, Journal of the American Chemical Society.

A circular dichroic method for determining the linkage to symmetric hexocyclitols and hexocyclitolamines; structure of two antibiotics from Nocardia sp.

K. Nakanishi, Hung‐wen Liu, G. Ellestad, 1981 .

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Purification, crystallization and molecular symmetry of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis.

G. Petsko, D. Ringe, Hung‐wen Liu, 2002, Acta crystallographica. Section D, Biological crystallography.

Distinguishing Concerted versus Stepwise Mechanisms Using Isotope Effects on Isotope Effects.

Hung‐wen Liu, M. Ruszczycky, 2021, Biochemistry.

Studies of complex enzymic pyridine nucleotide-dependent transformations: structure and cofactor binding correlation in CDP-D-glucose oxidoreductase

J. Thorson, Hung‐wen Liu, E. Oh, 1992 .

Investigation of binding of UDP-Galf and UDP-[3-F]Galf to UDP-galactopyranose mutase by STD-NMR spectroscopy, molecular dynamics, and CORCEMA-ST calculations.

Hung‐wen Liu, D. Sanders, Yue Yuan, 2008, Journal of the American Chemical Society.

Mechanistic investigation of UDP-galactopyranose mutase from Escherichia coli using 2- and 3-fluorinated UDP-galactofuranose as probes.

Hung‐wen Liu, Q. Zhang, Qibo Zhang, 2001, Journal of the American Chemical Society.

Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis.

C. Thibodeaux, Hung‐wen Liu, Wei‐chen Chang, 2012, Chemical reviews.

Dynamically Complex [6+4] and [4+2] Cycloadditions in the Biosynthesis of Spinosyn A.

Hung‐wen Liu, Zhuo Chen, K. Houk, 2016, Journal of the American Chemical Society.

Toona Sinensis ameliorates insulin resistance via AMPK and PPARγ pathways.

Hung‐wen Liu, Wenlan Yu, Sue-Joan Chang, 2015, Food & function.

Influence of water and enzyme SpnF on the dynamics and energetics of the ambimodal [6+4]/[4+2] cycloaddition

K. Houk, C. Doubleday, Song Yang, 2018, Proceedings of the National Academy of Sciences.

Structural Studies of the Spinosyn Forosaminyltransferase, SpnP

Hung‐wen Liu, A. Keatinge-Clay, Byung-sun Jeon, 2014, Biochemistry.

The Ketogenic Effect of Medium-Chain Triacylglycerides

T. Hung, Hung‐wen Liu, Ting-Yu Lin, 2021, Frontiers in Nutrition.