M. Shapiro

发表

Bacterial two-component signalling as a therapeutic target in drug design. Inhibition of NRII by the diphenolic methanes (bisphenols).

J. Domagala, M. Cummings, D. Alessi, 1998, Advances in experimental medicine and biology.

Structure-activity relationships of the quinolone antibacterials against mycobacteria: effect of structural changes at N-1 and C-7.

J. Domagala, S. Gracheck, M. Shapiro, 1996, Journal of medicinal chemistry.

Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones.

H. D. Showalter, M. Huband, M. Shapiro, 2008, Bioorganic & medicinal chemistry letters.

In vivo therapeutic efficacies of PD 138312 and PD 140248, two novel fluoronaphthyridines with outstanding gram-positive potency

M. Shapiro, J. Dever, E. Joannides, 1995, Antimicrobial agents and chemotherapy.

Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.

S. Hagen, J. Domagala, M. Schroeder, 1993, Journal of medicinal chemistry.

3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.

J. Domagala, H. D. Showalter, J. Bronstein, 2006, Journal of medicinal chemistry.

Synthesis and structural-activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents.

J. Domagala, H. D. Showalter, S. Gracheck, 2004, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors.

J. Domagala, H. D. Showalter, S. Gracheck, 2007, Bioorganic & medicinal chemistry letters.

The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy- and 5-amino-8-alkoxyquinolone antibacterial agents.

M. Cohen, J. Domagala, S. Gracheck, 1995, Journal of medicinal chemistry.

Effect of lipophilicity at N-1 on activity of fluoroquinolones against mycobacteria.

J. Domagala, S. Gracheck, M. Shapiro, 1995, Journal of medicinal chemistry.

Novel nonpeptidic inhibitors of peptide deformylase.

M. Shapiro, T. Holler, M. Dermyer, 2000, Archives of biochemistry and biophysics.

A novel rapid throughput phototolerance screen in mice.

M. Shapiro, C. L. Heifetz, J. Dever, 1996, Journal of pharmacological and toxicological methods.

Comparison of microdilution and agar dilution procedures for testing antibiotic susceptibility of Neisseria gonorrhoeae

M. Shapiro, C. L. Heifetz, J. C. Sesnie, 1984, Journal of clinical microbiology.

Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position

J. Domagala, R. Reynolds, S. Gracheck, 1996, Antimicrobial agents and chemotherapy.

New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk.

S. Hagen, J. Domagala, M. Shapiro, 1992, Journal of medicinal chemistry.

Broad Spectrum Antimicrobial Biocides Target the FabI Component of Fatty Acid Synthesis*

R. Heath, C. Rock, M. Shapiro, 1998, The Journal of Biological Chemistry.

In vitro evaluation of cefdinir (FK482), a new oral cephalosporin with enhanced antistaphylococcal activity and beta-lactamase stability.

M. Cohen, M. Huband, M. Shapiro, 1994, Diagnostic microbiology and infectious disease.

Comparative therapeutic efficacy of clinafloxacin in a pneumococcal meningitis mouse model.

M. Shapiro, J. W. Gage, K. Donovan, 2000, Journal of Antimicrobial Chemotherapy.