B. Valdez

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ABT199/venetoclax potentiates the cytotoxicity of alkylating agents and fludarabine in acute myeloid leukemia cells

D. Murray, B. Andersson, B. Valdez, 2022, Oncotarget.

Panobinostat and venetoclax enhance the cytotoxicity of gemcitabine, busulfan, and melphalan in multiple myeloma cells.

D. Murray, B. Andersson, B. Valdez, 2020, Experimental hematology.

Epigenetic modification enhances the cytotoxicity of busulfan and4-hydroperoxycyclophosphamide in AML cells.

Y. Li, D. Murray, B. Andersson, 2018, Experimental hematology.

The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells

D. Murray, B. Andersson, B. Valdez, 2017, Leukemia & lymphoma.

Myeloablative Fractionated Busulfan with Fludarabine in Older Patients: Long Term Disease-Specific Outcomes of a Prospective Phase II Clinical Trial.

K. Rezvani, D. Marin, E. Shpall, 2021, Transplantation and cellular therapy.

A randomized phase III study of pretransplant conditioning for AML/MDS with fludarabine and once daily IV busulfan ± clofarabine in allogeneic stem cell transplantation

P. Thall, K. Rezvani, S. Parmar, 2022, Bone Marrow Transplantation.

Long-term Outcomes After Treatment with Clofarabine ± Fludarabine with Once Daily IV Busulfan as Pretransplant Conditioning Therapy for Advanced Myeloid Leukemia and MDS

P. Thall, P. Fox, B. Andersson, 2016 .

PHASE II TRIAL OF HIGH-DOSE GEMCITABINE/BUSULFAN/MELPHALAN WITH AUTOLOGOUS STEM-CELL TRANSPLANTATION FOR PRIMARY REFRACTORY OR POOR-RISK RELAPSED HODGKIN’S LYMPHOMA

Paolo, P. Thall, Y. Oki, 2021 .

High-dose infusional gemcitabine combined with busulfan and melphalan with autologous stem-cell transplantation in patients with refractory lymphoid malignancies.

P. Thall, S. Parmar, E. Shpall, 2012, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Apoptosis in human tumor cells following treatment with p120 antisense oligodeoxynucleotide ISIS 3466.

B. Valdez, L. Perlaky, H. Busch, 1994, Cancer letters.

Cloning and functional characterization of the Xenopus orthologue of the Treacher Collins syndrome (TCOF1) gene product.

B. Valdez, D. Henning, B. Gonzales, 2005, Gene.

Down-regulation of RNA Helicase II/Gu Results in the Depletion of 18 and 28 S rRNAs in Xenopus Oocyte*

B. Valdez, R. Ochs, D. Henning, 2003, Journal of Biological Chemistry.

Expression, cellular localization, and enzymatic activities of RNA helicase II/Gu(beta).

B. Valdez, L. Perlaky, D. Henning, 2002, Experimental cell research.

Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs.

B. Valdez, Eugene P. Hong, Hushan Yang, 2002, Gene.

Vorinostat combined with Busulfan, Fludarabine, and Clofarabine Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Leukemia: Long-term Study Outcomes.

P. Thall, D. Marin, E. Shpall, 2022, Transplantation and cellular therapy.

Unique epitopes in RNA helicase II/Gu protein recognized by serum from a watermelon stomach patient.

F. Arnett, B. Valdez, D. Henning, 2000, Molecular immunology.

5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis.

D. Murray, P. Corn, B. Andersson, 2010, Leukemia research.

Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23.

B. Valdez, L. Perlaky, H. Busch, 1994, The Journal of biological chemistry.

Immunodominant RNA recognition motifs of human nucleolin/C23.

B. Valdez, H. Busch, D. Henning, 1995, Molecular immunology.

Drug-induced translocation of nucleolar proteins fused to green fluorescent protein.

B. Valdez, L. Perlaky, 2002, Methods in molecular biology.

Synergistic cytotoxicity of gemcitabine, clofarabine and edelfosine in lymphoma cell lines

A. Zander, D. Murray, B. Andersson, 2014, Blood Cancer Journal.

A randomized phase III study of pretransplant conditioning for AML/MDS with fludarabine and once daily IV busulfan ± clofarabine in allogeneic stem cell transplantation

P. Thall, K. Rezvani, S. Parmar, 2022, Bone Marrow Transplantation.

Nucleolin stimulates viral internal ribosome entry site-mediated translation.

A. Dasgupta, B. Valdez, R. Izumi, 2001, Virus research.

Cloning and characterization of a new silver‐stainable protein SSP29, a member of the LRR family

L. Zhu, B. Valdez, L. Perlaky, 1997, Biochemistry and molecular biology international.

A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease.

J. Hurwitz, H. Flores-Rozas, B. Valdez, 1996, Nucleic acids research.

Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines.

D. Murray, B. Andersson, B. Valdez, 2012, Experimental hematology.

Synergistic cytotoxicity of the DNA alkylating agent busulfan, nucleoside analogs and suberoylanilide hydroxamic acid in lymphoma cell lines

D. Murray, B. Andersson, B. Valdez, 2012, Leukemia & lymphoma.

Evaluation of the Safety, Cell Migration, and Mucoadhesive Properties of a Mucoadhesive Polymer Blend in Human Oral Mucosa

B. Valdez, A. Bassani, D. Banov, 2017, AAPS PharmSciTech.

Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators.

D. Murray, B. Andersson, B. Valdez, 2015, Experimental hematology.

Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells.

D. Murray, B. Andersson, B. Valdez, 2016, Leukemia research.

Romidepsin targets multiple survival signaling pathways in malignant T cells

D. Murray, B. Andersson, B. Valdez, 2015, Blood Cancer Journal.

Interstrand crosslink inducing agents in pretransplant conditioning therapy for hematologic malignancies

B. Andersson, B. Valdez, 2010, Environmental and molecular mutagenesis.

Comparison of the disinfection efficacy of chlorine-based products for inactivation of viral indicators and pathogenic bacteria in produce wash water

B. Valdez, C. Chaidez, M. Angulo, 2003, International journal of environmental health research.

HDAC inhibitors suppress protein poly(ADP-ribosyl)ation and DNA repair protein levels and phosphorylation status in hematologic cancer cells: implications for their use in combination with PARP inhibitors and chemotherapeutic drugs

D. Murray, B. Andersson, B. Valdez, 2022, Oncotarget.

Enhanced cytotoxicity of bisantrene when combined with venetoclax, panobinostat, decitabine and olaparib in acute myeloid leukemia cells

D. Murray, B. Andersson, B. Valdez, 2022, Leukemia & lymphoma.

Phosphorothioate oligonucleotides bind in a non sequence‐specific manner to the nucleolar protein C23/nucleolin

B. Valdez, D. Weidner, S. Greenberg, 1995, FEBS letters.

Mechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: relevance of p53 and its clinical implications.

Michael L. Wang, D. Murray, F. Turturro, 2013, Experimental hematology.

Synergistic cytotoxicity of busulfan, melphalan, gemcitabine, panobinostat, and bortezomib in lymphoma cells

B. Andersson, B. Valdez, Y. Nieto, 2016, Leukemia & lymphoma.

Evaluation of an Anhydrous Permeation-Enhancing Vehicle for Percutaneous Absorption of Hormones

B. Valdez, A. Bassani, D. Banov, 2022, AAPS PharmSciTech.

Identification of an epitope region of the human proliferation-associated nucleolar antigen P120.

B. Valdez, H. Busch, R. Busch, 1990, Cancer research.

Fludarabine with Myeloablative Timed-Sequential Busulfan in Older Patients: Results of a Randomized Phase II Clinical Trial

K. Rezvani, D. Marin, S. Parmar, 2019 .

Fludarabine with a higher versus lower dose of myeloablative timed-sequential busulfan in older patients and patients with comorbidities: an open-label, non-stratified, randomised phase 2 trial.

K. Rezvani, D. Marin, S. Parmar, 2018, The Lancet. Haematology.

Site-directed mutagenesis at the regulatory site of fructose 6-phosphate-1-kinase from Bacillus stearothermophilus.

B. Valdez, E. S. Younathan, S. Chang, 1988, Biochemical and biophysical research communications.

RNA-unwinding and RNA-folding activities of RNA helicase II/Gu--two activities in separate domains of the same protein.

B. Valdez, H. Busch, D. Henning, 1997, European journal of biochemistry.

Another face of the Treacher Collins syndrome (TCOF1) gene: identification of additional exons.

M. Dixon, B. Valdez, D. Henning, 2004, Gene.

Green Fluorescent Protein Tag for Studies of Drug-Induced Translocation of Nucleolar Protein RH-II /

B. Valdez, Z. Cai, L. Perlaky, 1999 .

Development of an assay for cellular efflux of pharmaceutically active agents and its relevance to understanding drug interactions.

B. Andersson, B. Valdez, Moustapha Hassan, 2017, Experimental hematology.

A myeloablative fractionated busulfan conditioning regimen with post-transplant cyclophosphamide in HLA-matched and haploidentical transplantation: results of a phase II study

D. Marin, E. Shpall, B. Andersson, 2022, Haematologica.

Low-dose decitabine as part of a modified Bu-Cy conditioning regimen improves survival in AML patients with active disease undergoing allogeneic hematopoietic stem cell transplantation

B. Andersson, B. Valdez, Zi X. Chen, 2021, Bone Marrow Transplantation.

A Randomized Study of Fludarabine-Clofarabine Vs Fludarabine Alone Combined with Busulfan and Allogeneic Hematopoietic Transplantation for AML and MDS

P. Thall, D. Marin, E. Shpall, 2019, Blood.

Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway

B. Valdez, Yang Li, B. Dhillon, 2021, PloS one.

UTILIZACIÓN DE EXTRACTOS DE PLANTAS PARA EL CONTROL DE GORGOJO PARDO ACANTHOSCELIDES OBTECTUS (SAY) EN FRIJOL ALMACENADO USE OF EXTRACTS OF PLANTS FOR THE CONTROL OF BROWN WEEVIL ACANTHOSCELIDES OBTECTUS (SAY) STORED IN BEAN

B. Valdez, C. Bernal-Ruíz, Eusebio Nava-Pérez, 2010 .

Specific aspartic acid-rich sequences are responsible for silver staining of nucleolar proteins.

B. Valdez, H. Busch, D. Henning, 1995, Biochemical and biophysical research communications.

Silver ( AgNOR) Staining of Nucleolar Transcription Factor UBF Requires Adjacent Aspartic Acid Residues

B. Valdez, D. Henning, Liangjin Zhu, 1998 .

A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation.

W. Zhang, B. Valdez, C. Zhu, 1992, Cancer research.

Expression of p40/Epstein-Barr virus nuclear antigen 1 binding protein 2.

B. Valdez, D. Henning, Benigno C. Valdez, 2001, Biochemical and biophysical research communications.

Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct.

W. Zhang, M. Brattain, S. Jhiang, 1992, Cancer research.

Phosphorylation of the human cell proliferation-associated nucleolar protein p120.

B. Valdez, H. Busch, R. Busch, 1990, Biochemical and biophysical research communications.

Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120.

A. Fónagy, S. Jhiang, B. Valdez, 1989, Cancer communications.

Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA.

C. Taylor, B. Valdez, W. C. Gustafson, 1998, The Biochemical journal.

The effect of antisense p120 construct on p120 expression and cell proliferation in human breast cancer MCF-7 cells.

W. Zhang, B. Valdez, L. Perlaky, 1993, Cancer letters.

C23 interacts with B23, a putative nucleolar-localization-signal-binding protein.

Yi-Ping Li, B. Valdez, H. Busch, 1996, European journal of biochemistry.

Pharmacologic Basis for High‐dose Chemotherapy

B. Andersson, B. Valdez, Roy B. Jones, 2016 .

Biotechnology and Human Tumor Nucleolar Antigens

J. Freeman, S. Jhiang, B. Valdez, 1990 .

c-Jun Supports Ribosomal RNA Processing and Nucleolar Localization of RNA Helicase DDX21*

T. Salminen, J. Westermarck, Ű. Langel, 2008, Journal of Biological Chemistry.

Altered gene expression in busulfan-resistant human myeloid leukemia.

L. Ramdas, D. Murray, S. Kornblau, 2008, Leukemia research.

The DEXD/H‐box RNA helicase RHII/Gu is a co‐factor for c‐Jun‐activated transcription

B. Séraphin, W. Ansorge, A. Musti, 2002, The EMBO journal.

The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNA methylation.

Michael J Dixon, M. Dixon, B. Valdez, 2005, Human molecular genetics.

The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor.

Michael J Dixon, M. Dixon, B. Valdez, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling.

D. Murray, B. Andersson, B. Valdez, 2011, Biochemical pharmacology.

Silencing of RNA Helicase II/Guα Inhibits Mammalian Ribosomal RNA Production*

Lester F. Lau, L. Lau, B. Valdez, 2003, Journal of Biological Chemistry.

Structural domains involved in the RNA folding activity of RNA helicase II/Gu protein.

B. Valdez, 2000, European journal of biochemistry.

Mapping and characterization of the functional domains of the nucleolar protein RNA helicase II/Gu.

J. B. Rattner, M. Fritzler, B. Valdez, 1999, Experimental cell research.

Cloning and characterization of Gu/RH-II binding protein.

B. Valdez, L. Perlaky, H. Busch, 1997, Biochemical and biophysical research communications.

Differential effects of histone deacetylase inhibitors on cellular drug transporters and their implications for using epigenetic modifiers in combination chemotherapy

D. Murray, B. Andersson, B. Valdez, 2016, Oncotarget.

Conditioning with busulfan plus melphalan versus melphalan alone before autologous haemopoietic cell transplantation for multiple myeloma: an open-label, randomised, phase 3 trial.

P. Thall, P. Fox, S. Parmar, 2019, The Lancet. Haematology.

Fludarabine with pharmacokinetically-guided IV busulfan is superior to fixed-dose delivery in pretransplant conditioning of AML/MDS patients

P. Thall, S. Parmar, E. Shpall, 2016, Bone Marrow Transplantation.

Long-Term Outcomes after Treatment with Clofarabine ± Fludarabine with Once-Daily Intravenous Busulfan as Pretransplant Conditioning Therapy for Advanced Myeloid Leukemia and Myelodysplastic Syndrome.

P. Thall, P. Fox, E. Shpall, 2016, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Double epigenetic modulation of high‐dose chemotherapy with azacitidine and vorinostat for patients with refractory or poor‐risk relapsed lymphoma

P. Thall, Y. Oki, E. Shpall, 2016, Cancer.

Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas.

P. Thall, Y. Oki, E. Shpall, 2015, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Autologous stem cell transplantation for refractory or poor-risk relapsed Hodgkin's lymphoma: effect of the specific high-dose chemotherapy regimen on outcome.

S. Parmar, E. Shpall, B. Valdez, 2013, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Clofarabine Plus Busulfan is an Effective Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Lymphoblastic Leukemia: Long-Term Study Results.

K. Rezvani, D. Marin, E. Shpall, 2017, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

The histone deacetylase inhibitor SAHA sensitizes acute myeloid leukemia cells to a combination of nucleoside analogs and the DNA-alkylating agent busulfan

P. Corn, B. Andersson, B. Valdez, 2014, Leukemia & lymphoma.

Clofarabine ± fludarabine with once daily i.v. busulfan as pretransplant conditioning therapy for advanced myeloid leukemia and MDS.

P. Thall, E. Shpall, B. Andersson, 2011, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Eltrombopag for Post-Transplantation Thrombocytopenia: Results of Phase II Randomized, Double-Blind, Placebo-Controlled Trial.

S. Parmar, E. Shpall, B. Andersson, 2021, Transplantation and cellular therapy.

Eltrombopag for Post-Transplant Thrombocytopenia: Results of Phase II Randomized Double Blind Placebo Controlled Trial

S. Parmar, E. Shpall, B. Andersson, 2015 .

Functional interaction between RNA helicase II/Guα and ribosomal protein L4

B. Valdez, D. Henning, Hushan Yang, 2005 .

Protein inhibitor of activated signal transducer and activator of transcription (STAT)-1 (PIAS-1) regulates the IFN-gamma response in macrophage cell lines.

E. Coccia, E. Giacomini, B. Valdez, 2002, Cellular signalling.

High-dose gemcitabine, busulfan, and melphalan for autologous stem-cell transplant in patients with relapsed or refractory myeloma: a phase 2 trial and matched-pair comparison with melphalan.

S. Parmar, B. Andersson, R. Orlowski, 2017, The Lancet. Haematology.

Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production.

L. Lau, B. Valdez, Lester F Lau, 2003, The Journal of biological chemistry.

Functional interaction between RNA helicase II/Gu(alpha) and ribosomal protein L4.

B. Valdez, D. Henning, Hushan Yang, 2005, The FEBS journal.

Cancer Research Technique s Green Fluorescent Protein Tag for Studies o f Drug-Induced Translocation of Nucleola r Protein RH-II/Gu

B. Valdez, L. Perlaky, H. Busch, 1998 .

Effects of cytotoxic drugs on translocation of nucleolar RNA helicase RH-II/Gu.

B. Valdez, L. Perlaky, H. Busch, 1997, Experimental cell research.

Synergistic cytotoxicity of sorafenib with busulfan and nucleoside analogs in human FMS-like tyrosine kinase 3 internal tandem duplications-positive acute myeloid leukemia cells.

B. Andersson, B. Valdez, Yang Li, 2014, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Comparable and Robust Immune Reconstitution after HLA-Haploidentical or HLA-Matched Allogeneic Transplantation (BMT) Utilizing Posttransplantation Cyclophosphamide

Shannon R. McCurdy, E. Warren, Richard J. Jones, 2015 .

Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression.

W. Wang, B. Valdez, 2000, Genomics.

Overexpression of human nucleolar proteins in insect cells: characterization of nucleolar protein p120.

C. Taylor, K. Smetana, B. Valdez, 1996, Protein expression and purification.

Functional domains of nucleolar phosphoprotein p120.

C. Taylor, B. Valdez, W. C. Gustafson, 1995, Physiological chemistry and physics and medical NMR.

Cladribine, gemcitabine, busulfan, and SAHA combination as a potential pretransplant conditioning regimen for lymphomas: A preclinical study.

B. Andersson, B. Valdez, Y. Nieto, 2016, Experimental hematology.

Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis

K. Rezvani, S. Parmar, E. Shpall, 2021, Haematologica.