M. Fenaux

发表

The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.

F. A. Romero, Christopher Jones, Yingzi Xu, 2020, Journal of medicinal chemistry.

Novel Mutations in a Tissue Culture-Adapted Hepatitis C Virus Strain Improve Infectious-Virus Stability and Markedly Enhance Infection Kinetics

W. Zhong, R. K. Beran, Maria V. Pokrovskii, 2011, Journal of Virology.

Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.

M. Fenaux, A. Ray, Joy Y. Feng, 2014, Bioorganic & medicinal chemistry letters.

A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′-C-Methylguanosine for the Treatment of Dengue Virus Infection

Yen-Liang Chen, W. Zhong, P. Shi, 2020, Antimicrobial Agents and Chemotherapy.

A Cyclic Phosphoramidate Prodrug of 2’-deoxy-2’-fluoro-2’-C-methylguanosine for the Treatment of Dengue Infection

Yen-Liang Chen, W. Zhong, P. Shi, 2020, bioRxiv.

Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug

W. Zhong, M. Fenaux, K. Kitrinos, 2014, Antimicrobial Agents and Chemotherapy.

Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase

S. Leavitt, T. Appleby, M. Fenaux, 2012, Antimicrobial Agents and Chemotherapy.

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

M. Fenaux, A. Ray, Joy Y. Feng, 2015, Bioorganic & medicinal chemistry letters.

A Chimeric Porcine Circovirus (PCV) with the Immunogenic Capsid Gene of the Pathogenic PCV Type 2 (PCV2) Cloned into the Genomic Backbone of the Nonpathogenic PCV1 Induces Protective Immunity against PCV2 Infection in Pigs

T. Opriessnig, P. Halbur, M. Fenaux, 2004, Journal of Virology.

Two Amino Acid Mutations in the Capsid Protein of Type 2 Porcine Circovirus (PCV2) Enhanced PCV2 Replication In Vitro and Attenuated the Virus In Vivo

T. Opriessnig, P. Halbur, M. Fenaux, 2004, Journal of Virology.

Molecular Pathogenesis and Development of a Genetically Engineered Vaccine for Type-2 Porcine Circovirus

M. Fenaux, 2004 .

Safety, Pharmacokinetics, Pharmacodynamics, and Formulation of Liver‐Distributed Farnesoid X‐Receptor Agonist TERN‐101 in Healthy Volunteers

Christopher Jones, M. Fenaux, M. Charlton, 2021, Clinical pharmacology in drug development.

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

W. Zhong, M. Fenaux, H. Ye, 2014, Journal of medicinal chemistry.

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.

Huiling Yang, T. Appleby, M. Fenaux, 2017, Bioorganic & medicinal chemistry letters.

Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk

K. Mansfield, W. Zhong, M. Fenaux, 2016, Antimicrobial Agents and Chemotherapy.

Inhibition of Hepatitis C Virus Replication by GS-6620 , A Potent C-Nucleoside 1 Monophosphate Prodrug 2 3 Running Title : In Vitro Pharmacology of GS-6620 4 5

W. Zhong, M. Fenaux, G. Cheng, 2014 .

Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

Huiling Yang, M. Fenaux, Neeraj Tirunagari, 2018, Antimicrobial Agents and Chemotherapy.

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase.

Yen-Liang Chen, W. Zhong, P. Shi, 2018, Bioorganic & medicinal chemistry letters.

1 Non-proteinogenic Amino Acid Containing Nucleotide Prodrug to Improve Oral Delivery of a 1 Hepatitis C Virus Treatment 2

Huiling Yang, M. Fenaux, Neeraj Tirunagari, 2018 .

Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection.

S. Leavitt, T. Appleby, M. Fenaux, 2014, Journal of medicinal chemistry.

Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase

William A. Lee, I. Shih, W. Zhong, 2011, Antimicrobial Agents and Chemotherapy.

Experimental Reproduction of Postweaning Multisystemic Wasting Syndrome in Pigs by Dual Infection with Mycoplasma hyopneumoniae and Porcine Circovirus Type 2

S. Yu, T. Opriessnig, P. Halbur, 2004, Veterinary pathology.

Effect of Vaccination with Selective Bacterins on Conventional Pigs Infected with Type 2 Porcine Circovirus

S. Yu, T. Opriessnig, P. Halbur, 2003, Veterinary pathology.

Effects of Porcine Circovirus Type 2 (PCV2) Maternal Antibodies on Experimental Infection of Piglets with PCV2

T. Opriessnig, P. Halbur, M. Fenaux, 2005, Clinical Diagnostic Laboratory Immunology.

Immunogenicity and Pathogenicity of Chimeric Infectious DNA Clones of Pathogenic Porcine Circovirus Type 2 (PCV2) and Nonpathogenic PCV1 in Weanling Pigs

T. Opriessnig, P. Halbur, M. Fenaux, 2003, Journal of Virology.

Cloned Genomic DNA of Type 2 Porcine Circovirus Is Infectious When Injected Directly into the Liver and Lymph Nodes of Pigs: Characterization of Clinical Disease, Virus Distribution, and Pathologic Lesions

P. Halbur, M. Fenaux, M. Gill, 2002, Journal of Virology.

Detection and in vitro and in vivo characterization of porcine circovirus DNA from a porcine-derived commercial pepsin product.

T. Opriessnig, P. Halbur, M. Fenaux, 2004, The Journal of general virology.

Explorer Immunogenicity and pathogenicity of chimeric infectious DNA clones of pathogenic porcine circovirus type 2 ( PCV 2 ) and nonpathogenic PCV 1 in weanling pigs

T. Opriessnig, P. Halbur, M. Fenaux, 2017 .

Molecular characterization of porcine TT virus, an orphan virus, in pigs from six different countries.

P. Halbur, M. Fenaux, X. Meng, 2004, Veterinary microbiology.

Explorer Effects of porcine circovirus type 2 ( PCV 2 ) maternal antibodies on experimental infection of piglets with PCV 2

T. Opriessnig, P. Halbur, M. Fenaux, 2017 .

Halbur Disease and Lesions Evidence of Breed-dependent Differences in Susceptibility to Porcine Circovirus Type-2-associated

T. Opriessnig, M. Rothschild, M. Fenaux, 2017 .

Evidence of Breed-dependent Differences in Susceptibility to Porcine Circovirus Type-2-associated Disease and Lesions

T. Opriessnig, P. Halbur, M. Rothschild, 2006, Veterinary pathology.

Effects of the timing of the administration of Mycoplasma hyopneumoniae bacterin on the development of lesions associated with porcine circovirus type 2

S. Yu, T. Opriessnig, P. Halbur, 2006, Veterinary Record.

Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus.

S. Yu, T. Opriessnig, P. Halbur, 2004, Veterinary microbiology.

Explorer Two amino acid mutations in the capsid protein of type 2 porcine circovirus ( PCV 2 ) enhanced PCV 2 replication in vitro and attenuated the virus in vivo

T. Opriessnig, P. Halbur, M. Fenaux, 2017 .

Mechanistic characterization of GS-9190, a novel non-nucleoside inhibitor of HCV NS5B polymerase with potent antiviral activity and a unique mechanism of action

I. Shih, W. Zhong, W. Tse, 2007 .

Role of Interferon in Homologous and Heterologous Rotavirus Infection in the Intestines and Extraintestinal Organs of Suckling Mice

M. Omary, H. Greenberg, M. Fenaux, 2008, Journal of Virology.

Active Viremia in Rotavirus-Infected Mice

H. Greenberg, M. Fenaux, S. Blutt, 2006, Journal of Virology.

Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.

Melanie H. Wong, T. Appleby, M. Fenaux, 2012, Bioorganic & medicinal chemistry letters.

Quantitative evaluation of rotaviral antigenemia in children with acute rotaviral diarrhea.

Sumit Sharma, R. Glass, H. Greenberg, 2006, The Journal of infectious diseases.

The putative capsid protein of the newly identified avian hepatitis E virus shares antigenic epitopes with that of swine and human hepatitis E viruses and chicken big liver and spleen disease virus.

M. Fenaux, F. Pierson, X. Meng, 2002, The Journal of general virology.

Extraintestinal Spread and Replication of a Homologous EC Rotavirus Strain and a Heterologous Rhesus Rotavirus in BALB/c Mice

M. Jaimes, H. Greenberg, M. Fenaux, 2006, Journal of Virology.

Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors

Melanie H. Wong, S. E. Boyce, T. Appleby, 2014, PloS one.

Selective Thyroid Hormone Receptor β Agonists with Oxadiazolone Acid Isosteres.

Christopher Jones, Yingzi Xu, M. Fenaux, 2020, Bioorganic & medicinal chemistry letters.

1198 NUCLEOTIDE INHIBITOR RESISTANCE SELECTIONS USING GT2A INFECTIOUS VIRUS: PSI-7851 AND GS-6620 SELECT FOR A NOVEL RESISTANCE PATHWAY INCLUDING SUBSTITUTIONS OF M289V/L FOLLOWED BY S282T

Xiaohong Liu, W. Zhong, M. Fenaux, 2011 .

Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection.

T. Appleby, M. Fenaux, Xiaowu Chen, 2014, Journal of medicinal chemistry.