R. Halcomb

发表

The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.

F. A. Romero, Christopher Jones, Yingzi Xu, 2020, Journal of medicinal chemistry.

On the direct epoxidation of glycals: application of a reiterative strategy for the synthesis of .beta.-linked oligosaccharides

R. Halcomb, S. Danishefsky, 1989 .

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.

J. R. Somoza, Melanie H. Wong, W. Tse, 2015, Biochemistry.

Synthesis of CMP-sialic acid conjugates: Substrates for the enzymatic synthesis of natural and designed sialyl oligosaccharides

R. Halcomb, M. Chappell, 1997 .

Inhibition of CMP-sialic acid transport into Golgi vesicles by nucleoside monophosphates.

W. Miller, C. Wagner, R. Halcomb, 2001, Biochemistry.

GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees.

R. Lanford, R. Halcomb, K. Brasky, 2013, Gastroenterology.

Ligand Recognition by E-Selectin: Synthesis, Inhibitory Activity and Conformational Analysis of Bivalent Sialyl Lewis x Analogs

Chi‐Huey Wong, J. Paulson, R. Halcomb, 1995 .

Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases.

R. Halcomb, L. Whalen, Kerry A McEvoy, 2003, Bioorganic & medicinal chemistry letters.

Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B.

R. Halcomb, Peng Yue, B. Tennant, 2015, Journal of hepatology.

Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.

R. Halcomb, T. Migone, Jan-Willem Theunissen, 2015, Molecular pharmaceutics.

Mild oxidation of cytidine-sialic acid phosphite derivatives using dimethyldioxirane

R. Halcomb, M. Chappell, 1999 .

Enzymes in Organic Synthesis: Application to the Problems of Carbohydrate Recognition (Part 1)

Chi‐Huey Wong, R. Halcomb, Y. Ichikawa, 1995 .

Synthesis and characterization of an anomeric sulfur analogue of CMP-sialic acid.

R. Halcomb, S. Cohen, 2000, The Journal of organic chemistry.

Synthesis of oligosaccharides, glycopeptides, and glycolipids

Chi‐Huey Wong, R. Halcomb, 1993 .

RECENT DEVELOPMENTS IN TECHNOLOGY FOR GLYCOSYLATION WITH SIALIC ACID

R. Halcomb, M. Chappell, 2002 .

Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase α

R. Halcomb, R. Kuchta, J. Engels, 2005, Nucleic acids research.

Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis.

Hong Yang, R. Halcomb, B. Gallagher, 2013, Journal of medicinal chemistry.

Synthesis of a six-carbon sialic acid using an indium-mediated coupling.

R. Halcomb, M. Chappell, 2000, Organic letters.

Convergent enantioselective synthesis of the tricyclic core of phomactin A.

R. Halcomb, P. Mohr, 2002, Organic letters.

Synthesis of the Core Trisaccharide of Esperamicin: Corroboration of the Proposed Structure for Its Rearrangement Product and Stabilization of the Core Trisaccharide Domain.

R. Halcomb, S. Danishefsky, S. Olson, 1991 .

Glycosyl Phosphites as Glycosylation Reagents: Scope and Mechanism

Chi‐Huey Wong, H. Kondo, S. Aoki, 1994 .

A New Method for the Stereoselective Synthesis of α-Substituted Serine Amino Acid Analogues

R. Halcomb, J. W. Lane, 2003 .

Total synthesis of (+)-phomactin a using a B-alkyl Suzuki macrocyclization.

R. Halcomb, P. Mohr, 2003, Journal of the American Chemical Society.

Synthesis of the ring system of phomactin D using a Suzuki macrocyclization.

R. Halcomb, N. Kallan, 2000, Organic letters.

On the conversion of biologically interesting amines to hydroxylamines

R. Halcomb, S. Danishefsky, M. Wittman, 1990 .

A route to glycals in the allal and gulal series: synthesis of the thiosugar of esperamicin A1

R. Halcomb, S. Danishefsky, M. Wittman, 1990 .

Synthesis of an isostere of an O-linked glycopeptide.

R. Halcomb, L. Whalen, 2004, Organic letters.

Enzyme-Catalyzed Synthesis of Oligosaccharides That Contain Functionalized Sialic Acids

R. Halcomb, M. Chappell, 1997 .

Enzymatic synthesis of 7-deoxy-N-acetylneuraminic acid and 7-O-methyl-N-acetylneuraminic acid

Chi‐Huey Wong, R. Halcomb, W. Fitz, 1994 .

Solution- and Solid-Phase Synthesis of Inhibitors of H. pylori Attachment and E-Selectin-Mediated Leukocyte Adhesion

Chi‐Huey Wong, R. Halcomb, Hong-Yan Huang, 1994 .

A symmetry-based approach to zaragozic acid: Synthesis and end-differentiation of an advanced intermediate

R. Halcomb, K. Freeman-Cook, 1998 .

Application of serine- and threonine-derived cyclic sulfamidates for the preparation of S-linked glycosyl amino acids in solution- and solid-phase peptide synthesis.

R. Halcomb, Scott B. Cohen, 2002, Journal of the American Chemical Society.

Synthesis of S-linked glycosyl amino acids in aqueous solution with unprotected carbohydrates.

R. Halcomb, S. Cohen, 2001, Organic letters.

Unusual stereoselectivity in sialic acid aldolase-catalyzed aldol condensations: Synthesis of both enantiomers of high carbon monosaccharides

Chi-Huey Wong, Yoshitaka Ichikawa, Chun-Hung Lin, 1992 .

Synthesis of Bicyclic Ketals Related to Zaragozic Acid by a Novel Photoannulation.

R. Halcomb, K. Freeman-Cook, 1996 .

Enzymes in Organic Synthesis: Application to the Problems of Carbohydrate Recognition. Part 2.

Chi‐Huey Wong, R. Halcomb, Y. Ichikawa, 1995 .

Clinical targeting of HIV capsid protein with a long-acting small molecule

J. R. Somoza, W. Sundquist, Xiaohong Liu, 2020, Nature.

A symmetry-based formal synthesis of zaragozic acid A.

R. Halcomb, K. Freeman-Cook, 2000, The Journal of organic chemistry.

A Symmetry‐Based Formal Synthesis of Zaragozic Acid A.

R. Halcomb, K. Freeman-Cook, 2001 .

Pharmacokinetic and Pharmacodynamic Properties of GS-9620, a Novel Toll-Like Receptor 7 Agonist, Demonstrate Interferon-Stimulated Gene Induction without Detectable Serum Interferon at Low Oral Doses

R. Halcomb, S. Pflanz, C. Frey, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Selective Thyroid Hormone Receptor β Agonists with Oxadiazolone Acid Isosteres.

Christopher Jones, Yingzi Xu, M. Fenaux, 2020, Bioorganic & medicinal chemistry letters.

Pharmacokinetic and Pharmacodynamic Properties of GS-9620 , a Novel Toll-Like Receptor 7 Agonist , Demonstrate Interferon-Stimulated Gene Induction without Detectable Serum Interferon at Low Oral Doses s

R. Halcomb, S. Pflanz, C. Frey, 2013 .

New design concepts for constraining glycosylated amino acids

R. Halcomb, J. W. Lane, 2001 .

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.

J. R. Somoza, Melanie H. Wong, W. Tse, 2015, Biochemistry.

K. Liu, R. Halcomb, S. Danishefsky, 1995 .