M. O’connor

发表

Age‐Dependent Changes in AMPK Metabolic Pathways in the Lung in a Mouse Model of Hemorrhagic Shock

Lindsey R. Klingbeil, P. Kim, G. Piraino, 2017, American journal of respiratory cell and molecular biology.

Role of peroxynitrite and activation of poly (ADP‐ribose) synthetase in the vascular failure induced by zymosan‐activated plasma

S. Cuzzocrea, M. O’connor, B. Zingarelli, 1997, British journal of pharmacology.

Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFκB activation

H. Wong, M. O’connor, B. Zingarelli, 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide.

H. Wong, M. O’connor, B. Zingarelli, 1996, Journal of immunology.

Proinsulin c-peptide exerts beneficial effects in endotoxic shock in mice

G. Piraino, M. O’connor, P. Hake, 2007, Critical care medicine.

Immunopathology and Infectious Diseases Peroxisome Proliferator-Activated Receptor Regulates Inflammation via NF-B Signaling in Polymicrobial Sepsis

G. Piraino, M. O’connor, P. Hake, 2010 .

Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase.

S. Cuzzocrea, E. Kun, M. O’connor, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Effect of L‐buthionine‐(S,R)‐sulphoximine, an inhibitor of γ‐glutamylcysteine synthetase on peroxynitrite‐ and endotoxic shock‐induced vascular failure

S. Cuzzocrea, M. O’connor, B. Zingarelli, 1998, British journal of pharmacology.

Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.

M. O’connor, P. Hake, B. Zingarelli, 2003, European journal of pharmacology.

Endogenously produced peroxynitrite induces the oxidation of mitochondrial and nuclear proteins in immunostimulated macrophages

M. O’connor, C. Szabó, A. Salzman, 1997, FEBS letters.

Lung injury after hemorrhage is age dependent: Role of peroxisome proliferator-activated receptor &ggr;*

Timothy J. Burroughs, H. Wong, J. Solomkin, 2009, Critical care medicine.

Peroxynitrite causes energy depletion and increases permeability via activation of poly (ADP-ribose) synthetase in pulmonary epithelial cells.

M. O’connor, C. Szabó, A. Salzman, 1997, American journal of respiratory cell and molecular biology.

Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis.

Timothy J. Burroughs, H. Wong, M. O’connor, 2008, European journal of pharmacology.

Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation.

Xiaohong Wang, Yigang Wang, G. Fan, 2009, Journal of molecular and cellular cardiology.

Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.

V. Malhotra, H. Wong, M. O’connor, 2002, Molecular pharmacology.

Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice

G. Piraino, M. O’connor, V. Wolfe, 2022, Frontiers in Immunology.

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

S. Cuzzocrea, M. O’connor, B. Zingarelli, 1997, The Journal of clinical investigation.

Reply to Angé et al.

G. Piraino, M. O’connor, P. Hake, 2019, American journal of physiology. Heart and circulatory physiology.

Ursodeoxycholate inhibits induction of NOS in human intestinal epithelial cells and in vivo.

M. O’connor, C. Szabó, A. Salzman, 1997, The American journal of physiology.

Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.

B. Aronow, H. Wong, M. O’connor, 2004, American journal of physiology. Heart and circulatory physiology.

Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers.

M. O’connor, C. Szabó, A. Salzman, 1996, The American journal of physiology.

15-DEOXY-Δ12,14-PROSTAGLANDIN J2 (15D-PGJ2), A PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR γ LIGAND, REDUCES TISSUE LEUKOSEQUESTRATION AND MORTALITY IN ENDOTOXIC SHOCK

Timothy J. Burroughs, M. O’connor, P. Hake, 2005 .

ROLE OF PEROXYNITRITE IN THE PROTEIN OXIDATION AND APOPTOTIC DNA FRAGMENTATION IN VASCULAR SMOOTH MUSCLE CELLS STIMULATED WITH BACTERIAL LIPOPOLYSACCHARIDE AND INTERFERON‐&ggr;

M. O’connor, C. Szabó, A. Salzman, 1995, Shock.

GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.

J. Whitsett, B. Trapnell, M. O’connor, 2007, American journal of respiratory cell and molecular biology.

INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE AMELIORATE MYOCARDIAL REPERFUSION INJURY BY MODULATION OF ACTIVATOR PROTEIN-1 AND NEUTROPHIL INFILTRATION

M. O’connor, P. Hake, B. Zingarelli, 2005, Shock.

Liver X Receptor &agr; Activation with the Synthetic Ligand T0901317 Reduces Lung Injury and Inflammation After Hemorrhage and Resuscitation Via Inhibition of the Nuclear Factor &kgr;B Pathway

A. Lentsch, G. Piraino, M. O’connor, 2011, Shock.

Poly(ADP-Ribose) Polymerase-1 Regulates Activation of Activator Protein-1 in Murine Fibroblasts1

M. O’connor, P. Hake, B. Zingarelli, 2003, The Journal of Immunology.

Fibroblasts Activation of Activator Protein-1 in Murine Poly ( ADP-Ribose ) Polymerase-1 Regulates

M. O’connor, P. Hake, B. Zingarelli, 2003 .

The AMPK Activator Aicar Ameliorates Age-Dependent Myocardial Injury in Murine Hemorrhagic Shock

Lindsey R. Klingbeil, G. Piraino, M. O’connor, 2017, Shock.

Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock.

G. Piraino, M. O’connor, P. Hake, 2010, International journal of clinical and experimental medicine.

Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock.

G. Piraino, M. O’connor, P. Hake, 2010, American journal of physiology. Gastrointestinal and liver physiology.

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

M. O’connor, B. Zingarelli, C. Szabó, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform

M. O’connor, B. Zingarelli, C. Szabó, 1996, British journal of pharmacology.

Absence of inducible nitric oxide synthase modulates early reperfusion‐induced NF‐κB and AP‐1 activation and enhances myocardial damage

H. Wong, M. O’connor, P. Hake, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ IS REQUIRED FOR THE INHIBITORY EFFECT OF CIGLITAZONE BUT NOT 15-DEOXY-Δ12,14-PROSTAGLANDIN J2 ON THE NFκB PATHWAY IN HUMAN ENDOTHELIAL CELLS

M. O’connor, B. Zingarelli, J. Cook, 2007 .

Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells.

M. O’connor, B. Zingarelli, J. Cook, 2007, Shock.

Hepatocyte-Specific Deletion of AMPKα1 Results in Worse Outcomes in Mice Subjected to Sepsis in a Sex-Specific Manner

G. Piraino, M. O’connor, V. Wolfe, 2020, Frontiers in Immunology.

Activator protein‐1 signalling pathway and apoptosis are modulated by poly(ADP‐ribose) polymerase‐1 in experimental colitis

Timothy J. Burroughs, G. Piraino, M. O’connor, 2004, Immunology.

Absence of Poly(ADP-ribose) Polymerase-1 Alters Nuclear Factor-κB Activation and Gene Expression of Apoptosis Regulators after Reperfusion Injury

B. Aronow, M. O’connor, P. Hake, 2003, Molecular medicine.

Age-dependent cardiac function during experimental sepsis: effect of pharmacological activation of AMP-activated protein kinase by AICAR.

G. Piraino, M. O’connor, P. Hake, 2018, American journal of physiology. Heart and circulatory physiology.

Conditional Deletion of Cardiomyocyte Peroxisome Proliferator-Activated Receptor &ggr; Enhances Myocardial Ischemia-Reperfusion Injury in Mice

G. Piraino, M. O’connor, P. Hake, 2014, Shock.

Metformin Exerts Beneficial Effects in Hemorrhagic Shock in An AMPK&agr;1-Independent Manner

P. Kim, G. Piraino, M. O’connor, 2017, Shock.

Autophagy and mitochondrial biogenesis impairment contribute to age‐dependent liver injury in experimental sepsis: dysregulation of AMP‐activated protein kinase pathway

John R. Ledford, G. Piraino, M. O’connor, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Effects of radiodetoxified endotoxin on nitric oxide production in J774 macrophages and in endotoxin shock

M. O’connor, B. Zingarelli, E. Gilad, 1996 .

Short-Term High Fat Feeding Increases Organ Injury and Mortality After Polymicrobial Sepsis

M. O’connor, P. Hake, B. Zingarelli, 2012, Obesity.

Metformin ameliorates gender-and age-dependent hemodynamic instability and myocardial injury in murine hemorrhagic shock.

G. Piraino, M. O’connor, P. Hake, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Combined Zinc Supplementation With Proinsulin C-Peptide Treatment Decreases the Inflammatory Response and Mortality in Murine Polymicrobial Sepsis

John R. Ledford, H. Wong, G. Piraino, 2014, Shock.

Activation of AMP-Activated Protein Kinase by A769662 Ameliorates Sepsis-Induced Acute Lung Injury in Adult Mice.

John R. Ledford, G. Piraino, M. O’connor, 2019, Shock.

C-Peptide Ameliorates Kidney Injury Following Hemorrhagic Shock

Ranjit S. Chima, G. Piraino, M. O’connor, 2011, Shock.

Peroxisome Proliferator Activator Receptor-γ Ligands, 15-Deoxy-Δ12,14-Prostaglandin J2 and Ciglitazone, Reduce Systemic Inflammation in Polymicrobial Sepsis by Modulation of Signal Transduction Pathways 1

M. O’connor, P. Hake, B. Zingarelli, 2003, The Journal of Immunology.

The inhibitory effects of mercaptoalkylguanidines on cyclo‐oxygenase activity

M. O’connor, B. Zingarelli, E. Gilad, 1997, British journal of pharmacology.

Age-dependent therapeutic effects of liver X receptor-α activation in murine polymicrobial sepsis

John R. Ledford, G. Piraino, M. O’connor, 2015, Innate immunity.

Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity.

M. O’connor, C. Szabó, L. Virág, 1999, Molecular pharmacology.

Deficiency of AMPKα1 Exacerbates Intestinal Injury and Remote Acute Lung Injury in Mesenteric Ischemia and Reperfusion in Mice

G. Piraino, M. O’connor, V. Wolfe, 2021, International journal of molecular sciences.

PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS

G. Piraino, M. O’connor, V. Wolfe, 2023, Shock.

SYNERGISTIC EFFECT OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-&ggr; AND LIVER X RECEPTOR-&agr; IN THE REGULATION OF INFLAMMATION IN MACROPHAGES

Timothy J. Burroughs, G. Piraino, M. O’connor, 2006, Shock.

DIVERSE CARDIOPROTECTIVE SIGNALING MECHANISMS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ LIGANDS, 15-DEOXY-Δ12,14-PROSTAGLANDIN J2 AND CIGLITAZONE, IN REPERFUSION INJURY: ROLE OF NUCLEAR FACTOR-κB, HEAT SHOCK FACTOR 1, AND AKT

Timothy J. Burroughs, H. Wong, G. Piraino, 2007, Shock.

Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways.

H. Wong, E. Vizi, E. Kun, 1997, International journal of oncology.

Parthenolide, an Inhibitor of the Nuclear Factor- (cid:1) B Pathway, Ameliorates Cardiovascular Derangement and Outcome in Endotoxic Shock in Rodents

V. Malhotra, H. Wong, M. O’connor, 2002 .

Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways.

M. O’connor, P. Hake, B. Zingarelli, 2003, Journal of immunology.

Lung injury after hemorrhage is age dependent: Role of peroxisome proliferator-activated receptor &ggr;*

Timothy J. Burroughs, H. Wong, J. Solomkin, 2009, Critical care medicine.