A. Tee

发表

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1

C. Walker, D. Tripathi, Rajdeep Chowdhury, 2013, Proceedings of the National Academy of Sciences.

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

David J. Kwiatkowski, Lewis C. Cantley, J. Blenis, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

J. Blenis, L. Cantley, B. Manning, 2002, Molecular cell.

Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin*

J. Blenis, R. Anjum, A. Tee, 2003, Journal of Biological Chemistry.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

P. Carmeliet, E. Verdin, A. Sickmann, 2018, Cell metabolism.

systems: definition and solutions

L. Zaccarian, G. Grimm, A. Tee, 2003 .

DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

C. Proud, A. Tee, Andrew R. Tee, 2000, Oncogene.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Control of HIF-1α and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock

A. Tee, E. Cwiklinski, D. Walker, 2010, American Journal of Physiology - Lung cellular and Molecular Physiology.

Hypoxia-inducible Factor 1α Is Regulated by the Mammalian Target of Rapamycin (mTOR) via an mTOR Signaling Motif*

A. Tee, S. Land, Andrew R. Tee, 2007, Journal of Biological Chemistry.

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

R. Jaenisch, S. Sarkar, V. Korolchuk, 2016, eLife.

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

R. Jaenisch, S. Sarkar, V. Korolchuk, 2015, eLife.

Caspase Cleavage of Initiation Factor 4E-Binding Protein 1 Yields a Dominant Inhibitor of Cap-Dependent Translation and Reveals a Novel Regulatory Motif

C. Proud, A. Tee, Andrew R. Tee, 2002, Molecular and Cellular Biology.

A TSC signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

R. Folkerth, M. Sahin, M. Kastan, 2013, Nature Cell Biology.

STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors

M. Upadhyaya, L. Thomas, A. Tee, 2015, Molecular Cancer Research.

Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours

D. Cooper, M. Mort, M. Upadhyaya, 2015, Human Genomics.

FLCN is a novel regulator of autophagy 1 FLCN , a novel autophagy component , interacts with GABARAP and is regulated by ULK 1 1 phosphorylation 2 3

J. Blenis, S. Wilkinson, A. Tee, 2014 .

Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence

S. McKee, H. Kingston, A. Tee, 2011, European Journal of Human Genetics.

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

A. Tee, Lucy Granat, J. Bateman, 2022, bioRxiv.

Leucine and mTORC1: a complex relationship.

A. Tee, K. Dodd, 2012, American journal of physiology. Endocrinology and metabolism.

Bidirectional Regulation of Nuclear Factor-&kgr;B and Mammalian Target of Rapamycin Signaling Functionally Links Bnip3 Gene Repression and Cell Survival of Ventricular Myocytes

L. Kirshenbaum, A. Tee, V. Margulets, 2013, Circulation. Heart failure.

Intracellular Signals for Skeletal Muscle Adaptation Leucine and mTORC 1 : a complex relationship

A. Tee, K. Dodd, 2012 .

Birt–Hogg–Dubé: tumour suppressor function and signalling dynamics central to folliculin

A. Pause, A. Tee, 2013, Familial Cancer.

REVIEWS Intracellular Signals for Skeletal Muscle Adaptation Leucine and mTORC1: a complex relationship

A. Tee, K. Dodd, 2012 .

Staurosporine inhibits phosphorylation of translational regulators linked to mTOR

C. Proud, A. Tee, Christopher G Proud, 2001, Cell Death and Differentiation.

The Role of Mitochondria-Linked Fatty-Acid Uptake-Driven Adipogenesis in Graves Orbitopathy

D. Turnbull, A. Tee, M. Ludgate, 2021, Endocrinology.

The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites*

C. Proud, A. Tee, T. Herbert, 2002, The Journal of Biological Chemistry.

Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death

T. Hay, R. Errington, A. Tee, 2018, Oncogene.

Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells

R. Errington, A. Tee, M. Wiltshire, 2017, Oncotarget.

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition.

A. Tee, E. Dunlop, K. Dodd, 2009, Cellular signalling.

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

A. Tee, Lucy Granat, J. Bateman, 2022, bioRxiv.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

STAT3 and mTOR: co-operating to drive HIF and angiogenesis

A. Tee, K. Dodd, 2015, Oncoscience.

The Target of Rapamycin and Mechanisms of Cell Growth

A. Tee, Andrew R Tee, 2018, International journal of molecular sciences.

Characterizing the interaction of the mammalian eIF4E‐related protein 4EHP with 4E‐BP1

J. Blenis, A. Tee, Jennifer Tee, 2004, FEBS letters.

Localisation and regulation of the eIF4E‐binding protein 4E‐BP3

G. Scheper, C. Proud, A. Tee, 2002, FEBS letters.

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action*

D. Fingar, A. Tee, B. Ekim, 2009, The Journal of Biological Chemistry.

Characterization of a Conserved C-terminal Motif (RSPRR) in Ribosomal Protein S6 Kinase 1 Required for Its Mammalian Target of Rapamycin-dependent Regulation*

J. Blenis, A. Tee, S. Schalm, 2005, Journal of Biological Chemistry.

In vitro mTORC1 Kinase Assay for Mammalian Cells Protocol

A. Tee, K. Dodd, 2016 .

mTOR, translational control and human disease.

J. Blenis, A. Tee, Andrew R. Tee, 2005, Seminars in cell & developmental biology.

Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy.

A. Tee, C. Dayan, M. Ludgate, 2014, The Journal of clinical endocrinology and metabolism.

Reversal of Pathological Features of Graves' Orbitopathy by Activation of Forkhead Transcription Factors, FOXOs.

A. Tee, C. Dayan, F. Ruge, 2016, The Journal of clinical endocrinology and metabolism.

Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes.

A. Tee, H. S. Hundal, F. E. Baird, 2009, American Journal of Physiology. Endocrinology and Metabolism.

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Shuye Tian, A. Zannettino, S. Fitter, 2020, Cellular and Molecular Life Sciences.

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

J. Blenis, L. Cantley, Philippe P Roux, 2003, Current Biology.

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

J. Blenis, S. Wilkinson, J. Murray, 2014, Autophagy.

mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E

J. Blenis, D. Fingar, A. Tee, 2004, Molecular and Cellular Biology.

mTOR and autophagy: a dynamic relationship governed by nutrients and energy.

A. Tee, E. Dunlop, 2014, Seminars in cell & developmental biology.

Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer.

A. Tee, Ellie Rad, 2016, Seminars in cell & developmental biology.

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

A. Tee, J. Sampson, M. Shen, 2014, Oncogene.

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation.

Ming Yan, B. Faubert, Russell G. Jones, 2014, The Journal of clinical investigation.

Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression

J. Murray, A. Tee, Ellie Rad, 2018, Cancers.

Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.

A. Tee, E. Dunlop, 2009, Cellular signalling.

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

A. Tee, Jianling Xie, T. Herbert, 2011, Cellular signalling.

The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses*

C. Proud, S. G. Finn, A. Tee, 2005, Journal of Biological Chemistry.

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Shuye Tian, A. Zannettino, S. Fitter, 2020, Cellular and Molecular Life Sciences.

The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex.

A. Tee, J. Sampson, J. Bateman, 2016, Seminars in cell & developmental biology.

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis.

A. Tee, E. Dunlop, 2013, Biochemical Society transactions.

Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours

D. Cooper, M. Mort, M. Upadhyaya, 2015, Human Genomics.

Analysis of mTOR signaling by the small G‐proteins, Rheb and RhebL1

J. Blenis, C. Proud, A. Tee, 2005, FEBS letters.

Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours

K. Pollok, R. Bai, A. Tee, 2021, British Journal of Cancer.

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling*

N. Sonenberg, R. Andersen, T. Alain, 2012, The Journal of Biological Chemistry.

Absence of the Birt–Hogg–Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

A. Pause, A. Tee, D. M. Davies, 2011, Oncogene.

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.

C. Proud, A. Tee, Anne Beugnet, 2003, The Biochemical journal.

Distinctive Features of Orbital Adipose Tissue (OAT) in Graves’ Orbitopathy

S. Edkins, D. Turnbull, R. Berlinguer-Palmini, 2020, International journal of molecular sciences.

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

C. Walker, A. Tee, Jianjun Shen, 2006, The Journal of cell biology.

Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells

E. Henske, A. Tee, D. M. Davies, 2022, Cancers.

Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalance.

A. Tee, Charlotte E. Johnson, 2017, Essays in biochemistry.

Finding a cure for tuberous sclerosis complex: From genetics through to targeted drug therapies.

A. Tee, Lauren J McEneaney, 2019, Advances in genetics.

Birt-Hogg-Dube syndrome is a novel ciliopathy.

A. Tee, R. Giles, J. Broers, 2013, Human molecular genetics.

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

D. Fingar, A. Tee, Hugo A Acosta-Jaquez, 2011, Autophagy.

Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment

R. Errington, A. Tee, D. M. Davies, 2018, Cancers.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Birt–Hogg–Dubé: tumour suppressor function and signalling dynamics central to folliculin

A. Pause, A. Tee, 2013, Familial Cancer.

Tuberous Sclerosis Complex cell‐derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers

A. Tee, E. Dunlop, J. Webber, 2023, Journal of extracellular vesicles.

Endoplasmic reticulum stress and cell death in mTORC1‐overactive cells is induced by nelfinavir and enhanced by chloroquine

R. Errington, A. Tee, J. Sampson, 2015, Molecular oncology.

Control of HIF-1α and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock

David J. Walker, A. Tee, E. Cwiklinski, 2010, American Journal of Physiology - Lung Cellular and Molecular Physiology.

The zinc finger/RING domain protein Unkempt regulates cognitive flexibility

C. Hobbs, A. Tee, J. Bateman, 2021, Scientific Reports.

Nonholonomic control systems: from steering to stabilization with sinusoids

Richard M. Murray, Andrew R. Teel, G. C. Walsh, 1992, [1992] Proceedings of the 31st IEEE Conference on Decision and Control.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

P. Carmeliet, E. Verdin, A. Sickmann, 2018, Cell metabolism.

Fundamental for life: mTOR orchestrates developing biological systems.

A. Tee, 2014, Seminars in cell & developmental biology.

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action*

D. Fingar, A. Tee, B. Ekim, 2009, The Journal of Biological Chemistry.