G. Seebohm

C. Theiss, G. Seebohm, N. Strutz‐Seebohm, 2019, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Long QT Syndrome–Associated Mutations in KCNQ1 and KCNE1 Subunits Disrupt Normal Endosomal Recycling of IKs Channels

A. Pfeufer, M. Sanguinetti, B. Attali, 2008, Circulation research.

Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations

C. Mummery, G. Seebohm, B. Greber, 2015, Proceedings of the National Academy of Sciences.

Through modulation of cardiac Ca2+ handling, UCP2 affects cardiac electrophysiology and influences the susceptibility for Ca2+‐mediated arrhythmias

L. Eckardt, G. Seebohm, U. Hoppe, 2017, Experimental physiology.

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

M. Hollmann, T. Budde, G. Seebohm, 2019, Communications Biology.

Residues at the tip of the pore loop of NR3B-containing NMDA receptors determine Ca2+ permeability and Mg2+ block

M. Hollmann, G. Seebohm, Nora A Cavara, 2010, BMC Neuroscience.

A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction

E. Schulze-Bahr, G. Seebohm, S. Rinné, 2017, Circulation research.

Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse

H. Lipp, R. Hellweg, F. Lang, 2006, Behavioural Brain Research.

In Vitro Analyses of Novel HCN4 Gene Mutations

E. Schulze-Bahr, S. Meuth, G. Seebohm, 2018, Cellular Physiology and Biochemistry.

PIKfyve in the SGK1 Mediated Regulation of the Creatine Transporter SLC6A8

F. Lang, J. Tavaré, G. Seebohm, 2007, Cellular Physiology and Biochemistry.

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.

Sebastian A. Leidel, Guiscard Seebohm, Boris Greber, 2016, Cell stem cell.

Klotho sensitivity of the hERG channel

F. Lang, J. Voelkl, Tatsiana Pakladok, 2013, FEBS letters.

Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation

Mark A. Zaydman, Xianjin Xu, X. Zou, 2019, Nature Communications.

Differential modulation of cardiac potassium channels by Grb adaptor proteins.

F. Lang, G. Seebohm, N. Strutz‐Seebohm, 2009, Biochemical and biophysical research communications.

The ubiquitination landscape of the In uenza A Virus polymerase

Drexler, Sebastian A. Leidel, S. Leidel, 2022 .

Tau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2

S. Meuth, F. Lang, G. Seebohm, 2016, Cellular Physiology and Biochemistry.

Glucocorticoid adrenal steroids and glucocorticoid‐inducible kinase isoforms in the regulation of GluR6 expression

M. Hollmann, H. Wagner, F. Lang, 2005, The Journal of physiology.

Association of the Serum and Glucocorticoid Regulated Kinase (sgk1) Gene with QT Interval

A. Busjahn, F. Luft, P. Nürnberg, 2004, Cellular Physiology and Biochemistry.

Potassium viroporins as model systems for understanding eukaryotic ion channel behaviour.

G. Seebohm, R. Stoll, Purva Asrani, 2022, Virus research.

Regulation of the Glutamate Transporter EAAT2 by PIKfyve

F. Lang, J. Tavaré, U. Lang, 2009, Cellular Physiology and Biochemistry.

Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells

S. Meuth, T. Budde, G. Seebohm, 2022, Cellular and Molecular Life Sciences.

Phenol‐benzoxazolone bioisosteres of GluN2B‐NMDA receptor antagonists: Unexpected rearrangement during reductive alkylation with phenylcyclohexanone

R. Fröhlich, G. Seebohm, C. Daniliuc, 2022, Archiv der Pharmazie.

Phenol—Benzoxazolone bioisosteres: Synthesis and biological evaluation of tricyclic GluN2B‐selective N‐methyl‐ d‐aspartate receptor antagonists

G. Seebohm, B. Wünsch, D. Schepmann, 2022, Archiv der Pharmazie.

Deconstruction - Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold.

G. Seebohm, B. Wünsch, Marvin Korff, 2021, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.

G. Seebohm, N. Strutz‐Seebohm, B. Wünsch, 2017, European journal of medicinal chemistry.

Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B‐Selective NMDA Receptor Antagonists with a Benzo[7]annulen‐7‐amine Scaffold

W. Sippl, G. Seebohm, Alessandro Bonifazi, 2017, ChemMedChem.

Loss-of-function variants in the KCNQ5 gene are implicated in genetic generalized epilepsies

P. May, R. Krause, B. Steinhoff, 2022, EBioMedicine.

Up-Regulation of Amino Acid Transporter SLC6A19 Activity and Surface Protein Abundance by PKB/Akt and PIKfyve

S. Bröer, F. Lang, I. Alesutan, 2012, Cellular Physiology and Biochemistry.

NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody

C. Elger, A. Becker, H. Hartung, 2017, Annals of clinical and translational neurology.

Early repolarization pattern: a marker of increased risk in patients with catecholaminergic polymorphic ventricular tachycardia.

M. Borggrefe, E. Schulze-Bahr, G. Seebohm, 2016, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography

E. Schulze-Bahr, K. Schäfers, L. Stegger, 2017, Heart.

Structural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T)

E. Schulze-Bahr, G. Seebohm, N. Strutz‐Seebohm, 2016, HeartRhythm case reports.

The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels

S. Meuth, F. Lang, G. Seebohm, 2016, Cellular Physiology and Biochemistry.

A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B

A. Brüggemann, G. Seebohm, K. Steinmeyer, 2001, British journal of pharmacology.

Potential in targeting classical inward rectifier channels.

G. Seebohm, Eva Wrobel, 2011, Heart rhythm.

Functional Coassembly of KCNQ4 with KCNE-ß- Subunits in Xenopus Oocytes

F. Lang, G. Seebohm, J. Engel, 2006, Cellular Physiology and Biochemistry.

A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling

Mark A. Zaydman, S. Meuth, G. Seebohm, 2022, Communications Biology.

An Activator Locks Kv7.1 Channels Open by Electro-Mechanical Uncoupling and Allosterically Modulates its Pore

Mark A. Zaydman, G. Seebohm, N. Strutz‐Seebohm, 2021, bioRxiv.

Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting

J. White, H. Pape, S. Meuth, 2022, International journal of molecular sciences.

Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds

C. Gerloff, F. Artunc, F. Lang, 2006, Hearing Research.

Paving the Way to Understand Autoantibody-Mediated Epilepsy on the Molecular Level

G. Seebohm, N. Strutz‐Seebohm, I. Piccini, 2015, Front. Neurol..

Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?

W. González, G. Seebohm, S. Rinné, 2014, Pflügers Archiv - European Journal of Physiology.

Modulation of human Kv1.5 channel kinetics by N-cadherin.

F. Lang, G. Seebohm, O. Ureche, 2007, Biochemical and biophysical research communications.

Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system

S. Meuth, K. Klingel, T. Budde, 2022, Cellular and Molecular Life Sciences.

Structural Prerequisites for Receptor Binding of Helicokinin I, a Diuretic Insect Neuropeptide from Helicoverpa zea

G. Seebohm, O. Zerbe, J. Scherkenbeck, 2014 .

Synthesis and Pharmacological Evaluation of Enantiomerically Pure GluN2B Selective NMDA Receptor Antagonists

S. Ametamey, G. Seebohm, N. Strutz‐Seebohm, 2018, ChemMedChem.

Chemical, pharmacodynamic and pharmacokinetic characterization of the GluN2B receptor antagonist 3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol – starting point for PET tracer development

S. Meuth, G. Seebohm, B. Wünsch, 2022, Biological chemistry.

Regulation of the Na(+), glucose cotransporter by PIKfyve and the serum and glucocorticoid inducible kinase SGK1.

F. Lang, J. Tavaré, G. Seebohm, 2007, Biochemical and biophysical research communications.

Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue

G. Seebohm, B. Greber, I. Piccini, 2015, Genomics data.

The First Viral Expression Model in Human Induced Pluripotent Stem Cells to Observe Enteroviral Infections In vitro

G. Seebohm, N. Strutz‐Seebohm, H. Ho, 2021 .

Regulation of the Glutamate Transporter EAAT4 by PIKfyve

F. Lang, J. Tavaré, U. Lang, 2010, Cellular Physiology and Biochemistry.

(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.

F. Lang, V. Vallon, G. Seebohm, 2006, Physiological reviews.

Regulation of the Na+-coupled glutamate transporter EAAT3 by PIKfyve

J. Rothstein, F. Lang, J. Tavaré, 2009, Neurochemistry International.

PIKfyve-dependent regulation of the Cl- channel ClC-2.

F. Lang, G. Seebohm, N. Strutz‐Seebohm, 2009, Biochemical and biophysical research communications.

Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes.

G. Seebohm, K. Busch, V. Eisner, 2022, Biochimica et biophysica acta. Bioenergetics.

MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD

H. Schöler, H. Wiendl, S. Meuth, 2022, Redox biology.

A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

Jie Wu, Henrik Renner, Martha Grabos, 2020, eLife.

Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells

B. Trimmer, M. Levin, G. Seebohm, 2008, Proceedings of the National Academy of Sciences.

Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring.

G. Seebohm, B. Wünsch, D. Schepmann, 2020, European journal of medicinal chemistry.

A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels

F. Lang, U. Lang, G. Seebohm, 2008, Psychopharmacology.

PIKfyve upregulates CFTR activity.

F. Lang, J. Tavaré, G. Seebohm, 2009, Biochemical and biophysical research communications.

A novel NMDA receptor test model based on hiPSC-derived neural cells

H. Wiendl, S. Meuth, T. Budde, 2023, Biological chemistry.

The New Anticonvulsant Retigabine Favors Voltage-Dependent Opening of the Kv7.2 (KCNQ2) Channel by Binding to Its Activation Gate

Holger Lerche, Guiscard Seebohm, H. Lerche, 2005, Molecular Pharmacology.

Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations.

M. Vikkula, G. Seebohm, F. Jansen, 2020, Structure.

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.

Sebastian A. Leidel, S. Leidel, M. Araúzo-Bravo, 2016, Cell stem cell.

Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES

G. Seebohm, A. Röpke, B. Greber, 2018, Nature Communications.

Molecular genetic diagnostics for ventricular arrhythmias and sudden cardiac death syndromes

E. Schulze-Bahr, G. Seebohm, B. Stallmeyer, 2017, Herz.

Cardiac α-Actin (ACTC1) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy.

E. Schulze-Bahr, W. Linke, W. Zimmermann, 2019, Circulation. Genomic and precision medicine.

Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome.

E. Schulze-Bahr, F. Sachse, A. Coffey, 2015, Journal of molecular and cellular cardiology.

An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis

H. Hartung, H. Wiendl, S. Meuth, 2019, Front. Neurol..

Coxsackievirus B3 modulates cardiac ion channels

E. Schulze-Bahr, F. Sachse, L. Pott, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity.

G. Seebohm, C. Daniliuc, B. Wünsch, 2022, European journal of medicinal chemistry.

Cardiac K+ Channels and Channelopathies.

G. Seebohm, Julian A. Schreiber, J. A. Schreiber, 2021, Handbook of experimental pharmacology.

Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity

G. Seebohm, N. Strutz‐Seebohm, J. Scherkenbeck, 2020, ChemMedChem.

Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.

M. Sanguinetti, H. Lerche, K. Kamiya, 2006, Biophysical journal.

Bioelectric Signaling Regulates Size in Zebrafish Fins

Stephen L. Johnson, C. Nüsslein-Volhard, G. Seebohm, 2014, PLoS genetics.

Altered stress stimulation of inward rectifier potassium channels in Andersen‐Tawil syndrome

L. Pott, S. Bendahhou, F. Lang, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Comparison of cellular effects of starch-coated SPIONs and poly(lactic-co-glycolic acid) matrix nanoparticles on human monocytes

Harald Fuchs, Kristina Riehemann, Guiscard Seebohm, 2016, International journal of nanomedicine.

Stress-Kinase Regulation of TASK-1 and TASK-3

G. Seebohm, S. Rinné, N. Decher, 2017, Cellular Physiology and Biochemistry.

PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3

F. Lang, U. Lang, M. Sopjani, 2009, Psychopharmacology.

KV7 channelopathies

Holger Lerche, Guiscard Seebohm, H. Lerche, 2010, Pflügers Archiv - European Journal of Physiology.

Physiological Functions, Biophysical Properties, and Regulation of KCNQ1 (KV7.1) Potassium Channels.

M. Sanguinetti, G. Seebohm, 2021, Advances in experimental medicine and biology.

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue

Milena Bellin, Christine L Mummery, Eric Schulze-Bahr, 2014, Proceedings of the National Academy of Sciences.

The KCNE Tango – How KCNE1 Interacts with Kv7.1

G. Seebohm, Eva Wrobel, D. Tapken, 2012, Front. Pharmacol..

Hypothyroidism of gene-targeted mice lacking Kcnq1

F. Lang, K. Boini, M. Föller, 2010, Pflügers Archiv - European Journal of Physiology.

Molecular determinants of KCNQ1 channel block by a benzodiazepine.

M. Sanguinetti, C. Culberson, G. Seebohm, 2003, Molecular pharmacology.

Molecular Cloning and Functional Expression of KCNQ5, a Potassium Channel Subunit That May Contribute to Neuronal M-current Diversity*

A. Wei, G. Seebohm, K. Steinmeyer, 2000, The Journal of Biological Chemistry.

Can Unlikely Neanderthal Chloride Channel CLC-2 Gene Variants Provide Insights in Modern Human Infertility?

G. Seebohm, N. Strutz‐Seebohm, B. Wünsch, 2021, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

In Vitro Model Systems of Coxsackievirus B3-Induced Myocarditis: Comparison of Commonly Used Cell Lines and Characterization of CVB3-Infected iCell® Cardiomyocytes

K. Klingel, G. Seebohm, M. Sauter, 2021, Viruses.

Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea‐pig cardiomyocytes

A. Brüggemann, G. Seebohm, W. Kummer, 2001, The Journal of physiology.

Overlapping Cardiac Phenotype Associated with a Familial Mutation in the Voltage Sensor of the KCNQ1 Channel

E. Schulze-Bahr, F. Lang, G. Seebohm, 2012, Cellular Physiology and Biochemistry.

Functional characterization of novel alpha-helical rod domain desmin (DES) pathogenic variants associated with dilated cardiomyopathy, atrioventricular block and a risk for sudden cardiac death.

E. Schulze-Bahr, W. Linke, G. Seebohm, 2020, International journal of cardiology.

A Plant Homolog of Animal Glutamate Receptors Is an Ion Channel Gated by Multiple Hydrophobic Amino Acids

M. Hollmann, G. Seebohm, D. Becker, 2013, Science Signaling.

14‐3‐3 Proteins regulate K2P5.1 surface expression on T lymphocytes

H. Wiendl, S. Meuth, T. Budde, 2017, Traffic.

Regulation of Endocytic Recycling of KCNQ1/KCNE1 Potassium Channels

A. Pfeufer, M. Sanguinetti, B. Attali, 2007, Circulation research.

The ubiquitination landscape of the influenza A virus polymerase

Sebastian A. Leidel, S. Leidel, A. Mellmann, 2022, Nature Communications.

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.

Stefan A. Mann, J. Svendsen, T. Preiss, 2014, Journal of molecular and cellular cardiology.

Modulation of Human Ether A Gogo Related Channels by CASQ2 Contributes to Etiology of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

L. Pott, W. Linke, F. Lang, 2010, Cellular Physiology and Biochemistry.

Pathophysiological Mechanisms of Cardiac Dysfunction in Transgenic Mice with Viral Myocarditis

J. Stypmann, W. Linke, K. Klingel, 2023, Cells.

Virus-Host Interactions of Enteroviruses and Parvovirus B19 in Myocarditis.

G. Seebohm, N. Strutz‐Seebohm, H. Ho, 2021, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Electrophysiological alterations in a murine model of chronic coxsackievirus B3 myocarditis

J. Olligs, L. Eckardt, K. Klingel, 2017, PloS one.

Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells

G. Seebohm, A. Röpke, B. Greber, 2017, Front. Physiol..

Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds.

W. Sippl, G. Seebohm, B. Wünsch, 2020, European journal of medicinal chemistry.

Structural Basis of Slow Activation Gating in the Cardiac IKs Channel Complex

B. Attali, K. Gerwert, Steffen Wolf, 2011, Cellular Physiology and Biochemistry.

Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin

Stephen L. Johnson, G. Seebohm, J. Lanni, 2018, Scientific Reports.

Neutralization of a negative charge in the S1–S2 region of the KV7.2 (KCNQ2) channel affects voltage‐dependent activation in neonatal epilepsy

H. Lerche, F. Lehmann-Horn, K. Jurkat-Rott, 2008, The Journal of physiology.

K2P18.1 translates T cell receptor signals into thymic regulatory T cell development

U. Dannlowski, T. Marschall, N. Opel, 2021, Cell research.

Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation

S. Meuth, T. Budde, G. Seebohm, 2023, Biological chemistry.

Rab GTPases are required for early orientation of the left–right axis in Xenopus

Laura N. Vandenberg, Ryan D Morrie, M. Levin, 2013, Mechanisms of Development.

Functional Analysis of Caenorhabditis elegans Glutamate Receptor Subunits by Domain Transplantation*

A. V. Maricq, M. Hollmann, David M. Madsen, 2003, Journal of Biological Chemistry.

The Linker Pivot in Ci-VSP: The Key to Unlock Catalysis

T. Friedrich, G. Seebohm, Kirstin Hobiger, 2013, PloS one.

Solid phase synthesis, NMR structure determination of α-KTx3.8, its in silico docking to Kv1.x potassium channels, and electrophysiological analysis provide insights into toxin-channel selectivity.

G. Seebohm, H. Kalbacher, R. Stoll, 2015, Toxicon : official journal of the International Society on Toxinology.

Regulation of KCNQ4 Potassium Channel Prepulse Dependence and Current Amplitude by SGK1 in Xenopus oocytes

F. Lang, G. Seebohm, J. Engel, 2005, Cellular Physiology and Biochemistry.

Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels

M. Sanguinetti, G. Seebohm, M. Pusch, 2003, The Journal of physiology.

Identification of Specific Pore Residues Mediating KCNQ1 Inactivation

G. Seebohm, A. Busch, C. Lerche, 2001, The Journal of Biological Chemistry.

Klotho

E. Schulze-Bahr, G. Seebohm, N. Strutz‐Seebohm, 2014, Channels.

[2.2]Paracyclophane‐Based TCN‐201 Analogs as GluN2A‐Selective NMDA Receptor Antagonists

G. Seebohm, B. Wünsch, J. Jose, 2021, ChemMedChem.

Pharmacological Activation of Normal and Arrhythmia-Associated Mutant KCNQ1 Potassium Channels

M. Sanguinetti, G. Seebohm, Jun Chen, 2003, Circulation research.

From iPSC towards cardiac tissue—a road under construction

G. Seebohm, N. Strutz‐Seebohm, B. Greber, 2017, Pflügers Archiv - European Journal of Physiology.

Beyond Hot and Spicy: TRPV Channels and their Pharmacological Modulation.

G. Seebohm, Julian A. Schreiber, J. A. Schreiber, 2021, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

M. Hollmann, T. Budde, G. Seebohm, 2019, Communications Biology.

Activation of voltage gated K⁺ channel Kv1.5 by β-catenin.

F. Lang, I. Alesutan, Carlos Muñoz, 2012, Biochemical and biophysical research communications.

Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes

G. Seebohm, N. Strutz‐Seebohm, B. Wünsch, 2023, Biomedicines.

The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition

F. Glorius, S. Meuth, T. Budde, 2023, Biological chemistry.

Inherited long QT syndrome

L. Eckardt, E. Schulze-Bahr, G. Seebohm, 2012, Herzschrittmachertherapie + Elektrophysiologie.

Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?

W. González, G. Seebohm, S. Rinné, 2015, Pflügers Archiv - European Journal of Physiology.

Additive regulation of GluR1 by stargazin and serum- and glucocorticoid-inducible kinase isoform SGK3

F. Lang, G. Seebohm, N. Strutz‐Seebohm, 2006, Pflügers Archiv.

Regulation of GluR1 abundance in murine hippocampal neurones by serum‐ and glucocorticoid‐inducible kinase 3

R. Nicoll, M. Hollmann, N. Rouach, 2005, The Journal of physiology.

Identification of a Novel Signaling Pathway and Its Relevance for GluA1 Recycling

D. Manahan‐Vaughan, M. Hollmann, F. Lang, 2012, PloS one.

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

P. Calabresi, D. Rowitch, Matthias Heidenreich, 2023, The Journal of clinical investigation.

Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18

H. Wiendl, S. Meuth, T. Budde, 2023, Archiv der Pharmazie.

Novel Insights into the Structural Basis of pH-Sensitivity in Inward Rectifier K+ Channels Kir2.3

F. Lang, G. Seebohm, N. Strutz‐Seebohm, 2008, Cellular Physiology and Biochemistry.

Loss-of-function variants in the KCNQ5 gene are associated with genetic generalized epilepsies

P. May, R. Krause, B. Steinhoff, 2021, medRxiv.

Novel Kv7.1-Phosphatidylinositol 4,5-Bisphosphate Interaction Sites Uncovered by Charge Neutralization Scanning*

L. Pott, G. Seebohm, N. Strutz‐Seebohm, 2014, The Journal of Biological Chemistry.

Functional high-resolution time-course expression analysis of human embryonic stem cells undergoing cardiac induction

M. Araúzo-Bravo, G. Seebohm, B. Greber, 2016, Genomics data.

Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three‐Dimensional Formats: Implications for In Vitro Maturation

P. Kirchhof, M. Araúzo-Bravo, H. Schöler, 2015, Stem cells.

Structural basis of PI(4,5)P2-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A)

E. Schulze-Bahr, L. Pott, M. Hollmann, 2014, Pflügers Archiv - European Journal of Physiology.

4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region.

S. Meuth, T. Budde, G. Seebohm, 2020, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

An inactivation gate in the selectivity filter of KCNQ1 potassium channels.

B. Attali, N. Dascal, G. Seebohm, 2007, Biophysical journal.

Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.

G. Seebohm, C. Daniliuc, B. Wünsch, 2022, European journal of medicinal chemistry.

Functional Significance of the Kainate Receptor GluR6(M836I) Mutation that is Linked to Autism

M. Hollmann, F. Lang, G. Seebohm, 2006, Cellular Physiology and Biochemistry.

Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter

S. Meuth, G. Seebohm, T. Ruck, 2023, Communications biology.

The Special One: Architecture, Physiology and Pharmacology of the TRESK Channel.

G. Seebohm, M. Düfer, J. A. Schreiber, 2022, Cellular Physiology and Biochemistry.

A Common Structural Component for β-Subunit Mediated Modulation of Slow Inactivation in Different KV Channels

E. Schulze-Bahr, G. Seebohm, N. Strutz‐Seebohm, 2013, Cellular Physiology and Biochemistry.

Systematic variation of the benzoylhydrazine moiety of the GluN2A selective NMDA receptor antagonist TCN-201.

G. Seebohm, N. Strutz‐Seebohm, B. Wünsch, 2018, European journal of medicinal chemistry.

Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation.

G. Seebohm, A. Röpke, B. Greber, 2017, Stem cell research.

Molecular impact of MinK on the enantiospecific block of IKs by chromanols

B Attali, B. Attali, U. Gerlach, 2000, British journal of pharmacology.

Stimulation of HERG Channel Activity by β-catenin

F. Lang, Tatsiana Pakladok, Carlos Muñoz, 2012, PloS one.

Knockout of the Cardiac Transcription Factor NKX2-5 Results in Stem Cell-Derived Cardiac Cells with Typical Purkinje Cell-like Signal Transduction and Extracellular Matrix Formation

G. Seebohm, N. Strutz‐Seebohm, S. Sandmann, 2023, International journal of molecular sciences.

From iPSC towards cardiac tissue—a road under construction

G. Seebohm, N. Strutz‐Seebohm, B. Greber, 2017, Pflügers Archiv - European Journal of Physiology.

Kv7.1 in atrial fibrillation.

G. Seebohm, 2009, Heart rhythm.

NDRG2 phosphorylation provides negative feedback for SGK1-dependent regulation of a kainate receptor in astrocytes

E. Schulze-Bahr, M. Hollmann, F. Lang, 2015, Front. Cell. Neurosci..

Alterations in the Cytoplasmic Domain of CLCN2 Result in Altered Gating Kinetics

F. Lang, P. Kremsner, G. Seebohm, 2007, Cellular Physiology and Biochemistry.

Dependence of IKs biophysical properties on the expression system

G. Seebohm, C. Lerche, A. Busch, 2001, Pflügers Archiv.

Systematic variation of the benzenesulfonamide part of the GluN2A selective NMDA receptor antagonist TCN-201.

G. Seebohm, N. Strutz‐Seebohm, B. Wünsch, 2017, European journal of medicinal chemistry.

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives

S. Ametamey, T. Budde, G. Seebohm, 2023, Molecular Neurobiology.

PIKfyve upregulates CFTR activity.

F. Lang, J. Tavaré, G. Seebohm, 2009, Biochemical and biophysical research communications.

Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists.

G. Seebohm, B. Wünsch, J. Schmidt, 2023, Journal of Medicinal Chemistry.

Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.

G. Seebohm, C. Daniliuc, B. Wünsch, 2021, Journal of medicinal chemistry.

Selective Inhibition of N -Methyl- D -aspartate Receptors with GluN2B Subunit Protects b Cells against Stress-Induced Apoptotic Cell Death S

G. Seebohm, A. Gresch, Death, 2021 .

Overlapping Cardiac Phenotype Associated with a Familial Mutation in the Voltage Sensor of the KCNQ1 Channel

E. Schulze-Bahr, F. Lang, G. Seebohm, 2012, Cellular Physiology and Biochemistry.

Long QT Syndrome-associated Mutations in the Voltage Sensor of IKs Channels

F. Lang, G. Seebohm, M. Duszenko, 2009, Cellular Physiology and Biochemistry.

Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome.

E. Schulze-Bahr, F. Sachse, A. Coffey, 2015, Journal of molecular and cellular cardiology.

C-terminal interaction of KCNQ2 and KCNQ3 K+ channels

H. Lerche, G. Seebohm, S. Maljevic, 2003 .

Rapid Report

H. Lerche, G. Seebohm, S. Maljevic, 2003 .

Novel Insights into the Structural Basis of pH-Sensitivity in Inward Rectifier K+ Channels Kir2.3

F. Lang, G. Seebohm, N. Strutz‐Seebohm, 2008, Cellular Physiology and Biochemistry.

Tagging of Exo70 at the N-terminus compromises its assembly with the exocyst complex and changes its spatiotemporal behavior at the plasma membrane

G. Seebohm, Michael Holtmannspötter, Hiteshika Gosain, 2024, bioRxiv.

RETIGABINE :B ENDING POTASSIUM CHANNELS TO OUR WILL The New Anticonvulsant Retigabine Favors Voltage-dependent Opening of the Kv7.2 (KCNQ2) Channel by Binding to Its Activation Gate

G. Seebohm, S. Maljevic, S. Bail, 2005 .

Refinement of the Binding Site and Mode of Action of the Anticonvulsant Retigabine on KCNQ K+ Channels

T. Friedrich, M. Schwake, G. Seebohm, 2009, Molecular Pharmacology.

Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K+ Channel) Channel Function

E. Schulze-Bahr, L. Pott, G. Seebohm, 2019, Circulation. Genomic and precision medicine.

Serum- and Glucocorticoid-inducible Kinases (SGK) regulate KCNQ1/KCNE potassium channels

F. Lang, G. Seebohm, N. Strutz‐Seebohm, 2009, Channels.