P. Heldin

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Hyaluronan Synthesis Is Inhibited by Adenosine Monophosphate-activated Protein Kinase through the Regulation of HAS2 Activity in Human Aortic Smooth Muscle Cells*

V. Hascall, D. Vigetti, M. Viola, 2011, The Journal of Biological Chemistry.

Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors.

N. Karamanos, R. Iozzo, P. Heldin, 2019, Matrix biology : journal of the International Society for Matrix Biology.

Hyaluronan production regulation from porcine hyalocyte cell line by cytokines.

H. Yamashita, P. Heldin, N. Tojo, 2006, Experimental eye research.

CD44-Regulated Intracellular Proliferation of Listeria monocytogenes

E. Eriksson, L. Dons, P. Heldin, 2003, Infection and Immunity.

Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts.

C. Heldin, P. Heldin, T. Laurent, 1989, The Biochemical journal.

The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function

C. Heldin, P. Heldin, C. Heldin, 2017, Oncogenesis.

Improvement of rat liver graft function after storage in University of Wisconsin solution containing testicular hyaluronidase

P. Heldin, V. Papanikolaou, D. Vrochides, 2002, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Efficient TGFβ-induced epithelial–mesenchymal transition depends on hyaluronan synthase HAS2

C. Heldin, A. Theocharis, P. Heldin, 2012, Oncogene.

Growth factor regulation of hyaluronan deposition in malignancies.

P. Heldin, S. Skandalis, E. Karousou, 2009 .

The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination*

U. Hellman, C. Heldin, A. Passi, 2010, The Journal of Biological Chemistry.

Hyaluronan content in experimental carcinoma is not correlated to interstitial fluid pressure.

P. Heldin, K. Rubin, C. Sundberg, 2003, Biochemical and biophysical research communications.

Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells

A. Aletras, N. Karamanos, P. Heldin, 2020, Matrix biology plus.

Hyaluronan production increases the malignant properties of mesothelioma cells

P. Heldin, Y. Li, 2001, British Journal of Cancer.

Functional Cloning of the cDNA for a Human Hyaluronan Synthase*

T. Yoshino, E. Butcher, P. Heldin, 1996, The Journal of Biological Chemistry.

Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation.

P. Heldin, 2003, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Proteomic identification of CD44 interacting proteins

U. Hellman, P. Heldin, S. Skandalis, 2010, IUBMB life.

High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity

C. Heldin, J. Tenhunen, P. Heldin, 2019, EBioMedicine.

Functional hyaluronan receptors are expressed on a squamous cell lung carcinoma cell line but not on other lung carcinoma cell lines.

J. Bergh, P. Heldin, P. Teder, 1995, Cancer research.

Differential expression of platelet-derived growth factor alpha- and beta- receptors on fat-storing cells and endothelial cells of rat liver.

C. Heldin, P. Heldin, T. Laurent, 1991, Experimental cell research.

Expression of recombinant hyaluronan synthase (HAS) isoforms in CHO cells reduces cell migration and cell surface CD44.

P. Heldin, J. Brinck, Jonas Brinck, 1999, Experimental cell research.

Hyaluronan receptors are expressed on human malignant mesothelioma cells but not on normal mesothelial cells.

P. Heldin, T. Asplund, 1994, Cancer research.

Molecular mechanisms that regulate hyaluronan synthesis

P. Heldin, 1998 .

CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

C. Heldin, P. Heldin, C. Castillejo-López, 2022, Cancers.

Differential expression of platelet-derived growth factor alpha- and beta- receptors on fat-storing cells and endothelial cells of rat liver.

C. Heldin, P. Heldin, T. Laurent, 1991, Experimental cell research.

Mechanism of impaired local hyaluronan turnover in bleomycin-induced lung injury in rat.

P. Heldin, P. Teder, 1997, American journal of respiratory cell and molecular biology.

Phase I and Pharmacokinetic Evaluation of Intravenous Hyaluronic Acid in Combination with Doxorubicin or 5-Fluorouracil

P. Gibbs, P. Heldin, M. Rosenthal, 2005, Chemotherapy.

Intracellular hyaluronan: Importance for cellular functions.

P. Heldin, S. Skandalis, Theodoros T. Karalis, 2020, Seminars in cancer biology.

Renal hyaluronan accumulation and hyaluronan synthase expression after ischaemia-reperfusion injury in the rat.

P. Heldin, P. Hansell, V. Göransson, 2004, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Hyaluronan Fragments Induce Endothelial Cell Differentiation in a CD44- and CXCL1/GRO1-dependent Manner*boxs

A. Moustakas, P. Heldin, Yoshinori Takahashi, 2005, Journal of Biological Chemistry.

Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer.

C. Heldin, A. Moustakas, P. Heldin, 2019, Matrix biology : journal of the International Society for Matrix Biology.

Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C.

Paraskevi, C. Heldin, P. Heldin, 1995, The Biochemical journal.

Hyaluronan and its binding proteins in the epithelium and intraluminal fluid of the bovine oviduct

H. Rodríguez-Martínez, P. Heldin, E. Sato, 2005, Zygote.

Irradiation-induced expression of hyaluronan (HA) synthase 2 and hyaluronidase 2 genes in rat lung tissue accompanies active turnover of HA and induction of types I and III collagen gene expression.

M. Rahmanian, P. Heldin, Y. Li, 2000, American journal of respiratory cell and molecular biology.

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.

C. Heldin, P. Heldin, T. Astériou, 2007, The Biochemical journal.

Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44*

C. Heldin, P. Heldin, Lingli Li, 2006, Journal of Biological Chemistry.

Hyaluronan oligosaccharides induce tube formation of a brain endothelial cell line in vitro.

M. Rahmanian, P. Heldin, S. Kanda, 1997, Experimental cell research.

Characterization of hyaluronan synthase from a human glioma cell line.

P. Heldin, M. Suzuki, M. Briskin, 1998, Biochimica et biophysica acta.

Biosynthesis of hyaluronan

P. Heldin, T. C. Laurent, 2008 .

Effect of phosphorylation in vitro of human fibrinogen with protein kinase C on thrombin-induced gelation.

E. Humble, L. Engström, P. Heldin, 1987, Thrombosis research.

Importance of Hyaluronan-CD44 Interactions in Inflammation and Tumorigenesis

P. Heldin, S. Skandalis, Koichi Nishitsuka, 2008, Connective tissue research.

HGF/SF induces mesothelial cell migration and proliferation by autocrine and paracrine pathways.

G. Laurent, P. Heldin, S. Mutsaers, 2001, Experimental cell research.

Human mesothelioma cells produce factors that stimulate the production of hyaluronan by mesothelial cells and fibroblasts.

P. Heldin, M. Versnel, T. Laurent, 1993, Cancer research.

Stimulatory effects of pleural fluids from mesothelioma patients on CD44 expression, hyaluronan production and cell proliferation in primary cultures of normal mesothelial and transformed cells

P. Heldin, M. Versnel, P. Teder, 1996, International journal of cancer.

Chondroitin sulfate proteoglycan modulates the permeability of hyaluronan‐containing coats around normal human mesothelial cells

P. Heldin, M. Suzuki, H. Pertoft, 1995, Journal of cellular physiology.

Characterization of the mechanism involved in bleomycin-induced increased hyaluronan production in rat lung.

P. Heldin, P. Teder, O. Nettelbladt, 1995, American journal of respiratory cell and molecular biology.

Synthesis and assembly of the hyaluronan-containing coats around normal human mesothelial cells.

P. Heldin, H. Pertoft, 1993, Experimental cell research.

Characterization of the molecular mechanism involved in the activation of hyaluronan synthetase by platelet-derived growth factor in human mesothelial cells.

P. Heldin, T. Laurent, T. Asplund, 1992, The Biochemical journal.

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo

M. Dunning, P. Heldin, A. Gad, 2022, Scientific Reports.

Proteoglycans/Glycosaminoglycans: From Basic Research to Clinical Practice

I. Kovalszky, P. Heldin, G. Tzanakakis, 2014, BioMed research international.

Editorial Proteoglycans/Glycosaminoglycans: From Basic Research to Clinical Practice

I. Kovalszky, P. Heldin, G. Tzanakakis, 2014 .

Fluorescence Resonance Energy Transfer (FRET) and Proximity Ligation Assays Reveal Functionally Relevant Homo- and Heteromeric Complexes among Hyaluronan Synthases HAS1, HAS2, and HAS3*

M. Tammi, S. Kellokumpu, P. Heldin, 2015, The Journal of Biological Chemistry.

1 Fluorescence Resonance Energy Transfer ( FRET ) and Proximity Ligation Assays Reveal Functionally Relevant Homo-and Heteromeric Complexes among Hyaluronan Synthases HAS 1 , HAS 2 and HAS 3

M. Tammi, S. Kellokumpu, P. Heldin, 2015 .

Differential synthesis and binding of hyaluronan by human breast cancer cell lines.

J. Bergh, P. Heldin, D. Ytterberg, 1996, Oncology reports.

Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.

M. Waltham, S. Nilsson, P. Heldin, 2005, Cancer research.

Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer.

M. Waltham, S. Nilsson, P. Heldin, 2005, Cancer research.

TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation

C. Heldin, P. Heldin, S. Skandalis, 2021, Cancers.

Phosphorylation in vitro of fibrinogen from three mammalian species with four different protein kinases.

E. Humble, L. Engström, P. Heldin, 1985, Archives of biochemistry and biophysics.

The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism.

M. Götte, D. Vigetti, M. Viola, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Hyaluronan–CD44 interactions as potential targets for cancer therapy

R. Markwald, S. Ghatak, S. Misra, 2011, The FEBS journal.

TGFβ and matrix-regulated epithelial to mesenchymal transition.

A. Moustakas, P. Heldin, Aristidis Moustakas, 2014, Biochimica et biophysica acta.

Hyaluronan synthase expression in bovine eyes.

P. Heldin, K. Miyata, S. Amano, 1999, Investigative ophthalmology & visual science.

Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production.

P. Heldin, S. Skandalis, Chun-Yu Lin, 2018, Matrix biology : journal of the International Society for Matrix Biology.

Hyaluronan accumulation in thyroid tissue: evidence for contributions from epithelial cells and fibroblasts.

Terry J. Smith, C. Sheehan, P. Heldin, 2007, Endocrinology.

Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer.

P. Heldin, K. Basu, K. Kahata, 2013, Journal of biochemistry.

Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors

M. Rahmanian, P. Heldin, K. Rubin, 2002, International journal of cancer.

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

C. Heldin, A. Moustakas, L. P. van der Heide, 2019, The Journal of Biological Chemistry.

Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NFκB-Mediated Chemokine Production

P. Heldin, B. Olofsson, H. Porsch, 2014, PloS one.

HAS2 and CD44 in breast tumorigenesis.

P. Heldin, K. Basu, I. Kozlova, 2014, Advances in cancer research.

Platelet-derived Growth Factor β-Receptor, Transforming Growth Factor β Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability*

C. Heldin, P. Heldin, B. Olofsson, 2014, The Journal of Biological Chemistry.

Expression of hyaluronan synthase-3 in porcine oviducal epithelium during oestrus.

H. Rodríguez-Martínez, P. Heldin, E. Sato, 2003, Reproduction, fertility, and development.

Immunohistochemical localization and expression of the hyaluronan receptor CD44 in the epithelium of the pig oviduct during oestrus.

H. Rodríguez-Martínez, P. Heldin, E. Sato, 2003, Reproduction.

Involvement of hyaluronan and CD44 in cancer and viral infections.

C. Heldin, P. Heldin, Chun-Yu Lin, 2019, Cellular signalling.

Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells

P. Heldin, Tracey J Brown, Yuejuan Li, 2007, International journal of cancer.

Hyaluronan production in vitro by fetal lung fibroblasts and epithelial cells exposed to surfactants of N-acetylcysteine.

P. Heldin, T. Laurent, G. Sedin, 1997, Upsala journal of medical sciences.

Testicular hyaluronidase induces tubular structures of endothelial cells grown in three‐dimensional colagen gel through a CD44‐mediated mechanism

M. Rahmanian, P. Heldin, 2002, International journal of cancer.

Expression of human hyaluronan synthases in response to external stimuli.

P. Heldin, A. Spicer, A. Jacobson, 2000, The Biochemical journal.

Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.

H. Yamashita, P. Heldin, Kaori Suzuki, 2003, Japanese journal of ophthalmology.

Hyaluronan Synthase 2 (HAS2) Promotes Breast Cancer Cell Invasion by Suppression of Tissue Metalloproteinase Inhibitor 1 (TIMP-1)*

P. Heldin, Paraskevi Heldin, Berit Bernert, 2011, The Journal of Biological Chemistry.

Expression regulation of hyaluronan synthase in corneal endothelial cells.

H. Yamashita, M. Araie, P. Heldin, 2000, Investigative ophthalmology & visual science.

Phosphorylation of human fibrinogen in vitro with protein kinase C: characterization of the phosphorylated sites.

E. Humble, P. Heldin, 1987, Archives of biochemistry and biophysics.

Expression of the CD44 glycoprotein (lymphocyte-homing receptor) in untreated human breast cancer and its relationship to prognostic markers.

J. Bergh, P. Heldin, M. de la Torre, 1995, Anticancer research.

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).

M. Tammi, D. Vigetti, A. Passi, 2019, Matrix biology : journal of the International Society for Matrix Biology.

IQGAP1 regulates hyaluronan-mediated fibroblast motility and proliferation.

P. Heldin, S. Skandalis, A. Ruusala, 2012, Cellular signalling.

Biosynthesis and degradation of hyaluronan by nonparenchymal liver cells during liver regeneration

P. Heldin, D. Vrochides, V. Papanikolaou, 1996, Hepatology.

Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study

M. Sallisalmi, J. Tenhunen, P. Heldin, 2021, Intensive Care Medicine Experimental.

Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells

C. Heldin, A. Shiau, P. Heldin, 2022, Cancers.

Growth factor regulation of hyaluronan metabolism in tumor progression

P. Heldin, 2009 .

Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival

C. Heldin, P. Heldin, A. Ruusala, 2023, Cancers.

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

C. Heldin, A. Moustakas, L. P. van der Heide, 2019, Journal of Biological Chemistry.

TGFβ and matrix-regulated epithelial to mesenchymal transition.

A. Moustakas, P. Heldin, 2014, Biochimica et biophysica acta.

Hyaluronan Synthase 2 (HAS2) Promotes Breast Cancer Cell Invasion by Suppression of Tissue Metalloproteinase Inhibitor 1 (TIMP-1)*

P. Heldin, H. Porsch, B. Bernert, 2011, The Journal of Biological Chemistry.

Listeria monocytogenes of CD 44-Regulated Intracellular Proliferation

E. Eriksson, L. Dons, P. Heldin, 2002 .

Hyaluronan synthase in trabecular meshwork cells

P. Heldin, R. Ideta, Y. Kaji, 2003, The British journal of ophthalmology.

Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation.

P. Heldin, 2003, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

A biological guide to glycosaminoglycans: current perspectives and pending questions.

P. Heldin, S. Skandalis, D. Nikitovic, 2024, The FEBS journal.

[Functions of the transforming growth factor-beta superfamily in eyes].

K. Miyazono, C. Heldin, P. Dijke, 1997, Nippon Ganka Gakkai zasshi.