C. Concannon

发表

AMP-activated Protein Kinase Mediates Apoptosis in Response to Bioenergetic Stress through Activation of the Pro-apoptotic Bcl-2 Homology Domain-3-only Protein BMF*

M. Byrne, J. Prehn, C. Wollheim, 2010, The Journal of Biological Chemistry.

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation

M. Rehm, H. Düssmann, C. Concannon, 2010, Cell Death and Differentiation.

Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy

Jochen H M Prehn, Jasmin Schmid, Elaine W Kay, 2011, Gut.

Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-α (HNF1A) function in INS-1 insulinoma cells

M. Byrne, M. Rehm, J. Prehn, 2008, Diabetologia.

'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.

J. Prehn, M. Ward, C. Concannon, 2012, Biochimica et biophysica acta.

Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons

J. Prehn, M. Ward, C. Concannon, 2009, The Journal of Neuroscience.

Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c.

S. Orrenius, C. Concannon, Afshin Samali, 2001, Gene expression.

Bone Morphogenetic Protein 3 Controls Insulin Gene Expression and Is Down-regulated in INS-1 Cells Inducibly Expressing a Hepatocyte Nuclear Factor 1A–Maturity-onset Diabetes of the Young Mutation*

M. Byrne, D. Kögel, J. Prehn, 2011, The Journal of Biological Chemistry.

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma

J. Prehn, E. Jimenez-Mateos, D. Henshall, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization

C. Holmberg, L. Sistonen, C. Concannon, 2005, Cell stress & chaperones.

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.

Donncha F. O’Brien, J. Lucas, Michael A. Farrell, 2013, Brain : a journal of neurology.

AMP‐activated protein kinase (AMPK)–induced preconditioning in primary cortical neurons involves activation of MCL‐1

H. Düssmann, J. Prehn, C. Concannon, 2013, Journal of neurochemistry.

Bcl‐2 homology domain 3‐only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo

J. Prehn, D. Henshall, M. Ward, 2011, The European journal of neuroscience.

Control of Motoneuron Survival by Angiogenin

O. Hardiman, C. Concannon, J. Prehn, 2008, The Journal of Neuroscience.

NMDA receptor‐mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner

J. Prehn, D. Henshall, C. Bonner, 2008, Journal of neurochemistry.

Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL

C. Concannon, Afshin Samali, A. Gorman, 2006, Apoptosis.

Erratum to: Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer

J. Prehn, C. Concannon, E. Kay, 2016, Journal of Translational Medicine.

Targeting the 19 S proteasomal subunit , Rpt 4 , for the treatment of colon cancer

C. Concannon, E. Kay, A. Byrne, 2019 .

INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighboring Cells

M. Byrne, J. Prehn, C. Wollheim, 2010, Diabetes.

On the role of Hsp27 in regulating apoptosis

C. Concannon, Afshin Samali, A. Gorman, 2004, Apoptosis.

Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis

H. Düssmann, C. Concannon, T. Bernaś, 2014, Journal of Cell Science.

ER stress signaling has an activating transcription factor 6α (ATF6)-dependent “off-switch”

H. Düssmann, J. Prehn, C. Concannon, 2018, The Journal of Biological Chemistry.

MicroRNA-224 is Readily Detectable in Urine of Individuals with Diabetes Mellitus and is a Potential Indicator of Beta-Cell Demise

M. Byrne, J. Prehn, C. Concannon, 2015, Genes.

microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

E. Jimenez-Mateos, C. Mooney, D. Henshall, 2015, Scientific Reports.

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer

P. Johnston, C. Concannon, E. Kay, 2012, British Journal of Cancer.

6‐Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK‐mediated, p53‐independent activation of Bax and PUMA

Nuria Llecha, M. Gomez-Lazaro, J. Jordán, 2008, Journal of neurochemistry.

Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase Activate Bax to Induce Mitochondrial Cytochrome c Release and Apoptosis in Response to Malonate

M. Gomez-Lazaro, J. Jordán, J. Prehn, 2007, Molecular Pharmacology.

Real Time Single Cell Analysis of Bid Cleavage and Bid Translocation during Caspase-dependent and Neuronal Caspase-independent Apoptosis*

Jochen H M Prehn, Heiko Duessmann, Markus Rehm, 2006, Journal of Biological Chemistry.

Bid Participates in Genotoxic Drug-Induced Apoptosis of HeLa Cells and Is Essential for Death Receptor Ligands' Apoptotic and Synergistic Effects

M. Rehm, D. Kögel, J. Prehn, 2008, PloS one.

Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy.

Jochen H M Prehn, Deborah A McNamara, Elaine W Kay, 2013, Cancer research.

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation

M. Rehm, J. Prehn, C. Concannon, 2010, Journal of Cell Science.

Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway

A. Strasser, D. Kögel, J. Prehn, 2007, Oncogene.

Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.

J. Prehn, D. Dávila, M. Ward, 2011, Antioxidants & redox signaling.

Motoneurons Secrete Angiogenin to Induce RNA Cleavage in Astroglia

Philippe Marin, P. Marin, C. Concannon, 2012, The Journal of Neuroscience.

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

H. Düssmann, C. Concannon, J. Prehn, 2015, Cell Death and Differentiation.

Identification of circulating microRNAs in HNF1A-MODY carriers

R. Stallings, M. Byrne, J. Prehn, 2013, Diabetologia.

Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.

Ritesh M Pabari, J. Prehn, C. Concannon, 2016, European journal of pharmacology.

Bone Morphogenetic Protein 3 Controls Insulin Gene Expression and Is Down-regulated in INS-1 Cells Inducibly Expressing a Hepatocyte Nuclear Factor 1A-Maturity-onset

M. Byrne, H. Düssmann, J. Prehn, 2011 .

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis

D. Kögel, J. Prehn, C. Bonner, 2012, Neurobiology of Aging.

Bid and Calpains Cooperate to Trigger Oxaliplatin-Induced Apoptosis of Cervical Carcinoma HeLa Cells

M. Rehm, H. Düssmann, D. Kögel, 2009, Molecular Pharmacology.

AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

A. Strasser, J. Prehn, D. Dávila, 2010, The Journal of cell biology.

Endoplasmic reticulum stress‐mediated upregulation of miR‐29a enhances sensitivity to neuronal apoptosis

Stefan J. Haunsberger, R. Stallings, J. Prehn, 2016, The European journal of neuroscience.

Effects of transient focal cerebral ischemia in mice deficient in puma

N. Plesnila, J. Prehn, D. Henshall, 2009, Neuroscience Letters.

The amyloid precursor protein intracellular domain (AICD) disrupts actin dynamics and mitochondrial bioenergetics

J. Prehn, M. Ward, C. Concannon, 2010, Journal of neurochemistry.

Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD).

D. Kögel, J. Prehn, M. Ward, 2006 .

Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate

H. Düssmann, D. Dávila, C. Concannon, 2012, Cell Death and Differentiation.

5-4-2010 AMP kinase-mediated activation of the BH 3-only protein Bim couples energy depletion to stress-induced apoptosis

A. Strasser, J. Prehn, D. Dávila, 2015 .

Increased Expression of MicroRNA-29a in ALS Mice: Functional Analysis of Its Inhibition

J. Prehn, E. Jimenez-Mateos, D. Henshall, 2014, Journal of Molecular Neuroscience.

Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer

J. Prehn, C. Concannon, E. Kay, 2016, Journal of Translational Medicine.

Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer

P. Johnston, J. Prehn, C. Concannon, 2012, International journal of cancer.

Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability

C. Bonner, M. Ward, C. Concannon, 2010, Journal of neurochemistry.

Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.

A. Vazquez, D. Green, R. McLendon, 2013, Cancer research.

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

Sara M. Levens, A. Kania, S. Perlmutter, 2012, The Journal of Neuroscience.

Characterization of Puma-Dependent and Puma-Independent Neuronal Cell Death Pathways following Prolonged Proteasomal Inhibition

J. Prehn, M. Ward, C. Concannon, 2010, Molecular and Cellular Biology.

Analysis of proteasomal subunit expression reveals Rpt4 as a prognostic marker in colorectal cancer

P. Johnston, Patrick, C. Concannon, 2015 .