J. Guh

发表

Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways.

S. Pan, Po-Cheng Chiang, Ssu-Chia Lin, 2010, Biochemical pharmacology.

Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine.

C. Teng, Po-Cheng Chiang, J. Guh, 2005, The Journal of urology.

EVODIAMINE REPRESSES HYPOXIA-INDUCED INFLAMMATORY PROTEINS EXPRESSION AND HYPOXIA-INDUCIBLE FACTOR 1&agr; ACCUMULATION IN RAW264.7

C. Teng, S. Pan, J. Guh, 2009, Shock.

Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.

Ching-Chow Chen, J. Guh, Wei-Jan Huang, 2011, European journal of medicinal chemistry.

Antileukemic Natural Product Induced Both Apoptotic and Pyroptotic Programmed Cell Death and Differentiation Effect

J. Guh, I. Chen, Hsun-Shuo Chang, 2021, International journal of molecular sciences.

Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy.

J. Guh, Chia-Chun Yu, P. Liang, 2013, Carbohydrate research.

Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways

J. Guh, Shih-Ping Liu, Chia-Chun Yu, 2016, Oncotarget.

Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer – a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation

C. Chen, J. Guh, Wei‐Ling Chang, 2015, Oncotarget.

Methoxychalcone induces cell‐cycle arrest and apoptosis in human hormone‐resistant prostate cancer cells through PI 3‐kinase‐independent inhibition of mTOR pathways

J. Guh, Wei-Jan Huang, C. Hsiao, 2010, The Prostate.

Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells

Chien-Chih Chen, C. Teng, S. Pan, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Repurposing of phentolamine as a potential anticancer agent against human castration‐resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway

J. Guh, C. Chao, Shih-Ping Liu, 2015, The Prostate.

2‐Phenyl‐5‐(pyrrolidin‐1‐yl)‐1‐(3,4,5‐trimethoxybenzyl)‐1H‐benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c‐Jun N‐terminal kinase

Kai-Wei Chang, Po-Cheng Chiang, J. Guh, 2010, British journal of pharmacology.

Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.

C. Teng, J. Guh, Yao-Ting Huang, 2004, Biochemical pharmacology.

Synthesis and biological evaluation of anthra [ 1 , 9-cd ] pyrazol-6 ( 2 H )-one scaffold derivatives as potential anticancer agents

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2015 .

Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2015 .

Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress

P. Lyu, J. Guh, Y. Ho, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.

S. Kuo, C. Teng, S. Pan, 2007, Biochemical pharmacology.

YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.

F. Lee, S. Kuo, C. Teng, 2007, Oncogene.

Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone‐refractory prostate cancers through mitochondrial damage stress and survivin downregulation

J. Guh, Y. Ho, Chia-Chun Yu, 2013, The Prostate.

Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells.

C. Teng, S. Pan, J. Guh, 2004, Biochemical pharmacology.

YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole] Exhibits a Novel Antiproliferative Effect and Arrests the Cell Cycle in G0-G1 in Human Hepatocellular Carcinoma Cells

S. Kuo, C. Teng, S. Pan, 2005, Journal of Pharmacology and Experimental Therapeutics.

Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy

J. Guh, S. P. Swain, Wohn-Jenn Leu, 2020, International journal of molecular sciences.

MOSCATILIN REPRESSED LIPOPOLYSACCHARIDE-INDUCED HIF-1&agr; ACCUMULATION AND NF-&kgr;B ACTIVATION IN MURINE RAW264.7 CELLS

C. Teng, S. Pan, J. Guh, 2010, Shock.

Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair.

C. Chen, J. Guh, Y. Ho, 2012, Cancer letters.

Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.

Po-Cheng Chiang, Mao-Tien Kuo, Wu-Che Wen, 2012, The Journal of nutritional biochemistry.

Moscatilin Induces Apoptosis in Human Colorectal Cancer Cells: A Crucial Role of c-Jun NH2-Terminal Protein Kinase Activation Caused by Tubulin Depolymerization and DNA Damage

C. Teng, S. Pan, J. Guh, 2008, Clinical Cancer Research.

Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma

S. Pan, Po-Cheng Chiang, J. Guh, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.

J. Guh, Shih-Wei Wang, G. Hsiao, 2014, Journal of natural products.

Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo.

Hui-Lung Sun, C. Teng, S. Pan, 2010, Cancer letters.

Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma

J. Guh, Chia-Chun Yu, Wei‐Ling Chang, 2015, Oncotarget.

YC-1 INDUCES HEAT SHOCK PROTEIN 70 EXPRESSION AND PREVENTS OXIDIZED LDL-MEDIATED APOPTOSIS IN VASCULAR SMOOTH MUSCLE CELLS

S. Kuo, C. Teng, S. Pan, 2008, Shock.

Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells.

C. Teng, J. Guh, F. Ko, 1996, Circulation.

CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo

S. Kuo, C. Teng, S. Pan, 2008, Molecular Cancer Therapeutics.

Investigation of anti-tumor mechanisms of K2154: characterization of tubulin isotypes, mitotic arrest and apoptotic machinery

S. Kuo, J. Guh, S. Chueh, 2006, Naunyn-Schmiedeberg's Archives of Pharmacology.

human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo

C. Teng, S. Pan, J. Guh, 2005 .

Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo.

C. Teng, S. Pan, J. Guh, 2005, Carcinogenesis.

Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells.

C. Teng, S. Pan, J. Guh, 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia.

C. Teng, J. Guh, Yu-Chun Huang, 2005, Journal of biomedical science.

Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens.

C. Teng, J. Guh, F. Ko, 1996, European journal of pharmacology.

Development of novel adenosine monophosphate-activated protein kinase activators.

Su-Lin Lee, S. Kulp, C. Chen, 2010, Journal of medicinal chemistry.

Antiplatelet Effect of Gingerol Isolated from Zingiber officinale

C. Teng, J. Guh, F. Ko, 1995, The Journal of pharmacy and pharmacology.

Characterization of a fluorescent glucose derivative 1-NBDG and its application in the identification of natural SGLT1/2 inhibitors

J. Guh, P. Liang, Shoei‐Sheng Lee, 2021, Journal of food and drug analysis.

Inhibitory effect of DCDC on lipopolysaccharide-induced nitric oxide synthesis in RAW 264.7 cells.

Y. L. Chang, C. Teng, J. Guh, 2001, Life sciences.

WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.

P. Lyu, J. Guh, C. Liao, 2008, Biochemical pharmacology.

Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

N. Zhong, J. Guh, Shih-Ping Liu, 2018, Front. Pharmacol..

Alterations in Cellular Cholesterol Content Can Be a Potential Anticancer Strategy

J. Guh, 2017 .

YC-1 [3-(5 (cid:1) -Hydroxymethyl-2 (cid:1) -furyl)-1-benzyl Indazole] Exhibits a Novel Antiproliferative Effect and Arrests the Cell Cycle in G 0 -G 1 in Human Hepatocellular Carcinoma Cells

S. Kuo, C. Teng, S. Pan, 2005 .

The Combination of a Novel GLUT1 Inhibitor and Cisplatin Synergistically Inhibits Breast Cancer Cell Growth By Enhancing the DNA Damaging Effect and Modulating the Akt/mTOR and MAPK Signaling Pathways

J. Guh, L. Hsu, F. Kung, 2022, Frontiers in Pharmacology.

A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models

S. Kuo, C. Teng, S. Pan, 2005, Thrombosis and Haemostasis.

Anti‐angiogenic effects and mechanism of prazosin

J. Guh, S. Chueh, C. Liao, 2011, The Prostate.

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway.

S. Pan, J. Guh, S. Chueh, 2007, European journal of pharmacology.

Cryptocaryone, a natural dihydrochalcone, induces apoptosis in human androgen independent prostate cancer cells by death receptor clustering in lipid raft and nonraft compartments.

J. Guh, I. Chen, F. Kung, 2010, The Journal of urology.

Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells.

S. Pan, Po-Cheng Chiang, J. Guh, 2006, European journal of pharmacology.

The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis

J. Guh, L. Hsu, Wohn-Jenn Leu, 2020, Molecules.

Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.

C. Teng, S. Pan, Po-Cheng Chiang, 2005, Journal of hepatology.

ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers.

J. Guh, Chia-Chun Yu, Jui‐Ling Hsu, 2011, Toxicology and applied pharmacology.

Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells.

J. Chern, S. Pan, J. Guh, 2003, Biochemical pharmacology.

Antiproliferative effect in human prostatic smooth muscle cells by nitric oxide donor.

C. Teng, J. Guh, S. Chueh, 1998, Molecular pharmacology.

YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole] Inhibits Neointima Formation in Balloon-Injured Rat Carotid through Suppression of Expressions and Activities of Matrix Metalloproteinases 2 and 9

S. Kuo, C. Teng, S. Pan, 2006, Journal of Pharmacology and Experimental Therapeutics.

YC-1 Inhibits Neointima Formation in Balloon-Injured Rat Carotid Through Suppression of Expressions and Activities of MMP-2 and MMP-9

S. Kuo, C. Teng, S. Pan, 2005 .

YC-1 prevents sodium nitroprusside-mediated apoptosis in vascular smooth muscle cells.

S. Kuo, C. Teng, S. Pan, 2004, Cardiovascular research.

Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades.

C. Chen, J. Guh, T. Hwang, 2013, Biochemical pharmacology.

A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.

S. Pan, J. Guh, Shih-Ping Liu, 2014, Biochemical pharmacology.

Effect of a potent cyclooxygenase inhibitor, 5‐ethyl‐4‐methoxy‐2‐phenylquinoline (KTC‐5), on human platelets

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, The Journal of pharmacy and pharmacology.

Potentiation of tumor necrosis factor-alpha expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway.

Chin‐Chung Wu, C. Teng, J. Guh, 2003, Biochemical pharmacology.

Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle.

P. Lyu, Ssu-Chia Lin, J. Guh, 2007, Neoplasia.

Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives.

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2012, European journal of medicinal chemistry.

Structural studies and anticancer activity of a novel class of β-peptides.

N. S. Zefirov, J. Guh, S. Bräse, 2015, Chemistry, an Asian journal.

A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways.

Po-Cheng Chiang, J. Guh, K. Lee, 2011, Biochemical pharmacology.

Functional identification of alpha 1-adrenoceptor subtypes in human prostate: comparison with those in rat vas deferens and spleen.

C. Teng, J. Guh, F. Ko, 1994, European journal of pharmacology.

An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia

J. Guh, P. Liang, She-Hung Chan, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult

J. Guh, Wei‐Ling Chang, Shoei‐Sheng Lee, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer.

S. Pan, J. Guh, Y. Ho, 2011, The Journal of urology.

Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78

Po-Cheng Chiang, J. Guh, Jui‐Ling Hsu, 2009, Naunyn-Schmiedeberg's Archives of Pharmacology.

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2016 .

Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity.

C. Teng, J. Guh, Yu-Chun Huang, 2005, Journal of biomedical science.

Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes.

C. Teng, J. Guh, Yu-Chun Huang, 2004, Life sciences.

A general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosides.

J. Guh, K. K. Mong, S. Mulani, 2014, Organic & biomolecular chemistry.

Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells.

C. Teng, J. Guh, Dong-Ming Huang, 2006, Cancer letters.

Synthesis, characterization and cancer cell growth inhibition activity of ruthenium(II) complexes bearing bidentate pyrrole-imine ligands

J. Guh, Chia‐Her Lin, Jui‐Hsien Huang, 2018, Journal of Organometallic Chemistry.

Catalytic transfer hydrogenation and anticancer activity of arene-ruthenium compounds incorporating bi-dentate precursors.

Yu-Hsiang Chang, J. Guh, Chia‐Her Lin, 2015, Dalton transactions.

Ring fusion strategy for the synthesis of anthra[2,3-d]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents.

J. Guh, D. Chang, Wen-Wei Chang, 2014, European journal of medicinal chemistry.

(−)‐Discretamine, a selective α1D‐adrenoceptor antagonist, isolated from Fissistigma glaucescens

C. Teng, J. Guh, F. Ko, 1994 .

Ruthenium (II) complexes containing dehydroacetic acid and its imine derivative ligands. Synthesis, characterization and cancer cell growth anti-proliferation activity (GI50) study

J. Guh, Chia‐Her Lin, Yong-Jie Li, 2018, Journal of Organometallic Chemistry.

YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activating JNK pathway

S. Kuo, C. Teng, S. Pan, 2007 .

YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells

S. Kuo, C. Teng, S. Pan, 2005, Molecular Cancer Therapeutics.

YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole] Inhibits Endothelial Cell Functions Induced by Angiogenic Factors in Vitro and Angiogenesis in Vivo Models

S. Kuo, C. Teng, S. Pan, 2005, Journal of Pharmacology and Experimental Therapeutics.

Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents.

J. Guh, Hsu-Shan Huang, Dah-Shyong Yu, 2015, European journal of medicinal chemistry.

Cytotoxic protobassic acid glycosides from Planchonella obovata leaf

J. Guh, Shoei‐Sheng Lee, She-Hung Chan, 2015 .

Synthesis and characterization of ruthenium compounds incorporating keto-amine ligands. The applications of catalytic transfer hydrogenation and cancer cell inhibition

J. Guh, Chia‐Her Lin, Jui‐Hsien Huang, 2016 .

Total synthesis of 14,21-diepi-squamocin-K

J. Guh, Chia-Chun Yu, Chun-Wei Liu, 2013 .

Menthols as Chiral Auxiliaries for Asymmetric Cycloadditive Oligomerization: Syntheses and Studies of β-Proline Hexamers.

N. S. Zefirov, J. Guh, J. Howard, 2015, Organic letters.

Design, synthesis and cytotoxic activity of N-Modified oleanolic saponins bearing A glucosamine.

J. Guh, You-Yu Lin, She-Hung Chan, 2018, European journal of medicinal chemistry.

1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Journal of medicinal chemistry.

Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates.

J. Guh, Tsai-Kun Li, Hung-Wei Chen, 2008, Bioorganic & medicinal chemistry.

New cytotoxic clerodane diterpenoids from the leaves and twigs of Casearia membranacea.

J. Guh, C. Chien, Yuan-Bin Cheng, 2004, Journal of natural products.

Flavonol Glycosides and Cytotoxic Triterpenoids from Alphitonia Philippinensis

Chun-Nan Lee, J. Guh, Shoei‐Sheng Lee, 2004 .

Bioactive diterpenes from Callicarpa longissima.

J. Guh, T. Hwang, Yuanbai Liu, 2012, Journal of natural products.

abeo‐Taxane Diterpenoids from the Taiwanese Yew Taxus sumatrana

J. Guh, C. Chien, Ya‐Ching Shen, 2009, Chemistry & biodiversity.

Three new taxane diterpenoids from Taxus sumatrana.

C. Teng, J. Guh, C. Chien, 2005, Journal of natural products.

Two new cytotoxic clerodane diterpenoids from Casearia membranacea.

J. Guh, Ya‐Ching Shen, A. Khalil, 2004, Chemical & pharmaceutical bulletin.

New Bioactive Clerodane Diterpenoids from the Roots of Casearia membranacea

J. Guh, C. Chien, Yuan-Bin Cheng, 2008, Chemistry & biodiversity.

Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells.

C. Teng, J. Guh, Dong-Ming Huang, 2004, European journal of pharmacology.

(-)-Discretamine, a selective alpha 1D-adrenoceptor antagonist, isolated from Fissistigma glaucescens.

C. Teng, J. Guh, F. Ko, 1994, British journal of pharmacology.

Two new sesquiterpene lactones from Ixeris chinensis.

J. Guh, Shi-Yie Cheng, Ya‐Ching Shen, 2005, Chemical & pharmaceutical bulletin.

Pharmacological evaluation of N-methyl-actinodaphnine, a new vascular alpha-adrenoceptor antagonist, isolated from Illigera luzonensis.

C. Teng, J. Guh, F. Ko, 1995, European journal of pharmacology.

Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells

J. Guh, D. Perrone, E. Marchesi, 2020, Frontiers in Pharmacology.

Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.

Tsung-Chih Chen, J. Guh, D. Chang, 2013, European journal of medicinal chemistry.

Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties.

J. Guh, D. Chang, Hsu-Shan Huang, 2013, Bioorganic & medicinal chemistry.

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies

J. Guh, Wei-Jan Huang, L. Hsu, 2020, Molecules.

Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis

Po-Cheng Chiang, J. Guh, Chia-Nan Chen, 2012, Natural product research.

New prostanoids with cytotoxic activity from Taiwanese octocoral Clavularia viridis.

C. Teng, J. Guh, Yu-Chi Lin, 2004, Journal of natural products.

Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines.

C. Teng, S. Pan, J. Guh, 2012, Cancer letters.

Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-κB activity in vascular smooth-muscle cells

C. Teng, S. Pan, J. Guh, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells

Shu-Wha Lin, J. Guh, L. Hsu, 2019, Front. Pharmacol..

Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathways.

J. Guh, S. Bräse, Shih-Ping Liu, 2017, Oncotarget.

Reevesioside A, a Cardenolide Glycoside, Induces Anticancer Activity against Human Hormone-Refractory Prostate Cancers through Suppression of c-myc Expression and Induction of G1 Arrest of the Cell Cycle

J. Guh, Chia-Chun Yu, I. Chen, 2014, PloS one.

The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cells

A. Cheng, J. Guh, L. Hsu, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

The Indazole Derivative YD-3 Specifically Inhibits Thrombin-Induced Angiogenesis In Vitro and In Vivo

S. Kuo, C. Teng, S. Pan, 2010, Shock.

ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.

Zhenghua Luo, Tae Jin Lee, Yong Peng, 2016, Cancer cell.

Inhibition of the expression of inducible nitric oxide synthase and cyclooxygenase-2 in macrophages by 7HQ derivatives: involvement of IκB-α stabilization

C. Teng, J. Guh, Ya-Ling Chang, 2001 .

Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells.

J. Guh, S. Hsiao, G. Hsiao, 2012, Chemico-biological interactions.

Armepavine oxalate induces cell death on CCRF-CEM leukemia cell line through an apoptotic pathway.

C. Teng, J. Guh, G. Jow, 2004, Life sciences.

KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity

J. Guh, Chia-Chun Yu, K. Kudryavtsev, 2015, Journal of Biomedical Science.

Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats.

C. Teng, S. Pan, J. Guh, 2003, Biochemical pharmacology.

Inhibition of Ras-Mediated Cell Proliferation by Benzyloxybenzaldehyde

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Journal of Biomedical Science.

YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia

F. Lee, S. Kuo, C. Teng, 2007, Oncogene.

Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator*

C. Shapiro, S. Kulp, Dasheng Wang, 2011, The Journal of Biological Chemistry.

Dihydroartemisinin–Bile Acid Hybridization as an Effective Approach to Enhance Dihydroartemisinin Anticancer Activity

J. Guh, D. Perrone, E. Marchesi, 2019, ChemMedChem.

Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: the roles of NF-κB and crosstalk between the extrinsic and intrinsic apoptotic pathways

J. Chern, J. Guh, Chiung-Hua Huang, 2010, Naunyn-Schmiedeberg's Archives of Pharmacology.

Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

J. Guh, Shih-Ping Liu, L. Hsu, 2020, Frontiers in Oncology.

CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.

S. Kuo, C. Teng, S. Pan, 2007, Cancer letters.

YC‐1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway

Y. L. Chang, C. Teng, S. Pan, 2008, British journal of pharmacology.

Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation.

J. Guh, F. Kung, Yean-Jang Lee, 2014, European journal of pharmacology.

Four New Briarane Diterpenoids from the Gorgonian Coral Junceella fragilis

J. Guh, T. Hwang, Ya‐Ching Shen, 2007 .

Effects of ouabain on tension response and [3H]noradrenaline release in human prostate.

C. Teng, J. Guh, S. Chueh, 2000, The Journal of urology.

CIL-102 Interacts with Microtubule Polymerization and Causes Mitotic Arrest following Apoptosis in the Human Prostate Cancer PC-3 Cell Line*

C. Tzeng, C. Teng, J. Guh, 2005, Journal of Biological Chemistry.

Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth.

J. Guh, R. Baruchello, L. Hsu, 2016, Biochemical pharmacology.

Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells.

J. Chern, C. Teng, S. Pan, 2003, The Journal of urology.

Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells

J. Guh, D. Perrone, E. Marchesi, 2023, Molecules.

Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.

Po-Cheng Chiang, J. Guh, Chieh-Yu Peng, 2007, Biochemical pharmacology.

Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems

J. Guh, Shih-Ping Liu, Chia-Chun Yu, 2019, Front. Oncol..

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities.

J. Guh, Wei-Jan Huang, Shi-Wei Chao, 2018, European journal of medicinal chemistry.

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

J. Guh, Y. Ho, Chia-Chun Yu, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

THE p38 MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY PLAYS A CRITICAL ROLE IN PAR2-INDUCED ENDOTHELIAL IL-8 PRODUCTION AND LEUKOCYTE ADHESION

Hui-Lung Sun, C. Teng, S. Pan, 2008, Shock.

Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer.

Po-Cheng Chiang, J. Guh, Y. Ho, 2011, The Journal of urology.

Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway.

J. Guh, Y. Ho, L. Hsu, 2012, Biochemical pharmacology.

Cardiac glycosides induce resistance to tubulin-dependent anticancer drugs in androgen-independent human prostate cancer.

C. Teng, J. Guh, Dong-Ming Huang, 2002, Journal of biomedical science.

Cardiac Glycosides Induce Resistance to Tubulin-Dependent Anticancer Drugs in Androgen-Independent Human Prostate Cancer

C. Teng, J. Guh, Dong-Ming Huang, 2002, Journal of Biomedical Science.

Extract From Plectranthus amboinicus Inhibit Maturation and Release of Interleukin 1β Through Inhibition of NF-κB Nuclear Translocation and NLRP3 Inflammasome Activation

J. Guh, Wohn-Jenn Leu, Jui-Ching Chen, 2019, Front. Pharmacol..

Modulation of anti‐adhesion molecule MUC‐1 is associated with arctiin‐induced growth inhibition in PC‐3 cells

C. Teng, J. Guh, Dong-Ming Huang, 2004, The Prostate.

WJ9708012 exerts anticancer activity through PKC-α related crosstalk of mitochondrial and endoplasmic reticulum stresses in human hormone-refractory prostate cancer cells

J. Guh, Wei-Jan Huang, T. Kuo, 2011, Acta Pharmacologica Sinica.

Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death against Human Non-Small Cell Lung Cancers

J. Guh, L. Hsu, Wohn-Jenn Leu, 2020, International journal of molecular sciences.

Total synthesis of moniliformediquinone and calanquinone A as potent inhibitors for breast cancer

C. Teng, J. Guh, Chun‐Cheng Lin, 2011 .

Investigation of the effects of some alkaloidal alpha1-adrenoceptor antagonists on human hyperplastic prostate.

C. Teng, J. Guh, C. Hsieh, 1999, European journal of pharmacology.

Characterization of α1‐adrenoceptor subtypes in tension response of human prostate to electrical field stimulation

C. Teng, J. Guh, S. Chueh, 1995, British journal of pharmacology.

Inhibition by tamsulosin of tension responses of human hyperplastic prostate to electrical field stimulation.

C. Teng, J. Guh, F. Ko, 1996, European journal of pharmacology.

Characterization of some novel α1-adrenoceptor antagonists in human hyperplastic prostate

J. Chern, C. Teng, J. Guh, 2002 .

Ouabain‐induced increases in resting tone of human hyperplastic prostate following repeated noradrenaline and electrical field stimulation

C. Teng, J. Guh, S. Chueh, 1996, British journal of pharmacology.

A novel hydroxysuberamide derivative potentiates MG132‐mediated anticancer activity against human hormone refractory prostate cancers—the role of histone deacetylase and endoplasmic reticulum stress

J. Guh, Wei-Jan Huang, Chia-Chun Yu, 2013, The Prostate.

A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway

J. Guh, Y. Ho, Hsu-Shan Huang, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer.

S. Pan, J. Guh, Wohn-Jenn Leu, 2014, The Journal of urology.

Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer

N. Zhong, J. Guh, Wohn-Jenn Leu, 2021, Molecules.

Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells – a critical role of Cdk1 in mitotic entry.

J. Guh, Chia-Chun Yu, Ching S. Chen, 2015, Biochemical pharmacology.

A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway

J. Guh, Y. Ho, Shih-Ping Liu, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

The Prostate

J. Guh, I. Chen, Hsun-Shuo Chang, 2020 .

KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity

J. Guh, Shih-Ping Liu, Chia-Chun Yu, 2015, Journal of Biomedical Science.

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer.

A. Dastur, Patricia Greninger, Xianming Deng, 2020, Cell chemical biology.

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

J. Guh, Y. Ho, Chia-Chun Yu, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based Assays

J. Guh, L. Hsu, F. Kung, 2022, Molecules.

The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cells

A. Cheng, J. Guh, L. Hsu, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of the expression of inducible nitric oxide synthase and cyclooxygenase-2 in macrophages by 7HQ derivatives: involvement of IkappaB-alpha stabilization.

Y. L. Chang, C. Teng, J. Guh, 2001, European journal of pharmacology.

Inhibition of Ras-mediated cell proliferation by benzyloxybenzaldehyde.

S. Kuo, Li‐Jiau Huang, C. Teng, 2002, Journal of biomedical science.

The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury

S. Kuo, C. Teng, S. Pan, 2004, Thrombosis and Haemostasis.

An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia

J. Guh, She-Hung Chan, Pi-Hui Liang, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.

C. Croce, F. Lovat, M. Fassan, 2016, Cancer cell.

Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.

S. Kuo, J. Guh, Z. Cheng, 1995, The Biochemical journal.

Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.

S. Kuo, J. Guh, Z. Cheng, 1995, Biochemical Journal.

Dual effects of ouabain on the regulation of proliferation and apoptosis in human prostatic smooth muscle cells.

C. Teng, J. Guh, M. Lai, 2001, The Journal of urology.

Moscatilin Induces Apoptosis in Human Colorectal Cancer Cells: A Crucial Role of c-Jun NH2-Terminal Protein Kinase Activation Caused by Tubulin Depolymerization and DNA Damage

C. Teng, S. Pan, J. Guh, 2008, Clinical Cancer Research.

Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.

J. Guh, Wei-Jan Huang, Chia-Chun Yu, 2011, European journal of medicinal chemistry.

Bioactive diterpenes from Callicarpa longissima.

J. Guh, T. Hwang, Yuanbai Liu, 2012, Journal of natural products.

A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer.

J. Guh, L. Hsu, Wohn-Jenn Leu, 2024, The Prostate.

Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanism.

J. Guh, L. Hsu, Wohn-Jenn Leu, 2024, Naunyn-Schmiedeberg's archives of pharmacology.

Synthesis, distribution analysis and mechanism studies of N-acyl glucosamine-bearing oleanolic saponins.

J. Guh, Jiun-Jie Shie, You-Yu Lin, 2020, Bioorganic chemistry.

Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia.

C. Teng, J. Guh, Yu-Chun Huang, 2005, Journal of biomedical science.

Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin.

J. Guh, L. Hsu, F. Kung, 2024, Biochemical pharmacology.