S. Javadov

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Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.

S. Javadov, V. Rajapurohitam, Ana Kilić, 2009, Journal of molecular and cellular cardiology.

Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role

S. Javadov, Sehwan Jang, Xavier R. Chapa-Dubocq, 2020, Journal of Molecular Medicine.

Cardiac Function is not Susceptible to Moderate Disassembly of Mitochondrial Respiratory Supercomplexes

S. Javadov, P. Brookes, Sehwan Jang, 2020, International journal of molecular sciences.

Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.

S. Javadov, A. Halestrap, S. Clarke, 2004, Cardiovascular research.

The role of NHE-1 in myocardial hypertrophy and remodelling.

S. Javadov, Ana Kilić, M. Karmazyn, 2008, Journal of molecular and cellular cardiology.

Leptin Induces Vascular Smooth Muscle Cell Hypertrophy through Angiotensin II- and Endothelin-1-Dependent Mechanisms and Mediates Stretch-Induced Hypertrophy

S. Javadov, V. Rajapurohitam, A. Zeidan, 2005, Journal of Pharmacology and Experimental Therapeutics.

Different approaches to modeling analysis of mitochondrial swelling.

S. Javadov, V. Makarov, Xavier R. Chapa-Dubocq, 2018, Mitochondrion.

Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats.

W. Frontera, P. Wipf, S. Javadov, 2014, Journal of molecular and cellular cardiology.

Angiotensin II and Ischemic Preconditioning Synergize to Improve Mitochondrial Function While Showing Additive Effects on Ventricular Postischemic Recovery

S. Javadov, Nelson Escobales, Rebeca E. Nuñez, 2014, Journal of cardiovascular pharmacology.

Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria

S. Javadov, Sehwan Jang, 2018, Scientific Reports.

Current Challenges in Elucidating Respiratory Supercomplexes in Mitochondria: Methodological Obstacles

S. Javadov, Sehwan Jang, 2018, Front. Physiol..

Role of NF-κB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy

S. Javadov, V. Rajapurohitam, Ana Kilić, 2012, Molecular and Cellular Biochemistry.

Divergent Effects of Cyclophilin-D Inhibition on the Female Rat Heart: Acute Versus Chronic Post-Myocardial Infarction

S. Javadov, Xavier R. Chapa-Dubocq, Rebecca M. Parodi-Rullán, 2018, Cellular Physiology and Biochemistry.

Effect of phosphocreatine and related compounds on the phospholipid metabolism of ischemic heart.

S. Javadov, V. Saks, E. P. Anyukhovsky, 1986, Biochemical medicine and metabolic biology.

Quantitative evaluation of relationship between cardiac energy metabolism and post-ischemic recovery of contractile function.

S. Javadov, A. Kuznetsov, V. Saks, 1989, Journal of molecular and cellular cardiology.

Protection of ischemic myocardium by exogenous phosphocreatine. I. Morphologic and phosphorus 31-nuclear magnetic resonance studies.

S. Javadov, V. Saks, Victor G. Sharov, 1987, The Journal of thoracic and cardiovascular surgery.

Synchronism in mitochondrial ROS flashes, membrane depolarization and calcium sparks in human carcinoma cells.

S. Javadov, R. Margreiter, A. Kuznetsov, 2017, Biochimica et biophysica acta. Bioenergetics.

Association between ROS production, swelling and the respirasome integrity in cardiac mitochondria.

S. Javadov, Sehwan Jang, 2017, Archives of biochemistry and biophysics.

Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion.

P. Wipf, C. Baines, S. Javadov, 2016, Antioxidants & redox signaling.

Analysis of Mitochondrial Calcium Retention Capacity in Cultured Cells: Permeabilized Cells Versus Isolated Mitochondria

S. Javadov, Sehwan Jang, Xavier R. Chapa-Dubocq, 2021, Frontiers in Physiology.

Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3

S. Javadov, Xavier R. Chapa-Dubocq, Rebecca M. Parodi-Rullán, 2018, Front. Physiol..

Effects of Ferroptosis on the Metabolome in Cardiac Cells: The Role of Glutaminolysis

P. Wipf, S. Javadov, Sehwan Jang, 2022, Antioxidants.

Inhibition of JNK Aggravates the Recovery of Rat Hearts after Global Ischemia: The Role of Mitochondrial JNK

S. Javadov, Sehwan Jang, 2014, PloS one.

Elucidating the Beneficial Role of PPAR Agonists in Cardiac Diseases

S. Javadov, Z. Khuchua, A. Strauss, 2018, International journal of molecular sciences.

Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition.

G. Angelini, S. Javadov, A. Halestrap, 2000, Cardiovascular research.

Actin Cytoskeleton Dynamics Promotes Leptin-Induced Vascular Smooth Muscle Hypertrophy via RhoA/ROCK- and Phosphatidylinositol 3-Kinase/Protein Kinase B-Dependent Pathways

S. Javadov, V. Rajapurohitam, A. Zeidan, 2007, Journal of Pharmacology and Experimental Therapeutics.

An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1.

L. Kirshenbaum, S. Javadov, V. Rajapurohitam, 2006, Journal of molecular and cellular cardiology.

NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition.

A. Basnakian, S. Javadov, V. Rajapurohitam, 2008, Cardiovascular research.

Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spec-trometry (GCIB-SIMS).

H. Bayır, S. Javadov, L. J. Sparvero, 2021, Angewandte Chemie.

Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB‐SIMS)

H. Bayır, S. Javadov, L. J. Sparvero, 2021, Angewandte Chemie.

Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria

S. Javadov, A. Kuznetsov, Z. Khuchua, 2014, Journal of cellular and molecular medicine.

NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodeling.

S. Javadov, A. Zeidan, M. Karmazyn, 2006, American journal of physiology. Heart and circulatory physiology.

Leptin-induced Cardiomyocyte Hypertrophy Involves Selective Caveolae and Rhoa/rock-dependent P38 Mapk Translocation to Nuclei

S. Javadov, A. Zeidan, M. Karmazyn, 2022 .

Direct Renin Inhibition Exerts an Anti-hypertrophic Effect Associated with Improved Mitochondrial Function in Post-infarction Heart Failure in Diabetic Rats

S. Javadov, Jose J Casasnovas, Rebecca M. Parodi-Rullán, 2012, Cellular Physiology and Biochemistry.

Distinct KATP Channels Mediate the Antihypertrophic Effects of Adenosine Receptor Activation in Neonatal Rat Ventricular Myocytes

Ying Xia, S. Javadov, M. Karmazyn, 2007, Journal of Pharmacology and Experimental Therapeutics.

Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts

S. Javadov, Nelson Escobales, Rebeca E. Nuñez, 2018, Pflügers Archiv - European Journal of Physiology.

Ischaemic Preconditioning Inhibits Opening of Mitochondrial Permeability Transition Pores in the Reperfused Rat Heart

S. Javadov, A. Halestrap, S. Clarke, 2003, The Journal of physiology.

High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities

S. Javadov, Sehwan Jang, Xavier R. Chapa-Dubocq, 2017, Front. Pharmacol..

Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats

L. MacMillan-Crow, S. Javadov, Xavier R. Chapa-Dubocq, 2020, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Cyclosporin A in left ventricular remodeling after myocardial infarction ”

S. Javadov, 2014 .

Angiotensin II‐preconditioning is associated with increased PKCε/PKCδ ratio and prosurvival kinases in mitochondria

S. Javadov, Nelson Escobales, Rebeca E. Nuñez, 2017, Clinical and experimental pharmacology & physiology.

Channels Mediate the Antihypertrophic Effects of Adenosine Receptor Activation in Neonatal Rat Ventricular Myocytes

Ying Xia, S. Javadov, M. Karmazyn, 2006 .

Simple kinetic model of mitochondrial swelling in cardiac cells

S. Javadov, V. Makarov, Xavier R. Chapa-Dubocq, 2018, Journal of cellular physiology.

The effects of ischaemic preconditioning, diazoxide and 5‐hydroxydecanoate on rat heart mitochondrial volume and respiration

S. Javadov, A. Halestrap, S. Clarke, 2002, The Journal of physiology.

Estrogen exerts concentration-dependent pro-and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy.

S. Javadov, Ana Kilić, M. Karmazyn, 2009, Journal of molecular and cellular cardiology.

OPA1 regulates respiratory supercomplexes assembly: the role of mitochondrial swelling.

S. Javadov, Sehwan Jang, 2019, Mitochondrion.

Mitochondrial Permeability Transition and Cell Death: The Role of Cyclophilin D

S. Javadov, A. Kuznetsov, 2013, Front. Physiol..

H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation.

S. Javadov, A. Kuznetsov, S. Sickinger, 2015, Biochimica et biophysica acta.

Antihypertrophic Effect of Na+/H+ Exchanger Isoform 1 Inhibition Is Mediated by Reduced Mitogen-Activated Protein Kinase Activation Secondary to Improved Mitochondrial Integrity and Decreased Generation of Mitochondrial-Derived Reactive Oxygen Species

L. Kirshenbaum, S. Javadov, V. Rajapurohitam, 2006, Journal of Pharmacology and Experimental Therapeutics.

Antihypertrophic Effect of NHE-1 Inhibition is Mediated by Reduced MAPK Activation Secondary to Improved Mitochondrial Integrity and Decreased Generation of Mitochondrial-Derived Reactive Oxygen Species

S. Javadov, V. Rajapurohitam, A. Zeidan, 2006 .

Mitochondria in Health and Diseases

S. Javadov, A. Camara, A. Kozlov, 2020, Cells.

Cytoskeleton and regulation of mitochondrial function: the role of beta-tubulin II

S. Javadov, A. Kuznetsov, R. Guzun, 2013, Front. Physiol..

Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats

W. Frontera, P. Wipf, S. Javadov, 2015, Oncotarget.

Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role

S. Javadov, Sehwan Jang, Xavier R. Chapa-Dubocq, 2020, Journal of Molecular Medicine.

Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation

S. Javadov, V. Rajapurohitam, M. Karmazyn, 2012, Molecular and Cellular Biochemistry.

Computational Modeling of In Vitro Swelling of Mitochondria: A Biophysical Approach

S. Javadov, I. Khmelinskii, V. Makarov, 2018, Molecules.

The Role of Adenine Nucleotide Translocase in the Assembly of Respiratory Supercomplexes in Cardiac Cells

S. Javadov, Sehwan Jang, Xavier R. Chapa-Dubocq, 2019, Cells.

Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation

S. Javadov, V. Rajapurohitam, M. Karmazyn, 2012, Molecular and Cellular Biochemistry.

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart.

S. Javadov, A. Halestrap, P. Kerr, 1998, Biochimica et biophysica acta.

The Permeability Transition Pore in Myocardial Ischemia and Reperfusion

S. Javadov, A. Halestrap, M. Suleiman, 2002 .

The Mitochondrial Permeability Transition: Role in Ischemia/Reperfusion Injury

S. Javadov, A. Halestrap, P. Kerr, 1999 .

The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury

J. Hagenbuchner, M. Ausserlechner, S. Javadov, 2019, Antioxidants.

Letter to the editor: "cyclosporin A in left ventricular remodeling after myocardial infarction".

S. Javadov, 2014, American journal of physiology. Heart and circulatory physiology.

Targeting the Mitochondrial Permeability Transition: Cardiac Ischemia-Reperfusion Versus Carcinogenesis

S. Javadov, Rebecca M. Parodi-Rullán, Giselle Barreto‐Torres, 2011, Cellular Physiology and Biochemistry.

Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases

S. Javadov, M. Karmazyn, Nelson Escobales, 2009, Journal of Pharmacology and Experimental Therapeutics.

Mitochondrial Permeability Transition Pore Opening as an Endpoint to Initiate Cell Death and as a Putative Target for Cardioprotection

S. Javadov, M. Karmazyn, 2006, Cellular Physiology and Biochemistry.

NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat.

L. Kirshenbaum, S. Javadov, M. Karmazyn, 2005, Journal of molecular and cellular cardiology.

Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance.

Y. Huang, J. Towbin, J. Balschi, 2014, American journal of physiology. Heart and circulatory physiology.

Mitochondrial permeability transition in cardiac ischemia–reperfusion: whether cyclophilin D is a viable target for cardioprotection?

S. Javadov, A. Kuznetsov, Sehwan Jang, 2017, Cellular and Molecular Life Sciences.

Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes

H. Bayır, S. Javadov, C. S. St. Croix, 2021, Redox biology.

Analysis of Mitochondrial Function, Structure, and Intracellular Organization In Situ in Cardiomyocytes and Skeletal Muscles

J. Hagenbuchner, M. Ausserlechner, S. Javadov, 2022, International journal of molecular sciences.

mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy

S. Javadov, A. Zeidan, M. Karmazyn, 2011, Molecular and Cellular Biochemistry.

Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

S. Javadov, S. Fossati, Rebecca M. Parodi-Rullán, 2021, Cells.

Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives.

S. Javadov, Sehwan Jang, B. Agostini, 2014, Pharmacology & therapeutics.

Cardiac Metabolic Pathways Affected in the Mouse Model of Barth Syndrome

Y. Huang, J. Towbin, S. Madala, 2015, PloS one.

In silico simulation of reversible and irreversible swelling of mitochondria: the role of membrane rigidity.

S. Javadov, I. Khmelinskii, V. Makarov, 2020, Mitochondrion.

Mitochondrial angiotensin receptors and cardioprotective pathways.

S. Javadov, Nelson Escobales, Rebeca E. Nuñez, 2019, American journal of physiology. Heart and circulatory physiology.

Mitochondria and ferroptosis.

S. Javadov, 2022, Current opinion in physiology.

The PPAR pan-agonist bezafibrate ameliorates cardiomyopathy in a mouse model of Barth syndrome

S. Javadov, Mindong Ren, Colin K. L. Phoon, 2017, Orphanet Journal of Rare Diseases.

The Effects of PPAR Stimulation on Cardiac Metabolic Pathways in Barth Syndrome Mice

S. Javadov, A. Glukhov, Z. Khuchua, 2018, Front. Pharmacol..

Expression of mitochondrial fusion–fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition

S. Javadov, V. Rajapurohitam, Ana Kilić, 2010, Basic Research in Cardiology.

Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells

J. Hagenbuchner, M. Ausserlechner, S. Javadov, 2020, Cells.

Single muscle fiber contractile properties in diabetic RAT muscle

W. Frontera, S. Javadov, Ana E. Rodríguez-Zayas, 2016, Muscle & nerve.

The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.

A. Basnakian, S. Javadov, Sehwan Jang, 2015, American journal of physiology. Heart and circulatory physiology.

The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats

S. Javadov, Rebecca M. Parodi-Rullán, Giselle Barreto‐Torres, 2012, International journal of molecular sciences.

Possible Role of Interaction between PPARα and Cyclophilin D in Cardioprotection of AMPK against In Vivo Ischemia-Reperfusion in Rats

S. Javadov, Giselle Barreto‐Torres, 2016, PPAR research.

Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts

S. Javadov, Nelson Escobales, Rebeca E. Nuñez, 2018, Pflügers Archiv - European Journal of Physiology.

The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion.

S. Javadov, Nelson Escobales, 2015, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.

S. Javadov, V. Rajapurohitam, Ana Kilić, 2009, Journal of molecular and cellular cardiology.

The Effects of Amyloid-β on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells.

S. Javadov, Sehwan Jang, S. Fossati, 2023, Journal of Alzheimer's disease : JAD.

Structural and functional remodeling of mitochondria as an adaptive response to energy deprivation.

J. Hagenbuchner, M. Ausserlechner, S. Javadov, 2021, Biochimica et biophysica acta. Bioenergetics.

Mitochondria: the cell powerhouse and nexus of stress

S. Javadov, A. Kuznetsov, 2013, Front. Physiol..

Unraveling the mechanisms of cardiolipin function: The role of oxidative polymerization of unsaturated acyl chains

S. Javadov, Sehwan Jang, 2023, Redox biology.

Regulation of Apoptotic Endonucleases by EndoG.

A. Basnakian, N. N. Sokolov, S. Javadov, 2015, DNA and cell biology.

Role of NF-κB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy

S. Javadov, V. Rajapurohitam, Ana Kilić, 2012, Molecular and Cellular Biochemistry.

Crosstalk between adenine nucleotide transporter and mitochondrial swelling: experimental and computational approaches

S. Javadov, Xavier R. Chapa-Dubocq, J. Bazil, 2022, Cell Biology and Toxicology.

Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria

S. Javadov, Sehwan Jang, 2018, Scientific Reports.

Beta-Amyloid Instigates Dysfunction of Mitochondria in Cardiac Cells

S. Javadov, Sehwan Jang, Xavier R. Chapa-Dubocq, 2022, Cells.

Mitochondrial Permeability Transition: Known Phenomenon with Unknown Molecular Identity

S. Javadov, 2012 .

Mitochondrial Volume Regulation and Swelling Mechanisms in Cardiomyocytes

S. Javadov, Xavier R. Chapa-Dubocq, Nelson Escobales, 2023, Antioxidants.

The Role of Swelling in the Regulation of OPA1-Mediated Mitochondrial Function in the Heart In Vitro

S. Javadov, Xavier R. Chapa-Dubocq, J. Bazil, 2023, Cells.

Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes.

S. Javadov, A. Zeidan, M. Karmazyn, 2006, Cardiovascular research.

Amyloid β induces cardiac dysfunction and neuro-signaling impairment in the heart of an Alzheimer’s disease model

S. Javadov, S. Fossati, Andrea Elia, 2023, bioRxiv.

The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.

A. Basnakian, S. Javadov, Sehwan Jang, 2015, American journal of physiology. Heart and circulatory physiology.

Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei.

S. Javadov, A. Zeidan, M. Karmazyn, 2008, Cardiovascular research.

Retraction Retracted : Possible Role of Interaction between PPAR α and Cyclophilin D in Cardioprotection of AMPK against In Vivo Ischemia-Reperfusion in Rats PPAR Research

S. Javadov, Giselle Barreto‐Torres, 2019 .

Corrigendum: High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities

S. Javadov, Sehwan Jang, Xavier R. Chapa-Dubocq, 2017, Front. Pharmacol..