D. Lefer

发表

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

S. Jha, S. Gundewar, J. Calvert, 2009, Circulation research.

A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number

R. Graham, J. Calvert, D. Lefer, 2014, Cell.

Nitrate and nitrite in biology, nutrition and therapeutics.

M. Gladwin, A. Schechter, J. Friedman, 2009, Nature chemical biology.

Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock.

A. M. Lefer, D. Lefer, A. Lefer, 1993, Annual review of pharmacology and toxicology.

Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor

N. Bryan, D. Lefer, K. Islam, 2016, Journal of cardiovascular pharmacology and therapeutics.

Statins as potent antiinflammatory drugs.

D. Lefer, 2002, Circulation.

Hydrogen Sulfide Improves Survival After Cardiac Arrest and Cardiopulmonary Resuscitation via a Nitric Oxide Synthase 3–Dependent Mechanism in Mice

D. Lefer, F. Ichinose, K. Bloch, 2009, Circulation.

Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis.

D. Lefer, Rakesh P. Patel, C. Kevil, 2007, Free radical biology & medicine.

Effects of storage‐aged red blood cell transfusions on endothelial function in hospitalized patients

James L. Newman, A. Quyyumi, D. Lefer, 2014, Transfusion.

Enhanced vasomotion of cerebral arterioles in spontaneously hypertensive rats.

P. Hutchins, D. Lefer, D J Lefer, 1990, Microvascular research.

Vasomotor Function Comparative Assessment at 1 and 2 Years Following Implantation of the Absorb Everolimus-Eluting Bioresorbable Vascular Scaffold and the Xience V Everolimus-Eluting Metallic Stent in Porcine Coronary Arteries: Insights From In Vivo Angiography, Ex Vivo Assessment, and Gene Analysis

A. Quyyumi, D. Giddens, B. Gogas, 2016, JACC. Cardiovascular interventions.

Selective &bgr;2-Adrenoreceptor Stimulation Attenuates Myocardial Cell Death and Preserves Cardiac Function After Ischemia–Reperfusion Injury

S. Bhushan, D. Lefer, Y. Tao, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Oxidative stress and cardiac disease.

D. Lefer, D. Granger, D. Granger, 2000, The American journal of medicine.

Inhibition of N-Ethylmaleimide–Sensitive Factor Protects Against Myocardial Ischemia/Reperfusion Injury

M. Yamakuchi, C. Lowenstein, W. Baldwin, 2007, Circulation research.

Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.

A. M. Lefer, D. Lefer, B. Campbell, 1997, The Journal of clinical investigation.

In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury.

A. M. Lefer, Xinliang Ma, D. Lefer, 1993, The Journal of clinical investigation.

Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis.

D. Lefer, H. Darius, A. Lefer, 1986, Science.

Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice.

Steven P Jones, D. Granger, D. Lefer, 1998, American journal of physiology. Heart and circulatory physiology.

Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice.

D. Lefer, D. Anderson, A. Palazzo, 1998, American journal of physiology. Heart and circulatory physiology.

Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients.

F. Greenway, T. Giordano, D. Lefer, 2012, Diabetes technology & therapeutics.

Nitrite Therapy for Ischemic Syndromes

D. Lefer, C. Kevil, 2010 .

Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice.

N. Bryan, S. Gundewar, J. Calvert, 2008, Free radical biology & medicine.

Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis

D. Lefer, Rakesh P. Patel, C. Kevil, 2008, Proceedings of the National Academy of Sciences.

Guidelines for experimental models of myocardial ischemia and infarction

Steven P Jones, J. Holmes, M. Lindsey, 2018, American journal of physiology. Heart and circulatory physiology.

cardioprotection acquired through exercise Perspectives in innate and acquired cardioprotection

J. Calvert, D. Lefer, David A. Brown, 2015 .

Hydrogen sulfide-mediated myocardial pre- and post-conditioning

D. Lefer, B. L. Predmore, B. Predmore, 2011, Expert review of clinical pharmacology.

Hydrogen sulfide : follow-through after breakthrough

D. Lefer, B. L. Predmore, B. Predmore, 2010 .

Protective ischaemia in patients: preconditioning and postconditioning.

D. Lefer, A. Granfeldt, J. Vinten-johansen, 2009, Cardiovascular research.

Initial contact and subsequent adhesion of human neutrophils or monocytes to human aortic endothelial cells releases an endothelial intracellular calcium store.

A. Passaniti, J. Zweier, M. Capogrossi, 1994, Circulation.

Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.

N. Nagahara, A. Papapetropoulos, Sofia-Iris Bibli, 2020, Biochemical pharmacology.

Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure

D. Lefer, M. Xian, David J. Polhemus, 2018, JACC. Basic to translational science.

Hydrogen Sulfide Attenuates Cardiac Dysfunction After Heart Failure Via Induction of Angiogenesis

T. Murohara, S. Bhushan, J. Calvert, 2013, Circulation. Heart failure.

H2S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase

T. Murohara, S. Bhushan, J. Calvert, 2013, Circulation.

Restoration of Hydrogen Sulfide Production in Diabetic Mice Improves Reparative Function of Bone Marrow Cells

D. Lefer, R. Kishore, J. Rabinowitz, 2016, Circulation.

3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S

D. Lefer, Y. Kimura, Norihiro Shibuya, 2017, Scientific Reports.

Is Cardioprotection Dead?

E. Marbán, D. Lefer, 2017, Circulation.

Role of intracellular antioxidant enzymes after in vivo myocardial ischemia and reperfusion.

Steven P Jones, Y. Ho, D. Lefer, 2003, American journal of physiology. Heart and circulatory physiology.

Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease.

D. Lefer, M. Grisham, D. Granger, 1998, Free radical biology & medicine.

Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury

D. Lefer, R. Muzumdar, E. Goetzman, 2020, JACC. Basic to translational science.

Coronary endothelial P-selectin in pathogenesis of myocardial ischemia-reperfusion injury.

D. Lefer, D. Anderson, A. Palazzo, 1998, The American journal of physiology.

Coronary endothelial P-selectin in pathogenesis of myocardial ischemia-reperfusion injury.

Steven P Jones, D. Granger, D. Lefer, 1998, American journal of physiology. Heart and circulatory physiology.

Development of Anti-Inflammatory Drugs for Cardiovascular Disease

D. Lefer, Melanie Smith, Melanie B. Smith, 2003 .

Sodium Nitrite Fails to Limit Myocardial Infarct Size: Results from the CAESAR Cardioprotection Consortium (LB645)

Steven P Jones, Carlos C. Chang, R. Bolli, 2014 .

Administration of Sildenafil at Reperfusion Fails to Reduce Infarct Size: Results from the CAESAR Cardioprotection Consortium (LB650)

Steven P Jones, Carlos C. Chang, R. Bolli, 2014 .

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver.

Mark R. Duranski, M. Gladwin, D. Lefer, 2005, The Journal of clinical investigation.

Leukocyte-Endothelial Interactions Following Myocardial Ischemia

Steven P Jones, D. Lefer, 2003 .

Do neutrophils contribute to myocardial reperfusion injury?

D. Lefer, 2002, Basic Research in Cardiology.

Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury.

D. Bullard, D. Granger, D. Lefer, 2000, American journal of physiology. Heart and circulatory physiology.

An anti-CD18 antibody limits infarct size and preserves left ventricular function in dogs with ischemia and 48-hour reperfusion.

M. Arai, L. Becker, D. Lefer, 1996, Journal of the American College of Cardiology.

A novel sialyl LewisX analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion.

A. Buda, D. Lefer, D. Flynn, 1994, Circulation.

Zofenopril Protects Against Myocardial Ischemia–Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability

D. Lefer, G. Cirino, K. Islam, 2016, Journal of the American Heart Association.

Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation.

S. Jha, S. Bhushan, S. Gundewar, 2011, Journal of the American College of Cardiology.

Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System.

D. Lefer, C. White, J. Reilly, 2018, Journal of the American College of Cardiology.

Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling

D. Lefer, K. Mcdonough, Juan Gao, 2016, Circulation research.

Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure.

Steven P Jones, Lewis J. Watson, D. Lefer, 2006, American journal of physiology. Heart and circulatory physiology.

Simvastatin Treatment Ameliorates Autoimmune Disease Associated with Accelerated Atherosclerosis in a Murine Lupus Model1

H. Perlman, K. Walsh, D. Lefer, 2006, The Journal of Immunology.

Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease.

A. M. Lefer, D. Lefer, A. Lefer, 2001, Cardiovascular research.

Simvastatin Exerts Both Anti-inflammatory and Cardioprotective Effects in Apolipoprotein E—Deficient Mice

A. M. Lefer, Michaela R. Hoffmeyer, P. Huang, 2001, Circulation.

Reperfusion injury is not affected by blockade of P-selectin in the diabetic mouse heart.

Steven P Jones, D. Granger, D. Lefer, 1999, American journal of physiology. Heart and circulatory physiology.

Acute exposure to a high cholesterol diet attenuates myocardial ischemia–reperfusion injury in cholesteryl ester transfer protein mice

Steven P Jones, T. Aw, D. Lefer, 2001, Coronary artery disease.

Using gene-targeted mice to investigate the pathophysiology of myocardial reperfusion injury

Steven P Jones, D. Lefer, S. P. Jones, 2000, Basic Research in Cardiology.

Effects of hypercholesterolemia on myocardial ischemia-reperfusion injury in LDL receptor-deficient mice.

T. Aw, D. Lefer, W. G. Girod, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Review Paper: Pathophysiology of Myocardial Reperfusion Injury: The Role of Genetically Engineered Mouse Models

S. Jha, A. Ramachandran, D. Lefer, 2008, Veterinary pathology.

Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size.

D. Lefer, J. Vinten-johansen, W. Johnston, 1992, The American journal of physiology.

Antineutrophil and Myocardial Protecting Actions of a Novel Nitric Oxide Donor After Acute Myocardial Ischemia and Reperfusion in Dogs

D. Lefer, J. Vinten-johansen, W. Johnston, 1993, Circulation.

An endovascular model of ischemic myopathy from peripheral arterial disease: From the Southern Association for Vascular Surgery

I. Pipinos, L. Timmins, D. Lefer, 2017, Journal of vascular surgery.

1116-1 Preconditioning of the diabetic myocardium with acute metformin treatment

D. Lefer, William H. Bestermann, James J. M. Greer, 2004 .

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Mark R. Duranski, M. Gladwin, N. Raghavachari, 2007, The Journal of experimental medicine.

Statin mediated protection of the ischemic myocardium.

D. Lefer, Douglas G Wright, 2005, Vascular pharmacology.

Cardioprotective actions of acute HMG-CoA reductase inhibition in the setting of myocardial infarction.

D. Lefer, S. P. Jones, 2001, Acta physiologica Scandinavica.

Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor.

Steven P Jones, D. Lefer, D. M. Rimmer, 2002, Journal of the American College of Cardiology.

Colonic blood flow responses in experimental colitis: time course and underlying mechanisms.

T. Hibi, K. Stokes, D. Lefer, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Review focus on inorganic nitrite and nitrate in cardiovascular health and disease.

D. Lefer, C. Kevil, 2011, Cardiovascular research.

Pharmacology of selectin inhibitors in ischemia/reperfusion states.

D. Lefer, 2000, Annual review of pharmacology and toxicology.

Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase.

P. Huang, D. Lefer, A. Palazzo, 1999, The American journal of physiology.

D. Lefer, L. Flint, J. Ferrara, 1998, Surgery.

Postischemic endothelium-dependent vascular reactivity is preserved in adhesion molecule-deficient mice.

D. Lefer, D. Granger, M. A. Banda, 1997, The American journal of physiology.

Postischemic endothelium-dependent vascular reactivity is preserved in adhesion molecule-deficient mice.

D. Granger, D. Lefer, M. A. Banda, 1997, American journal of physiology. Heart and circulatory physiology.

H2S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase

T. Murohara, S. Bhushan, J. Calvert, 2013, Circulation.

H S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase

T. Murohara, S. Bhushan, J. Calvert, 2013 .

Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.

Carlos C. Chang, I. Pipinos, J. Calvert, 2015, American journal of physiology. Heart and circulatory physiology.

Sildenafil Promotes Ischemia-Induced Angiogenesis Through a PKG-Dependent Pathway

D. Lefer, C. Kevil, Srikar Veerareddy, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury.

C. Nichols, D. Lefer, W. Coetzee, 2009, Trends in cardiovascular medicine.

Nitric Oxide Contributes to Vasomotor Tone in Hypertensive African Americans Treated With Nebivolol and Metoprolol

A. Quyyumi, D. Lefer, E. Veledar, 2016, Journal of clinical hypertension.

An Esterase-Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species.

D. Lefer, B. Wang, Zhen Li, 2017, Angewandte Chemie.

Determines the Outcome to Cardiac Ischemic Injury Convergence of G Protein-Coupled Receptor and S-Nitrosylation Signaling `

J. Stamler, W. Koch, M. Madesh, 2013 .

Convergence of G Protein–Coupled Receptor and S-Nitrosylation Signaling Determines the Outcome to Cardiac Ischemic Injury

J. Stamler, W. Koch, M. Madesh, 2013, Science Signaling.

Exercise Training Promotes Cardiac Hydrogen Sulfide Biosynthesis and Mitigates Pyroptosis to Prevent High-Fat Diet-Induced Diabetic Cardiomyopathy

D. Lefer, P. Mishra, S. Yadav, 2019, Antioxidants.

Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: exploring modalities for improving cell therapy efficacy

E. Marbán, D. Lefer, David J. Polhemus, 2019, Basic Research in Cardiology.

Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury.

Mark R. Duranski, N. Bryan, J. Calvert, 2006, American journal of physiology. Heart and circulatory physiology.

Cardiac venous endothelial dysfunction after myocardial ischemia and reperfusion in dogs.

A. M. Lefer, X. Ma, D. Lefer, 1992, The American journal of physiology.

Differential response to myocardial reperfusion injury in eNOS-deficient mice.

Steven P Jones, D. Lefer, D. M. Rimmer, 2002, American journal of physiology. Heart and circulatory physiology.

A transgenic mouse model expressing exclusively human hemoglobin E: indications of a mild oxidative stress.

D. Lefer, E. Bouhassira, F. Kuypers, 2012, Blood cells, molecules & diseases.

Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice

Steven P Jones, D. Lefer, D. Duncker, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cardioprotective actions of endogenous IL-10 are independent of iNOS.

D. Lefer, S. Trocha, S. P. Jones, 2001, American journal of physiology. Heart and circulatory physiology.

Cardioprotective Actions of a Monoclonal Antibody Against CD‐18 in Myocardial Ischemia‐Reperfusion Injury

J. Zweier, P. Kuppusamy, D. Lefer, 1993, Circulation.

Endothelial Cell Overexpression of Fas Ligand Attenuates Ischemia-Reperfusion Injury in the Heart*

Steven P Jones, D. Nelson, H. Perlman, 2003, The Journal of Biological Chemistry.

Lipoxins A4 and B4: comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity.

A. M. Lefer, M. Brezinski, D. Lefer, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Monoclonal antibody to ICAM‐1 preserves postischemic blood flow and reduces infarct size after ischemia‐reperfusion in rabbit

Hiroki Sato, D. Lefer, J. Vinten-johansen, 1997, Journal of leukocyte biology.

HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells.

K. Walsh, Y. Kureishi, D. Lefer, 2003, Cardiovascular research.

Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function

M. Todaro, G. Stassi, C. Croce, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Increased disease activity in eNOS-deficient mice in experimental colitis.

D. Lefer, J. Alexander, M. Grisham, 2003, Free radical biology & medicine.

Role of nitric oxide in the regulation of acute and chronic inflammation.

S. Kawachi, D. Lefer, M. Grisham, 2000, Antioxidants & redox signaling.

Vascular endothelial growth factor attenuates leukocyte–endothelium interaction during acute endothelial dysfunction: essential role of endothelium‐derived nitric oxide

D. Lefer, R. Scalia, G. Booth, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

II. Nitric oxide protects in intestinal inflammation.

A. M. Lefer, D. Lefer, A. Lefer, 1999, American journal of physiology. Gastrointestinal and liver physiology.

themes Nitric Oxide II . Nitric oxide protects in intestinal inflammation *

A. M. Lefer, D. Lefer, A. Lefer, 1999 .

The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability.

S. Bhushan, D. Lefer, J. P. Aragon, 2012, American journal of physiology. Heart and circulatory physiology.

Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential.

S. Bhushan, D. Lefer, Madhav Lavu, 2011, Clinical science.

Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice

S. Jha, S. Gundewar, J. Calvert, 2010, Circulation.

Cardiomyocyte-Specific Overexpression of NO Synthase-3 Protects Against Myocardial Ischemia-Reperfusion Injury

N. Bryan, D. Lefer, S. Janssens, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Myocardial Reperfusion Injury: Insights Gained from Gene-Targeted Mice.

Steven P Jones, D. Lefer, 2000, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

Acute erythropoietin cardioprotection is mediated by endothelial response

A. Schechter, Masayuki Yamamoto, J. Calvert, 2011, Basic Research in Cardiology.

Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.

J. Calvert, D. Lefer, C. Chow, 2013, Journal of molecular and cellular cardiology.

A sialyl Lewis(x)-containing carbohydrate reduces infarct size: role of selectins in myocardial reperfusion injury.

A. Buda, D. Lefer, D. Flynn, 1996, The American journal of physiology.

Leukocyte and endothelial adhesion molecule studies in knockout mice.

D. Lefer, A. K. Kakkar, Aman K. Kakkar, 2004, Current opinion in pharmacology.

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure

S. Hazen, S. Bhushan, D. Lefer, 2016, Circulation. Heart failure.

Nitric oxide attenuates neutrophil-mediated myocardial contractile dysfunction after ischemia and reperfusion.

A. Buda, D. Lefer, M. Curtis, 1996, Circulation research.

Deficiency of iNOS does not attenuate severe congestive heart failure in mice.

Steven P Jones, K. Walsh, Jiang Yang, 2005, American journal of physiology. Heart and circulatory physiology.

Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of &bgr;3-Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols

D. Seals, S. Gundewar, J. Calvert, 2011, Circulation research.

Combined inhibition of P-selectin and ICAM-1 reduces myocardial injury following ischemia and reperfusion.

A. Buda, D. Lefer, D. Anderson, 1996, The American journal of physiology.

Effects of peptide leukotrienes on cardiac dynamics in rat, cat, and guinea pig hearts.

C. E. Hock, D. Lefer, A. Lefer, 1985, The American journal of physiology.

Schlaich, M. P. (2019). Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-

G. Dibona, Y. Sharabi, R. Schmieder, 2019 .

A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.

S. Bhushan, D. Lefer, G. Wilson, 2017, American journal of physiology. Heart and circulatory physiology.

REVIEW Guidelines in Cardiovascular Research Guidelines for experimental models of myocardial ischemia and infarction

J. Holmes, M. Lindsey, P. Ping, 2018 .

Hydrogen Sulfide Mediates Cardioprotection Through Nrf2 Signaling

S. Jha, S. Gundewar, J. Calvert, 2009, Circulation research.

Leveraging Adipocyte-Cardiomyocyte Signaling to Treat Ischemic Heart Failure.

D. Lefer, Jake E. Doiron, 2022, Circulation research.

Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure

N. Nagahara, J. Calvert, D. Lefer, 2022, Circulation research.

Renal Denervation to Treat Heart Failure.

D. Lefer, Thomas E Sharp Iii, 2020, Annual review of physiology.

Coronary Endothelial and Cardiac Protective Effects of a Monoclonal Antibody to Intercellular Adhesion Molecule‐1 in Myocardial Ischemia and Reperfusion

A. M. Lefer, R. Rothlein, Xinliang Ma, 1992, Circulation.

Potentiation of leukotriene formation in pulmonary and vascular tissue

A. M. Lefer, D. Lefer, A. Lefer, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease

D. Lefer, David J. Polhemus, Zhen Li, 2018, Circulation research.

PAF-acether induced cardiac dysfunction in the isolated perfused guinea pig heart

D. Lefer, A. Lefer, G. Stahl, 1987, Naunyn-Schmiedeberg's Archives of Pharmacology.

Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury.

S. Bhushan, D. Lefer, Yu Zhao, 2013, ACS chemical biology.

A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury.

D. Lefer, D. M. Rimmer, M. B. Strange, 2005, American journal of physiology. Heart and circulatory physiology.

Red blood cells stored for increasing periods produce progressive impairments in nitric oxide–mediated vasodilation

James L. Newman, D. Lefer, J. Roback, 2013, Transfusion.

Nitrite therapy for protection against ischemia-reperfusion injury.

D. Lefer, 2006, American journal of physiology. Renal physiology.

Effect of short-term treatment with a monoclonal antibody to P-selectin on balloon catheter-induced: Intimal hyperplasia, re-endothelialization, and attenuation of endothelial-dependent relaxation

A. Buda, D. Lefer, J. Rice, 1997, Molecular and Cellular Biochemistry.

Cardioprotective effects of abciximab (ReoPro) in an isolated perfused rat heart model of ischemia and reperfusion.

A. M. Lefer, D. Lefer, B. Campbell, 1999, Methods and findings in experimental and clinical pharmacology.

Differential Structure of Atrial and Ventricular KATP: Atrial KATP Channels Require SUR1

T. Flagg, C. Nichols, M. Magnuson, 2008, Circulation research.

Induction of HIF-1alpha and iNOS with siRNA: a novel mechanism for myocardial protection.

D. Lefer, 2006, Circulation research.

Induction of HIF-1α and iNOS With siRNA

D. Lefer, 2005 .

Control of myocardial oxygen consumption in transgenic mice overexpressing vascular eNOS.

D. Lefer, T. Hintze, R. van Haperen, 2004, American journal of physiology. Heart and circulatory physiology.

Statin therapy and myocardial no‐reflow

J. Calvert, D. Lefer, 2006, British journal of pharmacology.

Is there a better time of day to have a heart attack?

D. Lefer, 2010, Circulation research.

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

I. Shiojima, W. Sessa, K. Walsh, 2000, Nature Medicine.

Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction.

D. Granger, D. Lefer, R. Hebbel, 2006, Free radical biology & medicine.

Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury.

A. M. Lefer, X. Ma, D. Lefer, 1993, Agents and actions. Supplements.

New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop.

J. Downey, R. Gibbons, E. Braunwald, 2011, Circulation.

Cardiac Effects of Peptidoleukotrienes

C. E. Hock, D. Lefer, A. Lefer, 1985 .

Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP.

B. O’Rourke, Ting Liu, D. Lefer, 2020, Journal of molecular and cellular cardiology.

Myocardial protective actions of nitric oxide donors after myocardial ischemia and reperfusion.

D. Lefer, 1995, New horizons.

Nitrite Therapy Improves Left Ventricular Function During Heart Failure via Restoration of Nitric Oxide–Mediated Cytoprotective Signaling

J. Butler, T. Murohara, S. Bhushan, 2014, Circulation research.

Thrombopoietin emerges as a new haematopoietic cytokine that confers cardioprotection against acute myocardial infarction.

J. Calvert, D. Lefer, 2008, Cardiovascular research.

eNOS Gene Therapy Exacerbates Hepatic Ischemia–Reperfusion Injury in Diabetes: A Role for eNOS Uncoupling

Mark R. Duranski, D. Lefer, H. Champion, 2006, Circulation research.

Role for eNOS Uncoupling eNOS Gene Therapy Exacerbates Hepatic Ischemia-Reperfusion Injury in Diabetes : A Print

Mark R. Duranski, D. Lefer, H. Champion, 2006 .

Additive Beneficial Effects of Two Inhibitors of Vasoconstrictor Mediators in Acute Myocardial Ischemia 1

A. M. Lefer, H. Bitterman, D. Lefer, 1987, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Novel mechanism of action of a prostacyclin enhancing agent in haemorrhagic shock

H. Bitterman, D. Lefer, A. Lefer, 1988, Naunyn-Schmiedeberg's Archives of Pharmacology.

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.

J. Calvert, D. Lefer, S. Shiva, 2018, Journal of molecular and cellular cardiology.

Synergism between platelets and neutrophils in provoking cardiac dysfunction after ischemia and reperfusion: role of selectins.

A. M. Lefer, D. Lefer, B. Campbell, 1998, Circulation.

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent

Paul L Huang, S. Bhushan, J. Calvert, 2014, Proceedings of the National Academy of Sciences.

Effects of a monoclonal antibody directed against P-selectin after myocardial ischemia and reperfusion.

A. Buda, D. Lefer, D. Flynn, 1996, The American journal of physiology.

Intracoronary nitric oxide improves postischemic coronary blood flow and myocardial contractile function.

A. Buda, D. Lefer, D. Flynn, 1995, The American journal of physiology.

Therapeutic role of nitric oxide donors in the treatment of cardiovascular disease

D. Lefer, A. Lefer, 1994 .

Endothelial and Myocardial Cell Protection by a Cysteine‐Containing Nitric Oxide Donor After Myocardial Ischemia and Reperfusion

D. Lefer, J. Vinten-johansen, K. Nakanishi, 1993, Journal of cardiovascular pharmacology.

Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models.

D. Lefer, M. Xian, Zhen Li, 2017, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors

S. Bhushan, D. Lefer, M. Xian, 2015, Journal of medicinal chemistry.

Soluble urokinase plasminogen activator receptor: from biomarker to active participant in atherosclerosis and cardiovascular disease

D. Lefer, Zhen Li, T. Goodchild, 2022, The Journal of clinical investigation.

Mild preischemia hypothermia adversely affects postischemic myocardial function in the neonatal piglet heart.

J. Melancon, D. Lefer, L. Flint, 1997, The Journal of surgical research.

Cystathionine γ-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure.

D. Lefer, K. Tokuda, F. Ichinose, 2014, Antioxidants & redox signaling.

Monoclonal Antibody to L‐Selectin Attenuates Neutrophil Accumulation and Protects Ischemic Reperfused Cat Myocardium

A. M. Lefer, Xinliang Ma, D. Lefer, 1993, Circulation.

Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat.

A. M. Lefer, P. Tsao, G. Johnson, 1990, Circulation.

Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure.

D. Lefer, E. Donnarumma, R. Trivedi, 2017, Comprehensive Physiology.

H 2 S Mediated Cardioprotection Comprehensive Physiology Evolution of H 2 S from toxic gas to physiological mediator Toxicology Physiology and medicine

D. Lefer, E. Donnarumma, R. Trivedi, 2017 .

The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion.

A. M. Lefer, D. Lefer, A. Lefer, 1996, Cardiovascular research.

messengers in cerebrovascular circulation Carbon monoxide and hydrogen sulfide: gaseous

D. Lefer, L. Brewster, W. Arendshorst, 2015 .

Redox Pioneer: Professor Hideo Kimura

D. Lefer, 2019, Antioxidants & redox signaling.

Redox pioneer: Professor Arne Holmgren.

Elias S. J. Arnér, D. Lefer, 2011, Antioxidants & redox signaling.

A fluorescent probe for fast and quantitative detection of hydrogen sulfide in blood.

D. Lefer, B. Wang, Adrienne L. King, 2011, Angewandte Chemie.

Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling.

Mark R. Duranski, S. Jha, J. Calvert, 2008, American journal of physiology. Heart and circulatory physiology.

Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease.

D. Lefer, David J. Polhemus, 2014, Circulation research.

A new gaseous signaling molecule emerges: Cardioprotective role of hydrogen sulfide

D. Lefer, 2007, Proceedings of the National Academy of Sciences.

pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury.

D. Lefer, M. Xian, Zhen Li, 2016, Journal of the American Chemical Society.

Hydrogen sulfide in biochemistry and medicine.

D. Lefer, Benjamin Lee Predmore, David Joseph Lefer, 2012, Antioxidants & redox signaling.

Novel insights into hydrogen sulfide--mediated cytoprotection.

J. Calvert, D. Lefer, W. Coetzee, 2010, Antioxidants & redox signaling.

Hydrogen Sulfide Levels and Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI)

D. Lefer, L. Brewster, K. Islam, 2015, Journal of the American Heart Association.

Garlic-Derived Organic Polysulfides and Myocardial Protection.

D. Lefer, Chelsea L. Organ, J. Bradley, 2016, The Journal of nutrition.

Clinical translation of nitrite therapy for cardiovascular diseases.

J. Calvert, D. Lefer, 2010, Nitric oxide : biology and chemistry.

Studies on the mechanism of the vasodilator action of nicorandil.

D. Lefer, A. Lefer, 1988, Life sciences.

Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice.

Steven P Jones, Paul L Huang, D. Lefer, 1999, American journal of physiology. Heart and circulatory physiology.

Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice.

P. Huang, Paul L Huang, D. Lefer, 1999, American journal of physiology. Heart and circulatory physiology.

Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction

D. Lefer, P. Mishra, S. Yadav, 2019, Front. Physiol..

Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function

Csaba Szabo, John W. Elrod, John W. Calvert, 2007, Proceedings of the National Academy of Sciences.

PR-39, a potent neutrophil inhibitor, attenuates myocardial ischemia-reperfusion injury in mice.

Michaela R. Hoffmeyer, C. Ross, D. Lefer, 2000, American journal of physiology. Heart and circulatory physiology.

Sexual dimorphism in reduced-size liver ischemia and reperfusion injury in mice: Role of endothelial cell nitric oxide synthase

D. Lefer, M. Grisham, R. Wolf, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes.

S. Gundewar, J. Calvert, D. Lefer, 2007, American journal of physiology. Heart and circulatory physiology.

Thromboxane induced red blood cell lysis.

A. M. Lefer, M. Brezinski, D. Lefer, 1987, Prostaglandins.

Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury

T. Flagg, C. Nichols, M. Magnuson, 2008, Circulation.

The MEK1–ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

R. Kitsis, J. Molkentin, L. D. de Windt, 2000, The EMBO journal.

Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

S. Hazen, D. Lefer, W. Tang, 2020, Journal of the American Heart Association.

Development of an NIH Consortium for PreclinicAl AssESsment of CARdioprotective Therapies (CAESAR): A Paradigm Shift in Studies of Infarct Size Limitation

Roberto Bolli, R. Bolli, D. Lefer, 2011, Journal of cardiovascular pharmacology and therapeutics.

The Apoptosis Inhibitor ARC Undergoes Ubiquitin-Proteasomal-mediated Degradation in Response to Death Stimuli

K. Mani, R. Kitsis, R. Foo, 2007, Journal of Biological Chemistry.

Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice

M. Lisanti, D. Lefer, M. J. Charron, 2015, PloS one.

CD8+-T-Cell Depletion Ameliorates Circulatory Shock in Plasmodium berghei-Infected Mice

D. Granger, D. Lefer, H. C. van der Heyde, 2001, Infection and Immunity.

Coronary Vascular Actions of the Converting Enzyme Inhibitor, Enalapril 1

D. Lefer, A. Lefer, Allan M. Lefer, 1984, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Controlled coronary hydrodynamics at the time of reperfusion reduces postischemic injury

A. Cordell, D. Lefer, J. Vinten-johansen, 1992 .

Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia

A. M. Lefer, P. Tsao, Xinliang Ma, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.

A. M. Lefer, Xinliang Ma, D. Lefer, 1993, Circulation research.

Sphingolipid therapy in myocardial ischemia-reperfusion injury.

S. Gundewar, D. Lefer, 2008, Biochimica et biophysica acta.

Time course of endothelial dysfunction and myocardial injury during coronary arterial occlusion.

A. M. Lefer, D. Lefer, A. Lefer, 1991, The American journal of physiology.

Lymph isolated from a regional scald injury produces a negative inotropic effect in dogs.

D. Lefer, L. Flint, D. Flynn, 1998, The Journal of burn care & rehabilitation.

Endothelial dysfunction in myocardial ischemia and reperfusion: role of oxygen-derived free radicals.

D. Lefer, A. Lefer, 1991, Basic research in cardiology.

Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics

N. Bryan, D. Lefer, 2019, Molecular Pharmacology.

Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain

N. Nagahara, D. Lefer, Y. Kimura, 2015, Scientific Reports.

HMG-CoA reductase inhibitor attenuates platelet adhesion in intestinal venules of hypercholesterolemic mice.

D. Granger, D. Lefer, A. Tailor, 2004, American journal of physiology. Heart and circulatory physiology.

Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation.

J. Zweier, P. Kuppusamy, D. Lefer, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Ablation of Calcineurin Aβ Reveals Hyperlipidemia and Signaling Cross-talks with Phosphodiesterases*

Xiaoyong Yang, M. Lisanti, E. Hirsch, 2012, The Journal of Biological Chemistry.

Development of Hydrogen Sulfide-Based Therapeutics for Cardiovascular Disease

D. Lefer, B. Predmore, Benjamin L. Predmore, 2010, Journal of cardiovascular translational research.

Combined Angiotensin Receptor–Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure

H. Koiwaya, D. Lefer, David J. Polhemus, 2018, Journal of the American Heart Association.

Myocardial infarction and heart failure in the db/db diabetic mouse.

D. Lefer, James J. M. Greer, Derek P Ware, 2006, American journal of physiology. Heart and circulatory physiology.

Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts.

A. M. Lefer, D. Lefer, Y. Shin, 1999, Circulation.

Physiological concentrations of nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle.

A. M. Lefer, T. Murohara, D. Lefer, 1994, Circulation research.

Protective effects of a new specific thromboxane antagonist in arachidonate-induced sudden death.

D. Lefer, A. Lefer, R. Mentley, 1987, Archives internationales de pharmacodynamie et de therapie.

Monocyte rolling in early atherogenesis: vital role in lesion development.

D. Lefer, D. Granger, 1999, Circulation research.

Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo.

R. Kitsis, K. Walsh, D. Lefer, 2003, American journal of physiology. Heart and circulatory physiology.

Potential importance of alterations in hydrogen sulphide (H2S) bioavailability in diabetes

D. Lefer, 2008, British journal of pharmacology.

Garlic-Derived Organic Polysulfides and Myocardial Protection 1 – 3

D. Lefer, Chelsea L. Organ, J. Bradley, 2016 .

Angiotensin Receptor-Neprilysin Inhibitors Emerge as Potential Treatment for Acute Myocardial Infarction.

D. Lefer, Thomas E. Sharp, 2018, Journal of the American College of Cardiology.

Gene therapy for ischemic heart disease.

S. Gundewar, D. Lefer, Madhav Lavu, 2011, Journal of molecular and cellular cardiology.

HMG-CoA Reductase Inhibitors Inhibit Endothelial Exocytosis and Decrease Myocardial Infarct Size

M. Yamakuchi, C. Lowenstein, W. Baldwin, 2005, Circulation research.

HMG‐CoA reductase inhibition protects the diabetic myocardium from ischemia‐reperfusion injury

Steven P Jones, A. M. Lefer, Michaela R. Hoffmeyer, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers.

D. Burkhoff, D. Lefer, 2005, American heart journal.

Chapter 28 – Cardioprotection

R. Bolli, D. Lefer, 2012 .

Myocardial ischemia/reperfusion injury in NADPH oxidase-deficient mice.

Michaela R. Hoffmeyer, C. Ross, D. Lefer, 2000, Circulation Research.

Monoclonal Antibody Against CD-18 in Myocardial Ischemia-Reperfusion Injury

L. Becker, J. Zweier, P. Kuppusamy, 2005 .

Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury.

Steven P Jones, D. Lefer, R. van Haperen, 2004, American journal of physiology. Heart and circulatory physiology.

Levels of expression of P-selectin, E-selectin, and intercellular adhesion molecule-1 in coronary atherectomy specimens from patients with stable and unstable angina pectoris.

A. Buda, D. Lefer, A. Tenaglia, 1997, The American journal of cardiology.

Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice

S. Jha, G. Atzmon, S. Gundewar, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D

Mark R. Duranski, Xiaoyong Yang, M. Lisanti, 2010, Molecular and Cellular Biology.

Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney.

D. Lefer, K. Varner, H. Xia, 2017, Journal of the American College of Cardiology.

Obstructive Sleep Apnea: The Not-So-Silent Killer.

D. Lefer, T. Goodchild, 2020, Circulation research.

Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop

M. Gladwin, G. Howard, A. Ahluwalia, 2016, Journal of the American Heart Association.

Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia.

D. Lefer, David J. Polhemus, Zhen Li, 2019, Journal of vascular surgery.

Sustained release nitrite therapy results in myocardial protection in a porcine model of metabolic syndrome with peripheral vascular disease.

D. Lefer, L. Brewster, K. Islam, 2015, American journal of physiology. Heart and circulatory physiology.

Emerging role of nitrite in myocardial protection

D. Lefer, 2009, Archives of pharmacal research.

Myocardial protection by nitrite.

J. Calvert, D. Lefer, 2009, Cardiovascular research.

Potential importance of alterations in hydrogen sulphide (H2S) bioavailability in diabetes

D. Lefer, 2008 .

Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling

S. Jha, S. Gundewar, J. Calvert, 2008, Diabetes.

Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid.

D. Lefer, G. Lutty, D S McLeod, 1995, The American journal of pathology.

Hydrogen Sulfide as a Potential Therapy for Heart Failure—Past, Present, and Future

D. Lefer, David J. Polhemus, Zhen Li, 2021, Antioxidants.

Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.

T. Lohmeier, G. Grassi, M. Böhm, 2019, Journal of the American College of Cardiology.

The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure

J. Butler, J. Calvert, D. Lefer, 2014, Scientifica.

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging

Bradley S. Fleenor, D. Seals, J. Calvert, 2011, Aging cell.

CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury

A. Finn, D. Weiss, D. Lefer, 2015, Nature Communications.

Reperfusion injury is not affected by blockade of P-selectin in the diabetic mouse heart.

D. Lefer, A. Palazzo, D. Granger, 1999, The American journal of physiology.

D. Lefer, T. Goodchild, Thomas E. Sharp, 2021, JACC: Basic to Translational Science.

Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

D. Lefer, David J. Polhemus, Zhen Li, 2021, JACC. Basic to translational science.

Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a "2-Hit" Murine Model.

Ravi B. Patel, D. Lefer, H. Xia, 2023, Journal of the American Heart Association.

Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury

N. Bryan, S. Gundewar, J. Calvert, 2007, Proceedings of the National Academy of Sciences.

Pretreatment With Simvastatin Attenuates Myocardial Dysfunction After Ischemia and Chronic Reperfusion

D. Lefer, S. Trocha, S. P. Jones, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Cytoprotective actions of hydrogen sulfide in ischaemia–reperfusion injury

D. Lefer, Adrienne L. King, 2011, Experimental physiology.

Dietary nitrate biochemistry and physiology. An update on clinical benefits and mechanisms of action.

N. Bryan, D. Lefer, N. Hord, 2023, Nitric oxide : biology and chemistry.

Nitric oxide promotes distant organ protection: Evidence for an endocrine role of nitric oxide

N. Bryan, S. Gundewar, J. Calvert, 2008, Proceedings of the National Academy of Sciences.

Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure

S. Bhushan, D. Lefer, K. Islam, 2016, Journal of the American Heart Association.

Immunological Mechanisms in Myocardial Reperfusion Injury

D. Lefer, 1997 .

Quantification of neutrophil migration following myocardial ischemia and reperfusion in cats and dogs

A. M. Lefer, L. Becker, Xinliang Ma, 1994, Journal of leukocyte biology.

Role of β-adrenergic receptors and nitric oxide signaling in exercise-mediated cardioprotection.

J. Calvert, D. Lefer, 2013, Physiology.

Developmental programming resulting from maternal obesity in mice: effects on myocardial ischaemia–reperfusion injury

L. Poston, S. Gundewar, J. Calvert, 2009, Experimental physiology.

The effects of statins on endothelium, inflammation and cardioprotection.

D. Lefer, J. Elrod, 2005, Drug news & perspectives.

The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs.

Steven P Jones, Carlos C. Chang, R. Bolli, 2015, Circulation research.

The NHLBI-Sponsored Consortium for preclinicAl assESsment of cARdioprotective Therapies (CAESAR)Novelty and Significance

Steven P Jones, Carlos C. Chang, R. Bolli, 2015 .

Cardiometabolic Heart Failure and HFpEF

S. Houser, D. Lefer, Thomas E. Sharp, 2019, JACC. Basic to translational science.

3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S

D. Lefer, Y. Kimura, Norihiro Shibuya, 2017, Scientific Reports.

Cardioprotective actions of a selective thromboxane synthetase inhibitor in acute myocardial ischemia.

A. M. Lefer, D. Lefer, A. Lefer, 1983, Archives internationales de pharmacodynamie et de therapie.

Salutary Effects of CG‐4203, a Novel, Stable Prostacyclin Analog, in Hemorrhagic Shock

D. Lefer, Allan M. Lefer, Haim Bitterman, 1988, Journal of Cardiovascular Pharmacology.

IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction

R. Graham, J. Calvert, D. Lefer, 2016, Proceedings of the National Academy of Sciences.

Endothelial Cell Cystathionine γ‐Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury

J. Pfeilschifter, D. Lefer, H. Xia, 2020, Journal of the American Heart Association.

Nitrite and Nitrate in Ischemia–Reperfusion Injury

S. Gundewar, D. Lefer, Madhav Lavu, 2011 .

Myocardial reperfusion injury in neuronal nitric oxide synthase deficient mice

Paul L Huang, D. Lefer, W. G. Girod, 2000, Coronary artery disease.

Nitrite and nitrate: from bench to bedside.

D. Lefer, C. Kevil, 2012, Nitric oxide : biology and chemistry.

Sildenafil-mediated acute cardioprotection is independent of the NO/cGMP pathway.

D. Lefer, J. Elrod, James J. M. Greer, 2007, American journal of physiology. Heart and circulatory physiology.

A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure.

D. Lefer, L. Corral, Zhen Li, 2018, American journal of physiology. Heart and circulatory physiology.

Emerging roles for gasotransmitters

D. Lefer, C. Peers, 2011, Experimental physiology.

Chapter 6 – Overview of Cardiac Muscle Physiology

J. Calvert, D. Lefer, 2012 .

Abstract 264: Nitrite Therapy Ameliorates Myocardial Injury via H2S and Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2)-Dependent Signaling in Chronic Heart Failure

S. Bhushan, D. Lefer, K. Islam, 2015 .

Mechanism of the beneficial effect of dexamethasone on myocardial cell integrity in acute myocardial ischemia

A. M. Lefer, G. Grigonis, D. Lefer, 1980, Basic Research in Cardiology.

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

I. Shiojima, W. Sessa, K. Walsh, 2000, Nature Medicine.

Chapter 28 – Cardioprotection

R. Bolli, D. Lefer, Roberto Bolli, 2012 .

Significance of production of peptide leukotrienes in murine traumatic shock.

A. M. Lefer, C. E. Hock, D. Lefer, 1986, The American journal of physiology.

Nitric oxide attenuates ischaemia‐reperfusion (I/R) injury in the diabetic liver

D. Lefer, G. Zibari, R. Turnage, 2004, Clinical transplantation.

Guidelines for experimental models of myocardial ischemia and infarction

Steven P Jones, J. Holmes, M. Lindsey, 2018, American journal of physiology. Heart and circulatory physiology.

Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice

S. Jha, G. Atzmon, J. Calvert, 2010, Arteriosclerosis, thrombosis, and vascular biology.

1-2-2015 CD 163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury

A. Finn, D. Lefer, H. Akahori, 2016 .

Steven P Jones, Carlos C. Chang, R. Bolli, 2015, Circulation research.

The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure

J. Butler, J. Calvert, D. Lefer, 2014, Scientifica.

Hydrogen Sulfide Improves Survival After Cardiac Arrest and Cardiopulmonary Resuscitation via a Nitric Oxide Synthase 3–Dependent Mechanism in Mice

D. Lefer, F. Ichinose, K. Bloch, 2009, Circulation.

HMG-CoA Reductase Inhibitors Inhibit Endothelial Exocytosis and Decrease Myocardial Infarct Size

M. Yamakuchi, C. Lowenstein, W. Baldwin, 2005, Circulation research.

Renal Denervation Update From the International Sympathetic Nervous System Summit

T. Lohmeier, Y. Sharabi, D. Lefer, 2019 .

New Methods in Cardiovascular Biology The NHLBI-Sponsored Consortium for preclinicAl assESsment of cARdioprotective Therapies (CAESAR) A New Paradigm for Rigorous, Accurate, and Reproducible Evaluation of Putative Infarct-Sparing Interventions in Mice, Rabbits, and Pigs

Carlos C. Chang, R. Bolli, D. Lefer, 2015 .

Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease.

D. Lefer, David J. Polhemus, 2014, Circulation research.

Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential.

S. Bhushan, D. Lefer, Madhav Lavu, 2011, Clinical science.

Cystathionine γ-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure.

D. Lefer, K. Tokuda, F. Ichinose, 2014, Antioxidants & redox signaling.

Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of &bgr;3-Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols

D. Seals, J. Calvert, D. Lefer, 2011, Circulation research.

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure

S. Bhushan, D. Lefer, Zeneng Wang, 2016, Circulation. Heart failure.

The Ten Most Read Articles Published in Circulation Research in 2011

D. Seals, D. Lefer, Amy L. Sindler, 2012 .

Myocardial Ischemia / Reperfusion Injury in NADPH Oxidase – Deficient Mice

Michaela R. Hoffmeyer, D. Lefer, M. Grisham, 2000 .

Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury

T. Flagg, C. Nichols, M. Magnuson, 2008, Circulation.

compensatory hypertrophy to heart failure Hydrogen sulfide mitigates transition from

N. Mukhopadhyay, S. Tyagi, A. Abbate, 2015 .

Development of Hydrogen Sulfide-Based Therapeutics for Cardiovascular Disease

D. Lefer, B. Predmore, 2010, Journal of cardiovascular translational research.

Hydrogen Sulfide Modulates Endothelial–Mesenchymal Transition in Heart Failure

J. Pfeilschifter, A. Papapetropoulos, D. Lefer, 2022, Circulation research.