Tiangang Li

发表

Hepatocyte Growth Factor Family Negatively Regulates Hepatic Gluconeogenesis via Induction of Orphan Nuclear Receptor Small Heterodimer Partner in Primary Hepatocytes*

Chul-Ho Lee, Hueng-Sik Choi, D. Chanda, 2009, The Journal of Biological Chemistry.

TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.

J. Chiang, Tiangang Li, Huiyan Ma, 2008, Journal of lipid research.

Hepatocyte sortilin 1 knockout and treatment with a sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice

Tiangang Li, Cheng Chen, Jibiao Li, 2019, Journal of Lipid Research.

Sortilin 1 knockout alters basal adipose glucose metabolism but not diet‐induced obesity in mice

Tiangang Li, Jibiao Li, David J. Matye, 2017, FEBS letters.

Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1*

Tiangang Li, P. Krishnamurthy, Feng Li, 2016, The Journal of Biological Chemistry.

New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile

B. Neuschwander‐Tetri, P. Portincasa, D. Ford, 2017, Liver research.

Overexpression of cholesterol 7α‐hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

J. Chiang, Tiangang Li, G. Guo, 2011, Hepatology.

Glucose and Insulin Induction of Bile Acid Synthesis

J. Chiang, Tiangang Li, C. Klaassen, 2011, The Journal of Biological Chemistry.

Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation.

Li Yang, Tiangang Li, W. Ding, 2018, The American journal of pathology.

Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes.

Tiangang Li, W. Ding, Yuan Li, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization

J. Friedman, Tiangang Li, M. N. Hasan, 2022, Proceedings of the National Academy of Sciences.

A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism

Yunling Zhang, Tiangang Li, Rongjuan Guo, 2013, Evidence-based complementary and alternative medicine : eCAM.

Cholesterol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis.

Tiangang Li, W. Ding, Yifeng Wang, 2018, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1–AKT–mTOR Axis in Mice

J. Chiang, Tiangang Li, W. Ding, 2016, Cellular and molecular gastroenterology and hepatology.

Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment

A. Artigues, M. Villar, Tiangang Li, 2019, The Journal of Biological Chemistry.

Insulin Resistance Induces Posttranslational Hepatic Sortilin 1 Degradation in Mice*

Tiangang Li, Jibiao Li, David J. Matye, 2015, The Journal of Biological Chemistry.

Fish Oil and Fenofibrate Prevented Phosphorylation-dependent Hepatic Sortilin 1 Degradation in Western Diet-fed Mice*

Tiangang Li, M. Hulke, Jibiao Li, 2014, The Journal of Biological Chemistry.

Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice[S]

B. Roberts, J. Chiang, Tiangang Li, 2013, Journal of Lipid Research.

Transgenic expression of cholesterol 7α‐hydroxylase in the liver prevents high‐fat diet–induced obesity and insulin resistance in mice

J. Chiang, Tiangang Li, Michelle Matozel, 2010, Hepatology.

17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice

W. Freeman, Roshini Sathiaseelan, Tiangang Li, 2022, bioRxiv.

RIFAMPICIN INDUCTION OF CYP3A4 REQUIRES PREGNANE X RECEPTOR CROSS TALK WITH HEPATOCYTE NUCLEAR FACTOR 4α AND COACTIVATORS, AND SUPPRESSION OF SMALL HETERODIMER PARTNER GENE EXPRESSION

J. Chiang, Tiangang Li, 2006, Drug Metabolism and Disposition.

HNF4α Regulates CSAD to Couple Hepatic Taurine Production to Bile Acid Synthesis in Mice.

Tiangang Li, Nga T. Nguyen, Yuxia Zhang, 2018, Gene expression.

Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis

Xi C. He, Linheng Li, N. Davidson, 2022, Journal of hepatology.

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

Tiangang Li, W. Ding, S. Gunewardena, 2020, Nature Communications.

Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice

H. Jaeschke, Tiangang Li, B. Woolbright, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Bile acid receptors link nutrient sensing to metabolic regulation.

Tiangang Li, Jibiao Li, 2017, Liver research.

transcription -hydroxylase gene α inhibition of human cholesterol 7 Mechanism of rifampicin and pregnane X receptor

J. Chiang, Tiangang Li, 2013 .

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

J. Chiang, Tiangang Li, 2005, American journal of physiology. Gastrointestinal and liver physiology.

Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis

Huaiwen Wang, J. Friedman, Tiangang Li, 2021, Cellular and molecular gastroenterology and hepatology.

Bile Acid-Induced Liver Injury in Cholestasis

J. Chiang, Tiangang Li, 2017 .

Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis.

H. Xu, G. Feng, Tiangang Li, 2014, Cell metabolism.

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis[S]

J. Chiang, Tiangang Li, Yanqiao Zhang, 2011, Journal of Lipid Research.

Bile acids and cytokines inhibit the human cholesterol 7 α hydroxylase gene via the JNK/c-Jun pathway

J. Chiang, Tiangang Li, Asmeen Jahan, 2008 .

All‐trans‐retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade

D. Moore, J. Chiang, Tiangang Li, 2014, Hepatology.

J. Chiang, Tiangang Li, K. Song, 2006, Journal of Biological Chemistry.

Mechanism of Rifampicin and Pregnane X Receptor ( PXR ) inhibition of Human Cholesterol 7-Hydroxylase Gene ( CYP 7 A 1 ) Transcription

J. Chiang, Tiangang Li, 2004 .

Rats with high aerobic capacity display enhanced transcriptional adaptability and upregulation of bile acid metabolism in response to an acute high‐fat diet

U. Apte, K. Shankar, L. Koch, 2022, Physiological reports.

Hepatic Autophagy Deficiency Compromises FXR Functionality and Causes Cholestatic Injury

O. Cummings, S. Friedman, Xiao-Ming Yin, 2019 .

Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury

O. Cummings, S. Friedman, Xiao-Ming Yin, 2019, Hepatology.

Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.

D. Moore, S. Strom, J. Chiang, 2009, Biochimica et biophysica acta.

A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.

S. Strom, J. Chiang, Tiangang Li, 2010, Molecular endocrinology.

Hepatocytes A Novel Bile Acid-Activated Vitamin D Receptor Signaling in Human

S. Strom, J. Chiang, Tiangang Li, 2010 .

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast

Tiangang Li, Hui Shen, Huajiang Liu, 2021, Bioengineered.

Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation

R. Bataller, Tiangang Li, W. Ding, 2022, Hepatology.

Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.

J. Chiang, Tiangang Li, Asmeen Jahan, 2006, Hepatology.

Awareness of prenatal genetic tests and attitude towards termination of pregnancy regarding fetal congenital heart defects among clinicians in China: a multi-center cross-sectional study

Tiangang Li, Ailan Xie, K. Sun, 2020 .

Hepatic Cannabinoid Receptor Type 1 Mediates Alcohol-Induced Regulation of Bile Acid Enzyme Genes Expression Via CREBH

S. Koo, W. Jeong, Chul-Ho Lee, 2013, PloS one.

Effects of apical sodium-bile acid transporter inhibitor and obeticholic acid co-treatment in experimental non-alcoholic steatohepatitis.

Tiangang Li, M. N. Hasan, Xuan Qin, 2022, Liver research.

TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis

Shelly C. Lu, Huaiwen Wang, Yanhong Du, 2022, Nature Communications.

Regulation of Bile Acid and Cholesterol Metabolism by PPARs

J. Chiang, Tiangang Li, 2009, PPAR research.

Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury.

Tiangang Li, W. Ding, Katie Dennis, 2018, JCI insight.

A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes[S]

J. Chiang, Tiangang Li, K. Song, 2010, Journal of Lipid Research.

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)-Mixed Lineage Kinase Domain-Like Protein (MLKL)-Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers.

H. Jaeschke, Tiangang Li, W. Ding, 2019, The American journal of pathology.

Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice.

Xi C. He, A. Ballabio, Linheng Li, 2018, Gastroenterology.

Nuclear receptors in bile acid metabolism

J. Chiang, Tiangang Li, 2013, Drug metabolism reviews.

Genetic and non-genetic factors responsible for mitochondrial failure and Alzheimer’s disease

X. Tian, Tiangang Li, Kuo Gao, 2014 .

Elevated O-GlcNAcylation Enhances Pro-Inflammatory Th17 Function by Altering the Lipid Microenvironment

A. Artigues, M. Villar, Tiangang Li, 2018, bioRxiv.

Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α‐hydroxylase/steroid response element‐binding protein 2/microRNA‐33a axis in mice

J. Chiang, Tiangang Li, Shannon Boehme, 2013, Hepatology.

Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer.

U. Apte, Tiangang Li, 2015, Advances in pharmacology.

Bile Acid Signaling in Metabolic Disease and Drug Therapy

J. Chiang, Tiangang Li, John Y L Chiang, 2014, Pharmacological Reviews.

Retinoic Acid-related Orphan Receptor α Regulates Diurnal Rhythm and Fasting Induction of Sterol 12α-Hydroxylase in Bile Acid Synthesis*

J. Chiang, Tiangang Li, Preeti Pathak, 2013, The Journal of Biological Chemistry.

Autophagy in liver diseases: A review.

Tiangang Li, W. Ding, Sam Fulte, 2021, Molecular aspects of medicine.

Cannabinoid Receptor Type 1 (CB1R) Signaling Regulates Hepatic Gluconeogenesis via Induction of Endoplasmic Reticulum-bound Transcription Factor cAMP-responsive Element-binding Protein H (CREBH) in Primary Hepatocytes*

S. Koo, Chul-Ho Lee, Hueng-Sik Choi, 2011, The Journal of Biological Chemistry.

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α‐hydroxylase gene expression

S. Strom, J. Chiang, Tiangang Li, 2009, Hepatology.

Bile acids as metabolic regulators

J. Chiang, Tiangang Li, 2015, Current opinion in gastroenterology.

Bile Acid Signaling in Liver Metabolism and Diseases

J. Chiang, Tiangang Li, Tiangang Li, 2011, Journal of lipids.

Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.

J. Chiang, Tiangang Li, 2020, Hepatobiliary surgery and nutrition.

Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.

Yunpeng Qi, Changtao Jiang, F. Gonzalez, 2015, Biochimica et biophysica acta.

Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis

H. Jaeschke, Tiangang Li, B. Bruinsma, 2018, Journal of clinical and translational research.

Glucose stimulates cholesterol 7α-hydroxylase gene transcription in human hepatocytes[S]

Hueng-Sik Choi, D. Chanda, J. Chiang, 2010, Journal of Lipid Research.

Glucose stimulates cholesterol 7 α-hydroxylase gene ( CYP 7 A 1 ) transcription in human hepatocytes

Hueng-Sik Choi, D. Chanda, Tiangang Li, 2009 .

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine Published, JLR Papers in Press, November 6, 2006.

J. Chiang, Tiangang Li, Wenling Chen, 2007, Journal of Lipid Research.

Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.

B. Copple, Tiangang Li, 2016, Pharmacological research.

Bile acids and cytokines inhibit the human cholesterol 7α‐hydroxylase gene via the JNK/c‐jun pathway in human liver cells

J. Chiang, Tiangang Li, Asmeen Jahan, 2006 .

Orphan Nuclear Receptor Small Heterodimer Partner Negatively Regulates Growth Hormone-mediated Induction of Hepatic Gluconeogenesis through Inhibition of Signal Transducer and Activator of Transcription 5 (STAT5) Transactivation*

In-kyu Lee, S. Ahn, Y. D. Kim, 2012, The Journal of Biological Chemistry.

In-kyu Lee, S. Ahn, Y. D. Kim, 2012 .

Safety of Pregnancy After Surgical Treatment for Breast Cancer: A Meta-Analysis

Tiangang Li, M. Luo, Fu Li, 2014, International Journal of Gynecologic Cancer.

Pregnane X receptor regulation of bile acid metabolism and cholesterol homeostasis.

Tiangang Li, 2006 .

Bile Acid Metabolism in Health and Disease

J. Chiang, Tiangang Li, 2020, The Liver.

Regulation of cholesterol and bile acid homeostasis by the CYP 7 A 1 / SREBP 2 / miR-33 a axis

J. Chiang, Tiangang Li, Shannon Boehme, 2013 .

Acid Synthesis -Hydroxylase in Bile α Induction of Sterol 12 Regulates Diurnal Rhythm and Fasting α Retinoic Acid-related Orphan Receptor

Tiangang Li, Preeti Pathak, Y. John, 2014 .

Curcumin Differentially Regulates Endoplasmic Reticulum Stress through Transcriptional Corepressor SMILE (Small Heterodimer Partner-interacting Leucine Zipper Protein)-mediated Inhibition of CREBH (cAMP Responsive Element-binding Protein H)*

S. Koo, Hueng-Sik Choi, D. Chanda, 2011, The Journal of Biological Chemistry.

Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.

S. Strom, J. Chiang, Tiangang Li, 2006, The Journal of biological chemistry.

REGULATION OF BILE ACID SYNTHESIS BY THE GUT–LIVER SIGNALING AXIS

J. Chiang, Tiangang Li, 2015 .

C URRENT OPINION Bile acids as metabolic regulators

Tiangang Li, 2015 .

Liver-specific microRNA-185 knockout promotes cholesterol dysregulation in mice

Tiangang Li, Cheng Chen, David J. Matye, 2020, Liver research.

Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice

Huaiwen Wang, Yanhong Du, Tiangang Li, 2023, Journal of lipid research.

Glycine-β-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male Cyp2c70 Knockout Mice

Huaiwen Wang, Yanhong Du, Tiangang Li, 2023, Cells.

Bile acids as metabolic regulators: an update

J. Chiang, Tiangang Li, 2023, Current opinion in gastroenterology.

Gut-restricted apical sodium-dependent bile acid transporter inhibitor attenuates alcohol-induced liver steatosis and injury in mice.

Huaiwen Wang, Tiangang Li, W. Ding, 2021, Alcoholism, clinical and experimental research.

MicroRNA‐210 Promotes Bile Acid–Induced Cholestatic Liver Injury by Targeting Mixed‐Lineage Leukemia‐4 Methyltransferase in Mice

J. Kemper, Yang Zhang, Jian Ma, 2020, Hepatology.

Transgenic expression of CYP7A1 in the liver prevents high fat diet‐induced obesity and insulin resistance in mice

J. Chiang, Tiangang Li, Michelle Matozel, 2010 .

Insulin Regulation of Cholesterol 7α-Hydroxylase Expression in Human Hepatocytes

S. Strom, J. Chiang, Tiangang Li, 2006, Journal of Biological Chemistry.

A Novel Role of Transforming Growth Factor β1 in Transcriptional Repression of Human Cholesterol 7α-Hydroxylase Gene

J. Chiang, Tiangang Li, 2007 .

Hepatocyte Growth Factor Family Negatively Regulates Hepatic Gluconeogenesis via Induction of Orphan Nuclear Receptor Small Heterodimer Partner in Primary Hepatocytes*

Hueng-Sik Choi, D. Chanda, Yong-Hoon Kim, 2009, The Journal of Biological Chemistry.

Genetic and non-genetic factors responsible for mitochondrial failure and Alzheimer’s disease

X. Tian, Tiangang Li, Kuo Gao, 2014 .

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7α-hydroxylase gene transcription

Tiangang Li, John Y. L. Chiang, 2005 .