J. Wojtaszewski

A. Steensberg, B. Pedersen, H. Pilegaard, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

5′AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes

F. Dela, H. Pilegaard, J. Wojtaszewski, 2005, The Journal of physiology.

Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise.

N. Ruderman, J. Wojtaszewski, A. Saha, 2005, American journal of physiology. Endocrinology and metabolism.

Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise.

B. Saltin, H. Pilegaard, J. Wojtaszewski, 2002, Biochemical and biophysical research communications.

Role of 5′AMP‐activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease

B. Kemp, R. Haller, J. Vissing, 2002, The Journal of physiology.

Regulation of PDH in human arm and leg muscles at rest and during intense exercise.

H. Pilegaard, J. Wojtaszewski, R. Damsgaard, 2008, American journal of physiology. Endocrinology and metabolism.

The primary defect in glycogen synthase activity is not based on increased glycogen synthase kinase-3alpha activity in diabetic myotubes.

K. Højlund, H. Beck-Nielsen, J. Wojtaszewski, 2004, Biochemical and biophysical research communications.

PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

Y. Hellsten, H. Pilegaard, J. Wojtaszewski, 2008, American journal of physiology. Endocrinology and metabolism.

The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

B. Viollet, D. Hardie, P. Schjerling, 2004, Diabetes.

AXIN1 knockout does not alter AMPK/mTORC1 regulation and glucose metabolism in mouse skeletal muscle

Y. Hellsten, C. Henríquez-Olguín, Anika Offergeld, 2021, The Journal of physiology.

Epinephrine-stimulated glycogen breakdown activates glycogen synthase and increases insulin-stimulated glucose uptake in epitrochlearis muscles.

J. Wojtaszewski, A. Kolnes, J. Jensen, 2015, American journal of physiology. Endocrinology and metabolism.

Serum Is Not Necessary for Prior Pharmacological Activation of AMPK to Increase Insulin Sensitivity of Mouse Skeletal Muscle

J. Wojtaszewski, R. Kjøbsted, Nicolas O. Jørgensen, 2018, International journal of molecular sciences.

Low Muscle Glycogen and Elevated Plasma Free Fatty Acid Modify but Do Not Prevent Exercise-Induced PDH Activation in Human Skeletal Muscle

B. Saltin, C. Lundby, H. Pilegaard, 2009, Diabetes.

Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus.

K. Højlund, H. Beck-Nielsen, B. Hansen, 2009, The Journal of clinical endocrinology and metabolism.

PDH-E1α Dephosphorylation and Activation in Human Skeletal Muscle During Exercise

P. Neufer, B. Saltin, H. Pilegaard, 2006, Diabetes.

Effects of Exercise Training on Regulation of Skeletal Muscle Glucose Metabolism in Elderly Men.

Y. Hellsten, H. Pilegaard, J. Wojtaszewski, 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

Effects of Endurance Exercise Training on Insulin Signaling in Human Skeletal Muscle

J. Wojtaszewski, E. Richter, B. Kiens, 2007, Diabetes.

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates

L. Madsen, J. Wojtaszewski, E. Richter, 2016, Molecular metabolism.

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates

L. Madsen, J. Wojtaszewski, E. Richter, 2016 .

Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle–Signaling Interaction at the Level of TBC1 Domain Family Member 4

L. Goodyear, J. Wojtaszewski, E. Richter, 2012, Diabetes.

AS160 phosphorylation is associated with activation of (cid:1) 2 (cid:2) 2 (cid:3) 1 - but not (cid:1) 2 (cid:2) 2 (cid:3) 3 -AMPK trimeric complex in skeletal muscle during exercise in humans

J. Wojtaszewski, E. Richter, B. Kiens, 2007 .

Exercise training reduces the insulin‐sensitizing effect of a single bout of exercise in human skeletal muscle

J. Wojtaszewski, E. Richter, B. Kiens, 2018, The Journal of physiology.

Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

K. Højlund, H. Beck-Nielsen, B. Hansen, 2008, The Journal of clinical endocrinology and metabolism.

Glucose, exercise and insulin: emerging concepts

W. Derave, J. Wojtaszewski, E. Richter, 2001, The Journal of physiology.

Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle.

J. Wojtaszewski, E. Richter, B. Kiens, 2009, American journal of physiology. Endocrinology and metabolism.

Perfused rat hindlimb is suitable for skeletal muscle glucose transport measurements.

J. Wojtaszewski, E. Richter, T. Ploug, 1998, The American journal of physiology.

Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle.

B. Viollet, J. Zierath, Y. C. Long, 2009, Endocrinology.

Exercise regulation of glucose transport in skeletal muscle.

Tatsuya Hayashi, L. Goodyear, J. Wojtaszewski, 1997, American journal of physiology. Endocrinology and metabolism.

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

B. Viollet, P. Schjerling, J. Wojtaszewski, 2004, The Journal of biological chemistry.

Effect of glucose-6-phosphate and pH on glucose transport in skeletal muscle plasma membrane giant vesicles.

J. Wojtaszewski, E. Richter, S. Kristiansen, 1994, Acta physiologica Scandinavica.

Beta2-adrenoceptor agonist salbutamol increases leg glucose uptake and metabolic rate but not muscle glycogen resynthesis in recovery from resistance exercise of the quadriceps in lean young men

J. Bangsbo, J. Wojtaszewski, M. Hostrup, 2021, bioRxiv.

Perfused rat hindlimb is suitable for skeletal muscle glucose transport measurements.

J. Wojtaszewski, E. Richter, T. Ploug, 1998, American journal of physiology. Endocrinology and metabolism.

Prior exercise in humans redistributes intramuscular GLUT4 and enhances insulin-stimulated sarcolemmal and endosomal GLUT4 translocation

C. Henríquez-Olguín, P. Verkade, J. Wojtaszewski, 2020, Molecular metabolism.

TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction

J. Wojtaszewski, H. Al-Hasani, K. Kido, 2019, Diabetes.

A common variation of the PTEN gene is associated with peripheral insulin resistance.

P. Poulsen, A. Vaag, R. Ribel‐Madsen, 2016, Diabetes & metabolism.

Increased atypical PKC activity in endurance-trained human skeletal muscle.

M. Sajan, R. Farese, J. Wojtaszewski, 2003, Biochemical and biophysical research communications.

Skeletal muscle mitochondrial respiration in AMPKα2 kinase‐dead mice

S. Larsen, J. Helge, F. Dela, 2012, Acta physiologica.

Identifying the Heterotrimeric Complex Stoichiometry of AMPK in Skeletal Muscle by Immunoprecipitation.

J. Wojtaszewski, J. Birk, 2018, Methods in molecular biology.

Kinase Activity Determination of Specific AMPK Complexes/Heterotrimers in the Skeletal Muscle.

J. Wojtaszewski, J. Birk, 2018, Methods in molecular biology.

Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: metabolic implications.

L. Goodyear, J. Wojtaszewski, E. Richter, 1999, The American journal of physiology.

Extracellular-regulated protein kinase cascades are activated in response to injury in human skeletal muscle.

O. Ljungqvist, R. Fielding, D. Aronson, 1998, American Journal of Physiology - Cell Physiology.

Changes in Exercise-Induced Gene Expression in 5′-AMP–Activated Protein Kinase γ3–Null and γ3 R225Q Transgenic Mice

J. Zierath, D. Galuska, Y. C. Long, 2005 .

A possible role for AMP-activated protein kinase in exercise-induced glucose utilization: insights from humans and transgenic animals.

B. Viollet, J. Wojtaszewski, S. Vaulont, 2001, Biochemical Society transactions.

Extracellular-regulated protein kinase cascades are activated in response to injury in human skeletal muscle.

O. Ljungqvist, R. Fielding, D. Aronson, 1998, American journal of physiology. Cell physiology.

Exercise physiology: from performance studies to muscle physiology and cardiovascular adaptations.

J. Wojtaszewski, E. Richter, B. Kiens, 2014, Journal of applied physiology.

ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle

Dorte B. Bekker-Jensen, Ana Martinez del Val, Xiang Li, 2022, The EMBO journal.

Marathon running transiently increases c‐Jun NH2‐terminal kinase and p38γ activities in human skeletal muscle

R. Fielding, L. Goodyear, J. Wojtaszewski, 2000, The Journal of physiology.

Enhanced voluntary wheel running in GPRC6A receptor knockout mice

J. Wojtaszewski, C. Clemmensen, H. Bräuner‐Osborne, 2013, Physiology & Behavior.

Circulating follistatin and activin A and their regulation by insulin in obesity and type 2 diabetes.

K. Højlund, J. Wojtaszewski, E. Richter, 2020, The Journal of clinical endocrinology and metabolism.

Glucose transport and transporters in muscle giant vesicles: differential effects of insulin and contractions.

P. Hespel, J. Wojtaszewski, E. Richter, 1993, The American journal of physiology.

Regulation of glycogen synthase activity and phosphorylation by exercise

J. Wojtaszewski, J. Nielsen, 2004, The Proceedings of the Nutrition Society.

The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.

B. Viollet, M. Birnbaum, D. Carling, 2003, The Journal of clinical investigation.

pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise

Omar K. Yaghi, Edward T Chouchani, S. Gygi, 2020, Cell.

AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

B. Viollet, A. Deshmukh, J. Zierath, 2006, Diabetes.

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.

E. Carlsson, M. Ridderstråle, L. Groop, 2004, The Journal of clinical investigation.

Effect of endurance exercise training on Ca2+–calmodulin‐dependent protein kinase II expression and signalling in skeletal muscle of humans

J. Wojtaszewski, E. Richter, B. Kiens, 2007, The Journal of physiology.

Electronic Supplementary Material -methods

P. Poulsen, A. Vaag, T. Litman, 2022 .

AMPK in skeletal muscle function and metabolism

B. Viollet, A. Marette, M. Foretz, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

L. Joosten, C. Ling, A. Vaag, 2017, BMC Medicine.

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

Jean Tichet, Beverley Balkau, Philippe Froguel, 2009, Nature Genetics.

Quantification of exercise‐regulated ubiquitin signaling in human skeletal muscle identifies protein modification cross talk via NEDDylation

David E. James, J. Wojtaszewski, E. Richter, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

C. Ling, A. Vaag, B. Pedersen, 2020, Endocrine research.

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.

Nolan J Hoffman, David E James, Sean J Humphrey, 2015, Cell metabolism.

Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise

J. Wojtaszewski, S. Jørgensen, E. Richter, 2006, The Journal of physiology.

PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle

Y. Hellsten, H. Pilegaard, J. Wojtaszewski, 2008 .

Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes.

K. Højlund, J. Wojtaszewski, S. J. Petersson, 2016, Clinical science.

Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation

J. Wojtaszewski, E. Richter, B. Kiens, 2016, The Journal of physiology.

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

R. Helm, Xiaoyong Yang, D. Gerrard, 2018, Molecular metabolism.

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.

D. James, M. Febbraio, W. E. Hughes, 2018, Cell metabolism.

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training

J. Zierath, K. Højlund, H. Beck-Nielsen, 2010, Diabetologia.

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

B. Viollet, D. James, M. Foretz, 2018, Molecular metabolism.

Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

J. Wojtaszewski, B. Mortensen, J. Birk, 2013, Molecular and Cellular Endocrinology.

Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice.

J. Zierath, D. Galuska, Y. C. Long, 2005, Diabetes.

5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle.

D. Hardie, J. Wojtaszewski, S. Jørgensen, 2004, American journal of physiology. Endocrinology and metabolism.

5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle.

Henriette Pilegaard, D. Hardie, H. Pilegaard, 2003, Journal of applied physiology.

highlighted topics Exercise Effects on Muscle Insulin Signaling and Action Invited Review: Effect of acute exercise on insulin signaling and action in humans

J. Wojtaszewski, E. Richter, J. Nielsen, 2002 .

Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle*

Peter Schjerling, Jørgen F. P. Wojtaszewski, B. Viollet, 2004, Journal of Biological Chemistry.

Mechanisms Preserving Insulin Action during High Dietary Fat Intake.

Philipp E. Geyer, K. Kristiansen, B. Jensen, 2019, Cell metabolism.

Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training

M. Mann, M. Murgia, C. Schéele, 2021, Nature communications.

Exercise regulation of glucose transport in skeletal muscle.

Tatsuya Hayashi, L. Goodyear, J. Wojtaszewski, 1997, The American journal of physiology.

Resource Extracellular Vesicles Pro vide a Means for Tissue Crosstalk during Exercise Graphical

D. James, M. Febbraio, W. E. Hughes, 2019 .

Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes

K. Højlund, H. Beck-Nielsen, J. Frystyk, 2006, Diabetologia.

Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle

Bente Kiens, Maximilian Kleinert, Peter Schjerling, 2013, Diabetes.

Transgenic models--a scientific tool to understand exercise-induced metabolism: the regulatory role of AMPK (5'-AMP-activated protein kinase) in glucose transport and glycogen synthase activity in skeletal muscle.

J. Wojtaszewski, S. Jørgensen, E. Richter, 2003, Biochemical Society transactions.

Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver.

H. Pilegaard, J. Wojtaszewski, P. A. Pedersen, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Impaired Insulin-Stimulated Phosphorylation of Akt and AS160 in Skeletal Muscle of Women With Polycystic Ovary Syndrome Is Reversed by Pioglitazone Treatment

K. Højlund, H. Beck-Nielsen, J. Wojtaszewski, 2008, Diabetes.

Mechanisms Underlying Absent Training-Induced Improvement in Insulin Action in Lean, Hyperandrogenic Women With Polycystic Ovary Syndrome

J. Wojtaszewski, E. Richter, B. Kiens, 2020, Diabetes.

α-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK

B. Wulff, J. Wojtaszewski, M. Cowley, 2016, PloS one.

highlighted topics Exercise Effects on Muscle Insulin Signaling and Action Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation

R. Adams, J. Wojtaszewski, G. Adams, 2002 .

Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function

P. Poulsen, A. Vaag, H. Rasmussen, 2013 .

Carboxylesterase 1 Gene Duplication and mRNA Expression in Adipose Tissue Are Linked to Obesity and Metabolic Function

P. Poulsen, A. Vaag, H. Rasmussen, 2013, PloS one.

Role of AMP-Activated Protein Kinase for Regulating Post-exercise Insulin Sensitivity.

J. Wojtaszewski, R. Kjøbsted, J. T. Treebak, 2016, Experientia supplementum.

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

B. Viollet, A. Marette, M. Foretz, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle

N. Fujii, H. Esumi, K. Tsuchihara, 2010, Proceedings of the National Academy of Sciences.

Caffeine-induced Ca(2+) release increases AMPK-dependent glucose uptake in rodent soleus muscle.

Y. Hellsten, J. Wojtaszewski, E. Richter, 2007, American journal of physiology. Endocrinology and metabolism.

Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction.

P. Schjerling, J. Wojtaszewski, S. Jørgensen, 2007, American journal of physiology. Endocrinology and metabolism.

Higher skeletal muscle α2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise

H. Pilegaard, J. Wojtaszewski, E. Richter, 2006, The Journal of physiology.

GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance. Diabetes 2012;61:1090—1099

B. Saltin, C. Lundby, J. Calbet, 2014, Diabetes.

GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance

B. Saltin, C. Lundby, J. Calbet, 2012, Diabetes.

Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle.

Henriette Pilegaard, Carsten Lundby, Bengt Saltin, 2011, American journal of physiology. Endocrinology and metabolism.

Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest.

B. Saltin, C. Lundby, J. Calbet, 2011, Journal of applied physiology.

Exercise and insulin cause GLUT-4 translocation in human skeletal muscle.

O. Ljungqvist, L. Jorfeldt, E. Horton, 1999, The American journal of physiology.

Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial

L. Nybo, Christian Lillelund, J. Wojtaszewski, 2019, Physiological reports.

Functional sympatholysis in mouse skeletal muscle involves sarcoplasmic reticulum swelling in arterial smooth muscle cells

Y. Hellsten, J. Wojtaszewski, T. A. Jepps, 2021, Physiological reports.

Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle

B. Hansen, J. Wojtaszewski, E. Richter, 2000, The Journal of physiology.

Two Weeks of Metformin Treatment Enhances Mitochondrial Respiration in Skeletal Muscle of AMPK Kinase Dead but Not Wild Type Mice

S. Larsen, F. Dela, J. Wojtaszewski, 2013, PloS one.

Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle

P. Schjerling, L. Goodyear, J. Wojtaszewski, 2014, The Journal of physiology.

Molecular Mechanisms in Skeletal Muscle Underlying Insulin Resistance in Women Who Are Lean With Polycystic Ovary Syndrome.

J. Wojtaszewski, B. Kiens, Nicoline R. Andersen, 2018, The Journal of clinical endocrinology and metabolism.

Contraction-stimulated muscle glucose transport and GLUT-4 surface content are dependent on glycogen content.

W. Derave, J. Wojtaszewski, E. Richter, 1999, American journal of physiology. Endocrinology and metabolism.

Insulin Receptor Substrate-2 Is Not Necessary for Insulin- and Exercise-stimulated Glucose Transport in Skeletal Muscle*

M. White, H. Towery, Y. Higaki, 1999, The Journal of Biological Chemistry.

Contraction-stimulated muscle glucose transport and GLUT-4 surface content are dependent on glycogen content.

W. Derave, J. Wojtaszewski, E. Richter, 1999, The American journal of physiology.

Exercise induction of key transcriptional regulators of metabolic adaptation in muscle is preserved in type 2 diabetes.

K. Højlund, J. Wojtaszewski, R. Sabaratnam, 2019, The Journal of clinical endocrinology and metabolism.

Regulation of muscle glucose transport during exercise.

W. Derave, J. Wojtaszewski, E. Richter, 2001, International journal of sport nutrition and exercise metabolism.

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK

B. Viollet, J. Zierath, M. Foretz, 2016, Diabetes.

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

B. Viollet, R. Kurumbail, Jake E. Delmore, 2017, Cell metabolism.

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

B. Hansen, J. Wojtaszewski, G. S. Olsen, 2009, American journal of physiology. Cell physiology.

Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscle.

J. Wojtaszewski, E. Richter, A. Rose, 2006, Journal of applied physiology.

Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes.

F. Dela, J. Wojtaszewski, C. Juel, 2004, Diabetes.

AS160 phosphorylation is associated with activation of α2β2γ1- but not α2β2γ3-AMPK trimeric complex in skeletal muscle during exercise in humans

J. Wojtaszewski, E. Richter, B. Kiens, 2007 .

Insulin‐induced membrane permeability to glucose in human muscles at rest and following exercise

M. Nyberg, Y. Hellsten, G. McConell, 2019, The Journal of physiology.

Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: metabolic implications.

L. Goodyear, J. Wojtaszewski, E. Richter, 1999, American journal of physiology. Endocrinology and metabolism.

Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle.

P. Schjerling, L. Goodyear, J. Wojtaszewski, 2014, American journal of physiology. Endocrinology and metabolism.

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Y. Hellsten, B. Viollet, T. Dohlmann, 2020, Molecular Metabolism.

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle.

D. Hardie, C. MacKintosh, J. Wojtaszewski, 2009, American journal of physiology. Endocrinology and metabolism.

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

D. Hardie, J. Zierath, H. Pilegaard, 2009, Diabetologia.

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.

B. Viollet, P. Schjerling, H. Pilegaard, 2015, American journal of physiology. Endocrinology and metabolism.

PGC-1{alpha} is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle.

H. Pilegaard, J. Wojtaszewski, B. Kiens, 2010, American journal of physiology. Endocrinology and metabolism.

PGC-1 is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle

H. Pilegaard, J. Wojtaszewski, B. Kiens, 2010 .

Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise.

B. Ursø, W. Derave, F. Thong, 2002, Diabetes.

Effects of high-intensity exercise training on adipose tissue mass, glucose uptake and protein content in pre- and post-menopausal women Mandrup,

Camilla M. Mandrup, M. Nyberg, Y. Hellsten, 2020 .

AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans.

J. Wojtaszewski, E. Richter, B. Kiens, 2007, American journal of physiology. Endocrinology and metabolism.

Regulation of hormone‐sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise

Bente Kiens, D. Hardie, J. Wojtaszewski, 2004, The Journal of physiology.

Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age‐specific manner

J. Halling, H. Pilegaard, J. Wojtaszewski, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Fatty acid type–specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle

J. Wojtaszewski, E. Richter, B. Kiens, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle.

M. Vendelbo, L. Goodyear, J. Wojtaszewski, 2012, American journal of physiology. Endocrinology and metabolism.

AMP kinase expression and activity in human skeletal muscle: effects of immobilization, retraining, and creatine supplementation.

Peter Hespel, Wim Derave, Bert O Eijnde, 2005, Journal of applied physiology.

Dysregulation of muscle glycogen synthase in recovery from exercise in type 2 diabetes

K. Højlund, J. Wojtaszewski, M. Friedrichsen, 2015, Diabetologia.

Prior AICAR Stimulation Increases Insulin Sensitivity in Mouse Skeletal Muscle in an AMPK-Dependent Manner

B. Viollet, J. Zierath, P. Schjerling, 2014, Diabetes.

Impact of genetic versus environmental factors on the control of muscle glycogen synthase activation in twins.

P. Poulsen, A. Vaag, K. Christensen, 2005, Diabetes.

Metabolic and Transcriptional Changes in Cultured Muscle Stem Cells from Low Birth Weight Subjects.

A. Vaag, B. Pedersen, N. S. Hansen, 2016, The Journal of clinical endocrinology and metabolism.

The insulin‐sensitizing effect of a single exercise bout is similar in type I and type II human muscle fibres

J. Wojtaszewski, E. Richter, B. Kiens, 2020, The Journal of physiology.

AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice

B. Viollet, K. Thorsen, P. Schjerling, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Opposite Regulation of Insulin Sensitivity by Dietary Lipid Versus Carbohydrate Excess

L. Madsen, H. Pilegaard, J. Wojtaszewski, 2017, Diabetes.

New Nordic Diet-Induced Weight Loss Is Accompanied by Changes in Metabolism and AMPK Signaling in Adipose Tissue.

A. Astrup, H. Pilegaard, J. Wojtaszewski, 2015, The Journal of clinical endocrinology and metabolism.

PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle.

D. Hardie, H. Pilegaard, J. Wojtaszewski, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

PGC-1 (cid:1) increases PDH content but does not change acute PDH regulation in mouse skeletal muscle

D. Hardie, H. Pilegaard, J. Wojtaszewski, 2010 .

Lack of AMPKα2 enhances pyruvate dehydrogenase activity during exercise

B. Viollet, P. Schjerling, H. Pilegaard, 2007 .

Physical inactivity affects skeletal muscle insulin signaling in a birth weight-dependent manner.

A. Vaag, F. Dela, J. Wojtaszewski, 2014, Journal of diabetes and its complications.

Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle.

Y. Hellsten, A. Vaag, H. Pilegaard, 2013, American journal of physiology. Endocrinology and metabolism.

Skeletal muscle adaptations to exercise are not influenced by metformin treatment in humans: secondary analyses of two randomised, clinical trials.

B. Pedersen, J. Halling, H. Pilegaard, 2021, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance

K. Højlund, H. Beck-Nielsen, J. Wojtaszewski, 2014, Diabetologia.

Does Acute Exercise Increase Insulin‐Stimulated Skeletal Muscle Glucose Uptake, Blood Flow And Insulin Signalling In Response To A Meal?

G. McConell, J. Wojtaszewski, E. Richter, 2020, The FASEB Journal.

Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise.

B. Viollet, P. Schjerling, H. Pilegaard, 2007, American journal of physiology. Endocrinology and metabolism.

Corrigendum to “PGC-1 is required for training-induced prevention of age-associated decline in mitochondrial enzymes in mouse skeletal muscle” [EXG 45 (2010) 336–342]

Henriette Pilegaard, Lotte Leick, Stine Secher Lyngby, 2010, Experimental Gerontology.

muscleand mitochondrial proteins in mouse skeletal is required for AICAR-induced expression of α

H. Pilegaard, J. Wojtaszewski, Joachim Fentz, 2016 .

Bed Rest-Induced Changes in TBC1D4 Phosphorylation and Glycogen Synthase Activity. Effects of Acute Exercise

C. Lundby, J. Calbet, H. Pilegaard, 2010 .

transcriptional regulators of metabolic adaptation in muscle is preserved in type 2 diabetes

K. Højlund, J. Wojtaszewski, R. Sabaratnam, 2019 .

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

K. Højlund, J. Wojtaszewski, A. Handberg, 2018, Physiological reports.

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

K. Højlund, J. Wojtaszewski, A. Handberg, 2018, Physiological reports.

Mechanisms Preserving Insulin Action during High Dietary Fat Intake.

Philipp E. Geyer, K. Kristiansen, B. Jensen, 2019, Cell metabolism.

Can exercise mimetics substitute for exercise?

J. Wojtaszewski, E. Richter, B. Kiens, 2008, Cell metabolism.

Decreased insulin action in skeletal muscle from patients with McArdle's disease.

R. Haller, J. Vissing, J. Wojtaszewski, 2002, American journal of physiology. Endocrinology and metabolism.

Effects of one‐legged high‐intensity interval training on insulin‐mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes

S. Larsen, J. Helge, F. Dela, 2019, Acta physiologica.

PL - 026 Mismatch between skeletal muscle glucose delivery, interstitial concentration and membrane permeability may limit insulin sensitivity after exercise

M. Nyberg, Y. Hellsten, G. McConell, 2018, Exercise Biochemistry Review.

Strength Training Increases Insulin-Mediated Glucose Uptake, GLUT4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes

F. Dela, J. Wojtaszewski, C. Juel, 2004 .

Dissociation between skeletal muscle inhibitor-kappaB kinase/nuclear factor-kappaB pathway activity and insulin sensitivity in nondiabetic twins.

P. Poulsen, A. Vaag, R. Ribel‐Madsen, 2010, The Journal of clinical endocrinology and metabolism.

Muscle inflammatory signaling in response to 9 days of physical inactivity in young men with low compared with normal birth weight.

A. Vaag, F. Dela, C. N. Hansen, 2012, European journal of endocrinology.

Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle

Y. Hellsten, J. Wojtaszewski, Thorbjorn C A Akerstrom, 2015, Biochemistry and biophysics reports.

Two Weeks of Metformin Treatment Enhances Mitochondrial Respiration in Skeletal Muscle of AMPK Kinase Dead but Not Wild Type Mice

S. Larsen, F. Dela, J. Wojtaszewski, 2013, PloS one.

IL‐6 regulates exercise and training‐induced adaptations in subcutaneous adipose tissue in mice

H. Pilegaard, J. Wojtaszewski, J. Hidalgo, 2012, Acta physiologica.

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

B. Viollet, D. James, M. Foretz, 2018, Molecular metabolism.

Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study

M. Vendelbo, J. Wojtaszewski, N. Møller, 2017, Diabetes.

Use of Transgenic Models To Understand Effects of Exercise on Glucose Metabolism

B. Hansen, J. Wojtaszewski, 2002, Exercise and sport sciences reviews.

Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action

P. Poulsen, A. Vaag, H. Beck-Nielsen, 2010, Diabetologia.

AMPK in skeletal muscle function and metabolism

B. Viollet, A. Marette, M. Foretz, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling

C. S. Shaw, G. McConell, J. Wojtaszewski, 2017, Diabetes.

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.

D. James, M. Febbraio, W. E. Hughes, 2018, Cell metabolism.

Early Enhancements of Hepatic and Later of Peripheral Insulin Sensitivity Combined With Increased Postprandial Insulin Secretion Contribute to Improved Glycemic Control After Roux-en-Y Gastric Bypass

J. Holst, V. Kristiansen, J. Wojtaszewski, 2014, Diabetes.

Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH₂-terminal (sites 2 + 2a) phosphorylation.

P. Poulsen, A. Vaag, H. Beck-Nielsen, 2013, American journal of physiology. Endocrinology and metabolism.

The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate‐intensity exercise in human skeletal muscle

A. B. Kuhlman, F. Dela, D. Constantin-Teodosiu, 2016, The Journal of physiology.

Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle.

Y. Hellsten, A. Vaag, H. Pilegaard, 2013, American journal of physiology. Endocrinology and metabolism.

Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

J. Wojtaszewski, J. Birk, M. Friedrichsen, 2013, Molecular and Cellular Endocrinology.

Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle

J. Wojtaszewski, J. Birk, J. Wojtaszewski, 2006, The Journal of physiology.

Effects of Endurance Exercise Training on Insulin Signaling in Human Skeletal Muscle

J. Wojtaszewski, E. Richter, B. Kiens, 2007, Diabetes.

Personalized phosphoproteomics of skeletal muscle insulin resistance and exercise links MINDY1 to insulin action

Sean J. Humphrey, J. Wojtaszewski, E. Needham, 2024, medRxiv.

Repeated prolonged whole-body low-intensity exercise: effects on insulin sensitivity and limb muscle adaptations.

B. Saltin, J. Wojtaszewski, K. Hermansen, 2006, Metabolism: clinical and experimental.

Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest.

B. Saltin, C. Lundby, J. Calbet, 2011, Journal of applied physiology.

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle.

D. Hardie, J. Wojtaszewski, E. Richter, 2009, American journal of physiology. Endocrinology and metabolism.

AMPK and Insulin Action - Responses to Ageing and High Fat Diet

P. Schjerling, J. Wojtaszewski, E. Richter, 2013, PloS one.

Nitric oxide production is a proximal signaling event controlling exercise‐induced mRNA expression in human skeletal muscle

A. Steensberg, B. Pedersen, H. Pilegaard, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Human Muscle Fiber Type- Specific Insulin Signaling: Impact of Obesity and Type 2

K. Højlund, J. Wojtaszewski, J. Birk, 2015 .

Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle.

M. Vendelbo, J. Wojtaszewski, S. Pedersen, 2012, American journal of physiology. Endocrinology and metabolism.