C. Simone

发表

SWI/SNF: The crossroads where extracellular signaling pathways meet chromatin

C. Simone, Cristiano Simone, 2006, Journal of cellular physiology.

Differentiation-Induced Radioresistance in Muscle Cells

J. Bartek, J. Lukas, C. Simone, 2004, Molecular and Cellular Biology.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

John L Cleveland, Masaaki Komatsu, Katsuhiko Kitamoto, 2008, Autophagy.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality

M. Bartolini, G. Giannelli, L. Ottini, 2020, iScience.

Clinical and Functional Characterization of a Novel Mutation in Lamin A/C Gene in a Multigenerational Family with Arrhythmogenic Cardiac Laminopathy

C. Simone, S. Torretta, C. Forleo, 2015, PloS one.

Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells

A. Giordano, C. Simone, 2007, Cell Death and Differentiation.

Characterization of a rare variant (c.2635-2A>G) of the MSH2 gene in a family with Lynch syndrome

A. Di Carlo, M. Caruso, A. Valentini, 2018, The International journal of biological markers.

Activation of MyoD-dependent transcription by cdk9/cyclin T2

P. Stiegler, A. Giordano, A. Luca, 2002, Oncogene.

Signal-dependent control of autophagy and cell death in colorectal cancer cell: the role of the p38 pathway.

C. Simone, 2008, Autophagy.

A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cells

B. Nico, G. Ingravallo, C. Simone, 2007, Cell Death and Differentiation.

New insight in cdk9 function: from Tat to MyoD.

A. Giordano, C. Simone, 2001, Frontiers in bioscience : a journal and virtual library.

Spectrum of Germline Pathogenic Variants in BRCA1/2 Genes in the Apulian Southern Italy Population: Geographic Distribution and Evidence for Targeted Genetic Testing

S. Tommasi, A. Paradiso, M. Digennaro, 2021, Cancers.

CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype

D. Calvisi, G. Giannelli, C. Simone, 2022, Journal of Experimental & Clinical Cancer Research.

Correspondence on “Clinical spectrum of MTOR-related hypomelanosis of Ito with neurodevelopmental abnormalities,” by Carmignac et al.

C. Simone, A. Mussa, D. Carli, 2021, Genetics in Medicine.

A homozygous frameshift mutation in the ESCO2 gene: Evidence of intertissue and interindividual variation in Nmd efficiency

C. Simone, M. D. Di Giacomo, G. Guanti, 2006, Journal of cellular physiology.

Cdk9‐55: A new player in muscle regeneration

A. Musarò, A. Giordano, L. Bagella, 2008, Journal of cellular physiology.

Molecular and Functional Characterization of Three Different Postzygotic Mutations in PIK3CA-Related Overgrowth Spectrum (PROS) Patients: Effects on PI3K/AKT/mTOR Signaling and Sensitivity to PIK3 Inhibitors

M. Cutrone, R. Tenconi, L. Chessa, 2015, PloS one.

Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3.

M. Bartolini, M. Naldi, C. Simone, 2022, European journal of medicinal chemistry.

MyoD recruits the cdk9/cyclin T2 complex on Myogenic‐genes regulatory regions

A. Giordano, L. Bagella, C. Simone, 2006, Journal of cellular physiology.

c-MYC Protein Stability Is Sustained by MAPKs in Colorectal Cancer

G. Giannelli, A. Valentini, C. Simone, 2022, Cancers.

Germline pathogenic variant in PIK3CA leading to symmetrical overgrowth with marked macrocephaly and mild global developmental delay

C. Leoni, C. Simone, M. Zollino, 2019, Molecular genetics & genomic medicine.

SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1

Yusuke Nakamura, C. Simone, Takehiro Suzuki, 2016, Oncotarget.

Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis

C. Simone, C. Fasano, G. Forte, 2022, Cells.

A rare MSH2 mutation causes defective binding to hMSH6, normal hMSH2 staining, and loss of hMSH6 at advanced cancer stage.

G. Ingravallo, C. Simone, A. Stella, 2014, Human pathology.

Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality

M. Bartolini, G. Giannelli, L. Ottini, 2020, iScience.

The AMPK-FoxO3A axis as a target for cancer treatment

C. Simone, F. Chiacchiera, Fulvio Chiacchiera, 2010, Cell cycle.

Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism

C. Simone, F. Chiacchiera, 2009, Autophagy.

p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription

G. Ingravallo, C. Simone, A. Moschetta, 2009, Cell Death and Differentiation.

Updates from the Intestinal Front Line: Autophagic Weapons Against Inflammation and Cancer

F. Madia, C. Simone, A. Peserico, 2012, Cells.

Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma

D. Ribatti, L. N. Bell, P. Ditonno, 2018, Aging.

p38&agr; Is Required for Ovarian Cancer Cell Metabolism and Survival

C. Simone, F. Chiacchiera, G. Loverro, 2009, International Journal of Gynecologic Cancer.

p38α MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance.

C. Simone, A. Peserico, V. Grossi, 2014, World journal of gastroenterology.

p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci

C. Simone, A. Imbalzano, L. Latella, 2004, Nature Genetics.

Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape

V. Celestini, C. Simone, P. Sanese, 2019, Cancers.

Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α Kinase

C. Simone, V. Grossi, 2012, Journal of oncology.

FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response

C. Simone, V. Disciglio, C. Fasano, 2019, Cells.

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

V. Celestini, Domenico de Rasmo, A. Signorile, 2018, Cell Death & Disease.

Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids

G. Stassi, G. Giannelli, G. Ingravallo, 2021, Cell Death & Disease.

FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs

C. Simone, V. Disciglio, P. Sanese, 2019, Computational and structural biotechnology journal.

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer

C. Simone, N. Resta, F. Susca, 2018, Nucleic acids research.

In vitro efficacy of ARQ 092, an allosteric AKT inhibitor, on primary fibroblast cells derived from patients with PIK3CA-related overgrowth spectrum (PROS)

C. Simone, S. Di Tommaso, A. Selicorni, 2018, neurogenetics.

STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.

R Tenconi, R. Tenconi, N. Carlomagno, 1998, Cancer research.

Identifying novel SMYD3 interactors on the trail of cancer hallmarks

C. Simone, P. Sanese, C. Fasano, 2022, Computational and structural biotechnology journal.

From Genetics to Histomolecular Characterization: An Insight into Colorectal Carcinogenesis in Lynch Syndrome

A. Pisani, G. Ingravallo, C. Simone, 2021, International journal of molecular sciences.

Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer

P. Ditonno, S. Palazzo, M. Battaglia, 2015, Expert review of molecular diagnostics.

Playing on the Dark Side: SMYD3 Acts as a Cancer Genome Keeper in Gastrointestinal Malignancies

C. Simone, P. Sanese, C. Fasano, 2021, Cancers.

Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38

P. Ditonno, M. Battaglia, E. Maiorano, 2015, Autophagy.

Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A.

G. Ingravallo, C. Simone, G. Canettieri, 2014, Cancer letters.

Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models.

Fulvio Chiacchiera, Nicoletta Resta, M. Moyer, 2012, Cancer letters.

Advances in Brief STK 11 Mutations in Peutz-Jeghers Syndrome and Sporadic Colon Cancer 1

R. Tenconi, N. Carlomagno, C. Simone, 2006 .

Signal-dependent regulation of gene expression as a target for cancer treatment: inhibiting p38alpha in colorectal tumors.

C. Simone, F. Chiacchiera, Fulvio Chiacchiera, 2008, Cancer letters.

Signal-Dependent Control of Autophagy and Cell Death in Colorectal Cancer Cell: The Role of the p38 Pathway

C. Simone, 2007 .

Identification and Somatic Characterization of the Germline PTEN Promoter Variant rs34149102 in a Family with Gastrointestinal and Breast Tumors

A. Valentini, C. Simone, V. Disciglio, 2022, Genes.

Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis.

C. Simone, M. Gentile, G. Guanti, 2000, Human molecular genetics.

Mutational germline analysis of hMSH2 andhMLH1 genes in early onset colorectal cancer patients

C. Simone, G. Guanti, C. Mareni, 2000, Journal of medical genetics.

Physical interaction between pRb and cdk9/cyclinT2 complex

A. Giordano, L. Bagella, C. Simone, 2002, Oncogene.

Tumor-specific hyperactive low-molecular-weight cyclin E isoform detection and characterization in non-metastatic colorectal tumors

C. Simone, M. D. Di Giacomo, G. Guanti, 2006, Cancer biology & therapy.

APC Splicing Mutations Leading to In-Frame Exon 12 or Exon 13 Skipping Are Rare Events in FAP Pathogenesis and Define the Clinical Outcome

C. Simone, V. Disciglio, P. Sanese, 2021, Genes.

APC Splicing Mutations Leading to In-Frame Exon Skipping are Rare Events in FAP Pathogenesis and Define the Clinical Outcome

C. Simone, V. Disciglio, P. Sanese, 2021 .

SMYD3: An Oncogenic Driver Targeting Epigenetic Regulation and Signaling Pathways

C. Simone, A. Peserico, G. Caretti, 2020, Cancers.

A SMYD3 Small‐Molecule Inhibitor Impairing Cancer Cell Growth

Greta Varchi, Alberto Del Rio, Carlo Bertucci, 2015, Journal of cellular physiology.

Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation Balance

C. Simone, Cristiano Simone, A. Peserico, 2010, Journal of biomedicine & biotechnology.

Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin.

Eric P Hoffman, Po Zhao, E. Hoffman, 2004, Developmental cell.

Characterization of the rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes

M. Genuardi, V. Celestini, C. Simone, 2014, BMC Cancer.

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

C. Simone, Lydia W. S. Finley, M. Haigis, 2013, Cellular and Molecular Life Sciences.

Identification of murine cdk10: Association with Ets2 transcription factor and effects on the cell cycle

A. Giordano, L. Bagella, C. Simone, 2006, Journal of cellular biochemistry.

Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.

Ianessa Morantte, David R. Jones, C. Simone, 2007, Molecular cell.

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

C. Simone, Lydia W. S. Finley, M. Haigis, 2013, Cellular and Molecular Life Sciences.

Novel splice isoforms of STRADα differentially affect LKB1 activity, complex assembly and subcellular localization.

P. Marignani, C. Simone, G. Guanti, 2007, Cancer biology & therapy.

pRb: master of differentiation. Coupling irreversible cell cycle withdrawal with induction of muscle-specific transcription

C. Simone, F. Comes, G. Falco, 2006, Oncogene.

Colorectal Cancer Chemoprevention: A Dream Coming True?

C. Simone, C. Fasano, Martina Lepore Signorile, 2023, International journal of molecular sciences.

Cyclin E and chromosome instability in colorectal cancer cell lines

A. Giordano, L. Bagella, C. Simone, 2002, Molecular pathology : MP.

Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response

G. Ingravallo, C. Simone, S. Murzilli, 2012, Cancer biology & therapy.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Porous silicon surfaces – A candidate substrate for reverse protein arrays in cancer biomarker detection

Thomas Laurell, György Marko-Varga, Ginevra Guanti, 2007, Electrophoresis.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

Signal-dependent control of autophagy-related gene expression.

C. Simone, F. Chiacchiera, Fulvio Chiacchiera, 2009, Methods in enzymology.

Gastric polyposis and desmoid tumours as a new familial adenomatous polyposis clinical variant associated with APC mutation at the extreme 3′-end

C. Simone, V. Disciglio, A. Stella, 2019, Journal of Medical Genetics.

Deacetylase recruitment by the C/H3 domain of the acetyltransferase p300

P. Stiegler, A. Giordano, A. Luca, 2004, Oncogene.

Impact of High-to-Moderate Penetrance Genes on Genetic Testing: Looking over Breast Cancer

C. Simone, C. Forleo, N. Bukvic, 2023, Genes.

Clinical and Functional Characterization of a Novel Mutation in Lamin A/C Gene in a Multigenerational Family with Arrhythmogenic Cardiac Laminopathy

C. Simone, S. Torretta, C. Forleo, 2015, PloS one.

401 Loss of LKB1/STK11 expression is an early event in prostate cancer development and predicts therapeutic response to p38α inhibitor

P. Ditonno, M. Battaglia, C. Simone, 2015 .

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

V. Celestini, Domenico de Rasmo, A. Signorile, 2018, Cell Death & Disease.

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer

C. Simone, N. Resta, F. Susca, 2018, Nucleic acids research.

Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models.

M. Moyer, C. Simone, M. Simonatto, 2012, Cancer letters.

Functional evidence of mTORβ splice variant involvement in the pathogenesis of congenital heart defects

G. M. Ventola, R. Ficarella, C. Simone, 2020, Clinical genetics.