L. Fryer

发表

The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways*

David Carling, D. Carling, L. Fryer, 2002, The Journal of Biological Chemistry.

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Young-Bum Kim, David Carling, D. Carling, 2002, Nature.

Supplemental Data LKB 1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

David Carling, Theo Wallimann, Uwe Schlattner, 2003 .

Thr2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status*

David Carling, D. Carling, L. Fryer, 2004, Journal of Biological Chemistry.

Lipid metabolism and substrate oxidation during intravenous fructose administration in cirrhosis.

N. Mcintyre, L. Fryer, Y. Kruszynska, 1994, Metabolism: clinical and experimental.

Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase.

D. Carling, L. Fryer, J. Mccormack, 2003, Diabetes.

Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction.

J. Zierath, D. Carling, L. Fryer, 2002, Diabetes.

Differential regulation of glycogen synthase by insulin and glucose in vivo in skeletal muscles of the rat.

M. Holness, M. Sugden, L. Fryer, 1997, The American journal of physiology.

Protein kinase inhibitors block the stimulation of the AMP‐activated protein kinase by 5‐amino‐4‐imidazolecarboxamide riboside

D. Carling, L. Fryer, Asha Parbu-Patel, 2002, FEBS letters.

Insulin Resistance in High Fat Fed Rats

L. Fryer, Y. Kruszynska, 1993 .

Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.

D. Hardie, D. Carling, L. Fryer, 2000, Diabetes.

Protein restriction during early development enhances insulin responsiveness but selectively impairs sensitivity to insulin at low concentrations in white adipose tissue during a later pregnancy

M. Holness, M. Sugden, L. Fryer, 1999, British Journal of Nutrition.

The long-term regulation of skeletal muscle pyruvate dehydrogenase kinase by dietary lipid is dependent on fatty acid composition.

M. Holness, M. Sugden, L. Fryer, 1995, European journal of biochemistry.

Interactive effects of insulin and triiodothyronine on pyruvate dehydrogenase kinase activity in cardiac myocytes.

M. Holness, M. Sugden, L. Fryer, 1995, Journal of molecular and cellular cardiology.

Moderate protein restriction during pregnancy modifies the regulation of triacylglycerol turnover and leads to dysregulation of insulin’s anti-lipolytic action

M. Holness, M. Sugden, L. Fryer, 1998, Molecular and Cellular Endocrinology.

Activation of Glucose ' lhnsport by m-Activated Protein Kinase via Stimulation of Nitric O i d e Synthase

L. Fryer, Salt, F. Rencurel, 2008 .

Rapid Publication Activation of Glucose 'lhnsport by m-Activated Protein Kinase via Stimulation of

D. Grahame, D. Carling, L. Fryer, 2000 .

Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK).

David Carling, Stephen A Baldwin, S. Baldwin, 2002, Journal of cell science.

Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase.

D. Carling, A. Woods, L. Fryer, 2003, Biochemical Society transactions.

Selective modification of insulin action in adipose tissue by hyperthyroidism.

M. Holness, M. Sugden, L. Fryer, 1997, The Journal of endocrinology.

Increased hepatic pyruvate dehydrogenase kinase activity in fed hyperthyroid rats: studies in vivo and with cultured hepatocytes

M. Holness, M. Sugden, L. Fryer, 1996, Molecular and Cellular Endocrinology.

Long‐term regulation of pyruvate dehydrogenase kinase by high‐fat feeding

M. Holness, M. Sugden, L. Fryer, 1993, FEBS letters.

Studies of the long-term regulation of hepatic pyruvate dehydrogenase kinase.

M. Holness, M. Sugden, L. Fryer, 1998, The Biochemical journal.

Molecular mechanisms underlying the long-term impact of dietary fat to increase cardiac pyruvate dehydrogenase kinase: regulation by insulin, cyclic AMP and pyruvate.

M. Holness, M. Sugden, L. Fryer, 1997, Journal of molecular and cellular cardiology.

Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells.

S. Baldwin, D. Carling, A. Woods, 2002, The Biochemical journal.

Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells

D. Neal, L. Fryer, A. Ramos-Montoya, 2014, Oncotarget.

CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients[S]

Hetal N. Patel, S. Horswell, M. Salm, 2013, Journal of Lipid Research.

Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer.

Stephan A. Ohnmacht, S. Balasubramanian, M. Micco, 2013, Biochemistry.

Identification of potential therapeutic targets in prostate cancer through a cross‐species approach

M. Dunning, D. Neal, J. Carroll, 2018, EMBO molecular medicine.

A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy

D. Neal, L. Fryer, F. Baltazar, 2015, The Journal of pathology.

The Endoplasmic Reticulum Coat Protein II Transport Machinery Coordinates Cellular Lipid Secretion and Cholesterol Biosynthesis*

M. Nieuwdorp, C. Shoulders, L. Fryer, 2013, The Journal of Biological Chemistry.

Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise

J. Hawley, J. Zierath, D. Carling, 2003, The Journal of physiology.

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

G. Barsh, B. Viollet, J. Speakman, 2007, The Journal of clinical investigation.

AMP-activated protein kinase and the metabolic syndrome.

D. Carling, L. Fryer, Lee G. D. Fryer, 2005, Biochemical Society transactions.

acid-induced fatty liver metabolic approach to understanding orotic An integrated reverse functional genomic and

Hetal N. Patel, M. Salm, J. Griffin, 2015 .

Cardiac protein kinase C expression in two models of cardiac hypertrophy associated with an activated cardiac renin-angiotensin system: effects of experimental hyperthyroidism and genetic hypertension (the mRen-2 rat).

M. Holness, M. Sugden, L. Fryer, 1998, The Journal of endocrinology.

Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer

D. Neal, A. Lynch, L. Fryer, 2015, Oncotarget.

Neuregulin Signaling on Glucose Transport in Muscle Cells*

M. Palacín, A. Zorzano, J. Bertran, 2004, Journal of Biological Chemistry.

Endocrine and nutritional modulation of glucose disposal and storage in muscle.

M. Holness, M. Sugden, L. Fryer, 1997, Biochemical Society Transactions.

Mechanisms regulating cardiac fuel selection in hyperthyroidism.

M. Holness, M. Sugden, L. Fryer, 1992, The Biochemical journal.

Regulation of hepatic pyruvate dehydrogenase kinase by insulin and dietary manipulation in vivo. Studies with the euglycaemic-hyperinsulinaemic clamp.

M. Holness, M. Sugden, L. Fryer, 1996, Biochimica et biophysica acta.

Supplemental Data LKB 1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

M. Carlson, D. Carling, T. Wallimann, 2003 .