T. Leff

R. Hegele, T. Leff, J. Bonnett, 2007, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors.

J. Breslow, T. Leff, K. Reue, 1988, The Journal of biological chemistry.

Apo CIII gene transcription is regulated by a cytokine inducible NF-kappa B element.

T. Leff, M. L. Wolak, P. Gruber, 1994, Nucleic acids research.

Peroxisomal proliferator activated receptor-γ deficiency in a Canadian kindred with familial partial lipodystrophy type 3 (FPLD3)

G. Francis, R. Hegele, H. Cao, 2006, BMC Medical Genetics.

c-Jun N-Terminal Kinase Phosphorylates Peroxisome Proliferator-Activated Receptor- g 1 and Negatively Regulates Its Transcriptional Activity

T. Leff, H. Camp, S. Tafuri, 1998 .

Paolo Sassone-Corsi (1956–2020)

T. Leff, C. Goding, S. Masri, 2020, Cell.

PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy.

R. Hegele, H. Cao, T. Leff, 2002, Diabetes.

Familial partial lipodystrophy phenotype resulting from a single-base mutation in deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma.

R. Hegele, E. Kalkhoven, H. Cao, 2007, The Journal of clinical endocrinology and metabolism.

Altered promoter recycling rates contribute to dominant-negative activity of human peroxisome proliferator-activated receptor-gamma mutations associated with diabetes.

T. Leff, Gang Li, 2007, Molecular endocrinology.

CLINICAL CASE SEMINAR Familial Partial Lipodystrophy Phenotype Resulting from a Single-Base Mutation in Deoxyribonucleic Acid-Binding Domain of Peroxisome Proliferator-Activated Receptor- (cid:1)

R. Hegele, E. Kalkhoven, H. Cao, 2007 .

c-Myc Does Not Require Max for Transcriptional Activity in PC-12 Cells

A. Saltiel, T. Leff, V. Ribon, 1994, Molecular and Cellular Neuroscience.

Cell type-specific expression of the human apoB gene is controlled by two cis-acting regulatory regions.

J. Breslow, T. Leff, H. Das, 1988, The Journal of biological chemistry.

PER2 controls lipid metabolism by direct regulation of PPARγ.

P. Sassone-Corsi, D. Piomelli, J. Granneman, 2010, Cell metabolism.

Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.

J. Breslow, T. Leff, L., 1995, The Journal of clinical investigation.

Diabetes and Exposure to Environmental Lead (Pb)

T. Leff, P. Stemmer, R. Jog, 2018, Toxics.

Transcriptional analysis of the adenovirus-5 EIII promoter: absence of sequence specificity for stimulation by EIa gene products.

P. Sassone-Corsi, T. Leff, J. Corden, 1985, Nucleic acids research.

c-Jun N-Terminal Kinase Phosphorylates Peroxisome Proliferator-Activated Receptor-γ1 and Negatively Regulates Its Transcriptional Activity.

T. Leff, S. Tafuri, H. Camp, 1999, Endocrinology.

Regulation of Transcription by AMP-activated Protein Kinase

Wenbo Yang, T. Leff, H. Camp, 2001, The Journal of Biological Chemistry.

The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron.

C. L. Jackson, D. Miller, J. Breslow, 1987, Journal of Biological Chemistry.

Review: Peroxisome Proliferator-Activated Receptor-γ and Its Role in the Development and Treatment of Diabetes

T. Leff, H. Camp, S. Mathews, 2004, Experimental diabesity research.

Adipogenesis and fat-cell function in obesity and diabetes.

T. Leff, H. Camp, Delin Ren, 2002, Trends in molecular medicine.

A Novel Potent Antagonist of Peroxisome Proliferator-Activated Receptor γ Blocks Adipocyte Differentiation But Does Not Revert the Phenotype of Terminally Differentiated Adipocytes.

T. Leff, H. Camp, A. Chaudhry, 2001, Endocrinology.

Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma.

T. Leff, M. Wang, T. Su, 1999, Diabetes.

PPARγ mutations, lipodystrophy and diabetes

T. Leff, O. Astapova, Olga Astapova, 2014, Hormone molecular biology and clinical investigation.

Unbuckling lipodystrophy from insulin resistance and hypertension.

R. Hegele, T. Leff, 2004, The Journal of clinical investigation.

Threonine Catabolism: An Unexpected Epigenetic Regulator of Mouse Embryonic Stem Cells

T. Leff, R. Jog, Guohua Chen, 2019, Handbook of Nutrition, Diet, and Epigenetics.

c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity.

T. Leff, S. Tafuri, H. Camp, 1999, Endocrinology.

Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels.

J. Breslow, T. Leff, T Leff, 1994, Journal of lipid research.

Thiazolidinedione treatment and constitutive‐PPARγ activation induces ectopic adipogenesis and promotes age‐related thymic involution

T. Leff, Steven R Smith, Hyunwon Yang, 2010, Aging cell.

AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins.

T. Leff, 2001, Biochemical Society transactions.

Peroxisome Proliferator‐Activated Receptor‐γ: A Key Regulator of Adipose Tissue Formation, Remodeling, and Metabolism

T. Leff, O. Astapova, 2010 .

Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit.

P. Chambon, E. Borrelli, P. Sassone-Corsi, 1983, Nucleic acids research.

Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level.

M. Perricaudet, P. Chambon, P. Sassone-Corsi, 1984, Proceedings of the National Academy of Sciences of the United States of America.

A novel potent antagonist of peroxisome proliferator-activated receptor gamma blocks adipocyte differentiation but does not revert the phenotype of terminally differentiated adipocytes.

T. Leff, H. Camp, A. Chaudhry, 2001, Endocrinology.

A common Hpa I RFLP of apolipoprotein C-I increases gene transcription and exhibits an ethnically distinct pattern of linkage disequilibrium with the alleles of apolipoprotein E.

B. Tycko, R. Mayeux, Yan Xu, 1999, Journal of lipid research.

Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone.

X. Shen, T. Leff, R. Vanbogelen, 2000, Diabetes.

Lead (Pb) exposure promotes diabetes in obese rodents.

T. Leff, P. Stemmer, J. Tyrrell, 2017, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Sequence-specific activation of transcription by adenovirus EIa products is observed in HeLa cells but not in 293 cells

P. Chambon, T. Leff, 1986, Molecular and cellular biology.

Characterization of a dominant negative mutant form of the HNF-4 orphan receptor.

T. Leff, D. Taylor, David G. Taylor, 1996, Nucleic acids research.

D i fferential Activation of Peroxisome P r o l i f e r a t o r-Activated Receptor- by Tr o g l i t a z o n e and Rosiglitazone

T. Leff, 2000 .

Regulation of cytochrome P450 in cultured human colonic cells.

T. Leff, D. Rosenberg, D. Rosenberg, 1993, Archives of biochemistry and biophysics.

Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance.

T. Leff, Liyun Ding, R. Amin, 2010, American journal of physiology. Endocrinology and metabolism.

Three Isoforms of a Hepatocyte Nuclear Factor-4 Transcription Factor with Tissue- and Stage-specific Expression in the Adult Mosquito*

T. Leff, A. Raikhel, W. Cho, 1998, The Journal of Biological Chemistry.

controls lipid metabolism by direct regulation of

P. Sassone-Corsi, D. Piomelli, J. Granneman, 2014 .

Adiponectin secretion from cardiomyocytes produces canonical multimers and partial co-localization with calsequestrin in junctional SR

T. Leff, S. Cala, Naama H. Sleiman, 2019, Molecular and Cellular Biochemistry.