T. Matsuzaka

发表

Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non‐alcoholic steatohepatitis model

T. Oda, N. Ohkohchi, H. Shimano, 2020, Journal of Gastroenterology and Hepatology.

Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques

T. Tomonaga, H. Shimano, T. Matsuzaka, 2022, Mucosal immunology.

Molecular mechanisms involved in hepatic steatosis and insulin resistance

H. Shimano, T. Matsuzaka, 2011, Journal of diabetes investigation.

Protein Kinase A Suppresses Sterol Regulatory Element-binding Protein-1C Expression via Phosphorylation of Liver X Receptor in the Liver*

Hitoshi Shimano, Takashi Matsuzaka, Hirohito Sone, 2007, Journal of Biological Chemistry.

The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice

H. Shimano, T. Matsuzaka, H. Ohno, 2018, International journal of molecular sciences.

Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

Hitoshi Shimano, Takashi Matsuzaka, Yoko Iizuka, 2001, Molecular and Cellular Biology.

Disentangling the biological information encoded in disordered mitochondrial morphology through its rapid elicitation by iCMM

Hideki Uosaki, N. Hattori, F. Hakuno, 2020, bioRxiv.

High Mobility Group Protein-B1 Interacts with Sterol Regulatory Element-binding Proteins to Enhance Their DNA Binding*

T. Kadowaki, H. Shimano, N. Yahagi, 2005, Journal of Biological Chemistry.

TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin.

H. Sone, H. Shimano, N. Yahagi, 2013, Biochemical and biophysical research communications.

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

H. Sone, H. Shimano, N. Yahagi, 2016, Molecular metabolism.

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin

H. Shimano, N. Yahagi, N. Yamada, 2010, Journal of Lipid Research.

Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

H. Sone, H. Shimano, N. Yahagi, 2011, Arteriosclerosis, thrombosis, and vascular biology.

SREBP-1-independent regulation of lipogenic gene expression in adipocytes Published, JLR Papers in Press, April 24, 2007.

T. Kadowaki, H. Shimano, N. Yahagi, 2007, Journal of Lipid Research.

Elovl6 promotes nonalcoholic steatohepatitis

R. Matsumori, H. Sone, H. Shimano, 2012, Hepatology.

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

H. Shimano, N. Yahagi, T. Matsuzaka, 2019, Scientific Reports.

A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

Y. Izumida, T. Kadowaki, H. Shimano, 2017, FEBS letters.

TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice.

Kazuto Kobayashi, H. Sone, H. Shimano, 2012, American journal of physiology. Endocrinology and metabolism.

Predictive ability of current machine learning algorithms for type 2 diabetes mellitus: A meta‐analysis

C. Horikawa, K. Fujihara, Masaru Kitazawa, 2021, Journal of diabetes investigation.

SREBPs suppress IRS-2-mediated insulin signalling in the liver

A. Fukamizu, H. Sone, H. Shimano, 2004, Nature Cell Biology.

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice*

Satoru Takahashi, H. Sone, H. Shimano, 2011, The Journal of Biological Chemistry.

Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis

N. Ohkohchi, H. Isoda, H. Shimano, 2018, World journal of gastroenterology.

Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes.

H. Sone, H. Shimano, N. Yamada, 2005, Biochimica et biophysica acta.

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.

H. Sone, H. Shimano, N. Yahagi, 2004, Diabetes.

Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice

M. Syamsunarno, Hiroki Matsui, Hiroaki Sunaga, 2013, Nature Communications.

Lipid Synthetic Transcription Factor SREBP-1a Activates p21 WAF1/CIP1 , a Universal Cyclin-Dependent

H. Sone, H. Shimano, N. Yahagi, 2005 .

Lipid Synthetic Transcription Factor SREBP-1a Activates p21WAF1/CIP1, a Universal Cyclin-Dependent Kinase Inhibitor

H. Sone, H. Shimano, N. Yahagi, 2005, Molecular and Cellular Biology.

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.

H. Shimano, N. Yahagi, N. Yamada, 2008, Journal of lipid research.

Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance

H. Sone, Y. Higami, H. Shimano, 2018, Endocrinology.

TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis.

H. Sone, H. Shimano, N. Yahagi, 2013, Endocrinology.

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

H. Sone, H. Shimano, N. Yahagi, 2016, PloS one.

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

H. Shimano, N. Yahagi, N. Yamada, 2009, Biochemical and biophysical research communications.

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.

H. Gomi, Satoru Takahashi, H. Sone, 2006, Cell metabolism.

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice

Satoru Takahashi, H. Sone, H. Shimano, 2020, Hepatology.

Glucocorticoid receptor suppresses gene expression of Rev‐erbα (Nr1d1) through interaction with the CLOCK complex

Y. Izumida, H. Shimano, N. Yahagi, 2019, FEBS letters.

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.

H. Sone, H. Shimano, N. Yahagi, 2015, Biochemical and biophysical research communications.

Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor*

S. Perrey, H. Sone, H. Shimano, 2001, The Journal of Biological Chemistry.

New perspective on type 2 diabetes, dyslipidemia and non‐alcoholic fatty liver disease

H. Shimano, T. Matsuzaka, 2020, Journal of diabetes investigation.

Elovl6: a new player in fatty acid metabolism and insulin sensitivity

H. Shimano, T. Matsuzaka, 2009, Journal of Molecular Medicine.

glycogen supercompensation in rats Effect of endurance exercise training on muscle

N. Yahagi, T. Matsuzaka, L. Nolte, 2015 .

CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2.

R. Takano, H. Shimano, N. Yahagi, 2021, Biochemical and biophysical research communications.

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition

H. Sone, H. Shimano, N. Yamada, 2020, bioRxiv.

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

H. Sone, H. Shimano, T. Matsuzaka, 2020, iScience.

Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol

T. Kadowaki, K. Tsukamoto, H. Shimano, 2006, Diabetes.

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα

H. Sone, H. Shimano, N. Yahagi, 2016, Scientific Reports.

Mouse Elovl-6 promoter is an SREBP target.

H. Shimano, N. Yahagi, N. Yamada, 2008, Biochemical and biophysical research communications.

Novel non‐alcoholic steatohepatitis model with histopathological and insulin‐resistant features

N. Ohkohchi, H. Isoda, H. Shimano, 2018, Pathology international.

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.

H. Sone, H. Shimano, N. Yahagi, 2014, Biochemical and biophysical research communications.

A transcription factor of lipid synthesis, sterol regulatory element‐binding protein (SREBP)‐1a causes G1 cell‐cycle arrest after accumulation of cyclin‐dependent kinase (cdk) inhibitors

H. Shimano, N. Yahagi, N. Yamada, 2007, The FEBS journal.

Insulin‐dependent and ‐independent regulation of sterol regulatory element‐binding protein‐1c

H. Shimano, T. Matsuzaka, 2013, Journal of diabetes investigation.

Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit*

K. Kataoka, Y. Izumida, T. Kadowaki, 2010, The Journal of Biological Chemistry.

In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression.

Masayuki Yamamoto, T. Kadowaki, H. Shimano, 2007, Biochemical and biophysical research communications.

SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes*

H. Sone, H. Shimano, N. Yahagi, 2004, Journal of Biological Chemistry.

Dual regulation of mouse D 5-and D 6-desaturase gene expression by SREBP-1 and PPAR a

H. Sone, H. Shimano, N. Yahagi, 2002 .

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages

N. Shibayama, Sam-Yong Park, H. Shimano, 2018, Arteriosclerosis, thrombosis, and vascular biology.

Corrigendum: Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization

K. Kataoka, Y. Izumida, T. Kadowaki, 2013, Nature Communications.

Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization

K. Kataoka, Y. Izumida, T. Kadowaki, 2013, Nature Communications.

1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation

N. Ohkohchi, T. Matsuzaka, S. Murata, 2015, International journal of molecular sciences.

Effect of taurine supplementation on the alterations in amino Acid content in skeletal muscle with exercise in rat.

T. Miyazaki, T. Matsuzaka, Song-Gyu Ra, 2011, Journal of sports science & medicine.

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice.

H. Sone, N. Yahagi, T. Matsuzaka, 2022, Biochimica et biophysica acta. Molecular basis of disease.

ELOVL5‐mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma

H. Negoro, H. Shimano, T. Matsuzaka, 2022, Cancer science.

High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.

T. Kadowaki, H. Shimano, N. Yahagi, 2005, The Journal of biological chemistry.

ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma

H. Nishiyama, H. Negoro, H. Shimano, 2021, Oncology reports.

Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice

H. Shimano, N. Yamada, T. Matsuzaka, 2016, PloS one.

expression in human skeletal muscle Effects of exercise on GLUT-4 and glycogenin gene

M. Huss, M. Lindholm, S. Kjellqvist, 2015 .

Role of fatty acid elongase Elovl6 in the regulation of energy metabolism and pathophysiological significance in diabetes

T. Matsuzaka, 2020, Diabetology International.

Cyclin-dependent Kinase Inhibitor, p21 WAF1/CIP1 , Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Cyclin-dependent Kinase Inhibitor , p 21 WAF 1 / CIP 1 , Is Involved in Adipocyte Differentiation and Hypertrophy , Linking to Obesity , and Insulin Resistance *

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Estimated Stearoyl-CoA-desaturase (SCD)-1 and Elongase of Very Long Chain Fatty Acids (Elovl) 6 Activities From Serum Fatty Acids Are Reciprocally Associated with Visceral Fat Area in Type 2 Diabetic Patients

H. Shimano, T. Matsuzaka, Ommega Internationals, 2018, Journal of Diabetes and Obesity.

Macrophage Elovl6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

R. Matsumori, H. Sone, H. Shimano, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation

H. Shimano, T. Matsuzaka, Yoshiyuki Nakamura, 2018, Cell Death & Disease.

Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells

H. Sone, H. Shimano, T. Matsuzaka, 2022, Nutrients.

Serum lactate dehydrogenase level as a possible predictor of treatment preference in psoriasis.

Y. Fujisawa, R. Watanabe, N. Okiyama, 2021, Journal of dermatological science.

p53 Activation in Adipocytes of Obese Mice*

H. Shimano, N. Yahagi, N. Yamada, 2003, Journal of Biological Chemistry.

p53 Involvement in the Pathogenesis of Fatty Liver Disease*

T. Kadowaki, H. Shimano, N. Yahagi, 2004, Journal of Biological Chemistry.

Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance inLep ob /Lep ob Mice*

H. Shimano, N. Yahagi, N. Yamada, 2002, The Journal of Biological Chemistry.

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.

H. Sone, H. Shimano, N. Yahagi, 2003, Molecular endocrinology.

Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis.

H. Sone, N. Yahagi, T. Matsuzaka, 2023, BBA advances.

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes DOI 10.1194/jlr.M100417-JLR200

Hitoshi Shimano, Takashi Matsuzaka, Yoko Iizuka, 2002, Journal of Lipid Research.

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

Hitoshi Shimano, Takashi Matsuzaka, Hirohito Sone, 2003, Molecular endocrinology.

Cross-Talk between Peroxisome Proliferator-Activated Receptor ( PPAR ) and Liver X Receptor ( LXR ) in Nutritional Regulation of Fatty Acid Metabolism

H. Sone, H. Shimano, N. Yahagi, 2003 .

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

H. Sone, H. Shimano, N. Yahagi, 2006, Nature Medicine.

Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.

M. Makuuchi, K. Hasegawa, T. Kadowaki, 2005, European journal of cancer.

A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling

N. Okada, H. Shimano, T. Matsuzaka, 2017, Oncogenesis.

Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

H. Sone, H. Shimano, N. Yahagi, 2002 .

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP‐1 suppression

H. Shimano, N. Yahagi, N. Yamada, 2003, Hepatology.

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.

Y. Izumida, T. Kadowaki, H. Shimano, 2017, Biochemical and biophysical research communications.

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets

H. Sone, H. Shimano, N. Yahagi, 2008, Diabetes.

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C‐FOS in hepatocytes

Y. Izumida, H. Shimano, N. Yahagi, 2018, FEBS letters.

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism.

A. Saghatelian, C. Glass, N. Spann, 2017, Cell metabolism.

Sterol Regulatory Element-binding Proteins Activate Insulin Gene Promoter Directly and Indirectly through Synergy with BETA2/E47*

H. Sone, H. Shimano, N. Yahagi, 2005, Journal of Biological Chemistry.

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements*

H. Sone, H. Shimano, N. Yahagi, 2002, The Journal of Biological Chemistry.

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2007, Nature Medicine.

The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation.

T. Matsuzaka, S. Chiba, J. Sasaki, 2023, Leukemia.

Advanced Oxidation Protein Products Contribute to Renal Tubulopathy via Perturbation of Renal Fatty Acids.

H. Shimano, T. Matsuzaka, Soken Tsuchiya, 2020, Kidney360.

Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation

H. Shimano, T. Matsuzaka, A. Shibuya, 2018, Cell Death & Disease.

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity

Hui Zhao, H. Sone, H. Shimano, 2017, Diabetes.

Elongation of Long‐Chain Fatty Acid Family Member 6 (Elovl6)‐Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP‐Activated Protein Kinase/Krüppel‐Like Factor 4 (AMPK/KLF4) Signaling

N. Koitabashi, Hiroki Matsui, Hiroaki Sunaga, 2016, Journal of the American Heart Association.

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr−/− mouse model

T. Fujimura, R. Matsumori, H. Sone, 2015, Scientific Reports.

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

H. Sone, H. Shimano, N. Yahagi, 2014, Endocrinology.

National Cholesterol Awareness Month Article Macrophage Elovl 6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

R. Matsumori, H. Sone, H. Shimano, 2011 .

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

H. Sone, H. Shimano, N. Yahagi, 2002, Journal of lipid research.

Identification of human ELOVL5 enhancer regions controlled by SREBP.

Y. Izumida, H. Shimano, N. Yahagi, 2015, Biochemical and biophysical research communications.

FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin

Y. Izumida, N. Yahagi, T. Matsuzaka, 2021, iScience.

High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways.

Y. Izumida, H. Shimano, N. Yahagi, 2021, Biochemical and biophysical research communications.

FoxO-KlLF5 Pathway Switches the Flow of Macronutrients Under the Control of Insulin

Y. Izumida, H. Shimano, N. Yahagi, 2021, SSRN Electronic Journal.

Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance*

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2008, Journal of Biological Chemistry.

Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.

H. Shimano, N. Yahagi, N. Yamada, 2012, Biochemical and biophysical research communications.

The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis

T. Hirokawa, K. Tsumoto, S. Nakano, 2021, Nature Communications.

The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice.

N. Aoki, H. Shimano, N. Yahagi, 2009, Biochemical and biophysical research communications.

Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα.

V. Sládek, Y. Shigeta, H. Shimano, 2018, Biochemical and biophysical research communications.

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha.

H. Sone, H. Shimano, N. Yahagi, 2002, Journal of lipid research.

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice.

H. Shimano, T. Matsuzaka, Y. Nakagawa, 2017, Journal of pharmacological sciences.

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.

K. Kataoka, Y. Izumida, T. Kadowaki, 2016, Cell reports.

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.

H. Shimano, N. Yahagi, T. Matsuzaka, 2019, Biochemical and biophysical research communications.

Rapid manipulation of mitochondrial morphology in a living cell with iCMM

Hideki Uosaki, N. Hattori, F. Hakuno, 2021, Cell reports methods.

Selective peroxisome proliferator‐activated receptor‐α modulator K‐877 efficiently activates the peroxisome proliferator‐activated receptor‐α pathway and improves lipid metabolism in mice

H. Shimano, N. Yahagi, N. Yamada, 2017, Journal of diabetes investigation.

Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling

Satoru Takahashi, H. Sone, H. Shimano, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids

H. Sone, H. Shimano, N. Yahagi, 2021, bioRxiv.

Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711

Yasunaga Takeda, C. Horikawa, K. Fujihara, 2021, Nutrients.

Rho‐associated, coiled‐coil‐containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis

H. Shimano, T. Matsuzaka, Takafumi Miyamoto, 2019, Journal of diabetes investigation.

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.

H. Shimano, N. Yamada, T. Matsuzaka, 2010, Biochemical and biophysical research communications.

New liver–β‐cell axis that controls insulin secretory capacity

H. Shimano, T. Matsuzaka, 2014, Journal of diabetes investigation.

Oxidative stress and LXR agonist induce hepatocellular carcinoma in NASH model.

T. Oda, H. Shimano, Y. Shimizu, 2020, Journal of gastroenterology and hepatology.

Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function.

N. Yahagi, T. Matsuzaka, H. Ohno, 2023, Cell reports.

A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction

T. Matsuzaka, Y. Suehara, S. Chiba, 2022, Endocrinology, diabetes & metabolism case reports.

Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

Satoru Takahashi, H. Sone, H. Shimano, 2016, Scientific Reports.

Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity

N. Yahagi, T. Matsuzaka, Kenji Saito, 2023, The Journal of biological chemistry.

Macrophages rely on extracellular serine to suppress aberrant cytokine production

T. Matsuzaka, H. Ohta, T. Suganami, 2021, Scientific Reports.

Macrophages rely on extracellular serine to suppress aberrant cytokine production

H. Shimano, T. Matsuzaka, H. Arima, 2021, Scientific reports.

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

H. Shimano, N. Yahagi, N. Yamada, 2009, Biochemical and biophysical research communications.

Rho‐associated, coiled‐coil‐containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis

H. Shimano, T. Matsuzaka, Takafumi Miyamoto, 2019, Journal of diabetes investigation.

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism.

A. Saghatelian, C. Glass, N. Spann, 2017, Cell metabolism.

Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis.

H. Sone, N. Yahagi, T. Matsuzaka, 2023, BBA advances.

Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids

H. Daitoku, N. Yahagi, T. Matsuzaka, 2023, PNAS nexus.

Macrophage SREBP1 regulates skeletal muscle regeneration

Y. Miki, T. Matsuzaka, Y. Nakagawa, 2024, Frontiers in immunology.

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity

Hui Zhao, H. Sone, H. Shimano, 2017, Diabetes.

Label-free imaging of cellular organization in living mammalian cells via external apodization phase-contrast microscopy

T. Matsuzaka, Motohiro Sekiya, Yosuke Yoneyama, 2024, bioRxiv.