J. Che

发表

Development of differentiation modulators and targeted agents for treating neuroblastoma.

Xiaowu Dong, Zegao Jin, Yang Lu, 2020, European journal of medicinal chemistry.

Discovery of novel indoleaminopyrimidine NIK inhibitors based on molecular docking-based support vector regression (SVR) model

Jia Li, Huazhou Ying, Xiaowu Dong, 2019, Chemical Physics Letters.

Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and challenges ahead.

Xiaowu Dong, J. Che, Rui Song, 2019, European journal of medicinal chemistry.

Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation.

Xiaowu Dong, J. Che, Canliang Ma, 2021, European journal of medicinal chemistry.

Visible-light-mediated guest trapping in a photosensitizing porous coordination network: metal-free C-C bond-forming modification of metal-organic frameworks for aqueous-phase herbicide adsorption.

Xiaowu Dong, Yizhe Wu, J. Che, 2019, Chemical communications.

Alkenyl/thiol-derived metal-organic frameworks (MOFs) by means of postsynthetic modification for effective mercury adsorption.

Yongzhou Hu, C. Che, Xiaowu Dong, 2014, Chemistry.

Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells.

Huazhou Ying, Xiaowu Dong, J. Che, 2020, European journal of medicinal chemistry.

Identification of new IDH2R140Q inhibitors by discriminatory analysis‐based molecular docking and biological evaluation

Huazhou Ying, Xiaowu Dong, J. Che, 2019, Archiv der Pharmazie.

Metabolomics reveals the response of the phenylpropanoid biosynthesis pathway to starvation treatment in the grape endophyte Alternaria sp. MG1.

J. Che, Junling Shi, B. Pang, 2019, Journal of agricultural and food chemistry.

Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents

Yongzhou Hu, Xiaowu Dong, J. Che, 2018, Royal Society Open Science.

Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells.

Xiaowu Dong, Yang Lu, J. Che, 2022, European journal of medicinal chemistry.

Compartmentalization of Incompatible Polymers within Metal-Organic Frameworks towards Homogenization of Heterogeneous Hybrid Catalysts for Tandem Reactions.

Yongzhou Hu, Xiaowu Dong, J. Che, 2018, Chemistry.

A New Approach to Produce Resveratrol by Enzymatic Bioconversion.

J. Che, Junling Shi, Yan Zhang, 2016, Journal of microbiology and biotechnology.

Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1

Chao Ye, J. Che, Junling Shi, 2019, Microbial Cell Factories.

Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader.

Xiaowu Dong, Yizhe Wu, J. Che, 2022, European journal of medicinal chemistry.

Correction: Bioconversion of Pinoresinol Diglucoside and Pinoresinol from Substrates in the Phenylpropanoid Pathway by Resting Cells of Phomopsis sp.XP-8

J. Che, Junling Shi, D. Shao, 2016, PloS one.

Bioconversion of Pinoresinol Diglucoside and Pinoresinol from Substrates in the Phenylpropanoid Pathway by Resting Cells of Phomopsis sp.XP-8

J. Che, Junling Shi, D. Shao, 2015, PloS one.

Nitrogen and sulfur co-doped carbon dots derived from granatums and ammonium persulfate to detect tetracyclines in milk

J. Che, Xiumei Chen, 2022, Food Chemistry Advances.

Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity.

Qiaojun He, Yongzhou Hu, Xiaowu Dong, 2021, Journal of medicinal chemistry.

Discovery of new macrophage M2 polarization modulators as multiple sclerosis treatment agents that enable the inflammation microenvironment remodeling.

Xiaowu Dong, J. Che, Jiajia Wang, 2022, European journal of medicinal chemistry.

Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis.

Qiaojun He, Bo Yang, Yongzhou Hu, 2019, Journal of medicinal chemistry.

Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2.

Yongzhou Hu, Huazhou Ying, Xiaowu Dong, 2021, ACS medicinal chemistry letters.

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

R. Zhou, Luyang Yu, Wenqi Wang, 2022, Nature Communications.

Design, synthesis and biological evaluation of new dihydropyridine derivatives as PD-L1 degraders for enhancing antitumor immunity.

Qiaojun He, Xiaowu Dong, Yang Lu, 2022, Bioorganic chemistry.

Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy

J. Liu, Xiaowu Dong, J. Che, 2022, Molecules.

Design, Synthesis and Pharmacokinetic Study of Deuterated Ticagrelor Derivatives

Huazhou Ying, Xiaowu Dong, J. Che, 2020 .

p-Anisaldehyde Exerts Its Antifungal Activity Against Penicillium digitatum and Penicillium italicum by Disrupting the Cell Wall Integrity and Membrane Permeability

J. Che, N. Tao, Q. Ouyang, 2020, Journal of microbiology and biotechnology.

Screening of Oxygenated Aromatic Compounds for Potential Antifungal Activity against Geotrichum citri-aurantii through Structure-Activity Relationship Analysis.

J. Che, N. Tao, Yishan Fu, 2022, Journal of agricultural and food chemistry.

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-based Design.

Qiaojun He, Bo Yang, Yongzhou Hu, 2019, Journal of medicinal chemistry.

Heterogenization of homogeneous chiral polymers in metal–organic frameworks with enhanced catalytic performance for asymmetric catalysis

Yongzhou Hu, Xiaowu Dong, J. Che, 2018 .

Isolation of antofine from Cynanchum atratum BUNGE (Asclepiadaceae) and its antifungal activity against Penicillium digitatum

J. Che, Jinyin Chen, Chunpeng Wan, 2019, Postharvest Biology and Technology.

Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma.

Xiaowu Dong, Yizhe Wu, J. Che, 2022, Journal of medicinal chemistry.

AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells

Qiaojun He, Ji Cao, Xiaowu Dong, 2023, Acta pharmaceutica Sinica. B.

Altered pathways and targeted therapy in double hit lymphoma

Xiaowu Dong, J. Che, Mei-juan Wu, 2022, Journal of Hematology & Oncology.

An updated patent review of Akt inhibitors (2016-present)

Xiaowu Dong, J. Che, Yu Zhang, 2021, Expert opinion on therapeutic patents.

Inhibiting ferroptosis: a novel approach for stroke therapeutics.

Xiaowu Dong, J. Che, Yizhen Jin, 2021, Drug discovery today.

Integrating docking scores, interaction profiles and molecular descriptors to improve the accuracy of molecular docking: toward the discovery of novel Akt1 inhibitors.

Bo Yang, Xiaowu Dong, Yongzhou Hu, 2014, European journal of medicinal chemistry.

Antofine inhibits postharvest green mold due to imazalil-resistant Penicillium digitatum strain Pdw03 by triggering oxidative burst.

J. Che, Jia Zhou, N. Tao, 2021, Journal of food biochemistry.

Inhibitory effects of glutaraldehyde on Geotrichum citri‐aurantii and its possible mechanism

J. Che, Y. Yang, N. Tao, 2019, Journal of applied microbiology.

Metabolomics analysis reveals that myrcene stimulates the spore germination of Penicillium digitatum via the upregulation of central carbon and energy metabolism

J. Che, Yue-Yi Chen, N. Tao, 2020 .

Fabrication of γ-cyclodextrin-Based metal-organic frameworks as a carrier of cinnamaldehyde and its application in fresh-cut cantaloupes

J. Che, N. Tao, Keqin Chen, 2022, Current research in food science.

Design, synthesis, and biological evaluation of quinazoline derivatives with covalent reversible warheads as potential FGFR4 inhibitors.

Qiaojun He, Xiaowu Dong, Yang Lu, 2022, Bioorganic chemistry.

Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles.

Yongzhou Hu, Xiaowu Dong, J. Che, 2019, European journal of medicinal chemistry.

Evaluation of Artificial Intelligence in Participating Structure-Based Virtual Screening for Identifying Novel Interleukin-1 Receptor Associated Kinase-1 Inhibitors

Qiaojun He, Bo Yang, Xiaowu Dong, 2020, Frontiers in Oncology.

Genomic analysis reveals the biosynthesis pathways of diverse secondary metabolites and pinoresinol and its glycoside derivatives in Phomopsis sp.XP-8

J. Che, Junling Shi, Yanlin Liu, 2018 .

Advances of targeting the YAP/TAZ-TEAD complex in the hippo pathway for the treatment of cancers.

Xiaowu Dong, J. Che, Yiquan Wu, 2022, European journal of medicinal chemistry.

Comparison of pinoresinol diglucoside production by Phomopsis sp. XP-8 in different media and the characterisation and product profiles of the cultivation in mung bean.

J. Che, Junling Shi, D. Shao, 2016, Journal of the science of food and agriculture.

Validation of reference genes for normalization of gene expression by qRT-PCR in a resveratrol-producing entophytic fungus (Alternaria sp. MG1)

J. Che, Jun Shi, Yan Liu, 2016 .

Production of pinoresinol diglucoside, pinoresinol monoglucoside, and pinoresinol by Phomopsis sp. XP-8 using mung bean and its major components

J. Che, Junling Shi, Yanlin Liu, 2015, Applied Microbiology and Biotechnology.

Transcriptome Analysis Reveals the Genetic Basis of the Resveratrol Biosynthesis Pathway in an Endophytic Fungus (Alternaria sp. MG1) Isolated from Vitis vinifera

J. Che, Junling Shi, Yan Zhang, 2016, Front. Microbiol..

Bicyclo[2.2.1]heptane containing N,N′-diarylsquaramide CXCR2 selective antagonists as anti-cancer metastasis agents

Yongzhou Hu, J. Che, Youhong Hu, 2018, RSC advances.

ClusterX: a novel representation learning-based deep clustering framework for accurate visual inspection in virtual screening

Xiaowu Dong, J. Che, Jian Gao, 2023, Briefings Bioinform..

Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors.

Qiaojun He, Xiaowu Dong, Yang Lu, 2021, European journal of medicinal chemistry.

GSH Activated Biotin-tagged Near-Infrared Probe for Efficient Cancer Imaging

Yongzhou Hu, Xiaowu Dong, J. Che, 2019, Theranostics.

Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction.

Xiaowu Dong, Yizhe Wu, J. Che, 2021, European journal of medicinal chemistry.

TransFoxMol: predicting molecular property with focused attention

Tingjun Hou, Xiaowu Dong, Yang Lu, 2023, Briefings Bioinform..