Yongchang Chen

发表

Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine monophosphate-dependent protein kinase.

Xiaoyuan Yao, Yan Wu, Miaolin Zhu, 2015, Oncology letters.

Endogenous cGMP-dependent protein kinase reverses EGF-induced MAPK/ERK signal transduction through phosphorylation of VASP at Ser239.

Hai Qian, Yongchang Chen, Yan Tao, 2012, Oncology letters.

Nitric oxide inhibits gastric cancer cell growth through the modulation of the Akt pathway.

Yongchang Chen, Yan Tao, Jianrong Sang, 2011, Molecular medicine reports.

HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation

Jun Du, Yongchang Chen, L. Gu, 2018, Cell Death & Disease.

Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies.

Xiaoyuan Yao, Yan Wu, Hai Qian, 2017, Critical reviews in oncology/hematology.

The clinical significance of platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) in gastric cancer: A systematic review and meta-analysis.

Yan Wu, Hai Qian, Yongchang Chen, 2018, Critical reviews in oncology/hematology.

Structure and function of IQ-domain GTPase-activating protein 1 and its association with tumor progression (Review).

Yan Wu, Yongchang Chen, 2014, Biomedical reports.

Prognostic value of EpCAM/MUC1 mRNA-positive cells in non-small cell lung cancer patients

Yongchang Chen, Jian Li, Li-chao Yu, 2014, Tumor Biology.

Non-coding RNAs regulating androgen receptor signaling pathways in prostate cancer.

Yongchang Chen, Ke Lu, Muyuan Yu, 2020, Clinica chimica acta; international journal of clinical chemistry.

Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation.

Yan Wu, Hai Qian, Yongchang Chen, 2019, Biochemical and biophysical research communications.

Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823.

Yongchang Chen, Yan Tao, Jianrong Sang, 2010, Molecular medicine reports.

Secretory type II cGMP‐dependent protein kinase blocks activation of PDGFRβ via Ser254 in gastric cancer cells

Yan Wu, Hai Qian, Yongchang Chen, 2022, Cell biology international.

CK-19 mRNA-positive cells in peripheral blood predict treatment efficacy and survival in small-cell lung cancer patients

Y. Hu, Yan Wu, Yongchang Chen, 2013, Medical Oncology.

Curcumin reverses cisplatin resistance in cisplatin-resistant lung caner cells by inhibiting FA/BRCA pathway

Ping Chen, Jian Li, Yongchang Chen, 2014, Tumor Biology.

Type II cyclic guanosine monophosphate-dependent protein kinase inhibits epidermal growth factor receptor activation in different cancer cell lines.

L. Jiang, Yan Wu, Hai Qian, 2015, Oncology letters.

cGMP-dependent protein kinase (PKG II) inhibits epidermal growth factor (EGF)-induced MAPK/ERK and MAPK/JNK-mediated signal transduction through the inhi- bition of the phosphorylation/activation of the EGF receptor

Hai Qian, Yongchang Chen, Tin Lan, 2013 .

Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.

Yan Wu, Yongchang Chen, Tin Lan, 2011, Oncology reports.

Histological type of oncogenity and expression of cell cycle genes in tumor cells from human mesenchymal stem cells.

Yongchang Chen, Miao Chen, R. Jiang, 2006, Oncology reports.

Type II cGMP‑dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells.

Yan Wu, Hai Qian, Yongchang Chen, 2017, Molecular medicine reports.

Nuclear translocation of small G protein RhoA via active transportation in gastric cancer cells.

Yongchang Chen, Xiao-Ming Yang, Min Chen, 2013, Oncology reports.

Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells.

Huiling Cao, Yongchang Chen, Yongmin Yan, 2008, International journal of molecular medicine.

MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer

Jun Du, Yongchang Chen, L. Gu, 2016, Tumor Biology.

Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway.

Yongchang Chen, H. Qian, Wenrong Xu, 2016, Molecular medicine reports.

Vasodilator-stimulated Phosphoprotein Activation of Serum-response Element-dependent Transcription Occurs Downstream of RhoA and Is Inhibited by cGMP-dependent Protein Kinase Phosphorylation*

U. Walter, T. Jarchau, Yongchang Chen, 2004, Journal of Biological Chemistry.

Factors influencing RhoA protein distribution in the nucleus.

Yongchang Chen, Yue-ying Li, Jin Xu, 2011, Molecular medicine reports.

AKAPs competing peptide HT31 disrupts the inhibitory effect of PKA on RhoA activity.

Yongchang Chen, Ying Wang, Wenrong Xu, 2006, Oncology reports.

Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo.

Yongchang Chen, Miao Chen, Chongxu Han, 2006, Experimental and molecular pathology.

Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells.

Yongchang Chen, Wenbing Wang, Chongxu Han, 2005, International journal of molecular medicine.

PKG II inhibits PDGF‐BB triggered biological activities by phosphorylating PDGFRβ in gastric cancer cells

Yan Wu, Hai Qian, Yongchang Chen, 2018, Cell biology international.

Bilobol inhibits the lipopolysaccharide-induced expression and distribution of RhoA in HepG2 human hepatocellular carcinoma cells.

Yongchang Chen, Xiao-Ming Yang, Yali Liu, 2015, Oncology letters.

Protein Kinases Type II (PKG II) Combined with L-Arginine Significantly Ameliorated Xenograft Tumor Development: Is L-Arginine a Potential Alternative in PKG II Activation?

Y. Liu, Yan Wu, Hai Qian, 2018, Medical science monitor : international medical journal of experimental and clinical research.

The constitutively active PKG II mutant effectively inhibits gastric cancer development via a blockade of EGF/EGFR-associated signalling cascades

Xiaoyuan Yao, Yan Wu, Miaolin Zhu, 2018, Therapeutic advances in medical oncology.

Macrophages are involved in the protective role of human umbilical cord-derived stromal cells in renal ischemia-reperfusion injury.

Yongchang Chen, Wei Li, H. Qian, 2013, Stem cell research.

Human mesenchymal stem cells isolated from the umbilical cord

Yongchang Chen, R. Jiang, Yongmin Yan, 2008, Cell biology international.

EGF-reduced Wnt 5 a transcription induces epithelial-mesenchymal transition via Arf 6-ERK signaling in gastric cancer cells

Jun Du, Yongchang Chen, L. Gu, 2018 .

EGF-reduced Wnt5a transcription induces epithelial-mesenchymal transition via Arf6-ERK signaling in gastric cancer cells

Jun Du, Yongchang Chen, L. Gu, 2015, Oncotarget.

Mesenchymal Stern Cells from Adult Human Bone Marrow Differentiate into a Cardiomyocyte Phenotype In Vitro

Xiran Zhang, Yongchang Chen, Hong Zhou, 2004, Experimental biology and medicine.

Nitric Oxide Inhibits Methionine Synthase Activity in Vivo and Disrupts Carbon Flow through the Folate Pathway*

Yongchang Chen, G. Boss, V. Kharitonov, 2001, The Journal of Biological Chemistry.

RhoC Regulates the Proliferation of Gastric Cancer Cells through Interaction with IQGAP1

Yan Wu, Yongchang Chen, Yan Tao, 2012, PloS one.

FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma

Jun Du, Yongchang Chen, L. Gu, 2020, Frontiers in Molecular Biosciences.

mTORC2 mediate FLCN-induced HIF2α nuclear import and proliferation of clear cell renal cell carcinoma

Jun Du, Yongchang Chen, L. Gu, 2020, bioRxiv.

PKG II secreted via the classical endoplasmic reticulum-Golgi apparatus secretory pathway blocks the activation of EGFR through phosporalting its threonine 406 and has an anti-tumor effect.

Xiaoyuan Yao, Yan Wu, Miaolin Zhu, 2022, Frontiers in bioscience.

RhoA protein is generally distributed in the nuclei of cancer cells.

Yongchang Chen, Yan Tao, Miao Chen, 2010, Oncology reports.

The Cross Talk Between Protein Kinase A– and RhoA-Mediated Signaling in Cancer Cells

Yongchang Chen, Ying Wang, Wenrong Xu, 2005, Experimental biology and medicine.

Platelet-derived growth factor receptor/platelet-derived growth factor (PDGFR/PDGF) system is a prognostic and treatment response biomarker with multifarious therapeutic targets in cancers

Xiaoyuan Yao, Yan Wu, Hai Qian, 2016, Tumor Biology.

The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are major players in oncogenesis, drug resistance, and attractive oncologic targets in cancer

Xiaoyuan Yao, Yan Wu, Hai Qian, 2016, Growth factors.

Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast cancer cells.

Jun Du, Yongchang Chen, L. Gu, 2013, Cellular signalling.

HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation

Jun Du, Yongchang Chen, L. Gu, 2018, Cell Death & Disease.

Type II cGMP‑dependent protein kinase inhibits EGF‑induced JAK/STAT signaling in gastric cancer cells.

Yan Wu, Hai Qian, Yongchang Chen, 2016, Molecular medicine reports.

Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase/Akt signal transduction in gastric cancer cells

Hai Qian, Yongchang Chen, Tin Lan, 2013, Oncology letters.

PKG II Inhibits EGF/EGFR-Induced Migration of Gastric Cancer Cells

Yan Tao, Ying Wang, Luo Gu, 2013, PloS one.

Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells.

Yan Wu, Yongchang Chen, Yan Tao, 2012, Oncology reports.

Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival

Ping Chen, Hai Qian, Yongchang Chen, 2016, Oncotarget.

The functional status of DNA repair pathways determines the sensitization effect to cisplatin in non-small cell lung cancer cells

Hai Qian, Yongchang Chen, Tin Lan, 2016, Cellular Oncology.

RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistant lung cancer cells

Ping Chen, Yongchang Chen, Heping Jiang, 2015, Journal of Biomedical Science.

PKG II effectively reversed EGF‐induced protein expression alterations in human gastric cancer cell lines

Yan Wu, Hai Qian, Yongchang Chen, 2018, Cell biology international.

EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.

Jun Du, Yongchang Chen, L. Gu, 2016, Cancer letters.

The diagnostic value of extracellular protein kinase A (ECPKA) in serum for gastric and colorectal cancer

Yongchang Chen, Min Xu, Wei Li, 2020, Translational cancer research.

Active PKG II inhibited the growth and migration of ovarian cancer cells through blocking Raf/MEK and PI3K/Akt signaling pathways

Yan Wu, Yongchang Chen, Ying Liu, 2019, Bioscience reports.

Type II, but not type I, cGMP-dependent protein kinase reverses bFGF-induced proliferation and migration of U251 human glioma cells.

Yongchang Chen, Yan Tao, Yin-Jie Gu, 2013, Molecular medicine reports.

Phosphorylated vasodilator-stimulated phosphoprotein is localized on mitotic spindles of the gastric cancer cell line SGC-7901.

Yongchang Chen, Yan Tao, Ying Wang, 2006, World journal of gastroenterology.

Celastrol acts synergistically with afatinib to suppress non‐small cell lung cancer cell proliferation by inducing paraptosis

Yongchang Chen, Jian Li, Yi Wang, 2020, Journal of cellular physiology.

Analysis on the mechanism of Helicobacter pylori-induced apoptosis in gastric cancer cell line BGC-823.

Yongchang Chen, Ying Wang, Wenrong Xu, 2005, International journal of molecular medicine.

LPS-induced nuclear translocation of RhoA is dependent on NF-κB in the human lung cancer cell line A549.

Hai Qian, Yongchang Chen, Yan Tao, 2012, Oncology letters.

Synergism between Calcium and Cyclic GMP in Cyclic AMP Response Element-Dependent Transcriptional Regulation Requires Cooperation between CREB and C/EBP-β

S. Cassenaer, Yongchang Chen, G. Boss, 2003, Molecular and Cellular Biology.

Type II cGMP-dependent protein kinase inhibits ligand‑induced activation of EGFR in gastric cancer cells.

Hai Qian, Yongchang Chen, Tin Lan, 2014, Molecular medicine reports.

Cross-linked hyaluronan gel inhibits the growth and metastasis of ovarian carcinoma

Yan Wu, Hai Qian, Yongchang Chen, 2018, Journal of Ovarian Research.

Type II Cyclic Guanosine Monophosphate-Dependent ProteinKinase Inhibits Vegf-A/Vegfr-2 Pathway Activation In GastricCancer Cells

Yan Wu, Hai Qian, Yongchang Chen, 2016 .

Cross-linked hyaluronic acid gel inhibits metastasis and growth of gastric and hepatic cancer cells: in vitro and in vivo studies

Xiaoyuan Yao, Yan Wu, Miaolin Zhu, 2016, Oncotarget.

Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells.

Hai Qian, Yongchang Chen, Yan Tao, 2013, Biomedical reports.

bone cells gene expression in fos in mechanical induction of c- Selected Contribution: Regulatory pathways involved

N. Maffulli, Yongchang Chen, G. Boss, 2015 .

Type II cGMP-dependent Protein Kinase Mediates Osteoblast Mechanotransduction*

J. Frangos, Yongchang Chen, G. Boss, 2009, Journal of Biological Chemistry.

Type II cGMP-dependent protein kinase inhibits ERK/JNK-mediated activation of transcription factors in gastric cancer cells.

Yan Wu, Yongchang Chen, Yan Tao, 2012, Molecular medicine reports.

Type II cGMP‑dependent protein kinase inhibits RhoA activation in gastric cancer cells.

Hai Qian, Yongchang Chen, Tin Lan, 2014, Molecular medicine reports.

Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells.

Xiaoyuan Yao, Yan Wu, Miaolin Zhu, 2016, Molecular medicine reports.

PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells

Xiaoyuan Yao, Yan Wu, Miaolin Zhu, 2016, Oncotarget.

PI3K/Akt-dependent phosphorylation of GSK3β and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration.

Jun Du, Zhenzhen Hu, Yongchang Chen, 2013, Cellular signalling.

H pylori stimulates proliferation of gastric cancer cells through activating mitogen-activated protein kinase cascade.

Yongchang Chen, Ying Wang, Wenrong Xu, 2006, World journal of gastroenterology.

A novel tumor cell line cloned from mutated human embryonic bone marrow mesenchymal stem cells.

Yongchang Chen, Chongxu Han, Xiaochun Sun, 2004, Oncology reports.

Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901.

Yongchang Chen, Yan Tao, Wenrong Xu, 2008, World journal of gastroenterology.

RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1.

Yan Wu, Yongchang Chen, Jianrong Sang, 2011, Molecular medicine reports.

Cyclic GMP-dependent Protein Kinase Regulates CCAAT Enhancer-binding Protein β Functions through Inhibition of Glycogen Synthase Kinase-3*

Yongchang Chen, G. Boss, Shunhui Zhuang, 2005, Journal of Biological Chemistry.

Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells.

Yan Wu, Hai Qian, Yongchang Chen, 2015, Oncology letters.

Cyclic Guanosine Monophosphate (cGMP)-Dependent Protein Kinase II Blocks Epidermal Growth Factor (EGF)/Epidermal Growth Factor Receptor (EGFR)-Induced Biological Effects on Osteosarcoma Cells

Y. Hua, Yongchang Chen, Lu Jiang, 2018, Medical science monitor : international medical journal of experimental and clinical research.

Fibronectin increases RhoA activity through inhibition of PKA in the human gastric cancer cell line SGC-7901.

Yongchang Chen, Yan Tao, Ying Wang, 2010, Molecular medicine reports.

RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistant lung cancer cells

Ping Chen, Yongchang Chen, Heping Jiang, 2015, Journal of Biomedical Science.

Phosphorylation of vasodilator stimulated phosphoprotein is correlated with cell cycle progression in HeLa cells.

Yongchang Chen, Yan Tao, Jianrong Sang, 2010, Molecular medicine reports.

Type II cGMP‑dependent protein kinase inhibits RhoA activation in gastric cancer cells.

Hai Qian, Yongchang Chen, Tin Lan, 2014, Molecular medicine reports.

Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells.

Yan Wu, Yongchang Chen, Yan Tao, 2012, Oncology reports.

Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies.

Xiaoyuan Yao, Yan Wu, Hai Qian, 2017, Critical reviews in oncology/hematology.

Type II cGMP-dependent protein kinase inhibits ligand‑induced activation of EGFR in gastric cancer cells.

Hai Qian, Yongchang Chen, Tin Lan, 2014, Molecular medicine reports.