Sheng-quan Hu

发表

Preventing H2O2-induced toxicity in primary cerebellar granule neurons via activating the PI3- K/Akt/GSK3β pathway by kukoamine from Lycii Cortex

Yifan Han, Yuanyuan Li, Sheng-quan Hu, 2015 .

Discovery of Potent Succinate-Ubiquinone Oxidoreductase Inhibitors via Pharmacophore-linked Fragment Virtual Screening Approach.

Wenchao Yang, Sheng-quan Hu, Xiao-Lei Zhu, 2016, Journal of agricultural and food chemistry.

Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression

Yifan Han, Sheng-quan Hu, Z. Ke, 2019, Neurochemistry International.

Design, synthesis and biological evaluation of pyrimidine-based derivatives as VEGFR-2 tyrosine kinase inhibitors.

Hong Yan, Sheng-quan Hu, Wuji Sun, 2018, Bioorganic chemistry.

PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis

Wenming Li, Yifan Han, Sheng-quan Hu, 2011, Neurochemistry International.

Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B

G. Cui, Yifan Han, Sheng-quan Hu, 2017, Neuropharmacology.

Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine

Yifan Han, Sheng-quan Hu, Yuanjia Hu, 2016, NeuroMolecular Medicine.

Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway.

G. Cui, Yifan Han, Sheng-quan Hu, 2020, Chemico-biological interactions.

Sunitinib Produces Neuroprotective Effect Via Inhibiting Nitric Oxide Overproduction

Yi-fan Han, Sheng-quan Hu, Ming-Yuen Lee, 2014, CNS neuroscience & therapeutics.

Design, synthesis and biological evaluation of Lenalidomide derivatives as tumor angiogenesis inhibitor.

Hong Yan, Sheng-quan Hu, Zhigang Li, 2017, Bioorganic & medicinal chemistry letters.

Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation.

Yifan Han, Sheng-quan Hu, L. Du, 2015, European journal of pharmacology.

The anti‐cancer agent SU4312 unexpectedly protects against MPP+‐induced neurotoxicity via selective and direct inhibition of neuronal NOS

Z. Zuo, Wenming Li, Yifan Han, 2013, British journal of pharmacology.

Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.

P. Carlier, Wenming Li, Yifan Han, 2013, Chemico-biological interactions.

Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway

Jie Yu, Yifan Han, Sheng-quan Hu, 2017, Cellular and Molecular Neurobiology.

Dimeric Tacrine (10)-Hupyridone Effectively Combats Alzheimer’s Disease as A Multi-Target-Directed Ligand

P. Carlier, Yifan Han, Sheng-quan Hu, 2021 .

Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in vitro and in vivo.

G. Cui, Yifan Han, Sheng-quan Hu, 2020, ACS chemical neuroscience.

Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways

Yifan Han, Sheng-quan Hu, W. Cui, 2013, Neurochemistry International.

Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue

P. Carlier, Yifan Han, Sheng-quan Hu, 2014, Journal of Molecular Neuroscience.

Attenuation of secondary damage and Aβ deposits in the ipsilateral thalamus of dMCAO rats through reduction of cathepsin B by bis(propyl)-cognitin, a multifunctional dimer

Lixuan Zhan, Wei-wen Sun, E. Xu, 2019, Neuropharmacology.

Synergistic Inhibition on Acetylcholinesterase by the Combination of Berberine and Palmatine Originally Isolated from Chinese Medicinal Herbs

Yifan Han, Sheng-quan Hu, K. Tsim, 2014, Journal of Molecular Neuroscience.

Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β

Yifan Han, Sheng-quan Hu, K. Tsim, 2015, Journal of Molecular Neuroscience.

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

G. Cui, Yifan Han, Sheng-quan Hu, 2018, Front. Pharmacol..

Promising tacrine/huperzine A‐based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget

P. Carlier, Y. Pang, Wenming Li, 2021, Journal of neurochemistry.

Design, Synthesis and Biological Evaluation of 4-Aryl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one Derivatives as a PI3Kα Inhibitor.

Xiu-qing Song, Sheng-quan Hu, Zhichang Zhao, 2019, Biological & pharmaceutical bulletin.

Design , Synthesis and Biological Evaluation of 4-Aryl-5 , 7-dihydro-6 H-pyrrolo [ 2 , 3-d ] pyrimidin-6-one Derivatives as a PI 3 K α Inhibitor

Xiu-qing Song, Sheng-quan Hu, Zhichang Zhao, 2019 .

If small molecules immunotherapy comes, can the prime be far behind?

Xiaowu Dong, Sheng-quan Hu, Haiyan Yang, 2021, European journal of medicinal chemistry.

Discovery and optimization of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitors.

Sheng-quan Hu, Zhichang Zhao, H. Yan, 2019, Bioorganic chemistry.

Efficient synthesis of novel colchicine-magnolol hybrids and evaluation of their inhibitory activity on key proteases of 2019-nCoV replication and acute lung injury

Sheng-quan Hu, L. Pu, Zhengzhi Wu, 2022, Natural product research.

Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent

Sheng-quan Hu, Yeming Wang, H. Yan, 2019, Medicinal Chemistry Research.

Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation.

Qiaojun He, Xiaowu Dong, Yang Lu, 2021, European journal of medicinal chemistry.

Molecular Targets of Bis (7)-Cognitin and Its Relevance in Neurological Disorders: A Systematic Review

B. W. Lau, Sheng-quan Hu, D. Sánchez-Vidaña, 2019, Front. Neurosci..

Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

R. Anwyl, M. Rowan, Yifan Han, 2015, Scientific Reports.

Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease.

P. Carlier, Yifan Han, Sheng-quan Hu, 2021, ACS chemical neuroscience.

Substantial Neuroprotection Against K+ Deprivation‐Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)‐Cognitin Via the Activation of VEGFR‐2 Signaling Pathway

Y. Pang, Sheng-quan Hu, Daping Xu, 2013, CNS neuroscience & therapeutics.

[Neuroprotective effects of water extracts of American Ginseng on SH-SY5Y cells apoptosis induced by Abeta25-35].

Sheng-quan Hu, Hui-min Yu, Da-jian Yang, 2008, Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.

Robust Neuritogenesis‐Promoting Activity by Bis(heptyl)‐Cognitin Through the Activation of alpha7‐Nicotinic Acetylcholine Receptor/ERK Pathway

Yuan-Jia Hu, Y. Pang, Sheng-quan Hu, 2015, CNS neuroscience & therapeutics.

Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells.

Yifan Han, Sheng-quan Hu, Shinghung Mak, 2011, Journal of ethnopharmacology.

Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models

Yifan Han, Sheng-quan Hu, K. Tsim, 2016, Neurochemistry International.

Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase

Wei Cui, Shuai Yuan, Shengquan Hu, 2012, PloS one.

Highly efficient synthesis and monoamine oxidase B inhibitory profile of demethyleneberberine, columbamine and palmatine

Sheng-quan Hu, G. Cui, Jian Chen, 2020, Neurochemistry International.

Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla

Yifan Han, Sheng-quan Hu, Yuqiang Wang, 2018, Front. Pharmacol..

Discover Novel Covalent Inhibitors Targeting FLT3 through Hybrid Virtual Screening Strategy

Yubo Zhou, Xiaowu Dong, Sheng-quan Hu, 2021 .

Protection against H2O2-evoked toxicity in HT22 hippocampal neuronal cells by geissoschizine methyl ether via inhibiting ERK pathway

Sheng-quan Hu, Lei Yang, Zhengzhi Wu, 2022, Translational neuroscience.

Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β

Yifan Han, Sheng-quan Hu, K. Tsim, 2015, Journal of Molecular Neuroscience.

Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer.

Y. Pang, Yifan Han, Sheng-quan Hu, 2015, ACS chemical neuroscience.

Tacrine(2)–ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway

Wenming Li, R. Pi, Yifan Han, 2011, Neurochemistry International.

Chaihu Shugan San ameliorated cognitive deficits through regulating gut microbiota in senescence-accelerated mouse prone 8

Sheng-quan Hu, Sheng Wang, Q. Zeng, 2023, Frontiers in Pharmacology.

Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent

Yeming Wang, Sheng-quan Hu, Wuji Sun, 2019, Medicinal Chemistry Research.

Asymmetric Synthesis of (–)-Colchicine and Its Natural Analog (–)-N-Acetylcolchicine Methyl Ether

Sheng-quan Hu, L. Pu, Min Ma, 2023, Chinese Journal of Organic Chemistry.

Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR

P. Carlier, Wenming Li, Yifan Han, 2011, Brain Research.

Tacrine(10)-hupyridone, a dual-binding acetylcholinesterase inhibitor, potently attenuates scopolamine-induced impairments of cognition in mice

Yifan Han, Sheng-quan Hu, Qinwen Wang, 2018, Metabolic Brain Disease.

Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice.

Jie Yu, Yifan Han, Sheng-quan Hu, 2016, ACS chemical neuroscience.

Dimeric bis (heptyl)‐Cognitin Blocks Alzheimer's β‐Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils

Y. Pang, Sheng-quan Hu, Ming-Yuen Lee, 2015, CNS neuroscience & therapeutics.

Design, synthesis and biological evaluation of novel glucokinase activators

Yong Qiang Li, Yu Ling Wang, Zhiqiang Feng, 2011 .

Significant combination of Aβ aggregation inhibitory and neuroprotective properties in silico, in vitro and in vivo by bis(propyl)-cognitin, a multifunctional anti-Alzheimer's agent.

Y. Pang, R. Pi, Yifan Han, 2020, European journal of pharmacology.

Concise Enantioselective Total Synthesis of Isopavine Alkaloids.

Sheng-quan Hu, L. Pu, Zhengzhi Wu, 2023, Journal of Organic Chemistry.

Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue

P. Carlier, Yifan Han, Sheng-quan Hu, 2015, Journal of Molecular Neuroscience.

Bis(12)-Hupyridone, a Promising Multi-Functional Anti-Alzheimer’s Dimer Derived from Chinese Medicine

Z. Zuo, Wenming Li, Yifan Han, 2012 .

Title Unexpected Neuronal Protection of SU 5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase

Wenming Li, Yifan Han, Sheng-quan Hu, 2012 .

Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins

Yifan Han, Sheng-quan Hu, Ya-li Peng, 2012, Brain Research.

Synergistic Inhibition on Acetylcholinesterase by the Combination of Berberine and Palmatine Originally Isolated from Chinese Medicinal Herbs

Yifan Han, Sheng-quan Hu, K. Tsim, 2014, Journal of Molecular Neuroscience.

Design, synthesis and biological evaluation of a novel colchicine-magnolol hybrid for inhibiting the growth of Lewis lung carcinoma in Vitro and in Vivo

Sheng-quan Hu, L. Pu, Ke-xian Chen, 2022, Frontiers in Chemistry.

Discover Novel Covalent Inhibitors Targeting FLT3 through Hybrid Virtual Screening Strategy.

Yubo Zhou, Xiaowu Dong, Sheng-quan Hu, 2021, Biological & pharmaceutical bulletin.