G. Thomas

E. Geissler, G. Thomas, H. Schlitt, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

TOR : target of rapamycin

D. Sabatini, G. Thomas, M. Hall, 2004 .

Target of Rapamycin

G. Thomas, P. Dennis, 2002, Current Biology.

Expression of the p70s6k / p85s6k Isoforms from a Single Gene and Activation Following Mitogenic Stimulation

G. Thomas, S. Kozma, C. Reinhard, 1993 .

The Drosophila p 70 s 6 k homolog exhibits conserved regulatory elements and rapamycin sensitivity ( signal transduction / phosphorylation / Schneider cells )

C. A. Berry, G. Thomas, S. Kozma, 2005 .

The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity.

G. Thomas, S. Kozma, C. O. Berry, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The ins and outs of protein phosphorylation

J. Schlessinger, J. Moscat, G. Thomas, 2000, EMBO reports.

Cancer biology: The director's cut

G. Thomas, A. Gentilella, 2012, Nature.

A stimulated S6 kinase from rat liver: identity with the mitogen activated S6 kinase of 3T3 cells.

M. Siegmann, S. Ferrari, G. Thomas, 1989, The EMBO journal.

Differential regulation of S6 phosphorylation by insulin and epidermal growth factor in Swiss mouse 3T3 cells: insulin activation of type 1 phosphatase.

G. Thomas, L. Ballou, A. Olivier, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The role of the mTOR pathway in regulating food intake.

G. Thomas, B. Wiczer, 2010, Current opinion in drug discovery & development.

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

A. Gingras, N. Sonenberg, G. Thomas, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Rapamycin, FRAP and the Control of 5’TOP mRNA Translation

G. Thomas, S. Fumagalli, 1997 .

Phytohormones Participate in an S6 Kinase Signal Transduction Pathway in Arabidopsis1

F. Nagy, F. Turck, G. Thomas, 2004, Plant Physiology.

The Mitogen-Activated p70s6k / p85s6k

G. Thomas, 1993 .

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

G. Thomas, S. Kozma, C. Reinhard, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Mitogenesis and protein synthesis: A role for ribosomal protein S6 phosphorylation?

G. Thomas, M. J. Stewart, George Thomas, 1994, BioEssays : news and reviews in molecular, cellular and developmental biology.

Purification and properties of mitogen-activated S6 kinase from rat liver and 3T3 cells.

H. Lane, G. Thomas, 1991, Methods in enzymology.

Phosphatase 2A puts the brakes on mTORC1 nutrient signaling.

G. Thomas, A. Selvaraj, 2010, Cell metabolism.

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

R. Pearson, G. Thomas, S. Fumagalli, 1997, The EMBO journal.

Identification and early activation of a Xenopus laevis p70s6k following progesterone‐induced meiotic maturation.

M. Dorée, G. Thomas, S. Kozma, 1992, The EMBO journal.

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin.

E. Hafen, S. Oldham, G. Thomas, 2000, Genes & development.

- S6K: Ribosomal protein S6 kinase (vertebrates) p70S6 kinaseαI andαII (p70S6Kp85S6K)

G. Thomas, S. Kozma, 1995 .

Control of S6 phosphorylation during the mitogenic response.

G. Thomas, P. Jenö, L. Ballou, 1988, Advances in experimental medicine and biology.

Criteria for establishment of the biological significance of ribosomal protein phosphorylation.

H. Towbin, G. Thomas, K. Manchester, 1982, Current topics in cellular regulation.

Multiple phosphorylation of ribosomal protein S6 during transition of quiescent 3T3 cells into early G1, and cellular compartmentalization of the phosphate donor.

M. Siegmann, G. Thomas, J. Gordon, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of p70s6k

G. Thomas, P. Dennis, 1997 .

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

P. Pandolfi, F. Natt, Jonathan Hall, 2009, Nature Cell Biology.

The mitogen activated S6 kinase; sites of phosphorylation which lead to activation and identification of a putative kinase kinase.

S. Ferrari, G. Thomas, S. Morley, 1993, Biochemical Society transactions.

p70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-α expression in the lung.

S. Madala, G. Thomas, W. Hardie, 2016, American journal of physiology. Lung cellular and molecular physiology.

The mTOR Inhibitor RAD 001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p 21 Translation

H. Lane, F. Natt, Jonathan Hall, 2005 .

23 S6 Phosphorylation and Signal Transduction

G. Thomas, S. Fumagalli, 2000 .

Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis

Yi Zheng, J. Cancelas, G. Thomas, 2013, Haematologica.

Junı́n virus infection impairs stress-granule formation in Vero cells treated with arsenite via inhibition of eIF 2 a phosphorylation

G. Thomas, G. Boccaccio, F. Linero, 2011 .

The mitogen-activated p70s6k.

G. Thomas, 1992, Biochemical Society transactions.

Ribosomal S6 kinase signaling and the control of translation.

G. Thomas, A. Dufner, George Thomas, 1999, Experimental cell research.

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

C. Nobes, A. Hall, D. Cantrell, 1996, Current Biology.

S6K1 Phosphorylates and Regulates Fragile X Mental Retardation Protein (FMRP) with the Neuronal Protein Synthesis-dependent Mammalian Target of Rapamycin (mTOR) Signaling Cascade*

S. Ceman, Mika Nakamoto, S. Warren, 2008, Journal of Biological Chemistry.

Regulation of an Activated S6 Kinase 1 Variant Reveals a Novel Mammalian Target of Rapamycin Phosphorylation Site*

P. Brennan, D. Cantrell, G. Thomas, 2002, The Journal of Biological Chemistry.

Activation of phospholipase D by endothelin-1 in rat myometrium. Role of calcium and protein kinase C.

S. Harbon, G. Thomas, H. Le Stunff, 1997, The Journal of pharmacology and experimental therapeutics.

Nuclear localization of RelB is associated with effective antigen-presenting cell function.

G. Thomas, R. Thomas, Ranjeny Thomas, 1997, Journal of immunology.

S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment.

M. Siegmann, G. Thomas, L. Ballou, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Drosophila S6 kinase: a regulator of cell size.

E. Hafen, G. Thomas, S. Kozma, 1999, Science.

Bending the path to TOR

G. Thomas, B. Wiczer, Adem Kalender, 2010, Nature Cell Biology.

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

N. Sonenberg, T. Alain, O. Larsson, 2010, Science.

mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer.

G. Thomas, A. Selvaraj, S. Dann, 2007, Trends in molecular medicine.

Purification and characterization of a 40 S ribosomal protein S6 kinase from vanadate-stimulated Swiss 3T3 cells.

M. Siegmann, G. Thomas, P. Jenö, 1989, The Journal of biological chemistry.

Ordered phosphorylation of 40S ribosomal protein S6 after serum stimulation of quiescent 3T3 cells.

J. Martín-Pérez, G. Thomas, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

F. Natt, S. Kim, J. Backer, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Activation of multiple S6 phosphorylation and its possible role in the alteration of mRNA expression.

G. Thomas, 1982, Progress in brain research.

A guide to analysis of mouse energy metabolism

Robert V Farese, E. Ravussin, R. Eckel, 2011, Nature Methods.

Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

F. Natt, G. Thomas, S. Kozma, 2008, Cell metabolism.

Increased phosphorylation of ribosomal protein S6 during meiotic maturation of Xenopus oocytes.

J. Maller, G. Thomas, P. Nielsen, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation.

G. Thomas, S. Fumagalli, P. Dennis, 1999, Current opinion in genetics & development.

The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k

A. Gingras, N. Sonenberg, G. Thomas, 1997, Molecular and cellular biology.

Analysis of 40S ribosomal protein S6 phosphorylation during the mitogenic response.

G. Thomas, J. Krieg, A. Olivier, 1988, Methods in enzymology.

[34] Separation of multiple phosphorylated forms of 40 S ribosomal protein S6 by two-dimensional polyacrylamide gel electrophoresis

M. Siegmann, G. Thomas, 1987 .

Separation of multiple phosphorylated forms of 40 S ribosomal protein S6 by two-dimensional polyacrylamide gel electrophoresis.

M. Siegmann, G. Thomas, 1987, Methods in enzymology.

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

G. Thomas, S. Kozma, N. Pullen, 1996, Molecular and cellular biology.

14 Ribosomal Protein S6 Phosphorylation and Signal Transduction

G. Thomas, H. B. Jefferies, Harold B. J. Jefferies, 1996 .

Growth Factor-Mediated Activation of S6 Phosphorylation and Protein Synthesis

G. Thomas, 1987 .

40 RAD001 sensitizes tumor cells to cisplatin-induced apoptosis in an mTOR dependent manner by inhibition of p53-induced p21 protein expression

H. Lane, F. Natt, Jonathan Hall, 2004 .

Effect of low doses of actinomycin D on neuroblastoma cell lines

George Thomas, J. Hernández-Losa, S. Ambrosio, 2016, Molecular Cancer.

P1.14A Dose Escalation Single Arm Phase Ib Combination Study of BEZ235 with Everolimus in Patients with Advanced Solid Malignancies

G. Thomas, S. Kozma, T. Wise-Draper, 2015 .

Her-2-neu expression and progression toward androgen independence in human prostate cancer.

J. Manola, M. Loda, P. Kantoff, 2000, Journal of the National Cancer Institute.

Sorting of tropomyosin isoforms in synchronised NIH 3T3 fibroblasts: evidence for distinct microfilament populations.

P. Gunning, G. Thomas, J. Percival, 2000, Cell motility and the cytoskeleton.

The effect of serum, EGF, PGF2α and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis

M. Siegmann, A. Otto, J. Martín-Pérez, 1982, Cell.

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

P. Pandolfi, M. Fraga, M. Esteller, 2019, Acta Neuropathologica.

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6.

L. Terracciano, M. Grompe, S. Volarevic, 2000, Science.

Regulation of 40S ribosomal protein S6 phosphorylation in Swiss mouse 3T3 cells

M. Siegmann, G. Thomas, J. Gordon, 1980, Cell.

5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.

S. Peddigari, G. Thomas, C. Mercer, 2013, Cell reports.

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

E. Hafen, J. Bos, G. Thomas, 2003, Molecular cell.

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

E. Hafen, J. van der Kaay, C. Downes, 2002, Nature cell biology.

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.

G. Thomas, S. Kozma, C. Reinhard, 1992, Proceedings of the National Academy of Sciences of the United States of America.

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

C. Cordon-Cardo, J. Baselga, K. Marks, 2017, Nature.

Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3.

A. Montag, G. Thomas, C. Albigès-Rizo, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

B. Viollet, S. Kim, N. Bardeesy, 2010, Cell metabolism.

Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

H. Lane, N. Ratner, J. Perentesis, 2008, Molecular Cancer Therapeutics.

Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone

Steven J. Marygold, R. Pearson, R. Hannan, 2011, PLoS genetics.

S6K1 plays a critical role in early adipocyte differentiation.

N. Sonenberg, G. Thomas, S. Kozma, 2010, Developmental cell.

Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

G. Thomas, S. Kozma, E. Brown, 2004, Molecular and Cellular Biology.

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K

George Thomas, G. Thomas, S. Kozma, 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

J. Clohessy, P. Pandolfi, H. Scher, 2010, The Journal of clinical investigation.

An encore for ribosome biogenesis in the control of cell proliferation

G. Thomas, 2000, Nature Cell Biology.

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

D. Steiner, R. Leduc, G. Thomas, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint.

G. Thomas, S. Fumagalli, Teng Teng, 2012, Genes & development.

The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation

H. Lane, F. Natt, Jonathan Hall, 2005, Cell.

Loss of Tumor Suppressor RPL5/RPL11 Does Not Induce Cell Cycle Arrest but Impedes Proliferation Due to Reduced Ribosome Content and Translation Capacity

G. Thomas, S. Fumagalli, C. Mercer, 2013, Molecular and Cellular Biology.

Reprogrammed mRNA translation drives metabolic response to therapeutic targeting of ribosome biogenesis

David P. De Souza, R. Pearson, G. McArthur, 2019, bioRxiv.

The phosphorylation of ribosomal protein S6 in rat tissues following cycloheximide injection, in diabetes, and after denervation of diaphragm. A simple immunological determination of the extent of S6 phosphorylation on protein blots.

H. Towbin, G. Thomas, K. Manchester, 1982, The Journal of biological chemistry.

Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo

S. Ramón y. Cajal, G. Thomas, T. Aasen, 2017, Oncotarget.

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

E. Hafen, S. Breuer, G. Thomas, 2003, Nature Cell Biology.

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.

G. Thomas, J. Montagne, M. Hemmings-Mieszczak, 2002, Genes & development.

Cell growth : control of cell size

M. Raff, G. Thomas, M. Hall, 2004 .

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

G. Thomas, S. Um, D. D’Alessio, 2006, Cell metabolism.

Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activity*

G. Rena, P. Lochhead, C. Sutherland, 2002, The Journal of Biological Chemistry.

ReviewNutrient overload , insulin resistance , and ribosomal protein S 6 kinase 1 , S 6 K 1

G. Thomas, S. Um, D. D’Alessio, 2022 .

The PI3K-mTOR Pathway

G. Thomas, S. Kozma, H. Thomas, 2016 .

Nutrient sensing in the mTOR/S6K1 signalling pathway.

G. Thomas, P. Gulati, Pawan Gulati, 2007, Biochemical Society transactions.

The amino acid sensitive TOR pathway from yeast to mammals

G. Thomas, S. Dann, 2006, FEBS letters.

Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage

R. Marcos, N. Agell, G. Thomas, 2020, EMBO Journal.

Phosphorylation and activation of p70s6k by PDK1.

M. Andjelkovic, B. Hemmings, G. Thomas, 1998, Science.

p70s6k function is essential for G1 progression

H. Lane, G. Thomas, N. Lamb, 1993, Nature.

Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis

M. Loda, J. Clohessy, P. Pandolfi, 2009, Science Signaling.

mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma

S. Thorgeirsson, P. Mischel, B. Aronow, 2012, Science Translational Medicine.

Thomas and Autophagy in Hepatocellular Carcinoma mTOR Inhibitors Synergize on Regression , Reversal of Gene Expression

S. Thorgeirsson, P. Mischel, B. Aronow, 2012 .

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Janet M. Thornton, David Carling, Linda Partridge, 2009, Science.

The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.

G. Thomas, Takahiro Nobukini, 2004, Novartis Foundation symposium.

S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis.

Min Gyu Lee, J. You, Sang-Jin Lee, 2016, Molecular cell.

Metabolic Control by S6 Kinases Depends on Dietary Lipids

P. Pfluger, M. Tschöp, D. Clegg, 2012, PLoS ONE.

The S6 kinase signaling pathway in the control of development and growth.

G. Thomas, 2002, Biological research.

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

A. Hodges, A. Jaeschke, G. Thomas, 2002, The Journal of cell biology.

Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes.

G. Thomas, S. Kozma, A. Gentilella, 2017, Molecular cell.

Alteration of polynucleotide secondary structure by ribosomal protein S1.

H. Noller, G. Thomas, D. Bear, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a ribosomal protein essential for peptidyl transferase activity.

H. Noller, R. Atchison, G. Thomas, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver.

G. Thomas, H. Flotow, 1992, The Journal of biological chemistry.

Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.

G. Thomas, P. Jenö, G Thomas, 1988, The Journal of biological chemistry.

Role of S6 phosphorylation and S6 kinase in cell growth.

S. Volarevic, G. Thomas, George Thomas, 2001, Progress in nucleic acid research and molecular biology.

p70s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes

P. Brennan, D. Cantrell, G. Thomas, 1999, Molecular and Cellular Biology.

Dual requirement for a newly identified phosphorylation site in p70s6k

R. Pearson, G. Thomas, S. Kozma, 1997, Molecular and Cellular Biology.

Nuclear localization of p85s6k: functional requirement for entry into S phase.

A. Fernández, G. Thomas, C. Reinhard, 1994, The EMBO journal.

Elongation factor-1 alpha mRNA is selectively translated following mitogenic stimulation.

G. Thomas, H. B. Jefferies, Thomas, 1994, The Journal of biological chemistry.

Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide.

J. Hofsteenge, G. Thomas, J. Krieg, 1988, The Journal of biological chemistry.

Translational control of mRNA expression during the early mitogenic response in Swiss mouse 3T3 cells: identification of specific proteins

G. Thomas, Gary Thomas, George Thomas Friedrich, 1986, The Journal of cell biology.

Involvement of S6K1 in mitochondria function and structure in HeLa cells.

Jisoo Park, G. Thomas, S. Kwon, 2016, Cellular signalling.

S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

M. Diamond, N. Sonenberg, T. Alain, 2016, Nature Immunology.

Translation Control and Insulin Signaling

G. Thomas, A. Selvaraj, 2010 .

S 6 K 1 Phosphorylation of H 2 B Mediates EZH 2 Trimethylation of H 3 : A Determinant of Early Adipogenesis Graphical Abstract Highlights

Min Gyu Lee, J. You, Sang-Jin Lee, 2022 .

Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.

G. Thomas, K. Walsh, L. Thomas, 1995, The EMBO journal.

Research and innovation in the development of everolimus for oncology

R. Motzer, H. Lane, T. O'reilly, 2011, Expert opinion on drug discovery.

Signaling control of mRNA translation in cancer pathogenesis

Nahum Sonenberg, Pier Paolo Pandolfi, George Thomas, 2004, Oncogene.

Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.

R. Pearson, S. Peddigari, G. Thomas, 2021, Blood.

Identification and characterization of a mitogen-activated S6 kinase.

G. Thomas, P. Jenö, L. Ballou, 1988, Proceedings of the National Academy of Sciences of the United States of America.

S6 kinase 1 plays a key role in mitochondrial morphology and cellular energy flow.

Jisoo Park, Hyunji Lee, G. Thomas, 2018, Cellular signalling.

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

B. Pulendran, N. Sonenberg, T. Alain, 2010, Proceedings of the National Academy of Sciences.

Micro- and macropurification methods for protein kinases.

S. Ferrari, G. Thomas, 1991, Methods in enzymology.

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

L. Schaeffer, J. Tanti, D. Freyssenet, 2009, The Journal of cell biology.

The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

R. Pearson, G. Thomas, S. Kozma, 1995, The EMBO journal.

The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor.

T. Nakayama, G. Thomas, J. Christian, 2001, Genes & development.

CHAPTER 315 – Translational Control and Insulin Signaling

G. Thomas, T. Radimerski, 2003 .

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs.

S. Ferrari, G. Thomas, S. Morley, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Mitogen-Activated Signalling Pathways

G. Thomas, 1993 .

Calcium Regulation of Smooth Muscle Actomyosin

G. Thomas, S. Chacko, A. Rosenfeld, 1985 .

EGF induces biphasic S6 kinase activation: Late phase is protein kinase C-dependent and contributes to mitogenicity

D. Fabbro, M. Šuša, G. Thomas, 1989, Cell.

Phospholipase D and mTORC1: Nutrients Are What Bring Them Together

G. Thomas, B. Wiczer, 2012, Science Signaling.

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR

A. Zorzano, S. Ramón y. Cajal, J. Hernández-Losa, 2018, Clinical Cancer Research.

The Mitogen/Oncogene-Activated p70s6k: Its Role in the G0/G1 Transition

S. Ferrari, G. Thomas, 1993 .

Tubers and tumors: rapamycin therapy for benign and malignant tumors.

D. Plas, G. Thomas, 2009, Current opinion in cell biology.

mTOR: a mediator of intracellular homeostasis.

A. Jaeschke, G. Thomas, P. Dennis, 2004, Current topics in microbiology and immunology.

Mitochondrial Complex I Activity Is Required for Maximal Autophagy

G. Thomas, S. Kozma, Jonathan A Stefely, 2018, Cell reports.

Epidermal Growth-Factor Mediation of S6 Phosphorylation During the Mitogenic Response: A Novel S6 Kinase

G. Thomas, 1986 .

EGF, PGF2α and insulin induce the phosphorylation of identical S6 peptides in Swiss mouse 3T3 cells: Effect of cAMP on early sites of phosphorylation

M. Siegmann, J. Martín-Pérez, G. Thomas, 1984, Cell.

Activation of S6 phosphorylation: Its possible role in the regulation of protein synthesis

J. Martín-Pérez, G. Thomas, G. Thomas, 1983 .

p70s6k/p85s6k: mechanism of activation, effects of rapamycin and role in mitogenesis.

G. Thomas, 1993, Biochemical Society transactions.

Inactivation of an S6 Kinase by Protein Phosphatases

G. Thomas, P. Jenö, L. Ballou, 1987 .

Identical Mr 70,000 S6 kinase is activated biphasically by epidermal growth factor: a phosphopeptide that characterizes the late phase.

M. Šuša, G. Thomas, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Solution structure of the phosphorylated sites of ribosomal protein S6 by 1H NMR spectroscopy.

G. Thomas, H. Flotow, A. Nosaka, 2009, International journal of peptide and protein research.

Characterization of the Phosphorylation Sites of 40S Ribosomal Protein S6

S. Ferrari, G. Thomas, H. Meyer, 1991 .

Molecular and Biochemical Characterization of the Mitogen-Activated S6 Kinase

G. Thomas, 1991 .

A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies

George Thomas, Carol A. Mercer, John C. Morris, 2017, Targeted Oncology.

Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex.

George Thomas, R. Pearson, K. Hannan, 2003, The Biochemical journal.

Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

C. Cordon-Cardo, J. Baselga, K. Marks, 2018, Nature.

Effect of low doses of actinomycin D on neuroblastoma cell lines

J. Hernández-Losa, S. Ambrosio, G. Thomas, 2016, Molecular Cancer.

Affinity purification of protein kinases using adenosine 5'-triphosphate, amino acid, and peptide analogs.

G. Thomas, P. Jenö, 1991, Methods in enzymology.

Combining TRAIL with PI3 Kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling

P. Workman, P. Clarke, M. Valenti, 2013, Oncotarget.

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

R. Pearson, G. McArthur, O. Larsson, 2020, The EMBO journal.

Fat fuels insulin resistance through Toll-like receptors

M. Tschöp, G. Thomas, 2006, Nature Medicine.

Mitochondrial Complex I Activity Is Required for Maximal Autophagy

G. Thomas, S. Kozma, Jonathan A Stefely, 2018, Cell reports.

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

P. Pandolfi, L. Salmena, J. Teruya-Feldstein, 2008, The Journal of clinical investigation.

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint.

G. Thomas, S. Fumagalli, Teng Teng, 2012, Genes & development.

A liaison between mTOR signaling, ribosome biogenesis and cancer.

G. Thomas, S. Kozma, A. Gentilella, 2015, Biochimica et biophysica acta.

S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

M. Diamond, N. Sonenberg, T. Alain, 2016, Nature Immunology.

Control of Protein Synthesis Initiation Factor eIF-2α Phosphorylation by Interferon

G. Thomas, 1987 .

Cell growth : control of cell size

M. Raff, G. Thomas, M. Hall, 2004 .

Phosphopeptide analysis of 40 S ribosomal protein S6.

J. Martín-Pérez, G. Thomas, 1987, Methods in enzymology.

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

L. Schaeffer, J. Tanti, D. Freyssenet, 2009, The Journal of cell biology.

mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma

S. Thorgeirsson, P. Mischel, B. Aronow, 2012, Science Translational Medicine.

Three forms of phosphatase type 1 in Swiss 3T3 fibroblasts. Free catalytic subunit appears to mediate s6 dephosphorylation.

G. Thomas, A. Olivier, 1990, The Journal of biological chemistry.