A. Olivera

E. Untersmayr, A. Olivera, E. Jensen‐Jarolim, 2012, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis

A. Olivera, E. Serrano-Candelas, R. Munoz-Cano, 2021, The Journal of Immunology.

A GTPase-independent Mechanism of p21-activated Kinase Activation

A. M. Reilly, C. C. King, S. Spiegel, 1998, The Journal of Biological Chemistry.

Shaping the landscape: metabolic regulation of S1P gradients.

R. Proia, A. Olivera, M. L. Allende, 2013, Biochimica et Biophysica Acta.

A Critical Function for the Transcription Factors GLI1 and GLI2 in the Proliferation and Survival of Human Mast Cells

D. Metcalfe, A. Olivera, Yuzhi Yin, 2022, Frontiers in Immunology.

S1P4 Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells

R. Proia, D. Metcalfe, A. Olivera, 2018, International journal of molecular sciences.

Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.

R. Proia, W. Watford, A. Olivera, 2010, The Journal of clinical investigation.

The alliance of sphingosine-1-phosphate and its receptors in immunity

R. Proia, A. Olivera, J. Rivera, 2008, Nature Reviews Immunology.

Distinct transcriptome profiles differentiate nonsteroidal anti-inflammatory drug-dependent from nonsteroidal anti-inflammatory drug-independent food-induced anaphylaxis.

D. Metcalfe, A. Olivera, J. Rivera, 2016, The Journal of allergy and clinical immunology.

Sphingosine‐1‐phosphate can promote mast cell hyper‐reactivity through regulation of contactin‐4 expression

R. Proia, Y. Yoshihara, A. Olivera, 2013, Journal of leukocyte biology.

IL-6 promotes an increase in human mast cell number and reactivity through suppression of SOCS3

A. Olivera, A. Gilfillan, C. Prussin, 2016 .

IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.

D. Metcalfe, A. Olivera, A. Gilfillan, 2016, The Journal of allergy and clinical immunology.

Adenosine activates mesangial cell proliferation.

A. Olivera, J. López-Novoa, C. Martínez-Salgado, 1997, Cellular signalling.

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

T. Hla, A. Olivera, Yanbao Xiong, 2019, Science Immunology.

Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy.

E. Untersmayr, A. Olivera, J. Rivera, 2012, Immunology letters.

Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function.

A. Olivera, R. Munoz-Cano, Joseph M. Kulinski, 2016, European journal of pharmacology.

Atrial natriuretic peptide in rats with experimental cirrhosis of the liver without ascites.

A. Olivera, J. López-Novoa, D. Rodríguez‐Puyol, 1988, Endocrinology.

Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation*

R. Proia, O. Gavrilova, A. Olivera, 2016, The Journal of Biological Chemistry.

Paradigm Shifts in Mast Cell and Basophil Biology and Function: An Emerging View of Immune Regulation in Health and Disease.

A. Olivera, J. Rivera, 2020, Methods in molecular biology.

Paradigm shifts in mast cell and basophil biology and function: an emerging view of immune regulation in health and disease.

A. Olivera, J. Rivera, 2014, Methods in molecular biology.

Effect of adenosine and adenosine analogues on cyclic AMP accumulation in cultured mesangial cells and isolated glomeruli of the rat

A. Olivera, J. López-Novoa, 1992, British journal of pharmacology.

Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1

S. Spiegel, A. Olivera, N. E. Buckley, 1996, Glycoconjugate Journal.

Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts.

S. Spiegel, C. Rani, A. Olivera, 1997, Biochimica et biophysica acta.

E‐prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA‐mediated suppression of IgE‐dependent signaling

A. Olivera, J. Rivera, C. Picado, 2012, Journal of leukocyte biology.

Roles of sphingosine-1-phosphate in cell growth, differentiation, and death.

S. Spiegel, O. Cuvillier, A. Olivera, 1998, Biochemistry. Biokhimiia.

The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis.

R. Proia, A. Olivera, J. Rivera, 2007, Immunity.

Mast cells signal their importance in health and disease.

D. Metcalfe, A. Olivera, M. Beaven, 2018, The Journal of allergy and clinical immunology.

Ganglioside GM1 and sphingolipid breakdown products in cellular proliferation and signal transduction pathways.

S. Spiegel, A. Olivera, 1992, Glycoconjugate journal.

Usage of Sphingosine Kinase Isoforms in Mast Cells Is Species and/or Cell Type Determined

R. Proia, A. Olivera, J. Rivera, 2013, The Journal of Immunology.

DeterminedMast Cells Is Species and/or Cell Type Usage of Sphingosine Kinase Isoforms in

R. Proia, A. Olivera, J. Rivera, 2013 .

An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease.

A. Olivera, J. Rivera, 2011, Advances in experimental medicine and biology.

Sphingolipids and the Balancing of Immune Cell Function: Lessons from the Mast Cell

A. Olivera, J. Rivera, 2005, The Journal of Immunology.

Cell Function: Lessons from the Mast Cell Sphingolipids and the Balancing of Immune

A. Olivera, J. Rivera, 2005 .

Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate.

S. Spiegel, Fang Wang, A. Olivera, 1999, Experimental cell research.

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation.

S. Spiegel, A. Olivera, H. Zhang, 1992, The Journal of biological chemistry.

Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production.

G. Bandara, V. Hox, D. Metcalfe, 2015, The Journal of allergy and clinical immunology.

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

J. Lyons, J. Milner, D. Metcalfe, 2019, The Journal of experimental medicine.

Cutting Edge: Persistence of Increased Mast Cell Numbers in Tissues Links Dermatitis to Enhanced Airway Disease in a Mouse Model of Atopy

A. Olivera, J. Rivera, A. Hershko, 2012, The Journal of Immunology.

of Atopy Enhanced Airway Disease in a Mouse Model Cell Numbers in Tissues Links Dermatitis to Cutting Edge: Persistence of Increased Mast

A. Olivera, J. Rivera, A. Hershko, 2011 .

Adenosine induces mesangial cell contraction by an A1-type receptor.

A. Olivera, J. López-Novoa, D. Rodríguez‐Puyol, 1989, Kidney international.

Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production.

L. Birnbaumer, D. Metcalfe, A. Olivera, 2013, Cell calcium.

Sphingosine-1-Phosphate - A New Lipid Signaling Molecule

S. Spiegel, O. Cuvillier, A. Olivera, 1996 .

Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle‐ and exosome‐like populations of KIT‐containing extracellular vesicles

D. E. Anderson, J. Zimmerberg, D. Metcalfe, 2022, Journal of extracellular vesicles.

PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability.

K. Tinsley, A. Olivera, J. Rivera, 2011, Blood.

Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells.

D. Metcalfe, A. Olivera, Yuzhi Yin, 2021, The Journal of allergy and clinical immunology.

A current understanding of FcɛRI-dependent mast cell activation

A. Olivera, J. Rivera, 2008 .

Cutting Edge: Lentiviral Short Hairpin RNA Silencing of PTEN in Human Mast Cells Reveals Constitutive Signals That Promote Cytokine Secretion and Cell Survival1

R. Casellas, K. Taira, M. Miyagishi, 2006, The Journal of Immunology.

IgE-dependent Activation of Sphingosine Kinases 1 and 2 and Secretion of Sphingosine 1-Phosphate Requires Fyn Kinase and Contributes to Mast Cell Responses*

R. Proia, A. Olivera, J. Rivera, 2006, Journal of Biological Chemistry.

Cytokine Secretion and Cell Survival Reveals Constitutive Signals That Promote Silencing of PTEN in Human Mast Cells Cutting Edge: Lentiviral Short Hairpin RNA

R. Casellas, K. Taira, M. Miyagishi, 2006 .

CRITICAL SIGNALING EVENTS IN THE MECHANOACTIVATION OF HUMAN MAST CELLS VIA P.C492Y-ADGRE2.

G. Bandara, D. Kastner, D. Metcalfe, 2020, The Journal of investigative dermatology.

Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.

S. Spiegel, A. Olivera, N. E. Buckley, 1992, The Journal of biological chemistry.

Actions of cyclosporin A on cultured rat mesangial cells.

A. Olivera, J. López-Novoa, D. Rodríguez‐Puyol, 1989, Kidney international.

Sphingosine kinase: a mediator of vital cellular functions.

S. Spiegel, A. Olivera, 2001, Prostaglandins & other lipid mediators.

Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases.

S. Spiegel, A. Olivera, J. Rosenthal, 1994, Analytical biochemistry.

Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.

S. Spiegel, A. Olivera, R. Schmidt, 1994, The Journal of biological chemistry.

Atrial natriuretic peptide and cGMP inhibit Na+/H+ antiporter in vascular smooth muscle cells in culture.

V. Briner, A. Olivera, K. Okada, 1994, Kidney international.

Assaying sphingosine kinase activity.

S. Spiegel, A. Olivera, K. Barlow, 2000, Methods in Enzymology.

Chromogranin A is not a biomarker of mastocytosis.

D. Metcalfe, A. Olivera, I. Maric, 2017, The journal of allergy and clinical immunology. In practice.

Atrial natriuretic peptide inhibits angiotensin II-induced contraction of isolated glomeruli and cultured glomerular mesangial cells of rats: the role of calcium.

A. Olivera, J. López-Novoa, D. Rodríguez‐Puyol, 1988, The Journal of laboratory and clinical medicine.

Sphingosine kinase. Assay and product analysis.

S. Spiegel, A. Olivera, 1998, Methods in molecular biology.

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation.

H. Kong, S. Holland, K. Stone, 2013, The Journal of allergy and clinical immunology.

Vibratory Urticaria Associated with a Missense Variant in ADGRE2.

K. Kidd, J. Mullikin, A. Pakstis, 2016, The New England journal of medicine.

Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2

G. Bandara, D. Kastner, D. Metcalfe, 2020 .

Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts

S. Spiegel, G. Brooker, A. Olivera, 1993, The Journal of cell biology.

The role of sphingosine in cell growth regulation and transmembrane signaling.

S. Spiegel, A. Olivera, R. Carlson, 1993, Advances in lipid research.

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

S. Spiegel, A. Olivera, 1993, Nature.

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

S. Spiegel, T. Hla, O. Cuvillier, 1998, The Journal of cell biology.

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

S. Spiegel, G. Brooker, A. Olivera, 1991, The Journal of cell biology.

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase*

S. Spiegel, A. Olivera, T. Kohama, 1998, The Journal of Biological Chemistry.

Purification and Characterization of Rat Kidney Sphingosine Kinase*

S. Milstien, S. Spiegel, A. Olivera, 1998, The Journal of Biological Chemistry.

Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications.

D. Metcalfe, A. Olivera, A. Pfeiffer, 2020, Pharmacology & therapeutics.

Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice.

A. Bielawska, C. Deng, R. Proia, 2007, The Journal of clinical investigation.

Essential Role for Sphingosine Kinases in Neural and Vascular Development

R. Proia, S. Spiegel, A. Olivera, 2005, Molecular and Cellular Biology.

Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells

S. Spiegel, A. Olivera, E. Thompson, 2004, Breast Cancer Research and Treatment.

Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

G. Bandara, Ho Min Kim, D. Metcalfe, 2021, Nature Communications.

Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis

G. Bandara, D. Metcalfe, A. Olivera, 2016, PloS one.

EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

J. P. Hobson, S. Milstien, S. Spiegel, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

New insights on mast cell activation via the high affinity receptor for IgE.

A. Olivera, J. Rivera, R. Suzuki, 2008, Advances in immunology.

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis.

V. Hox, S. Holland, D. Tweardy, 2016, The Journal of allergy and clinical immunology.

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

S. Spiegel, O. Cuvillier, A. Olivera, 1999, The Journal of cell biology.

Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production

G. Bandara, D. Metcalfe, A. Olivera, 2020, Haematologica.

Reply: To PMID 25553642.

V. Hox, D. Metcalfe, A. Olivera, 2015, The Journal of allergy and clinical immunology.

Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT

G. Bandara, D. Metcalfe, A. Olivera, 2018, Front. Immunol..

Overview of Mast Cells in Human Biology

D. Metcalfe, A. Olivera, Do-Kyun Kim, 2019 .

Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors*

S. Milstien, S. Spiegel, J. Chun, 2003, Journal of Biological Chemistry.

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

J. P. Hobson, M. Caron, S. Milstien, 2001, Science.

Sphingosine-1-Phosphate: A Lipid Second Messenger Regulating Cell Growth and Survival

S. Spiegel, O. Cuvillier, A. Olivera, 1998 .

Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins

S. Spiegel, A. Olivera, V. Ruíz-Gutiérrez, 2003, Cellular and Molecular Life Sciences CMLS.

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death a

S. Spiegel, G. Pirianov, O. Cuvillier, 1998, Annals of the New York Academy of Sciences.

Effect of acidic phospholipids on sphingosine kinase

S. Spiegel, A. Olivera, J. Rosenthal, 1996, Journal of cellular biochemistry.

Platelet‐derived growth factor‐induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ

S. Spiegel, A. Kazlauskas, A. Olivera, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation

G. Bandara, D. Metcalfe, A. Olivera, 2018, Proceedings of the National Academy of Sciences.

an A1-type receptor

A. Olivera, D. Rodríguez‐Puyol, S. Lamas, 1989 .

Effect of adenosine A1 and A2 agonists and antagonists on cAMP and Ca2+ in cultured rat mesangial cells.

A. Olivera, J. López-Novoa, M. Tomas, 1992, The American journal of physiology.

Atrial Natriuretic Peptide

A. Olivera, A Olivera, J M López Novoa, 1986, The Lancet.

Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase

A. Olivera, J. Rivera, A. Billich, 2004, Molecular and Cellular Biology.

An optimized protocol for the generation and functional analysis of human mast cells from CD34+ enriched cell populations.

D. Metcalfe, A. Olivera, Yuzhi Yin, 2017, Journal of immunological methods.

Interrogation of sphingosine-1-phosphate receptor 2 function in vivo reveals a prominent role in the recovery from IgE and IgG-mediated anaphylaxis with minimal effect on its onset.

A. Olivera, J. Rivera, Sandra E. Dillahunt, 2013, Immunology letters.

Activated mast cells synthesize and release soluble ST2‐a decoy receptor for IL‐33

G. Bandara, D. Metcalfe, A. Olivera, 2015, European journal of immunology.

A current understanding of Fc epsilon RI-dependent mast cell activation.

A. Olivera, J. Rivera, 2008, Current allergy and asthma reports.

Loss of TRPC1‐mediated Ca2+ influx contributes to impaired degranulation in Fyn‐deficient mouse bone marrow‐derived mast cells

A. Olivera, J. Rivera, Xibao Liu, 2010, Journal of leukocyte biology.

Adenosine stimulates Ca2+ fluxes and increases cytosolic free Ca2+ in cultured rat mesangial cells.

A. López-Rivas, A. Olivera, J. López-Novoa, 1992, The Biochemical journal.

Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate--caged SPP.

S. Spiegel, A. Olivera, L. Qiao, 1998, Bioorganic & medicinal chemistry letters.

Interaction of DJ‐1 with Lyn is essential for IgE‐mediated stimulation of human mast cells

D. Metcalfe, A. Olivera, M. Beaven, 2017, The Journal of allergy and clinical immunology.

Aldh2 Attenuates Stem Cell Factor/Kit-Dependent Signaling and Activation in Mast Cells

T. Kawamoto, D. Metcalfe, A. Olivera, 2019, International journal of molecular sciences.

S1P4 Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells

R. Proia, D. Metcalfe, A. Olivera, 2018, International journal of molecular sciences.

Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms.

G. Cruse, D. Metcalfe, A. Olivera, 2014, Immunology and allergy clinics of North America.

Research advances in mast cell biology and their translation into novel therapies for anaphylaxis.

D. Metcalfe, A. Olivera, M. Dispenza, 2023, The journal of allergy and clinical immunology. In practice.

An optimized protocol for the generation and functional analysis of human mast cells from CD34+ enriched cell populations.

D. Metcalfe, A. Olivera, Yuzhi Yin, 2017, JIM - Journal of Immunological Methods.