Lin-Li Li

发表

Systems Biology Modeling Reveals a Possible Mechanism of the Tumor Cell Death upon Oncogene Inactivation in EGFR Addicted Cancers

Yu-Quan Wei, Shi-Dong Luo, Sheng-Yong Yang, 2011, PloS one.

Discovery of novel mGluR1 antagonists: a multistep virtual screening approach based on an SVM model and a pharmacophore hypothesis significantly increases the hit rate and enrichment factor.

Jian-Ping Zhou, Shan Feng, Lin-Li Li, 2011, Bioorganic & medicinal chemistry letters.

Steered Molecular Dynamics Simulations Reveal the Likelier Dissociation Pathway of Imatinib from Its Targeting Kinases c-Kit and Abl

Lin-Li Li, Yuquan Wei, Sheng-yong Yang, 2009, PloS one.

PhDD: a new pharmacophore-based de novo design method of drug-like molecules combined with assessment of synthetic accessibility.

Sheng-Yong Yang, Lin-Li Li, Sheng-yong Yang, 2010, Journal of molecular graphics & modelling.

Discovery of Novel Bruton’s Tyrosine Kinase Inhibitors Using a Hybrid Protocol of Virtual Screening Approaches Based on SVM Model, Pharmacophore and Molecular Docking

P. Ji, Ze-Rong Wang, Lin-Li Li, 2012, Chemical biology & drug design.

Drug Discovery against Psoriasis: Identification of a New Potent FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor, 1-(4-((1H-Pyrazolo[3,4-d]pyrimidin-4-yl)oxy)-3-fluorophenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea, That Showed Potent Activity in a Psoriatic Animal Model.

Shuang-Jiang Ma, Lin-Li Li, Sheng-yong Yang, 2016, Journal of medicinal chemistry.

Discovery and structure-activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors.

L. Zhong, Shuang-Jiang Ma, Lin-Li Li, 2015, Bioorganic & medicinal chemistry letters.

Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain.

P. Ji, Ze-Rong Wang, Shuang-Jiang Ma, 2011, Bioorganic & medicinal chemistry letters.

Preclinical Evaluation of a Novel Orally Available SRC/Raf/VEGFR2 Inhibitor, SKLB646, in the Treatment of Triple-Negative Breast Cancer

L. Zhong, Lin-Li Li, Yuquan Wei, 2015, Molecular Cancer Therapeutics.

Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors.

Lin-Li Li, Sheng-yong Yang, Chenyu Tian, 2020, Bioorganic & medicinal chemistry letters.

Discovery of 6-phenylimidazo[2,1-b]thiazole derivatives as a new type of FLT3 inhibitors.

Shuang-Jiang Ma, Lin-Li Li, Sheng-yong Yang, 2015, Bioorganic & medicinal chemistry letters.

Structural optimization and structure-activity relationship studies of N-phenyl-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-amine derivatives as a new class of inhibitors of RET and its drug resistance mutants.

Lin-Li Li, Yuquan Wei, Sheng-yong Yang, 2018, European journal of medicinal chemistry.

Structural modification of an EGFR inhibitor that showed weak off-target activity against RET leading to the discovery of a potent RET inhibitor

Ze-Rong Wang, Lin-Li Li, Sheng-yong Yang, 2014, Molecular Diversity.

A Specific Pharmacophore Model of Aurora B Kinase Inhibitors and Virtual Screening Studies Based on it

Shi-Dong Luo, Lin-Li Li, Yuquan Wei, 2009, Chemical biology & drug design.

A novel orally available Syk/Src/Jak2 inhibitor, SKLB-850, showed potent anti-tumor activities in B cell lymphoma (BCL) models

Lin-Li Li, N. Zhang, Xiao Liang, 2017, Oncotarget.

SKLB-677, an FLT3 and Wnt/β-catenin signaling inhibitor, displays potent activity in models of FLT3-driven AML

L. Zhong, Shuang-Jiang Ma, Lin-Li Li, 2015, Scientific Reports.

Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors.

Lin-Li Li, Sheng-yong Yang, Jun Zou, 2017, Bioorganic & medicinal chemistry letters.

A preclinical evaluation of a novel multikinase inhibitor, SKLB‐329, as a therapeutic agent against hepatocellular carcinoma

L. Zhong, Lin-Li Li, Yuquan Wei, 2014, International journal of cancer.

Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis

Lin-Li Li, Rong Xiang, Sheng-Yong Yang, 2017, J. Chem. Inf. Model..

Identification of Novel Anaplastic Lymphoma Kinase (ALK) Inhibitors Using a Common Feature Pharmacophore Model Derived from Known Ligands Crystallized with ALK

You-Li Pan, Ze-Rong Wang, Lin-Li Li, 2013, Chemical biology & drug design.

Structural optimization and structure-activity relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine derivatives, a new class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations.

Yu-Quan Wei, Yong Xu, Ren-Lin Zheng, 2012, Journal of medicinal chemistry.

A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method

Hui Zhang, Lei Zhong, Chang-Ying Ma, 2011, Comput. Biol. Medicine.

Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.

Lin-Li Li, Yuquan Wei, Sheng-yong Yang, 2017, Journal of medicinal chemistry.

A combined molecular docking-based and pharmacophore-based target prediction strategy with a probabilistic fusion method for target ranking.

Yong Xu, Lin-Li Li, Sheng-Yong Yang, 2013, Journal of molecular graphics & modelling.

Pharmacophore modeling and virtual screening for designing potential PLK1 inhibitors.

Shi-Dong Luo, Lin-Li Li, Yuquan Wei, 2008, Bioorganic & medicinal chemistry letters.

Neighbor communities in drug combination networks characterize synergistic effect.

Jun Zou, Pan Ji, Lin-Li Li, 2012, Molecular bioSystems.

Pharmacophore Modeling and Hybrid Virtual Screening for the Discovery of Novel IκB Kinase 2 (IKK2) Inhibitors

Ji-Xia Ren, Huan-Zhang Xie, Ren-Lin Zheng, 2011, Journal of biomolecular structure & dynamics.

Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.

Chuan Cheng, Guo-Bo Li, Ling-Ling Yang, 2013, Journal of medicinal chemistry.

Identification of new p300 histone acetyltransferase inhibitors from natural products by a customized virtual screening method

Lin-Li Li, Sheng-yong Yang, Luyi Huang, 2016 .

Discovery of Novel Pim-1 Kinase Inhibitors by a Hierarchical Multistage Virtual Screening Approach Based on SVM Model, Pharmacophore, and Molecular Docking

Xin Chen, Lin-Li Li, Sheng-Yong Yang, 2011, J. Chem. Inf. Model..

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

Rong Xiang, Shen-Zhen Huang, Sheng-Yong Yang, 2017, Chemical biology & drug design.

ID-Score: A New Empirical Scoring Function Based on a Comprehensive Set of Descriptors Related to Protein-Ligand Interactions

Lin-Li Li, Sheng-Yong Yang, Wen-Jing Wang, 2013, J. Chem. Inf. Model..

RASA: A Rapid Retrosynthesis-Based Scoring Method for the Assessment of Synthetic Accessibility of Drug-like Molecules

Lin-Li Li, Sheng-Yong Yang, Qi Huang, 2011, J. Chem. Inf. Model..

From Lead to Drug Candidate: Optimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer.

L. Zhong, Lin-Li Li, Yuquan Wei, 2016, Journal of medicinal chemistry.

Pharmacophore modeling studies of type I and type II kinase inhibitors of Tie2.

Ji-Xia Ren, Huan-Zhang Xie, Sheng-Yong Yang, 2009, Journal of molecular graphics & modelling.

An integrated scheme for feature selection and parameter setting in the support vector machine modeling and its application to the prediction of pharmacokinetic properties of drugs

Hui Zhang, Chang-Ying Ma, Lin-Li Li, 2009, Artif. Intell. Medicine.

TS‐Chemscore, a Target‐Specific Scoring Function, Significantly Improves the Performance of Scoring in Virtual Screening

Lin-Li Li, Sheng-Yong Yang, Qi Huang, 2015, Chemical biology & drug design.

Rapid and accurate assessment of seizure liability of drugs by using an optimal support vector machine method.

Hui Zhang, Wei Li, Yang Xie, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

A prediction model of drug-induced ototoxicity developed by an optimal support vector machine (SVM) method

Lin-Li Li, Sheng-Yong Yang, Shu Zhou, 2014, Comput. Biol. Medicine.

Design, Synthesis, and Biological Evaluation of 1‐Benzyl‐1H‐pyrazole Derivatives as Receptor Interacting Protein 1 Kinase Inhibitors

Lin-Li Li, Sheng-yong Yang, Luyi Huang, 2016, Chemical biology & drug design.

Structural modification of an EGFR inhibitor that showed weak off-target activity against RET leading to the discovery of a potent RET inhibitor

Ze-Rong Wang, Lin-Li Li, Sheng-yong Yang, 2014, Molecular Diversity.

Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors.

Ji-Xia Ren, Li Yang, Sheng-Yong Yang, 2009, European journal of medicinal chemistry.