S. Ponnusamy

发表

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.

S. Ponnusamy, Marisa Meyers-Needham, C. Senkal, 2010, Future oncology.

Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation.

S. Ponnusamy, B. Ogretmen, J. Baatz, 2009, Journal of molecular biology.

Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer.

Duane D. Miller, Charles B. Duke, L. Selth, 2017, Cancer research.

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

E. Skordalakes, Y. Peterson, E. Garrett-Mayer, 2015, Science Signaling.

Antiapoptotic roles of ceramide‐synthase‐6‐generated C16‐ceramide via selective regulation of the ATF6/ CHOP arm of ER‐stress‐response pathways

Y. Hannun, S. Ponnusamy, C. Senkal, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

Y. Peterson, S. Ponnusamy, C. Senkal, 2012, Nature chemical biology.

Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer

Duane D. Miller, B. Sumpter, V. Bocharova, 2019, Clinical Cancer Research.

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.

L. Obeid, G. Marcucci, D. Perrotti, 2011, Blood.

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl 1 stability and drug resistance by modulation of protein phosphatase 2 A *

L. Obeid, G. Marcucci, D. Perrotti, 2011 .

Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+ and ER/Golgi Membrane Network*

P. Dent, S. Ponnusamy, Marisa Meyers-Needham, 2011, The Journal of Biological Chemistry.

Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies

Chad A. Corcoran, Qin He, M. Sheikh, 2008, Molecular Cancer Research.

Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy

L. Pfeffer, D. Bridges, S. Ponnusamy, 2017, Human molecular genetics.

Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice

S. Ponnusamy, R. Getzenberg, Ryan D. Sullivan, 2017, Journal of cellular biochemistry.

Pharmacologic activation of estrogen receptor α increases mitochondrial function, energy expenditure, and brown adipose tissue.

Duane D. Miller, D. Bridges, J. Dalton, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.

A. Bielawska, Y. Hannun, S. Ponnusamy, 2006, The Biochemical journal.

Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer.

Duane D. Miller, S. Ponnusamy, Michael L Mohler, 2020, Journal of medicinal chemistry.

Rapid Shortening of Telomere Length in Response to Ceramide Involves the Inhibition of Telomere Binding Activity of Nuclear Glyceraldehyde-3-phosphate Dehydrogenase*

Y. Hannun, L. Obeid, S. Ponnusamy, 2004, Journal of Biological Chemistry.

Tricistronic expression of MOAP-1, Bax and RASSF1A in cancer cells enhances chemo-sensitization that requires BH3L domain of MOAP-1

K. Shah, S. Ponnusamy, C. Poh, 2020, Journal of Cancer Research and Clinical Oncology.

Pharmacologic activation of estrogen receptor α increases mitochondrial function, energy expenditure, and brown adipose tissue

Duane D. Miller, D. Bridges, J. Dalton, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Integrin-Linked Kinase Is a Novel Therapeutic Target in Ovarian Cancer

S. Ponnusamy, M. Ulm, P. Blackburn, 2020, Journal of personalized medicine.

An Overview of Next-Generation Androgen Receptor-Targeted Therapeutics in Development for the Treatment of Prostate Cancer

Duane D. Miller, Arunima Sikdar, S. Ponnusamy, 2021, International journal of molecular sciences.

Therapeutic advances in hormone-dependent cancers: focus on prostate, breast and ovarian cancers

H. Sasano, S. Ponnusamy, K. McNamara, 2019, Endocrine connections.

Racial Differences in Androgen Receptor (AR) and AR Splice Variants (AR-SVs) Expression in Treatment-Naïve Androgen-Dependent Prostate Cancer

S. Ponnusamy, J. Fowke, R. Narayanan, 2023, Biomedicines.

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

S. Mehrotra, L. Obeid, S. Ponnusamy, 2012, EMBO molecular medicine.

Exploration and Biological Evaluation of Basic Heteromonocyclic Propanamide Derivatives as SARDs for the Treatment of Enzalutamide-Resistant Prostate Cancer.

Duane D. Miller, S. Ponnusamy, Michael L Mohler, 2021, Journal of medicinal chemistry.

Potent Antitumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or in Combination with Gemcitabine against Human Head and Neck Squamous Cell Carcinomas in Vitro and in Vivo

A. Bielawska, Y. Hannun, D. Sinha, 2006, Journal of Pharmacology and Experimental Therapeutics.

Potent Anti-Tumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or In Combination with Gemcitabine Against Human Head and Neck Squamous Cell Carcinomas In vitro and In vivo

A. Bielawska, Y. Hannun, D. Sinha, 2006 .

ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers

Jiong Wu, S. Ponnusamy, Wei Wang, 2020, Nature Communications.

Regulation of Telomere Length by Fatty Acid Elongase 3 in Yeast

S. Snyder, S. Jazwinski, S. Ponnusamy, 2008, Journal of Biological Chemistry.

Novel, isoform-selective, cholecystokinin A receptor antagonist inhibits colon and pancreatic cancers in preclinical models through novel mechanism of action.

S. Ponnusamy, R. Narayanan, T. Thiyagarajan, 2016, Oncology reports.

Destroying the androgen receptor (AR)-potential strategy to treat advanced prostate cancer

Duane D. Miller, S. Ponnusamy, R. Narayanan, 2017, Oncoscience.

Direct interaction between the inhibitor 2 and ceramide via sphingolipid‐protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

R. Sears, S. Ponnusamy, C. Senkal, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

Y. Hannun, S. Jazwinski, S. Ponnusamy, 2007, Molecular Cancer Therapeutics.

Androgen Receptor Is a Non-canonical Inhibitor of Wild-Type and Mutant Estrogen Receptors in Hormone Receptor-Positive Breast Cancers

Henry W. Long, E. Petricoin, H. Sasano, 2019, iScience.

New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity.

Duane D. Miller, I. McEwan, S. Ponnusamy, 2018, Journal of medicinal chemistry.

Metabolism-Guided Selective Androgen Receptor Antagonists: Design, Synthesis, and Biological Evaluation for Activity against Enzalutamide-Resistant Prostate Cancer.

Duane D. Miller, S. Ponnusamy, Michael L Mohler, 2023, Journal of Medicinal Chemistry.

Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells

S. Ponnusamy, Marisa Meyers-Needham, C. Senkal, 2012, EMBO molecular medicine.

An estrogen receptor β-selective agonist inhibits non-alcoholic steatohepatitis in preclinical models by regulating bile acid and xenobiotic receptors

Duane D. Miller, D. Bridges, S. Ponnusamy, 2017, Experimental biology and medicine.

Inhibiting androgen receptor splice variants with cysteine-selective irreversible covalent inhibitors to treat prostate cancer

Duane D. Miller, E. Petricoin, L. Pfeffer, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Alteration of Ceramide Synthase 6/C 16 -Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of

P. Dent, S. Ponnusamy, Marisa Meyers-Needham, 2011 .

Synthesis and properties of α‐Fe2O3 nanorods

K. Ashok, C. Muthamizhchelvan, S. Ponnusamy, 2010 .

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

E. Skordalakes, Y. Peterson, E. Garrett-Mayer, 2015, Science Signaling.

Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies

Chad A. Corcoran, Qin He, M. Sheikh, 2008, Molecular Cancer Research.

N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO

Chengqi Yi, Tao Pan, Chuan He, 2011, Nature chemical biology.