C. Senkal

发表

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.

S. Ponnusamy, Marisa Meyers-Needham, C. Senkal, 2010, Future oncology.

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis

P. Howe, C. Senkal, B. Ogretmen, 2017, Science Signaling.

Thermal Fluid Flow Transport Characteristics in Confined Channels With Two-Dimensional Dual Jet Impingement

S. Torii, C. Senkal, 2011 .

Thermal fluid flow transport characteristics in nanofluid jet array impingement

S. Torii, C. Senkal, 2015 .

Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation

M. Maceyka, S. Milstien, S. Spiegel, 2020, The Journal of Biological Chemistry.

Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas*

Y. Hannun, L. Obeid, S. Jazwinski, 2004, Journal of Biological Chemistry.

Antiapoptotic roles of ceramide‐synthase‐6‐generated C16‐ceramide via selective regulation of the ATF6/ CHOP arm of ER‐stress‐response pathways

Y. Hannun, S. Ponnusamy, C. Senkal, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for Monitoring Response

Y. Hannun, M. B. Gillespie, C. Senkal, 2011, Clinical Cancer Research.

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

Y. Peterson, S. Ponnusamy, C. Senkal, 2012, Nature chemical biology.

Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets.

Y. Hannun, A. Koller, L. Obeid, 2017, Cell metabolism.

Decreased ceramide underlies mitochondrial dysfunction in Charcot‐Marie‐Tooth 2F

Y. Hannun, L. Obeid, C. Senkal, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death*

Y. Hannun, L. Obeid, C. Senkal, 2015, Journal of Biological Chemistry.

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.

L. Obeid, G. Marcucci, D. Perrotti, 2011, Blood.

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl 1 stability and drug resistance by modulation of protein phosphatase 2 A *

L. Obeid, G. Marcucci, D. Perrotti, 2011 .

phosphatase 2A Bcr-Abl1 stability and drug resistance by modulation of protein Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate

L. Obeid, G. Marcucci, D. Perrotti, 2011 .

Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+ and ER/Golgi Membrane Network*

P. Dent, S. Ponnusamy, Marisa Meyers-Needham, 2011, The Journal of Biological Chemistry.

A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

M. Cabot, E. Bernhard, S. Jazwinski, 2009, PloS one.

Protein Kinase C-induced Activation of a Ceramide/Protein Phosphatase 1 Pathway Leading to Dephosphorylation of p38 MAPK*

Y. Hannun, L. Obeid, C. Senkal, 2006, Journal of Biological Chemistry.

Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking

S. Milstien, S. Spiegel, D. Ford, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Sustained PKCβII activity confers oncogenic properties in a phospholipase D‐ and mTOR‐dependent manner

Y. Hannun, L. Obeid, C. Senkal, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.

A. Bielawska, Y. Hannun, S. Ponnusamy, 2006, The Biochemical journal.

Alterations of Ceramide/Sphingosine 1-Phosphate Rheostat Involved in the Regulation of Resistance to Imatinib-induced Apoptosis in K562 Human Chronic Myeloid Leukemia Cells*

L. Obeid, C. Senkal, Arelis Salas, 2007, Journal of Biological Chemistry.

Sphingolipids in the Pathogenesis of Head and Neck and Lung Cancers: Translational Aspects for Therapy and Biomarker Development

L. Obeid, C. Senkal, 2015 .

Sphingolipids in mitochondria.

L. Obeid, C. Senkal, D. Canals, 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

Y. Peterson, D. Perrotti, E. Garrett-Mayer, 2012, EMBO molecular medicine.

Targeting Sphingosine Kinase Induces Apoptosis and Tumor Regression for KSHV-Associated Primary Effusion Lymphoma

L. Del Valle, C. Senkal, B. Ogretmen, 2013, Molecular Cancer Therapeutics.

Cancer Biology and Signal Transduction Targeting Sphingosine Kinase Induces Apoptosis and Tumor Regression for KSHV-Associated Primary Effusion Lymphoma

C. Senkal, B. Ogretmen, Z. Qin, 2013 .

Potent Antitumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or in Combination with Gemcitabine against Human Head and Neck Squamous Cell Carcinomas in Vitro and in Vivo

A. Bielawska, Y. Hannun, D. Sinha, 2006, Journal of Pharmacology and Experimental Therapeutics.

Potent Anti-Tumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or In Combination with Gemcitabine Against Human Head and Neck Squamous Cell Carcinomas In vitro and In vivo

A. Bielawska, Y. Hannun, D. Sinha, 2006 .

Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways

P. A. Young, R. Coleman, L. Obeid, 2018, The Journal of Biological Chemistry.

Mechanisms of ceramide‐mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

C. Senkal, B. Ogretmen, Besim Ogretmen, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells

P. Lu, L. Obeid, C. Senkal, 2008, Oncogene.

Direct interaction between the inhibitor 2 and ceramide via sphingolipid‐protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

R. Sears, S. Ponnusamy, C. Senkal, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

Y. Hannun, S. Jazwinski, S. Ponnusamy, 2007, Molecular Cancer Therapeutics.

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.

Y. Hannun, D. Sinha, M. B. Gillespie, 2007, Cancer letters.

A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis

E. Furth, L. Obeid, C. Senkal, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Ceramide synthase 2‐C24:1‐ceramide axis limits the metastatic potential of ovarian cancer cells

Y. Hannun, W. Sakamoto, N. Yaegashi, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Y. Hannun, M. García-Díaz, L. Obeid, 2017, Proceedings of the National Academy of Sciences.

Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells

S. Ponnusamy, Marisa Meyers-Needham, C. Senkal, 2012, EMBO molecular medicine.

Targeting I2PP2A by FTY720: A novel, mechanism-based treatment strategy for patients with advanced and previously treated non-small cell lung cancer (NSCLC).

Y. Hannun, Y. Peterson, D. Perrotti, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Alteration of Ceramide Synthase 6/C 16 -Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of

P. Dent, S. Ponnusamy, Marisa Meyers-Needham, 2011 .

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death*

Y. Hannun, L. Obeid, C. Senkal, 2015, The Journal of Biological Chemistry.

The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation

L. Obeid, C. Senkal, Grace R Mavodza, 2023, Cell reports.