B. Ogretmen

A. Bielawska, Y. Hannun, L. Obeid, 2005, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.

M. Caligiuri, O. Abdel-Wahab, R. Levine, 2013, Blood.

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

D. Häussinger, P. Dent, A. Yacoub, 2010, Molecular Cancer Therapeutics.

Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells

G. Hardiman, M. Nishimura, S. Mehrotra, 2019, The Journal of Biological Chemistry.

Down‐regulation of apoptosis‐related bcl‐2 but not bcl‐xL or bax proteins in multidrug‐resistant MCF‐7/Adr human breast cancer cells

B. Ogretmen, A. Safa, 1996, International journal of cancer.

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.

L. Obeid, G. Marcucci, D. Perrotti, 2011, Blood.

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl 1 stability and drug resistance by modulation of protein phosphatase 2 A *

L. Obeid, G. Marcucci, D. Perrotti, 2011 .

phosphatase 2A Bcr-Abl1 stability and drug resistance by modulation of protein Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate

L. Obeid, G. Marcucci, D. Perrotti, 2011 .

Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.

Jin H. Song, E. Garrett-Mayer, B. Ogretmen, 2014, Blood.

Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+ and ER/Golgi Membrane Network*

P. Dent, S. Ponnusamy, Marisa Meyers-Needham, 2011, The Journal of Biological Chemistry.

Sphingosine Kinase-2 Maintains Viral Latency and Survival for KSHV-Infected Endothelial Cells

B. Ogretmen, Z. Qin, Charles D Smith, 2014, PloS one.

Ceramide induced mitophagy and tumor suppression.

B. Ogretmen, M. Dany, 2015, Biochimica et biophysica acta.

Comparative analysis of antibodies to SARS-CoV-2 between asymptomatic and convalescent patients

S. Mehrotra, P. Howe, B. Ogretmen, 2021, iScience.

LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria

A. Bielawska, P. Lu, B. Ogretmen, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Primary Human Glioblastoma Multiforme Cells Induced Killing of −-7 / IL-24 mda Thioredoxin Play a Key Role in Dependent Regulation of Ceramide Synthase 6 and −

P. Fisher, S. Spiegel, P. Dent, 2010 .

Co‐ordinated over‐expression of the MRP and γ‐glutamylcysteine synthetase genes, but not MRD1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines

Mark R. Green, B. Ogretmen, A. Safa, 1998, International journal of cancer.

A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis

M. Cabot, E. Bernhard, S. Jazwinski, 2009, PloS one.

Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies

Chad A. Corcoran, Qin He, M. Sheikh, 2008, Molecular Cancer Research.

A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors

Y. Zhuang, M. Thomas, C. Britten, 2017, Clinical Cancer Research.

Protein Kinase C-induced Activation of a Ceramide/Protein Phosphatase 1 Pathway Leading to Dephosphorylation of p38 MAPK*

Y. Hannun, L. Obeid, C. Senkal, 2006, Journal of Biological Chemistry.

Polyploid giant cancer cells are dependent on cholesterol for progeny formation through amitotic division

P. Mulholland, B. Ogretmen, Alexis D. Stamatikos, 2022, Scientific Reports.

Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance.

B. Ogretmen, S. Selvam, 2013, Handbook of experimental pharmacology.

Plasma Sphingolipids and Lung Cancer: A Population-Based, Nested Case–Control Study

A. Bielawska, A. Alberg, E. Hill, 2013, Cancer Epidemiology, Biomarkers & Prevention.

A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels

P. Fisher, S. Spiegel, P. Dent, 2011, Molecular Pharmacology.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer Treatment

B. Ogretmen, Alhaji H. Janneh, Alhaji H Janneh, 2022, Cancers.

Sphingolipid metabolism in T cell responses after allogeneic hematopoietic cell transplantation

B. Ogretmen, Brian Y Chung, Xue-Zhong Yu, 2022, Frontiers in Immunology.

Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6

S. Olsen, E. Wasmuth, B. Ogretmen, 2022, Nature Communications.

FAS Activation Induces Dephosphorylation of SR Proteins DEPENDENCE ON THE DE NOVO GENERATION OF CERAMIDE AND ACTIVATION OF PROTEIN PHOSPHATASE 1*

Y. Hannun, B. Kroesen, C. Chalfant, 2001 .

Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia.

B. Ogretmen, A. Safa, J. Barredo, 2000, Journal of pediatric hematology/oncology.

Dietary Folic Acid Alters Metabolism of Multiple Vitamins in a CerS6- and Sex-Dependent Manner

B. Ogretmen, N. Krupenko, Keri Barron, 2021, Frontiers in Nutrition.

Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.

D. Fairlie, B. Ogretmen, C. Atkinson, 2018, JCI insight.

L-threo-C6-pyridinium-ceramide Bromide, a Novel Cationic Ceramide, Induces NADPH Oxidase Activation, Mitochondrial Dysfunction and Loss in Cell Viability in INS 832/13 β-cells

A. Kowluru, B. Ogretmen, Z. Szulc, 2012, Cellular Physiology and Biochemistry.

Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant

B. Ogretmen, A. Safa, Ching-Huang Wu, 2002, Oncogene.

Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease.

S. Mehrotra, N. Maulik, B. Ogretmen, 2019, The Journal of clinical investigation.

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis

Y. Peterson, B. Ogretmen, R. Stahelin, 2018, The Journal of Biological Chemistry.

Effects of sodium saccharin and linoleic acid on mRNA levels of Her2/neu and p53 in a human breast epithelial cell line.

S. Gendel, B. Ogretmen, B. Stark, 1996, Cancer letters.

S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission

S. Mehrotra, B. Ogretmen, M. Sofi, 2022, Cellular & Molecular Immunology.

Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress

Roger H. Johnson, B. Ogretmen, J. Lemasters, 2019, Science Advances.

Immunoprecipitation of human telomerase reverse transcriptase with telomerase activity.

L. Obeid, B. Ogretmen, J. Kraveka, 2001, Analytical biochemistry.

Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.

A. Bielawska, Y. Hannun, S. Ponnusamy, 2006, The Biochemical journal.

Role of Ceramide in Mediating the Inhibition of Telomerase Activity in A549 Human Lung Adenocarcinoma Cells*

Y. Hannun, L. Obeid, Y. Hannun, 2001, The Journal of Biological Chemistry.

Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK Pathway

H. Stark, S. Mehrotra, B. Ogretmen, 2022, Leukemia.

Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation

B. Ogretmen, J. Bielawski, Y. Baran, 2011, Journal of Cancer Research and Clinical Oncology.

De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells

Y. Hannun, L. Obeid, C. Chalfant, 2002, The Journal of Biological Chemistry.

Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

Y. Peterson, S. Mehrotra, B. Ogretmen, 2022, Cell reports.

A Role of Sphingosine Kinase 1 in head & neck carcinogenesis

Y. Hannun, L. Obeid, B. Ogretmen, 2010 .

Ceramide synthase 6 (CerS6) promotes alcohol-induced fatty liver by promoting metabolic dysfunction and upregulating lipid droplet-associated proteins

B. Ogretmen, R. Carr, E. Scorletti, 2022, bioRxiv.

Solenopsin A and analogs exhibit ceramide-like biological activity

J. Arbiser, Jin Zhang, J. P. Bowen, 2015, Vascular cell.

Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region.

B. Ogretmen, A. Safa, 1999, Biochemistry.

Sphingolipid metabolism in cancer signalling and therapy

B. Ogretmen, Besim Ogretmen, 2017, Nature Reviews Cancer.

Salivary gland neoplasms

M. B. Gillespie, B. Ogretmen, T. Day, 2004, Current treatment options in oncology.

Roles of bioactive sphingolipids in cancer biology and therapeutics.

S. Saddoughi, B. Ogretmen, P. Song, 2008, Sub-cellular biochemistry.

Sphingolipids in cancer: Regulation of pathogenesis and therapy

B. Ogretmen, 2006, FEBS letters.

Alterations of Ceramide/Sphingosine 1-Phosphate Rheostat Involved in the Regulation of Resistance to Imatinib-induced Apoptosis in K562 Human Chronic Myeloid Leukemia Cells*

L. Obeid, C. Senkal, Arelis Salas, 2007, Journal of Biological Chemistry.

Biologically active sphingolipids in cancer pathogenesis and treatment

Yusuf A. Hannun, Y. Hannun, B. Ogretmen, 2004, Nature Reviews Cancer.

Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells*

A. Bielawska, Y. Hannun, L. Obeid, 2007, Journal of Biological Chemistry.

Cystic Fibrosis Transmembrane Regulator Regulates Uptake of Sphingoid Base Phosphates and Lysophosphatidic Acid

Y. Hannun, L. Obeid, B. Ogretmen, 2001, The Journal of Biological Chemistry.

Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

B. Ogretmen, Wing-Kee Lee, F. Thévenod, 2021, The Journal of biological chemistry.

FAS Activation Induces Dephosphorylation of SR Proteins

Y. Hannun, B. Kroesen, C. Chalfant, 2001, The Journal of Biological Chemistry.

The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy

B. Ogretmen, M. Sheridan, 2021, Cancers.

Autophagy paradox and ceramide.

B. Ogretmen, Wen-hui Jiang, 2014, Biochimica et biophysica acta.

Rapid Shortening of Telomere Length in Response to Ceramide Involves the Inhibition of Telomere Binding Activity of Nuclear Glyceraldehyde-3-phosphate Dehydrogenase*

Y. Hannun, L. Obeid, S. Ponnusamy, 2004, Journal of Biological Chemistry.

Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance.

Y. Hannun, B. Ogretmen, Y. Hannun, 2001, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells.

L. Obeid, B. Ogretmen, J. Bielawski, 2003, Archives of biochemistry and biophysics.

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

Y. Peterson, D. Perrotti, E. Garrett-Mayer, 2012, EMBO molecular medicine.

Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line*

Y. Hannun, L. Obeid, B. Ogretmen, 2001, The Journal of Biological Chemistry.

The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020

B. Ogretmen, T. Day, Anand K. Sharma, 2020, Cancers.

HPV/E7 induces chemotherapy‐mediated tumor suppression by ceramide‐dependent mitophagy

B. Ogretmen, Jisun Kim, Z. Szulc, 2017, EMBO molecular medicine.

Sp1/Sp3-dependent Regulation of Human Telomerase Reverse Transcriptase Promoter Activity by the Bioactive Sphingolipid Ceramide*

B. Ogretmen, Leslie G Wooten, 2005, Journal of Biological Chemistry.

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing

P. Dent, A. Yacoub, S. Grant, 2012, Cancer biology & therapy.

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.

P. Fisher, S. Spiegel, D. Häussinger, 2010, Cancer research.

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

S. Mehrotra, L. Obeid, S. Ponnusamy, 2012, EMBO molecular medicine.

Targeting Sphingosine Kinase Induces Apoptosis and Tumor Regression for KSHV-Associated Primary Effusion Lymphoma

L. Del Valle, C. Senkal, B. Ogretmen, 2013, Molecular Cancer Therapeutics.

Cancer Biology and Signal Transduction Targeting Sphingosine Kinase Induces Apoptosis and Tumor Regression for KSHV-Associated Primary Effusion Lymphoma

C. Senkal, B. Ogretmen, Z. Qin, 2013 .

Potent Antitumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or in Combination with Gemcitabine against Human Head and Neck Squamous Cell Carcinomas in Vitro and in Vivo

A. Bielawska, Y. Hannun, D. Sinha, 2006, Journal of Pharmacology and Experimental Therapeutics.

Potent Anti-Tumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or In Combination with Gemcitabine Against Human Head and Neck Squamous Cell Carcinomas In vitro and In vivo

A. Bielawska, Y. Hannun, D. Sinha, 2006 .

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.

M. Caligiuri, J. Byrd, C. Croce, 2013, The Journal of clinical investigation.

Lack of correlation of MRP and γ-glutamylcysteine synthetase overexpression with doxorubicin resistance due to increased apoptosis in SV40 large T-antigen-transformed human mesothelial cells

Mark R. Green, B. Ogretmen, A. Safa, 1998, Cancer Chemotherapy and Pharmacology.

Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells

P. Lu, B. Ogretmen, J. Norris, 2021, Cancers.

Mechanisms of ceramide‐mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

C. Senkal, B. Ogretmen, Besim Ogretmen, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulation of Telomere Length by Fatty Acid Elongase 3 in Yeast

S. Snyder, S. Jazwinski, S. Ponnusamy, 2008, Journal of Biological Chemistry.

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells

P. Lu, L. Obeid, C. Senkal, 2008, Oncogene.

Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling

S. Spiegel, P. Dent, S. Grant, 2012, Cancer biology & therapy.

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

A. Bass, Kwok-Kin Wong, A. Rustgi, 2019, Nature Communications.

CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.

G. Hardiman, K. Helke, M. Nishimura, 2018, Cell metabolism.

Depletion of COPI in cancer cells: the role of reactive oxygen species in the induction of lipid accumulation, noncanonical lipophagy and apoptosis

B. Ogretmen, M. Shtutman, G. Piroli, 2022, Molecular biology of the cell.

Mechanisms of Ceramide-Dependent Cancer Cell Death.

B. Ogretmen, N. Oleinik, Rose Nganga, 2018, Advances in cancer research.

Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells

P. Fisher, P. Dent, S. Grant, 2013, Cancer biology & therapy.

The NMR‐based characterization of the FTY720‐SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET‐PP2A interaction

Y. Peterson, B. Ogretmen, Yitong Li, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Direct interaction between the inhibitor 2 and ceramide via sphingolipid‐protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

R. Sears, S. Ponnusamy, C. Senkal, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

Y. Hannun, S. Jazwinski, S. Ponnusamy, 2007, Molecular Cancer Therapeutics.

Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

Michael J. Zilliox, M. Zilliox, S. Mehrotra, 2019, Cell reports.

Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.

Y. Hannun, D. Sinha, M. B. Gillespie, 2007, Cancer letters.

Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients

S. Mehrotra, B. Ogretmen, P. Chakraborty, 2021, Scientific Reports.

Folate Stress Induces Apoptosis via p53-dependent de Novo Ceramide Synthesis and Up-regulation of Ceramide Synthase 6*

B. Ogretmen, S. Krupenko, Besim Ogretmen, 2013, The Journal of Biological Chemistry.

Site-directed mutagenesis by unique site elimination using filamentous phage-derived ssDNA templates for plasmids that are resistant to denaturation.

B. Ogretmen, A. Safa, C. Carpo, 1996, BioTechniques.

Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer

B. Ogretmen, V. Palanisamy, C. Atkinson, 2018, PloS one.

Effects of staining of RNA with ethidium bromide before electrophoresis on performance of northern blots.

S. Gendel, B. Ogretmen, B. Stark, 1993, BioTechniques.

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

A. Bass, Kwok-Kin Wong, A. Rustgi, 2019, Nature Communications.

mTOR inhibitor use in head and neck squamous cell carcinoma: A meta‐analysis on survival, tumor response, and toxicity

B. Ogretmen, C. Nathan, T. Day, 2020, Laryngoscope investigative otolaryngology.

Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer

U. McDermott, S. Buczacki, J. Parsons, 2020, Cells.

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress*

B. Ogretmen, S. Krupenko, N. Krupenko, 2016, The Journal of Biological Chemistry.

Molecular mechanisms of loss of beta 2-microglobulin expression in drug-resistant breast cancer sublines and its involvement in drug resistance.

B. Ogretmen, A. Safa, M. McCauley, 1998, Biochemistry.

Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells

S. Ponnusamy, Marisa Meyers-Needham, C. Senkal, 2012, EMBO molecular medicine.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Targeting I2PP2A by FTY720: A novel, mechanism-based treatment strategy for patients with advanced and previously treated non-small cell lung cancer (NSCLC).

Y. Hannun, Y. Peterson, D. Perrotti, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas

M. Korbelik, B. Ogretmen, A. Tarca, 2009, British Journal of Cancer.

A Role of Sphingosine Kinase 1 in Head and Neck Carcinogenesis

Y. Hannun, L. Obeid, B. Ogretmen, 2011, Cancer Prevention Research.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

Alteration of Ceramide Synthase 6/C 16 -Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of

P. Dent, S. Ponnusamy, Marisa Meyers-Needham, 2011 .

Mini-preparation of total RNA for RT-PCR from cultured human cells.

B. Ogretmen, A. Safa, 1995, BioTechniques.

Diverse functions of ceramide in cancer cell death and proliferation.

S. Saddoughi, B. Ogretmen, 2013, Advances in cancer research.

Alterations of lipid‐mediated mitophagy result in aging‐dependent sensorimotor defects

B. Ogretmen, J. Kurtz, Z. Szulc, 2023, Aging Cell.

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

E. Skordalakes, Y. Peterson, E. Garrett-Mayer, 2015, Science Signaling.

Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3

K. Helke, B. Ogretmen, Charles D Smith, 2018, The Journal of Biological Chemistry.

Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.

D. Fairlie, B. Ogretmen, C. Atkinson, 2018, JCI insight.

PlasmaSphingolipidsandLungCancer:APopulation-Based,

A. Bielawska, A. Alberg, E. Hill, 2013 .

Transcriptome analysis of polyploid giant cancer cells and their progeny reveals a functional role for p21 in polyploidization and depolyploidization

B. Ogretmen, J. Delaney, S. White-Gilbertson, 2024, The Journal of biological chemistry.

Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies

Chad A. Corcoran, Qin He, M. Sheikh, 2008, Molecular Cancer Research.

Sphingolipid metabolism and complement signaling in cancer progression.

B. Ogretmen, S. Tomlinson, Alhaji H Janneh, 2023, Trends in cancer.

Sphingosine-1-Phosphate Inhibition Increases Endoplasmic Reticulum Stress to Enhance Oxaliplatin Sensitivity in Pancreatic Cancer

B. Ogretmen, Harinarayanan Janakiraman, Zachary Gao, 2024, World journal of oncology.

p17/C18-ceramide–mediated mitophagy is an endogenous neuroprotective response in preclinical and clinical brain injury

B. Ogretmen, Habeeb Alsudani, B. Berber, 2024, PNAS nexus.

Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor, in relapsed and/or refractory multiple myeloma

S. Tuchman, B. Ogretmen, Charles D Smith, 2022, Annals of Hematology.

Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response

B. Ogretmen, B. Howley, S. Gencer, 2024, Cell reports.

H2S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T cell immunotherapeutic response

Susana Comte-Walters, B. Ogretmen, Vamsi K Gangaraju, 2024, Science advances.