O. Lequin

发表

High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide.

M. Desmadril, Y. Jacquot, I. Broutin, 2007, Bioorganic & medicinal chemistry.

Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates

Klaus Schulten, Viola Vogel, Mu Gao, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The C-terminal domain of the Uup protein is a DNA-binding coiled coil motif.

L. Carlier, O. Lequin, A. Haase, 2012, Journal of structural biology.

Comparison of penetratin and other homeodomain-derived cell-penetrating peptides: interaction in a membrane-mimicking environment and cellular uptake efficiency.

O. Lequin, G. Bolbach, G. Chassaing, 2006, Biochemistry.

Investigation of homeodomain membrane translocation properties: insights from the structure determination of engrailed-2 homeodomain in aqueous and membrane-mimetic environments.

A. Joliot, L. Carlier, O. Lequin, 2013, Biophysical journal.

A cationic motif in Engrailed-2 homeoprotein controls its internalization via selective cell-surface glycosaminoglycans interactions

A. Joliot, A. Walrant, S. Sagan, 2021, bioRxiv.

Different membrane behaviour and cellular uptake of three basic arginine-rich peptides.

I. Alves, A. Walrant, S. Sagan, 2011, Biochimica et biophysica acta.

Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent

O. Lequin, S. Casale, Tahar Bouceba, 2017, PloS one.

Temporin-SHf, a New Type of Phe-rich and Hydrophobic Ultrashort Antimicrobial Peptide*

O. Lequin, N. Goasdoué, A. Ladram, 2010, The Journal of Biological Chemistry.

Dermaseptin S9, an α-Helical Antimicrobial Peptide with a Hydrophobic Core and Cationic Termini†

Pierre Nicolas, Ali Ladram, O. Lequin, 2006 .

Electronic circular dichroism and nuclear magnetic resonance studies of peptides derived from the FKBP52‐interacting β‐turn of the hERα ligand‐binding domain

E. Baulieu, Y. Jacquot, O. Lequin, 2019, Peptide Science.

Prolinoamino acids as a tool to stabilize β-turns with the side chain of natural amino acids

A. Aubry, O. Lequin, P. Karoyan, 2004 .

Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline.

O. Lequin, A. Méjean, O. Ploux, 2009, Journal of the American Chemical Society.

Biophysical Investigation of the Membrane-Disrupting Mechanism of the Antimicrobial and Amyloid-Like Peptide Dermaseptin S9

J. Killian, O. Lequin, L. Caillon, 2013, PloS one.

3-Substituted Prolines: From Synthesis to Structural Applications, from Peptides to Foldamers †

O. Lequin, P. Karoyan, C. Caumes, 2013, Molecules.

Sequence-dependent enrichment of a model phosphopeptide: a combined MALDI-TOF and NMR study.

S. Sagan, O. Lequin, L. Mathéron, 2011, Analytical chemistry.

Antibody Recognition in multiple sclerosis and rett syndrome using a collection of linear and cyclic N‐glucosylated antigenic probes

O. Lequin, S. Lavielle, F. Lolli, 2015, Biopolymers.

Monitoring In Vivo Performances of Protein-Drug Conjugates Using Site-Selective Dual Radiolabeling and Ex Vivo Digital Imaging.

Ki Baek Lee, H. Nozach, F. Beau, 2022, Journal of medicinal chemistry.

The Combination of Prolinoamino Acids and Cyclopropylamino Acids Leads to Fully Functionalized, Stable β‐Turns in Water

O. Lequin, P. Karoyan, S. Lavielle, 2011, Chembiochem : a European journal of chemical biology.

Tryptophan within basic peptide sequences triggers glycosaminoglycan‐dependent endocytosis

I. Alves, S. Sagan, O. Lequin, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural Bases for the Involvement of Phosphatidylinositol-4,5-bisphosphate in the Internalization of the Cell-Penetrating Peptide Penetratin.

A. Walrant, S. Sagan, L. Carlier, 2022, ACS chemical biology.

Solution structure and model membrane interactions of temporins-SH, antimicrobial peptides from amphibian skin. A NMR spectroscopy and differential scanning calorimetry study.

O. Lequin, A. Ladram, Feten Abbassi, 2008, Biochemistry.

Anionic lipids induce a fold-unfold transition in the membrane-translocating engrailed homeodomain.

A. Joliot, L. Carlier, O. Lequin, 2022, Biochimica et biophysica acta. Biomembranes.

Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini.

O. Lequin, A. Ladram, P. Nicolas, 2006, Biochemistry.

Helical structure of dermaseptin B2 in a membrane-mimetic environment.

O. Lequin, P. Nicolas, G. Chassaing, 2003, Biochemistry.

A microplate fluorescence assay for DAPA aminotransferase by detection of the vicinal diamine 7,8-diaminopelargonic acid.

L. Eveleigh, O. Lequin, O. Ploux, 2013, Analytical biochemistry.

Antitumor Activity and Mechanism of Action of Hormonotoxin, an LHRH Analog Conjugated to Dermaseptin-B2, a Multifunctional Antimicrobial Peptide

A. De la taille, O. Lequin, M. Amiche, 2021, International journal of molecular sciences.

Identification of 7-Deoxy-desulfo-argino-cylindrospermopsin, the Missing Piece in Cylindrospermopsin Biosynthesis.

O. Lequin, A. Méjean, O. Ploux, 2022, Journal of the American Chemical Society.

Homooligomers of substituted prolines and β-prolines: syntheses and secondary structure investigation

L. Carlier, O. Lequin, P. Karoyan, 2013 .

In vivo characterization of the activities of novel cyclodipeptide oxidases: new tools for increasing chemical diversity of bioproduced 2,5-diketopiperazines in Escherichia coli

O. Lequin, L. Mathéron, M. Moutiez, 2020, Microbial Cell Factories.

β‐Amino acids containing peptides and click‐cyclized peptide as β‐turn mimics: a comparative study with ‘conventional’ lactam‐ and disulfide‐bridged hexapeptides

O. Lequin, P. Karoyan, S. Lavielle, 2011, Journal of peptide science : an official publication of the European Peptide Society.

N- and Cα-Methylation in Biologically Active Peptides: Synthesis, Structural and Functional Aspects

S. Sagan, O. Lequin, P. Karoyan, 2004 .

The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands

T. Ha-Duong, O. Lequin, B. Crousse, 2017, Beilstein journal of organic chemistry.

Access to novel amino trifluoromethyl cyclopropane carboxylic acid derivatives

O. Lequin, B. Crousse, S. Ongeri, 2013 .

Structural and biological effects of a β2‐ or β3‐amino acid insertion in a peptide

S. Sagan, O. Lequin, S. Lavielle, 2003 .

Designed Glycopeptidomimetics Disrupt Protein-Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability.

D. Allsop, M. Taylor, O. Lequin, 2016, Journal of medicinal chemistry.

Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization.

O. Lequin, M. Taverna, B. Crousse, 2014, European journal of medicinal chemistry.

Sugar-based peptidomimetics inhibit amyloid β-peptide aggregation.

O. Lequin, J. Soulier, Isabelle Correia, 2011, European journal of medicinal chemistry.

Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides.

O. Lequin, N. Tonali, Isabelle Correia, 2020, Organic & biomolecular chemistry.

(R)‐α‐trifluoromethylalanine containing short peptide in the inhibition of amyloid peptide fibrillation

O. Lequin, L. Caillon, V. Gasparik, 2015, Biopolymers.

Synthesis and conformational studies of a stable peptidomimetic β-hairpin based on a bifunctional diketopiperazine turn inducer

R. Fanelli, O. Lequin, Isabelle Correia, 2015 .

Chiral "basket handle" binaphthyl porphyrins: synthesis, catalytic epoxidation and NMR conformational studies

O. Lequin, E. Gallo, E. Rose, 2010 .

Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121

O. Lequin, M. Le Du, P. Belin, 2013, The Journal of Biological Chemistry.

Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

O. Lequin, J. Charbonnier, J. Pernodet, 2009, Proceedings of the National Academy of Sciences.

Mapping the Heparin-binding Site on the13–14F3 Fragment of Fibronectin*

I. Campbell, D. Staunton, Sachchidanand, 2002, The Journal of Biological Chemistry.

Membrane interactions of two arginine-rich peptides with different cell internalization capacities.

I. Alves, A. Walrant, S. Sagan, 2012, Biochimica et biophysica acta.

Letter to the Editor: 1H, 15N and 13C resonance assignment of human γS-crystallin, a 21 kDa eye-lens protein

O. Lequin, G. Chassaing, F. Bontems, 2004 .

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.

A. Jeltsch, O. Lequin, P. Karoyan, 2014, Journal of medicinal chemistry.

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease

H. Sokol, R. Marquant, L. Carlier, 2015, Gut.

Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids

O. Lequin, M. Moutiez, Isabelle Correia, 2019, Scientific Reports.

Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection

O. Lequin, P. Karoyan, V. Vieillard, 2021, Communications biology.

Structure and Inhibitory Effects on Angiogenesis and Tumor Development of a New Vascular Endothelial Growth Inhibitor*

A. Bikfalvi, O. Lequin, B. Rousseau, 2003, Journal of Biological Chemistry.

Mechanism of antibacterial action of dermaseptin B2: interplay between helix-hinge-helix structure and membrane curvature strain.

O. Lequin, A. Ladram, Feten Abbassi, 2009, Biochemistry.

Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation

P. Pelupessy, G. Bodenhausen, N. Salvi, 2015, Biophysical journal.

Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide

A. Jeltsch, R. Jurkowska, W. Nelson, 2012, Chembiochem : a European journal of chemical biology.

Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.

O. Lequin, P. Karoyan, H. Merle-Béral, 2016, Journal of medicinal chemistry.

Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection

O. Lequin, P. Karoyan, V. Vieillard, 2021, Communications Biology.

Iterative feedback tuning: theory and applications

Svante Gunnarsson, Michel Gevers, Håkan Hjalmarsson, 1998 .

Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy--characterization of histidine protonation states and pKa values.

O. Lequin, H. Thüring, J. Lallemand, 1997, European journal of biochemistry.

A Plant-Specific N-terminal Extension Reveals Evolutionary Functional Divergence within Translocator Proteins

O. Lequin, H. Batoko, Lucile Sénicourt, 2020, iScience.

CX3CL1 homo-oligomerization drives cell-to-cell adherence

A. Jawhari, O. Lequin, F. Pincet, 2020, Scientific Reports.

The CX3CL1 oligomerization is required for efficient CX3CR1-specific cell adherence

A. Jawhari, O. Lequin, F. Pincet, 2019, bioRxiv.

1H, 13C and 15N resonance assignment of a 114-residue fragment of Engrailed 2 homeoprotein, a partially disordered protein

G. Bodenhausen, F. Ferrage, R. Augustyniak, 2011, Biomolecular NMR assignments.

Novel Matrix Metalloproteinase 12 selective radiotracers for vascular molecular imaging.

Jakub Toczek, F. Beau, V. Dive, 2019, Journal of medicinal chemistry.

Glaser oxidative coupling on peptides: stabilization of β-turn structure via a 1,3-butadiyne constraint.

O. Lequin, S. Lavielle, A. Papini, 2014, Bioorganic & medicinal chemistry.

Ligand‐Directed Modification of Active Matrix Metalloproteases: Activity‐based Probes with no Photolabile Group

F. Beau, V. Dive, O. Lequin, 2021, Angewandte Chemie.

Ligand-directed modification of active Matrix Metalloproteases: New activity-based probes with no photolabile group.

F. Beau, V. Dive, O. Lequin, 2021, Angewandte Chemie.

Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells.

O. Lequin, P. Karoyan, H. Merle-Béral, 2019, Journal of medicinal chemistry.

Incorporation of Non-canonical Amino Acids into 2,5-Diketopiperazines by Cyclodipeptide Synthases.

O. Lequin, J. Seguin, M. Moutiez, 2018, Angewandte Chemie.

Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance P bound to the NK-1 receptor.

S. Sagan, O. Lequin, P. Karoyan, 2005, Chemistry & biology.

A cationic motif upstream Engrailed2 homeodomain controls cell internalization through selective interaction with heparan sulfates

A. Joliot, A. Walrant, S. Sagan, 2023, Nature Communications.

Biophysical studies of the interaction between calmodulin and the R²⁸⁷-T³¹¹ region of human estrogen receptor α reveals an atypical binding process.

G. Leclercq, M. Desmadril, L. Carlier, 2012, Biochemical and biophysical research communications.

Biophysical studies of the interaction between calmodulin and the R 287-T 311 region of human estrogen receptor a reveals an atypical binding process

G. Leclercq, M. Desmadril, L. Carlier, 2012 .

A Photochromic Azobenzene Peptidomimetic of a β-Turn Model Peptide Structure as a Conformational Switch

O. Lequin, A. Papini, R. Chelli, 2019, Front. Chem..

Methods to determine slow diffusion coefficients of biomolecules. Applications to Engrailed 2, a partially disordered protein

G. Bodenhausen, F. Ferrage, R. Augustyniak, 2011, Journal of biomolecular NMR.

Iterative feedback tuning of PID parameters: comparison with classical tuning rules

Magnus Mossberg, Michel Gevers, Olivier Lequin, 2003 .

Study of bicyclomycin biosynthesis in Streptomyces cinnamoneus by genetic and biochemical approaches

Matthieu Coupet, O. Lequin, J. Seguin, 2019, Scientific Reports.

A single mutation on the human amyloid polypeptide modulates fibril growth and affects the mechanism of amyloid-induced membrane damage.

J. Killian, O. Lequin, Lucie Khemtemourian, 2018, Biochimica et biophysica acta. Biomembranes.

Prolinoamino Acids as Tools to Build Bifunctionalized, Stable β‐Turns in Water

O. Lequin, N. Goasdoué, P. Karoyan, 2009, Chembiochem : a European journal of chemical biology.

Characterization of the bioactive conformation of the C-terminal tripeptide Gly-Leu-Met-NH2 of substance P using [3-prolinoleucine10]SP analogues.

S. Sagan, O. Lequin, P. Karoyan, 2003, European journal of biochemistry.

Secondary structure and NMR resonance assignments of the C-terminal DNA-binding domain of Uup protein

L. Carlier, O. Lequin, A. Haase, 2012, Biomolecular NMR assignments.

Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation.

O. Lequin, L. Caillon, Lucie Khemtemourian, 2013, Biochimica et biophysica acta.

Involvement of the Second Extracellular Loop (E2) of the Neurokinin-1 Receptor in the Binding of Substance P

S. Sagan, O. Lequin, S. Lavielle, 2002, The Journal of Biological Chemistry.

Investigating the role of GXXXG motifs in helical folding and self-association of plasticins, Gly/Leu-rich antimicrobial peptides.

L. Carlier, O. Lequin, P. Nicolas, 2015, Biophysical chemistry.

Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO

V. Papadopoulos, O. Lequin, Lucile Sénicourt, 2019, International journal of molecular sciences.

Structural Studies of TSPO, a Mitochondrial Membrane Protein

V. Papadopoulos, O. Lequin, P. Hellwig, 2014 .

CX3CL1 homo-oligomerization drives cell-to-cell adherence

A. Jawhari, O. Lequin, F. Pincet, 2020, Scientific Reports.

Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes

O. Lequin, L. Duma, L. Caillon, 2014, Molecular membrane biology.

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins† †Electronic supplementary information (ESI) available: Additional studies, experimental procedures, and compounds characterization. See DOI: 10.1039/c8sc00886h

I. Hamachi, S. Sagan, O. Lequin, 2018, Chemical science.

An hACE2 peptide mimic blocks SARS-CoV-2 Pulmonary Cell Infection

O. Lequin, P. Karoyan, V. Vieillard, 2020, bioRxiv.

Cα methylation in molecular recognition

S. Sagan, O. Lequin, S. Lavielle, 2001 .

Calpha methylation in molecular recognition. Application to substance P and the two neurokinin-1 receptor binding sites.

S. Sagan, O. Lequin, S. Lavielle, 2001, European journal of biochemistry.

Time dependence of NMR observables reveals salient differences in the accumulation of early aggregated species between human islet amyloid polypeptide and amyloid-β.

L. Carlier, O. Lequin, L. Caillon, 2018, Physical chemistry chemical physics : PCCP.

Hyperglucosylated adhesin‐derived peptides as antigenic probes in multiple sclerosis: Structure optimization and immunological evaluation

O. Lequin, A. Papini, P. Rovero, 2020, Journal of peptide science : an official publication of the European Peptide Society.

Synthesis and Characterization of Hairpin Mimics that Modulate the Early Oligomerization and Fibrillization of Amyloid β‐Peptide

R. Fanelli, O. Lequin, M. Taverna, 2017 .

Incorporation of Non-canonical Amino Acids into 2,5-Diketopiperazines by Cyclodipeptide Synthases.

O. Lequin, J. Seguin, M. Moutiez, 2018, Angewandte Chemie.

Introducing the Chiral Constrained α-Trifluoromethylalanine in Aib foldamers to Control, Quantify and Assign the Helical Screw-Sense.

O. Lequin, K. Guitot, N. Lensen, 2021, Chemistry.

What can be learnt from the comparison of multiscale brownian dynamics simulations, nuclear magnetic resonance and light scattering experiments on charged micelles?

V. Dahirel, O. Lequin, P. Turq, 2010 .