P. Hughes

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1α,25‐dihydroxyvitamin D3‐mediated stimulation of steroid sulphatase activity in myeloid leukaemic cell lines requires VDRnuc‐mediated activation of the RAS/RAF/ERK‐MAP kinase signalling pathway

P. Hughes, Geoffrey Brown, 2006, Journal of cellular biochemistry.

Novel inositol containing phospholipids and phosphates: their synthesis and possible new roles in cellular signalling

P. Hughes, R. Michell, 1993, Current Opinion in Neurobiology.

1α,25‐dihydroxyvitamin D3 stimulates steroid sulphatase activity in HL60 and NB4 acute myeloid leukaemia cell lines by different receptor‐mediated mechanisms

P. Hughes, Geoffrey Brown, A. Steinmeyer, 2005, Journal of cellular biochemistry.

Studies on the receptor mediating cyclic AMP‐independent enhancement by adenosine of IgE‐dependent mediator release from rat mast cells

P. Hughes, M. Church, C. Vardey, 1986, British journal of pharmacology.

Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism.

S. Holgate, P. Hughes, M. Church, 1984, Biochemical pharmacology.

Adenosine inhibits and potentiates IgE‐dependent histamine release from human basophils by an A2‐receptor mediated mechanism

S. Holgate, P. Hughes, M. Church, 1983, British journal of pharmacology.

Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle.

P. Hughes, R. Michell, C. J. Barker, 2004, The Biochemical journal.

Understanding the physiology, pharmacology and therapeutic uses of vitamin D

A. Kutner, P. Hughes, Geoffrey Brown, 2014 .

The physiology and pharmacology of vitamin D

A. Kutner, P. Hughes, Geoffrey Brown, 2013 .

Do dietary phytoestrogens influence susceptibility to hormone-dependent cancer by disrupting the metabolism of endogenous oestrogens?

P. Hughes, R. Waring, R. M. Harris, 2001, Biochemical Society transactions.

Use of Receptor Antagonists in Elucidating the Mechanism of Action of TRH in GH3 Cells a

A. H. Drummond, P. Hughes, F. Ruiz-Larrea, 1989, Annals of the New York Academy of Sciences.

Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity.

J. Putney, P. Hughes, M. E. Hodgson, 1991, The Journal of biological chemistry.

Inhibition of immunological and nonimmunological histamine release from human basophils by adenosine analogues that act at P-sites.

P. Hughes, M. Church, 1986, Biochemical pharmacology.

The versatility of haematopoietic stem cells: implications for leukaemia

P. Hughes, Geoffrey Brown, R. Ceredig, 2010, Critical reviews in clinical laboratory sciences.

Adenosine as a Putative Mediator in Asthma: Its Role in Bronchoconstriction and Modulation of Histamine Release from Human Lung Mast Cells and Basophil Leucocytes

S. Holgate, P. Hughes, M. Church, 1985 .

A role for caspase inhibitors in differentiation therapy of myeloid leukaemia.

P. Hughes, Geoffrey Brown, 2012, Leukemia research.

The relationship between cyclic AMP changes and histamine release from basophil-rich human leucocytes.

S. Holgate, P. Hughes, M. Church, 1983, Biochemical pharmacology.

The inhibition of antigen‐induced eosinophilia and bronchoconstriction by CDP840, a novel stereo‐selective inhibitor of phosphodiesterase type 4

R. Owens, M. Merriman, P. Hughes, 1996, British journal of pharmacology.

The cellular location of catechol-O-methyltransferase in rat liver

P. Hughes, M. Raxworthy, P. Gulliver, 1982, Naunyn-Schmiedeberg's Archives of Pharmacology.

Identification and characterization of inositol 1,4,5-trisphosphate receptors in rat testis.

K. Mikoshiba, S. Minchin, M. Mezna, 1997, Cell calcium.

Adenosine inhibits immunoglobulin E-dependent histamine secretion from human basophil leukocytes by two independent mechanisms.

P. Hughes, M. Church, R. Benyon, 1987, The Journal of pharmacology and experimental therapeutics.

Adenosine potentiates immunological histamine release from rat mast cells by a novel cyclic AMP‐independent cell‐surface action

P. Hughes, Martin K. Churchi, 1985, British journal of pharmacology.

The vitamin D receptor‐mediated activation of phosphatidylinositol 3‐kinase (PI3Kα) plays a role in the 1α,25‐dihydroxyvitamin D3‐stimulated increase in steroid sulphatase activity in myeloid leukaemic cell lines

N. Reiner, P. Hughes, Geoffrey Brown, 2008, Journal of cellular biochemistry.

Retinoid‐mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3‐kinase and ERK‐MAP kinase pathways

P. Hughes, Geoffrey Brown, Yi Zhao, 2006, Journal of cellular biochemistry.

Up-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1alpha,25-dihydroxyvitamin D3.

M. Drayson, P. Hughes, M. Choudhry, 2001, The Biochemical journal.

Differentiation and Cell Survival of Myeloid Leukemia Cells

G. P. Studzinski, P. Hughes, Geoffrey Brown, 2012, Leukemia research and treatment.

Cell differentiation and proliferation--simultaneous but independent?

P. Hughes, Geoffrey Brown, R. Michell, 2003, Experimental cell research.

Retinoid Differentiation Therapy for Common Types of Acute Myeloid Leukemia

P. Hughes, Geoffrey Brown, 2012, Leukemia research and treatment.

Interplay between signalling pathways mediates 1,25alpha-dihydroxyvitamin D3-driven monocytic differentiation--JNKs are important.

P. Hughes, Geoffrey Brown, 2009, Leukemia research.

The versatile landscape of haematopoiesis: Are leukaemia stem cells as versatile?

P. Hughes, Geoffrey Brown, R. Ceredig, 2012, Critical reviews in clinical laboratory sciences.

HL60 cells halted in G1 or S phase differentiate normally.

Roger Bird, M. Drayson, K. Toellner, 2002, Experimental cell research.

The sequential determination model of hematopoiesis.

A. Rolink, P. Hughes, Geoffrey Brown, 2007, Trends in immunology.

Vitamin D3-driven signals for myeloid cell differentiation--implications for differentiation therapy.

Ewa Marcinkowska, G. P. Studzinski, P. Hughes, 2010, Leukemia research.

Versatility and nuances of the architecture of haematopoiesis - Implications for the nature of leukaemia.

P. Hughes, Geoffrey Brown, R. Ceredig, 2012, Leukemia research.

Sulfation of “Estrogenic” Alkylphenols and 17β-Estradiol by Human Platelet Phenol Sulfotransferases*

P. Hughes, R. Waring, C. Kirk, 2000, The Journal of Biological Chemistry.

Purification and characterization of inositol-1,3,4-trisphosphate 5/6-kinase from rat liver using an inositol hexakisphosphate affinity column.

G. Prestwich, P. Hughes, J. Marecek, 1992, The Journal of biological chemistry.

The regulation of the phosphorylation of inositol 1,3,4-trisphosphate in cell-free preparations and its relevance to the formation of inositol 1,3,4,6-tetrakisphosphate in agonist-stimulated rat parotid acinar cells.

J. Putney, P. Hughes, A. R. Hughes, 1989, The Journal of biological chemistry.

Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate inhibit inositol-1,3,4,5-tetrakisphosphate 3-phosphatase in rat parotid glands.

P. Hughes, S. Shears, 1990, Journal of Biological Chemistry.

Formation of inositol phosphate isomers in GH3 pituitary tumour cells stimulated with thyrotropin-releasing hormone. Acute effects of lithium ions.

A. H. Drummond, P. Hughes, 1987, The Biochemical journal.

The action of purines on human airways.

S. Holgate, P. Hughes, M. Church, 1986, Archives internationales de pharmacodynamie et de therapie.

The versatile landscape of haematopoiesis: Are leukaemia stem cells as versatile?

P. Hughes, Geoffrey Brown, R. Ceredig, 2012, Critical reviews in clinical laboratory sciences.