S. Chandrasekhar

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Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects.

Y. Pei, A. Harvey, Xiao-peng Yu, 2006, Osteoarthritis and cartilage.

Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia

M. J. Fisher, B. Norman, A. Harvey, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Osteonectin/SPARC is a product of articular chondrocytes/cartilage and is regulated by cytokines and growth factors.

M. G. Johnson, A. Harvey, S. Chandrasekhar, 1994, Biochimica et biophysica acta.

Intra-articular administration of interleukin-1 causes prolonged suppression of cartilage proteoglycan synthesis in rats.

A. Harvey, S. Chandrasekhar, P. S. Hrubey, 1992, Matrix.

Transforming growth factor-beta is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation.

A. Harvey, S. Chandrasekhar, 1988, Biochemical and biophysical research communications.

The Osteoblast-specific Transcription Factor Cbfa1 Contributes to the Expression of Osteoprotegerin, a Potent Inhibitor of Osteoclast Differentiation and Function*

T. Martin, S. Chandrasekhar, K. Thirunavukkarasu, 2000, The Journal of Biological Chemistry.

Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).

J. Luz, M. Hickey, S. D. Kahl, 2020, Biochimica et biophysica acta. General subjects.

Proliferating cells in the primary spongiosa express osteoblastic phenotype in vitro.

A. Harvey, S. Chandrasekhar, J. Bidwell, 1997, Bone.

Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: effects of raloxifene HCl, tamoxifen, estrogen, and alendronate.

S. Chandrasekhar, H. Bryant, D. Magee, 1996, Bone.

A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.

K. Duffin, S. Chandrasekhar, K. Thirunavukkarasu, 2010, Osteoarthritis and cartilage.

Passive Role of Articular Chondrocytes in Quinolone-Induced Arthropathy in Guinea Pigs

A. Harvey, S. Chandrasekhar, A. Bendele, 1990, Toxicologic pathology.

Catabolic Effects of Continuous Human PTH (1-38) in Vivo Is Associated with Sustained Stimulation of RANKL and Inhibition of Osteoprotegerin and Gene-Associated Bone Formation.

R. L. Cain, T. Martin, S. Chandrasekhar, 2001, Endocrinology.

Comparison of Recombinant Human PTH(1–34) (LY333334) with a C‐Terminally Substituted Analog of Human PTH‐Related Protein(1–34) (RS‐66271): In Vitro Activity and In Vivo Pharmacological Effects in Rats

R. L. Cain, A. Harvey, S. Chandrasekhar, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Intermittent administration of parathyroid hormone (1‐34) stimulates matrix metalloproteinase‐9 (MMP‐9) expression in rat long bone

A. Harvey, S. Chandrasekhar, J. Bidwell, 1998, Journal of cellular biochemistry.

Novel and Selective Small Molecule Stimulators of Osteoprotegerin Expression Inhibit Bone Resorption

R. L. Cain, T. Martin, S. Chandrasekhar, 2004, Journal of Pharmacology and Experimental Therapeutics.

Structure and functional expression of a complementary DNA for porcine parathyroid hormone/parathyroid hormone-related peptide receptor.

H. Hsiung, A. Harvey, S. Chandrasekhar, 1996, Biochimica et biophysica acta.

Interaction of fibronectin with collagen: age-specific defect in the biological activity of human fibroblast fibronectin.

S. Chandrasekhar, A. J. Millis, J. Sorrentino, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Interaction of link protein with collagen.

H. Kleinman, S. Chandrasekhar, J. Hassell, 1983, The Journal of biological chemistry.

Induction of interleukin‐1 receptors on chondrocytes by fibroblast growth factor: A possible mechanism for modulation of interleukin‐1 activity

A. Harvey, S. Chandrasekhar, 1989, Journal of cellular physiology.

Differential regulation of metalloprotease steady‐state mRNA levels by IL‐1 and FGF in rabbit articular chondrocytes

A. Harvey, S. Chandrasekhar, Srinivasan Chandrasekhar, 1992, FEBS letters.

Identification of signal transduction pathways and promoter sequences that mediate parathyroid hormone 1–38 inhibition of osteoprotegerin gene expression

S. Chandrasekhar, K. Thirunavukkarasu, J. Onyia, 2001, Journal of cellular biochemistry.

The anti-rheumatic potential of a series of 2,4-di-substituted-4H-naphtho[1,2-b]pyran-3-carbonitriles

A. Harvey, S. Chandrasekhar, A. Kingston, 1995 .

Printed in U.S.A. Copyright © 2001 by The Endocrine Society Catabolic Effects of Continuous Human PTH (1–38) in Vivo Is Associated with Sustained Stimulation of RANKL and Inhibition of Osteoprotegerin and Gene-Associated Bone Formation

R. L. Cain, T. Martin, S. Chandrasekhar, 2022 .

Regulation of NFATc2 gene expression by the transcription factor Runx2

Y. Pei, S. Chandrasekhar, K. Thirunavukkarasu, 2007, Molecular Biology Reports.

Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines.

A. Geiser, Y. Pei, Xiao-peng Yu, 2006, Biochemical and biophysical research communications.

Interleukin-1-induced suppression of type II collagen gene transcription involves DNA regulatory elements.

W. Horton, A. Harvey, S. Chandrasekhar, 1990, Experimental cell research.

Transforming growth factor‐beta and fibroblast growth factor act synergistically to inhibit collagen II synthesis through a mechanism involving regulatory DNA sequences

W. Horton, S. Chandrasekhar, J. Higginbotham, 1989, Journal of cellular physiology.

Parathyroid Hormone-(1–34) Enhances Aggrecan Synthesis via an Insulin-like Growth Factor-I Pathway*

A. Harvey, Xiao-peng Yu, S. Chandrasekhar, 1999, The Journal of Biological Chemistry.

Development of a scintillation proximity assay for high-throughput measurement of intact parathyroid hormone.

S. Chandrasekhar, M. D. Adrian, C. Frolik, 1998, Analytical biochemistry.

Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.

Shobha N. Bhattachar, J. Luz, M. J. Fisher, 2016, Bioorganic & medicinal chemistry letters.

Transforming growth factor-? inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes

A. Harvey, S. Chandrasekhar, P. S. Hrubey, 1991 .

In Vivo Demonstration that Human Parathyroid Hormone 1–38 Inhibits the Expression of Osteoprotegerin in Bone with the Kinetics of an Immediate Early Gene

S. Chandrasekhar, D. McClure, J. Hale, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Arthritis induced by interleukin-1 is dependent on the site and frequency of intraarticular injection.

A. Harvey, S. Chandrasekhar, A. Bendele, 1990, Clinical immunology and immunopathology.

Anti-Rheumatic Potential of a Series of 2,4-Di-Substituted-4H-naphtho( 1,2-b)pyran-3-carbonitriles.

A. Harvey, S. Chandrasekhar, A. Kingston, 1996 .

Regulation of type I collagen fibril assembly by link protein and proteoglycans.

H. Kleinman, S. Chandrasekhar, G. Martin, 1984, Collagen and related research.

Distinct pathways of extracellular signal-regulated kinase activation by growth factors, fibronectin and parathyroid hormone 1-34.

S. Chandrasekhar, E. Kaiser, 2003, Biochemical and biophysical research communications.

Direct visualization of collagens and procollagens in polyacrylamide gels.

S. Chandrasekhar, P. McCormick, A. J. Millis, 1979, Analytical biochemistry.

Functional changes in cellular fibronectin from late passage fibroblasts in vitro.

S. Chandrasekhar, C. S. Izzard, A. J. Millis, 1983, Cell biology international reports.

Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-beta (TGF-beta). Mapping of the OPG promoter region that mediates TGF-beta effects.

R R Miles, T. Martin, S. Chandrasekhar, 2001, The Journal of biological chemistry.

Parathyroid hormone (1–34) regulates integrin expression in vivo in rat osteoblasts

S. Chandrasekhar, J. Onyia, Masahiko Sato, 2001, Journal of cellular biochemistry.

Parathyroid hormone (PTH 1-34) regulation of rat osteocalcin gene transcription.

Xiao-peng Yu, S. Chandrasekhar, X. P. Yu, 1997, Endocrinology.

Modulation of PDGF mediated osteoblast chemotaxis by leukemia inhibitory factor LIF

A. Harvey, S. Chandrasekhar, S Chandrasekhar, 1996, Journal of cellular physiology.

Activation of Osteocalcin Transcription Involves Interaction of Protein Kinase A- and Protein Kinase C-dependent Pathways*

Xiao-peng Yu, S. Chandrasekhar, J. Onyia, 2000, The Journal of Biological Chemistry.

Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.

S. Iturria, Yoko Yamamoto, S. Kato, 2006, The Journal of clinical investigation.

Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.

N. Chirgadze, S. Briggs, D. Clawson, 2000, The Journal of biological chemistry.

Protein Kinase C is a mediator of the synthesis and secretion of osteoprotegerin in osteoblast-like cells.

T. Martin, S. Chandrasekhar, J. Onyia, 2002, Biochemical and biophysical research communications.

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

Shobha N. Bhattachar, J. Luz, M. Hickey, 2016, Journal of medicinal chemistry.

Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.

J. Luz, M. J. Fisher, Matthew R. Lee, 2015, Journal of medicinal chemistry.

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.

B. Norman, S. Chandrasekhar, K. Thirunavukkarasu, 2016, ACS medicinal chemistry letters.

A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia

S. Chandrasekhar, S. Nagpal, C. Schmidt, 2011, Autoimmune diseases.

Degradative and repair responses of cartilage to cytokines and growth factors occur via distinct pathways.

A. Harvey, S. Chandrasekhar, S. Stack, 1993, Agents and actions. Supplements.

Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists.

M. J. Fisher, M. Blanco, A. Harvey, 2016, Bioorganic & medicinal chemistry letters.

Analgesic and anti‐inflammatory properties of novel, selective, and potent EP4 receptor antagonists

M. J. Fisher, M. Blanco, A. Harvey, 2017, Pharmacology research & perspectives.

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.

Shobha N. Bhattachar, J. Luz, M. J. Fisher, 2017, Bioorganic & medicinal chemistry letters.

R. L. Cain, T. Martin, S. Chandrasekhar, 2022 .

Intermittent administration of parathyroid hormone (1‐34) stimulates matrix metalloproteinase‐9 (MMP‐9) expression in rat long bone

A. Harvey, S. Chandrasekhar, J. Bidwell, 1998, Journal of cellular biochemistry.

Interleukin-1-induced alterations in proteoglycan metabolism and matrix assembly.

S. Chandrasekhar, K. Phadke, Srinivasan Chandrasekhar, 1988, Archives of biochemistry and biophysics.

Differential modulation of degradative and repair responses of interleukin-1-treated chondrocytes by platelet-derived growth factor.

A. Harvey, S. Chandrasekhar, S. Stack, 1993, The Biochemical journal.

Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists.

M. J. Fisher, M. Blanco, A. Harvey, 2016, Bioorganic & medicinal chemistry letters.

Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

Shobha N. Bhattachar, J. Luz, M. Hickey, 2016, Journal of medicinal chemistry.

In vitro regulation of cartilage matrix assembly by a Mr 54,000 collagen-binding protein.

G. Laurie, H. Kleinman, S. Chandrasekhar, 1986, Proceedings of the National Academy of Sciences of the United States of America.