Jiazhi Sun

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Disruption of the Rb-Raf-1 Interaction Inhibits Tumor Growth and Angiogenesis

Vicki Betts, Jiazhi Sun, S. Sebti, 2004, Molecular and Cellular Biology.

The Geranylgeranyltransferase I Inhibitor GGTI-298 Induces Hypophosphorylation of Retinoblastoma and Partner Switching of Cyclin-dependent Kinase Inhibitors

S. Sebti, A. Hamilton, Jiazhi Sun, 1999, The Journal of Biological Chemistry.

Systematic drug safety evaluation based on public genomic expression (Connectivity Map) data: myocardial and infectious adverse reactions as application cases.

Shu-Feng Zhou, Jiazhi Sun, Kejian Wang, 2015, Biochemical and biophysical research communications.

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients

Shufeng Zhou, Jiazhi Sun, D. Wood, 2014, Drug design, development and therapy.

Inhibition of angiogenesis by Abeta peptides.

D. Coppola, S. Brem, S. Sebti, 2004, Angiogenesis.

Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice

D. Coppola, S. Sebti, A. Hamilton, 2000, Nature Biotechnology.

CAR-T: Expression, Expansion, and Clinical Applications

Jiazhi Sun, Rehan Muhammad, C. Dupont, 2015 .

Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain

Shufeng Zhou, Jiazhi Sun, Wei-Min Chen, 2014, Drug design, development and therapy.

CAR-T: The Current and the Future

Jiazhi Sun, Shun-Feng Zhou, Kunal Mishra, 2015 .

This information is current as Kinase Signal Pathway Ras-Independent Mitogen-Activated Protein Direct Tumor Lysis by NK Cells Uses a

D. Gilvary, J. Trapani, Sheng Wei, 2000 .

Cytotoxic Agents Cisplatin , Taxol , and Gemcitabine Geranylgeranyltransferase I : Combination Therapy with the Peptidomimetic Inhibitors of Farnesyltransferase and Antitumor Efficacy of a Novel Class of Non-thiol-containing Updated Version

S. Sebti, A. Hamilton, Jiazhi Sun, 1999 .

Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.

S. Sebti, A. Hamilton, Jiazhi Sun, 2006, Organic & biomolecular chemistry.

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

J. Turkson, R. Jove, A. Cantor, 2003, Cancer research.

Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides.

Hong-Gang Wang, Jiazhi Sun, Roman Manetsch, 2008, Journal of the American Chemical Society.

Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

D. Coppola, S. Sebti, A. Hamilton, 2004, Oncogene.

Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor

D. Coppola, S. Brem, S. Sebti, 2004, Cancer Research.

Peptidomimetic-based inhibitors of farnesyltransferase

David A. Knowles, S. Sebti, S. Rosenberg, 2001 .

Inhibition of Angiogenesis by Aβ Peptides

D. Coppola, S. Brem, S. Sebti, 2004, Angiogenesis.

DCs-based therapies: potential strategies in severe SARS-CoV-2 infection

Jiazhi Sun, Guixin Zhang, Hailong Chen, 2021, International journal of medical sciences.

The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner*

S. Sebti, A. Hamilton, Jiazhi Sun, 1997, The Journal of Biological Chemistry.

Akt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis

K. Jiang, Sheng Wei, S. Sebti, 2004, Molecular and Cellular Biology.

Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.

D. Coppola, S. Sebti, A. Hamilton, 2003, Cancer research.

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

S. Sebti, A. Hamilton, Jiazhi Sun, 1998, Oncogene.

The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner*

S. Sebti, Aslamuzzaman Kazi, A. Hamilton, 2010, The Journal of Biological Chemistry.

Prediction of the likelihood of drug interactions with kinase inhibitors based on in vitro and computational studies

W. Duan, Shufeng Zhou, Jiazhi Sun, 2014, Fundamental & clinical pharmacology.

Protein Kinase Inhibitors for Clinical Targeted Cancer Treatment

Shufeng Zhou, Jiazhi Sun, Xiao-wu Chen, 2013 .

Investigation of the antifungal activity of the dicarboximide fungicide iprodione against Bipolaris maydis.

Xin Cheng, Jiazhi Sun, Wende Liu, 2022, Pesticide biochemistry and physiology.

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

D. Coppola, R. Jove, S. Sebti, 2005, Oncogene.

Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.

D. Coppola, Hua Yu, R. Jove, 2002, Molecular cancer therapeutics.

Direct Tumor Lysis by NK Cells Uses a Ras-Independent Mitogen-Activated Protein Kinase Signal Pathway 1

D. Gilvary, J. Trapani, Sheng Wei, 2000, The Journal of Immunology.

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes (*)

C. Der, S. Sebti, A. Hamilton, 1995, The Journal of Biological Chemistry.

A Guanidyl-based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf.

H. Fujii, Jiazhi Sun, P. Parvatkar, 2019, Chemistry.

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins

John Calvin Reed, S. Sebti, M. Pellecchia, 2009, Molecular Cancer Therapeutics.

Drug Design, Development and Therapy Dovepress Synthesis and Antibacterial Activities of Acylide Derivatives Bearing an Aryl-tetrazolyl Chain Ping-hua Sun

Shufeng Zhou, Jiazhi Sun, Wei-Min Chen, 2022 .

Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity

Lin He, Shufeng Zhou, Can Li, 2013, PLoS Comput. Biol..

Both Farnesylated and Geranylgeranylated RhoB Inhibit Malignant Transformation and Suppress Human Tumor Growth in Nude Mice*

S. Sebti, G. Favre, Jiazhi Sun, 2000, The Journal of Biological Chemistry.

H-Ras Transgenic Mice Breast Carcinoma Apoptosis and Tumor Regression in Geranylgeranyltransferase I Inhibitor GGTI-2154 Induces

D. Coppola, S. Sebti, A. Hamilton, 2003 .

Correction: Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity

Lun Yang, Kejian Wang, Shengying Qin, 2013, PLoS Computational Biology.

In Vitro Determination of Sensitivity of Fusarium fujikuroi to Fungicide Azoxystrobin and Investigation of Resistance Mechanism.

Jiazhi Sun, Haiqun Cao, Yujie Lin, 2022, Journal of agricultural and food chemistry.

GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.

S. Sebti, G. Favre, A. Hamilton, 1997, Cancer research.

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

S. Sebti, A. Hamilton, Jiazhi Sun, 1995, Cancer research.

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.

S. Sebti, A. Hamilton, Jiazhi Sun, 1999, Cancer research.

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in chinese patients

Jiazhi Sun, D. Wood, M. Zheng, 2014 .