K. Kikuchi

发表

Usage of Tautomycetin, a Novel Inhibitor of Protein Phosphatase 1 (PP1), Reveals That PP1 Is a Positive Regulator of Raf-1 in Vivo *

M. Ubukata, T. Kataoka, N. Tanuma, 2003, The Journal of Biological Chemistry.

Purification and properties of UDP-N-acetylglucosamine 2'-epimerase from rat liver.

K. Kikuchi, S. Tsuiki, 1973, Biochimica et biophysica acta.

Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.

M. Ubukata, H. Shima, N. Matsuura, 2001, Biochemical and biophysical research communications.

Metabolism of exogenous N-acetylglucosamine in extracts of rat kidney, liver and hepatoma.

K. Kikuchi, S. Tsuiki, 1979, Biochimica et biophysica acta.

Activities of sialic acid-synthesizing enzymes in rat liver and rat and mouse tumors.

K. Kikuchi, S. Tsuiki, H. Kikuchi, 1971, Biochimica et biophysica acta.

Increases in protein phosphatase 2B activity in lymphoid tissues and T-lymphocytes of autoimmune MRL/MpJ-lpr/lpr mice.

S. Matsuzawa, K. Kikuchi, Y. Mizuno, 1993, Journal of biochemistry.

Up-regulation of I-2(PP2A)/SET gene expression in rat primary hepatomas and regenerating livers.

N. Tanuma, H. Shima, K. Kikuchi, 2000, Cancer letters.

The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity.

H. Shima, S. Mitsuhashi, K. Kikuchi, 1999, Bioorganic & medicinal chemistry letters.

A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.

N. Yorioka, N. Kohno, Hideki Yamamoto, 2002, The Journal of biological chemistry.

Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38.

K. Takagaki, N. Tanuma, H. Shima, 2004, The Biochemical journal.

Gene expressions and activities of protein phosphatases PP1 and PP2A in rat liver regeneration after partial hepatectomy.

Y. Kakinoki, S. Matsuzawa, K. Kikuchi, 1992, Biochemical and biophysical research communications.

Purification of an Mg2+-dependent protein phosphatase.

K. Kikuchi, S. Tsuiki, S. Tamura, 1988, Methods in enzymology.

[41] Purification of an Mg2+-dependent protein phosphatase

K. Kikuchi, S. Tsuiki, S. Tamura, 1988 .

Molecular cloning of cDNA for the catalytic subunit of rat liver type 2A protein phosphatase, and detection of high levels of expression of the gene in normal and cancer cells.

T. Sugimura, T. Tahira, M. Nagao, 1988, Biochimica et biophysica acta.

Thyrsiferyl 23‐acetate is a novel specific inhibitor of protein phosphatase PP2A

S. Matsuzawa, K. Kikuchi, M. Suzuki, 1994, FEBS letters.

Characterization of protein phosphatases associated with the particulate fraction from rat liver.

K. Kikuchi, S. Tsuiki, S. Tamura, 1990, The Tohoku journal of experimental medicine.

Glycogen synthase phosphatase of rat liver. Its separation from phosphorylase phosphatase on DE-52 columns.

K. Kikuchi, S. Tsuiki, S. Tamura, 1977, Biochemical and biophysical research communications.

UDP-N-acetylglucosamine 2'-epimerase of rat hepatoma and its comparison with the enzyme of rat liver.

K. Kikuchi, S. Tsuiki, 1980, The Tohoku journal of experimental medicine.

Chromosomal localization of human, rat, and mouse protein phosphatase type 1β catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization

Y. Kakinoki, K. Kikuchi, M. Yoshida, 1994 .

Tissue distribution of isoforms of type-1 protein phosphatase PP1 in mouse tissues and its diabetic alterations.

K. Kikuchi, Y. Ito, Y. Mizuno, 1994, Journal of biochemistry.

Selective Increases in Isoform PP1α of Type‐1 Protein Phosphatase in Ascites Hepatoma Cells

K. Kikuchi, M. Saadat, Y. Mizuno, 1994, Japanese journal of cancer research : Gann.

mRNA Levels of Catalytic Subunits of Protein Phosphatases 1, 2A, and 2C in Hepatocarcinogenesis

M. Nagao, K. Kikuchi, S. Tsuiki, 1992, Japanese journal of cancer research : Gann.

The interconversion of protein phosphatase 2A between PP2A1 and PP2A0 during retinoic acid-induced granulocytic differentiation and a modification on the catalytic subunit in S phase of HL-60 cells.

M. Mumby, S. Matsuzawa, B. Hemmings, 1997, Archives of biochemistry and biophysics.

Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain.

M. Inagaki, K. Kikuchi, S. Tsuiki, 1990, The Journal of biological chemistry.

Different moieties of tautomycin involved in protein phosphatase inhibition and induction of apoptosis.

M. Ubukata, S. Matsuzawa, K. Kikuchi, 1998, Biochemical pharmacology.

Shigeru Tsuiki: a pioneer in the research fields of complex carbohydrates and protein phosphatases.

K. Kikuchi, S. Tamura, T. Miyagi, 2011, Journal of biochemistry.

Vimentin‐Ser82 as a memory phosphorylation site in astrocytes

M. Inagaki, K. Kaibuchi, H. Shima, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

[Liver phosphotyrosine protein phosphatase and tyrosine protein kinase in chemical hepatocarcinogenesis].

K. Kikuchi, S. Tsuiki, S. Tamura, 1987, Gan to kagaku ryoho. Cancer & chemotherapy.

Protein tyrosine phosphatase eC selectively inhibits interleukin-6– and interleukin- 10–induced JAK-STAT signaling

N. Tanuma, H. Shima, K. Kikuchi, 2001 .

Thyrsiferyl 23-acetate and its derivatives induce apoptosis in various T- and B-leukemia cells.

S. Matsuzawa, S. Mitsuhashi, K. Kikuchi, 1999, Bioorganic & medicinal chemistry.

Distinct promoters control transmembrane and cytosolic protein tyrosine phosphatase epsilon expression during macrophage differentiation.

N. Tanuma, K. Kikuchi, K. Nakamura, 1999, European journal of biochemistry.

Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis.

M. Watanabe, H. Shima, K. Kikuchi, 1999, The Biochemical journal.

Development of an assay method for activities of serine/threonine protein phosphatase type 2B (calcineurin) in crude extracts.

Y. Nomura, H. Shima, Y. Okuma, 2000, Analytical biochemistry.

Casein and histone kinases of a rat ascites hepatoma as compared with those of rat liver.

K. Kikuchi, H. Mitsui, R. Hirai, 1985, Japanese journal of cancer research : Gann.

Identification and characterization of Mg2+-dependent phosphotyrosyl protein phosphatase from rat liver cytosol.

K. Kikuchi, S. Tsuiki, S. Tamura, 1986, Biochemical and biophysical research communications.

Purification and characterization of Mg2+-dependent glycogen synthase phosphatase (phosphoprotein phosphatase IA) from rat liver.

K. Kikuchi, S. Tsuiki, S. Tamura, 1981, European journal of biochemistry.

Purification and subunit structure of a high-molecular-weight phosphoprotein phosphatase (phosphatase II) from rat liver.

K. Kikuchi, S. Tsuiki, S. Tamura, 1980, European journal of biochemistry.

Characterization of multiple forms of histone phosphatase in rat liver.

K. Kikuchi, S. Tsuiki, S. Tamura, 1978, Biochimica et biophysica acta.

Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10

Y. Matsuda, H. Shima, K. Kikuchi, 2000, Cytogenetic and Genome Research.

Regional localization of rat and mouse protein-tyrosine phosphatase PTP alpha/LRP gene (Ptpra) by fluorescence in situ hybridization.

M. Yoshida, K. Kikuchi, K. Nakamura, 1995, Idengaku zasshi.

Regional localization of rat and mouse protein-tyrosine phosphatase PTPα/LRP gene (Ptpra) by fluorescence in situ hybridization

K. Kikuchi, M. Yoshida, M. Saadat, 1995 .

TGFβ1 suppresses EGF‐induced increase in nuclear type 1 protein phosphatase activity at the G1/S transition of hepatocyte proliferation

Y. Kakinoki, K. Kikuchi, Y. Mizuno, 1994, FEBS letters.

Molecular cloning of rat type 2C (IA) protein phosphatase mRNA.

A. Yasui, J. Larner, K. Kikuchi, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Expression of the protein phosphatases PP1a and PP1g1 in rat ascites hepatoma cell lines and in rat hepatocyte cell line

K. Kikuchi, M. Saadat, 2005 .

pp32/ I-1PP2A negatively regulates the Raf-1/MEK/ERK pathway

N. Tanuma, H. Shima, K. Kikuchi, 2005 .

Analysis of isoform specific function of PP1 catalytic subunits in mammalian cells using siRNA.

N. Tanuma, H. Shima, S. Mitsuhashi, 2004, International journal of oncology.

MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm.

N. Tanuma, H. Shima, K. Kikuchi, 2010, Biochemical and biophysical research communications.

Phosphorylation of Ser-446 Determines Stability of MKP-7*

K. Yamashita, H. Shima, T. Urano, 2005, Journal of Biological Chemistry.

Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species.

H. Shima, S. Mitsuhashi, K. Kikuchi, 2004, Journal of natural products.

Phosphorylation of keratin intermediate filaments by protein kinase C, by calmodulin-dependent protein kinase and by cAMP-dependent protein kinase.

M. Inagaki, K. Kikuchi, T. Yano, 1991, European journal of biochemistry.

Cytosolic protein phosphatases of rat ascites hepatoma AH-13 as compared with those of rat liver: isolation and characterization of a novel protein phosphatase.

K. Kikuchi, S. Tsuiki, S. Tamura, 1984, Gan.

Effect of ethanol treatment on high molecular weight phosphoprotein phosphatases of rat liver.

K. Kikuchi, S. Tsuiki, S. Tamura, 1980, The Tohoku journal of experimental medicine.

Nuclear Inhibitor of Protein Phosphatase-1 (NIPP1) Directs Protein Phosphatase-1 (PP1) to Dephosphorylate the U2 Small Nuclear Ribonucleoprotein Particle (snRNP) Component, Spliceosome-associated Protein 155 (Sap155)*

M. Bollen, N. Tanuma, H. Shima, 2008, Journal of Biological Chemistry.

Reduced tumorigenicity of murine leukemia cells expressing protein-tyrosine phosphatase, PTPɛC

N. Tanuma, H. Shima, K. Kikuchi, 2003, Oncogene.

Activation of ERK Induces Phosphorylation of MAPK Phosphatase-7, a JNK Specific Phosphatase, at Ser-446*

Chiaki Katagiri, Hiroshi Shima, H. Shima, 2003, Journal of Biological Chemistry.

Tyrosine protein kinase in preneoplastic and neoplastic rat liver.

K. Kikuchi, R. Hirai, S. Tsuiki, 1988, Archives of biochemistry and biophysics.

Gene Expressions of Protein Tyrosine Phosphatases in Regenerating Rat Liver and Rat Ascites Hepatoma Cells

K. Kikuchi, Takaya Kitamura, Y. Mizuno, 1995, Japanese journal of cancer research : Gann.

Scapinin, a Putative Protein Phosphatase-1 Regulatory Subunit Associated with the Nuclear Nonchromatin Structure*

H. Shima, K. Kikuchi, J. Sagara, 2003, Journal of Biological Chemistry.

Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT signaling and differentiation induced by interleukin-6 and leukemia inhibitory factor in M1 leukemia cells.

N. Tanuma, H. Shima, K. Kikuchi, 2000, The Journal of biological chemistry.

Increased expression of NIPP-1 mRNA correlates positively with malignant phenotype in rat hepatomas.

H. Shima, K. Kikuchi, K. Nakamura, 2000, International journal of oncology.

Differences between Saccharomyces cerevisiae and Bacillus subtilis in secretion of human lysozyme.

M. Ikehara, M. Kikuchi, K. Kikuchi, 1987, Biochemical and biophysical research communications.

Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain

Masahiko Watanabe, K. Takagaki, N. Tanuma, 2007, Molecular and Cellular Biochemistry.

A-Kinase Anchoring Protein AKAP220 Binds to Glycogen Synthase Kinase-3β (GSK-3β) and Mediates Protein Kinase A-dependent Inhibition of GSK-3β*

N. Yorioka, N. Kohno, Hideki Yamamoto, 2002, The Journal of Biological Chemistry.

Broad specificity in binding of NIPP-1, nuclear inhibitor of protein phosphatase-1, to PP1 isoforms in vivo.

H. Shima, K. Kikuchi, K. Nakamura, 2000, The Tohoku journal of experimental medicine.

Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell–cell adhesion

K. Takagaki, R. Katakura, N. Tanuma, 2009, Oncogene.

MKP-7, a Novel Mitogen-activated Protein Kinase Phosphatase, Functions as a Shuttle Protein*

Masahiko Watanabe, H. Shima, K. Kikuchi, 2001, The Journal of Biological Chemistry.

The characteristic gene expressions of MAPK phosphatases 1 and 2 in hepatocarcinogenesis, rat ascites hepatoma cells, and regenerating rat liver.

K. Kikuchi, K. Nakamura, Y. Mizuno, 1997, Biochemical and biophysical research communications.

Analysis of glucose-6-phosphate translocase and hexose-6-phosphate phosphohydrolase, the two obligatory components of microsomal glucose-6-phosphatase system, in rat liver.

K. Tada, K. Kikuchi, S. Tsuiki, 1988, The Tohoku journal of experimental medicine.

Protein tyrosine phosphatase epsilonC selectively inhibits interleukin-6- and interleukin- 10-induced JAK-STAT signaling.

N. Tanuma, H. Shima, K. Kikuchi, 2001, Blood.

The apoptosis-inducing activity of the two protein phosphatase inhibitors, tautomycin and thyrsiferyl 23-acetate, is not due to the inhibition of protein phosphatases PP1 and PP2A (review).

H. Shima, S. Mitsuhashi, K. Kikuchi, 1999, International journal of molecular medicine.

Functional properties of the rat phosphatase 1α promoter

F. Müller, W. Schmitz, K. Kikuchi, 2001, Molecular and Cellular Biochemistry.

Molecular cloning and analysis of the 5'-flanking region of the rat PP1α gene

K. Kikuchi, Y. Mizuno, K. Nomoto, 1996 .

Gene expression of protein phosphatases in rat ascites hepatoma cell lines.

T. Kudo, K. Kikuchi, M. Saadat, 1994, Cancer detection and prevention.

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

N. Aoki, H. Shima, S. Mitsuhashi, 2006, Marine Drugs.

Protein phosphatase type 2A, PP2A, is involved in degradation of gp130

M. Ubukata, N. Tanuma, H. Shima, 2005, Molecular and Cellular Biochemistry.

Molecular cloning of a novel cytoplasmic protein tyrosine phosphatase PTPε

K. Kikuchi, K. Nakamura, Y. Mizuno, 1996 .

Molecular cloning of a novel cytoplasmic protein tyrosine phosphatase PTP epsilon.

K. Kikuchi, K. Nakamura, Y. Mizuno, 1996, Biochemical and biophysical research communications.

Alterations in type-1 serine/threonine protein phosphatase PP1alpha in response to B-cell receptor stimulation.

M. Inagaki, S. Matsuzawa, N. Inagaki, 1997, Journal of biochemistry.

Identification and characterization of a novel protein inhibitor of type 1 protein phosphatase.

H. Shima, K. Kikuchi, M. Ito, 2000, Biochemistry.

Up-regulation of nuclear PP1alpha and PP1delta in hepatoma cells.

Y. Kakinoki, H. Shima, K. Kikuchi, 1999, International journal of oncology.

Molecular cloning and sequence analysis of cDNA for the catalytic subunit 1 alpha of rat kidney type 1 protein phosphatase, and detection of the gene expression at high levels in hepatoma cells and regenerating livers as compared to rat livers.

A. Yasui, K. Kikuchi, S. Tsuiki, 1991, Journal of biochemistry.

Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells.

H. Shima, T. Urano, K. Kikuchi, 2003, Journal of biochemistry.

Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene.

Y. Matsuda, H. Nakagama, H. Shima, 2000, International journal of oncology.

The NMR structure of the NIPP1 FHA domain

K. Ogura, F. Inagaki, K. Kikuchi, 2008, Journal of biomolecular NMR.

IL-2 induces transient and specific decrease in cytosolic protein phosphatase PP1 activity in murine T cell lines.

S. Matsuzawa, K. Kikuchi, A. Matsuda, 1993, Biochemical and biophysical research communications.

Particulate‐associated Protein Phosphatases of Rat Hepatomas as Compared with the Enzymes of Rat Liver

K. Kikuchi, S. Tsuiki, S. Tamura, 1990, Japanese journal of cancer research : Gann.

Cell cycle dependent gene expressions and activities of protein phosphatases PP1 and PP2A in mouse NIH3T3 fibroblasts.

S. Matsuzawa, K. Kikuchi, K. Nakamura, 1992, Biochemical and biophysical research communications.

Tautomycetin suppresses the TNFα/NF-κB pathway via inhibition of IKK activation

M. Ubukata, T. Okamoto, N. Tanuma, 1992 .

Reduced tumorigenicity of murine leukemia cells expressing protein-tyrosine phosphatase, PTPepsilon C.

N. Tanuma, H. Shima, K. Kikuchi, 2003, Oncogene.

Defect of delta-sarcoglycan gene is responsible for development of dilated cardiomyopathy of a novel hamster strain, J2N-k: calcineurin/PP2B activity in the heart of J2N-k hamster.

H. Shima, S. Mitsuhashi, K. Kikuchi, 2003, Journal of biochemistry.

The selective reduction in PTPdelta expression in hepatomas.

K. Kikuchi, Y. Mizuno, K. Nakamura, 1998, International journal of oncology.

Distinct promoters control transmembrane and cytosolic′ protein tyrosine phosphatase _ expression during′ macrophage differentation.

N. Tanuma, K. Kikuchi, K. Nakamura, 1999 .

Neoplastic alterations in subcellular distribution of type 1 alpha protein phosphatase in rat ascites hepatoma cells.

Y. Kakinoki, K. Kikuchi, M. Saadat, 1995, Cancer letters.

Assignment of PTPRE encoding protein tyrosine phosphatase ε to human chromosome 10q26.2-q26.3

K. Kikuchi, K. Nakamura, M. Yoshida, 1997 .

Comparative mapping of the gene encoding the catalytic subunit of protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse chromosomes.

M. Yoshida, K. Kikuchi, M. Saadat, 1995, Cytogenetics and cell genetics.

Selective high expression of protein phosphatase pp1-alpha messenger-RNA in rat poorly differentiated ascites hepatomas.

K. Kikuchi, Y. Mizuno, K. Sato, 1993, International journal of oncology.

Expressions and activities of protein phosphatases during carcinogenesis, regeneration, and cell cycle.

K. Kikuchi, 1993 .