E. Masuda

发表

Systematic identification of regulatory proteins critical for T-cell activation

D. Payan, P. Chu, Jorge Pardo, 2003, Journal of biology.

A class of small molecules that inhibit TNFalpha-induced survival and death pathways via prevention of interactions between TNFalphaRI, TRADD, and RIP1.

D. Payan, E. Masuda, T. Kinoshita, 2007, Chemistry & biology.

A Class of Small Molecules that Inhibit TNFα-Induced Survival and Death Pathways via Prevention of Interactions between TNFαRI, TRADD, and RIP1

Donald G. Payan, Jianing Huang, D. Payan, 2007 .

Novel Immunosuppression: R348, a JAK3- and Syk-Inhibitor Attenuates Acute Cardiac Allograft Rejection

E. Masuda, R. Robbins, J. Velotta, 2008, Transplantation.

diaphragmced protease activation in the Oxidative stress is required for mechanical

S. Powers, L. Koch, S. Britton, 2015 .

NFATz: a novel rel similarity domain containing protein.

K. Arai, F. Bazan, K. Arai, 2000, Biochemical and biophysical research communications.

Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets.

K. Arai, E. Masuda, N. Arai, 1998, Journal of immunology.

Signalling into the T-cell nucleus: NFAT regulation.

K. Arai, E. Masuda, N. Arai, 1998, Cellular signalling.

Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation.

E. Gelfand, A. Joetham, E. Masuda, 2006, American journal of respiratory cell and molecular biology.

A Novel E3 Ubiquitin Ligase TRAC-1 Positively Regulates T Cell Activation

D. Payan, P. Chu, Jorge Pardo, 2005, The Journal of Immunology.

Inhibition of spleen tyrosine kinase decreases donor specific antibody levels in a rat model of sensitization

E. Masuda, C. Pusey, S. Tempest-Roe, 2022, Scientific Reports.

SYK inhibition attenuates autoantibody production and reverses Experimental Autoimmune Glomerulonephritis

E. Masuda, F. Tam, J. McDaid, 2015 .

Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN.

E. Masuda, C. Pusey, F. Tam, 2014, Journal of the American Society of Nephrology : JASN.

Therapeutic Targeting of Syk in Autoimmune Diabetes

A. Tarakhovsky, V. D’Agati, James W. Thomas, 2010, The Journal of Immunology.

Diabetes Therapeutic Targeting of Syk in Autoimmune

A. Tarakhovsky, V. D’Agati, James W. Thomas, 2010 .

Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing.

E. Masuda, V. Taylor, E. Grossbard, 2009, Birth defects research. Part A, Clinical and molecular teratology.

Immunotoxicity assessment for the novel Spleen tyrosine kinase inhibitor R406.

E. Masuda, E. Herlaar, E. Grossbard, 2007, Toxicology and applied pharmacology.

Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction

S. Powers, Ira J. Smith, D. Payan, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Chapter 24 Spleen Tyrosine Kinase (Syk) Biology, Inhibitors and Therapeutic Applications

E. Masuda, Rajinder Singh, 2007 .

Spleen Tyrosine Kinase Is Important in the Production of Proinflammatory Cytokines and Cell Proliferation in Human Mesangial Cells following Stimulation with IgA1 Isolated from IgA Nephropathy Patients

J. Barratt, E. Masuda, C. Pusey, 2012, The Journal of Immunology.

Isolated from IgA Nephropathy Patients Cells following Stimulation with IgA1 and Cell Proliferation in Human Mesangial Production of Proinflammatory Cytokines Spleen Tyrosine Kinase Is Important in the

J. Barratt, E. Masuda, C. Pusey, 2012 .

A Bacterial Artificial Chromosome Reporter System for Expression of the Human FOXP3 Gene in Mouse Regulatory T-Cells

Chihiro Ogawa, H. Waldmann, E. Masuda, 2017, Front. Immunol..

Regulation of expression of the IL-2 and IL-5 genes and the role of proteins related to nuclear factor of activated T cells.

K. Arai, T. Yokota, H. Lee, 1995, The Journal of allergy and clinical immunology.

Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells: involvement of the conserved lymphokine element 0.

K. Arai, H. Tokumitsu, E. Masuda, 1994, Molecular biology of the cell.

Activation of lymphokine genes in T cells: role of cis-acting DNA elements that respond to T cell activation signals.

Y. Yamaguchi-Iwai, E. Masuda, T. Heike, 1992, Pharmacology & therapeutics.

Tomosyn Binds t-SNARE Proteins via a VAMP-like Coiled Coil

R. Scheller, Ying Luo, Betty C. B. Huang, 1998, Neuron.

Quantitative measurement of mast cell degranulation using a novel flow cytometric annexin-V binding assay.

S. Demo, R. Scheller, D. Payan, 1999, Cytometry.

Identification of the Syk kinase inhibitor R112 by a human mast cell screen.

D. Payan, E. Masuda, Rajinder Singh, 2006, The Journal of allergy and clinical immunology.

A Novel JAK3 Inhibitor, R348, Attenuates Chronic Airway Allograft Rejection

E. Masuda, R. Robbins, J. Velotta, 2009, Transplantation.

Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP.

K. Arai, T. Yokota, H. Lee, 1995, Journal of immunology.

Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors

Yosuke Tanaka, Terumasa Umemoto, N. Komatsu, 2021, Nature Communications.

Transactivation Activity in T Cells Tissue-Specific Splicing and Is Essential for of NFATx1 Is Possibly Created by Carboxyl-Terminal 15-Amino Acid Sequence

K. Arai, E. Masuda, S. Imai, 1998 .

Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness.

E. Gelfand, E. Masuda, J. Lucas, 2006, American journal of respiratory and critical care medicine.

Rab37 is a novel mast cell specific GTPase localized to secretory granules

R. Scheller, D. Payan, M. Shen, 2000, FEBS letters.

Functional screening of genes suppressing TRAIL-induced apoptosis: distinct inhibitory activities of Bcl-XL and Bcl-2

D. Noh, E. Masuda, Chung-Hae Choi, 2003, British Journal of Cancer.

A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis.

E. Masuda, C. Pusey, F. Tam, 2010, Journal of the American Society of Nephrology : JASN.

Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice.

A. Beg, E. Masuda, B. Blazar, 2013, Blood.

NF-ATx 1 NF-ATx 1 Recruit Calcineurin to Murine Regions in the N-Terminal Domain of Murine Two Independent Calcineurin-Binding

K. Arai, E. Masuda, N. Arai, 1999 .

Regulation of bone homeostasis by MERTK and TYRO3

C. Bokemeyer, K. Pantel, E. Hesse, 2022, Nature communications.

Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

E. Masuda, C. Pusey, A. Cowburn, 2022, Arthritis & rheumatology.

Assessment of thrombotic risk during long-term treatment of immune thrombocytopenia with fostamatinib

V. Markovtsov, S. Watson, J. Bussel, 2021, Therapeutic advances in hematology.

Long-Term Safety Profile of the Oral Spleen Tyrosine Kinase Inhibitor Fostamatinib in Immune Thrombocytopenia (ITP) and Other Diseases

E. Masuda, R. Numerof, S. Tong, 2020 .

Retrovirally Delivered Random Cyclic Peptide Libraries Yield Inhibitors of Interleukin-4 Signaling in Human B Cells*

D. Payan, Weiqun Li, E. Pali, 2002, The Journal of Biological Chemistry.

Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells.

K. Arai, E. Masuda, S. Imai, 1998, Journal of immunology.

Definition of cis-Regulatory Elements of the Mouse Interleukin-5 Gene Promoter

K. Arai, T. Yokota, E. Masuda, 1995, The Journal of Biological Chemistry.

Discovery and development of spleen tyrosine kinase (SYK) inhibitors.

D. Payan, E. Masuda, Rajinder Singh, 2012, Journal of medicinal chemistry.

R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation

D. Payan, Haoran Zhao, K. Qu, 2006, Journal of Pharmacology and Experimental Therapeutics.

Retroviral delivery of peptide modulators of cellular functions.

G. Nolan, D. Payan, J. Lorens, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

Targeting Syk as a treatment for allergic and autoimmune disorders

D. Payan, E. Masuda, E. Grossbard, 2004, Expert opinion on investigational drugs.

A Novel Role for p21-Activated Protein Kinase 2 in T Cell Activation

Jun Wu, D. Payan, P. Chu, 2004, The Journal of Immunology.

A Novel Role for p 21-Activated Protein Kinase 2 in T Cell Activation

Jun Wu, D. Payan, P. Chu, 2004 .

Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling.

D. Payan, Haoran Zhao, E. Masuda, 2015, Bioorganic & medicinal chemistry letters.

Spleen tyrosine kinase inhibition is an effective treatment for established vasculitis in a pre-clinical model

E. Masuda, C. Pusey, F. Tam, 2020, Kidney international.

The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT

K. Arai, H. Tokumitsu, E. Masuda, 1993, Molecular and cellular biology.

Amisyn, a Novel Syntaxin-binding Protein That May Regulate SNARE Complex Assembly*

R. Scheller, E. Masuda, S. Scales, 2002, The Journal of Biological Chemistry.

Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain

K. Arai, E. Masuda, S. Imai, 1997, Molecular and cellular biology.

NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus

K. Arai, H. Tokumitsu, C. Hannum, 1995, Molecular and cellular biology.

Two developmental genes encoding sigma factor homologs are arranged in tandem in Bacillus subtilis.

E. Masuda, Kazunori Yamada, Y. Kobayashi, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Nucleotide sequence of the sporulation gene spoIIGA from Bacillus subtilis.

T. Sato, M. Takeuchi, Tsutomu Sato, 1990, Nucleic acids research.

Syk inhibitors as treatment for allergic rhinitis.

E. Masuda, J. Schmitz, 2008, Pulmonary pharmacology & therapeutics.

Two independent calcineurin-binding regions in the N-terminal domain of murine NF-ATx1 recruit calcineurin to murine NF-ATx1.

K. Arai, E. Masuda, N. Arai, 1999, Journal of immunology.

Optimization of Pyrimidine Compounds as Potent JAK1 Inhibitors and the Discovery of R507 as a Clinical Candidate.

D. Payan, E. Masuda, Hui Li, 2022, ACS Medicinal Chemistry Letters.

The transcription factor Sp1 is required for induction of the murine GM-CSF promoter in T cells.

K. Arai, Y. Yamaguchi-Iwai, E. Masuda, 1994, Biochemical and biophysical research communications.

Characterization of NF(P), the nuclear factor that interacts with the regulatory P sequence (5'-CGAAAATTTCC-3') of the human interleukin-4 gene: relationship to NF-kappa B and NF-AT.

K. Arai, E. Masuda, N. Arai, 1994, Biochemical and biophysical research communications.

Clinical Trial to Evaluate an Approved ITP Therapy Targeting Spleen Tyrosine Kinase (SYK) for Prevention and Treatment of COVID-19 Related Complications

V. Markovtsov, E. Masuda, W. Dummer, 2020, Blood.

Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling

B. Oh, Young-Jun Jeon, E. Masuda, 2008, Oncogene.

Purification of the 120 kDa component of the human nuclear factor of activated T cells (NF-AT): reconstitution of binding activity to the cis-acting element of the GM-CSF and IL-2 promoter with AP-1.

K. Arai, H. Tokumitsu, E. Masuda, 1993, Biochemical and biophysical research communications.

Immune and inflammatory mechanisms

J. Barratt, E. Masuda, T. Akizawa, 2011 .

Modulateurs de l'activation et de la migration des lymphocytes

P. Chu, Jorge Pardo, Haoran Zhao, 2002 .

Two developmental genes encoding cr factor homologs are arranged in tandem in Bacillus subtilis ( spore formation / transcriptional regulation / deletion mutation )

E. Masuda, Kazunori Yamada, H. Anaguchi, 2022 .

Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.

D. Payan, E. Masuda, Hui Li, 2022, Bioorganic & medicinal chemistry letters.

Discovery of 5-Aryl-2,4-diaminopyrimidine Compounds as Potent and Selective IRAK4 Inhibitors.

D. Payan, E. Masuda, V. Taylor, 2022, ACS medicinal chemistry letters.

OP0133 PRECLINICAL EFFICACY OF R835, A NOVEL IRAK1/4 DUAL INHIBITOR, IN RODENT MODELS OF JOINT INFLAMMATION

V. Markovtsov, E. Masuda, S. Yi, 2020 .

Inhibition of Immune Thrombocytopenic Purpura (ITP) by an Orally Bioavailable Inhibitor of Syk Kinase Activity.

J. Freedman, E. Masuda, A. Lazarus, 2005 .

Targeting autoimmunity: strategies and tactics.

D. Payan, E. Masuda, 2014, Drug discovery today.

Discovery and development of spleen tyrosine kinase (SYK) inhibitors.

D. Payan, E. Masuda, Rajinder Singh, 2012, Journal of medicinal chemistry.

Application of cultured human mast cells (CHMC) for the design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.

D. Payan, E. Masuda, Hui Li, 2015, Bioorganic & medicinal chemistry letters.

Spleen tyrosine kinase activation in circulating and tissue innate immune cells in ANCA associated vasculitis

E. Masuda, C. Pusey, A. Cowburn, 2022, Arthritis & Rheumatology.