D. Spitz

发表

Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures.

Edouard I Azzam, J. Little, E. Azzam, 2002, Cancer research.

Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells.

D. Spitz, G. Denning, Y. O’Malley, 2004, American journal of physiology. Lung cellular and molecular physiology.

Establishment of a hydrogen peroxide resistant variant of renal tubular epithelial cells: role of calcium-independent phospholipase A2 in cell damage.

M. Morgan, M. Goligorsky, D. Spitz, 1993, Archives of biochemistry and biophysics.

Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation

J. Yodoi, D. Spitz, D. Gius, 2002, Oncogene.

Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.

Junko Oshima, G. Hunninghake, M. Monick, 2009, American journal of respiratory and critical care medicine.

Alterations in heat-induced radiosensitization accompanied by nuclear structure alterations in Chinese hamster cells

Amanda Harvey, D. Spitz, J. R. Roti Roti, 2006, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.

Peter M. Scarbrough, D. Spitz, Yueming Zhu, 2011, Cancer research.

Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability.

Brian J. Smith, F. Domann, D. Spitz, 2006, Cancer research.

The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma.

L. Oberley, F. Domann, D. Spitz, 2003, Cancer research.

Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.

F. Domann, D. Spitz, N. Aykin-Burns, 2012, Free radical biology & medicine.

Mitochondrial Complex II Dysfunction Can Contribute Significantly to Genomic Instability after Exposure to Ionizing Radiation

C. Limoli, F. Domann, D. Spitz, 2009, Radiation research.

Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy.

J. Buatti, D. Spitz, G. Funk, 2008, International journal of radiation oncology, biology, physics.

Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents

D. Spitz, M. Milhem, B. Allen, 2020, Cancers.

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

Mark E. Anderson, S. Heymans, R. Weiss, 2011, Nature Medicine.

Radioresistance in Glioblastoma and the Development of Radiosensitizers

J. Buatti, Corinne E Griguer, D. Spitz, 2020, Cancers.

Superoxide Mediates the Actions of Angiotensin II in the Central Nervous System

D. Spitz, M. Zimmerman, E. Lazartigues, 2002, Circulation research.

Mitochondrial Calcium Uniporter Activity Is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival

Mark E. Anderson, D. Hall, F. Domann, 2014, PloS one.

Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue.

T. Waldron, D. Spitz, J. Cullen, 2019, Seminars in radiation oncology.

H2O2-induced O⨪2Production by a Non-phagocytic NAD(P)H Oxidase Causes Oxidant Injury*

L. Oberley, D. Spitz, N. Weintraub, 2001, The Journal of Biological Chemistry.

Transgenic Biosynthesis of Trypanothione Protects Escherichia coli from Radiation-Induced Toxicity

F. Domann, D. Spitz, R. Radi, 2010, Radiation research.

Role of Glutaredoxin in Metabolic Oxidative Stress

M. Suntharalingam, Yong J. Lee, Jae-Joon Song, 2002, The Journal of Biological Chemistry.

Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma

J. Mezhir, D. Spitz, D. Berg, 2018, Radiation Research.

Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation.

L. Oberley, D. Spitz, M. Robbins, 2001, Cancer research.

Plasminogen Activator Inhibitor-1 following Ionizing Radiation Redox Modulation of the Pro-Fibrogenic Mediator Updated

L. Oberley, D. Spitz, Weiling Zhao, 2001 .

The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency.

D. Spitz, A. Klingelhutz, F. Goldman, 2011, Antioxidants & redox signaling.

Expression of human Mn SOD in Chinese hamster ovary cells confers protection from oxidant injury.

D. Spitz, J. Wispé, B. Warner, 1993, The American journal of physiology.

Pharmacological ascorbate improves the response to platinum-based chemotherapy in advanced stage non-small cell lung cancer

Brian J. Smith, J. Buatti, J. Houtman, 2022, Redox biology.

Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats.

D. Spitz, H. Gurer, N. Ercal, 1998, Toxicology.

Hydrogen peroxide or heat shock induces resistance to hydrogen peroxide in Chinese hamster fibroblasts

W. Dewey, G. Li, Gloria C. Li, 1987, Journal of cellular physiology.

An alternative method to stereotactic inoculation of transplantable brain tumours in large numbers of rats

R. Higashikubo, D. Spitz, J. R. Roti Roti, 2000, Laboratory animals.

Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney Injury

J. Buatti, J. Holmlund, D. Spitz, 2021, Antioxidants.

Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer.

J. Buatti, D. Spitz, K. Gibson-Corley, 2018, Cancer research.

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells

J. Mezhir, F. Domann, D. Spitz, 2015, Redox biology.

Increased Oxidative Stress Created by Adenoviral MnSOD or CuZnSOD plus BCNU Inhibits Breast Cancer Cell Growth

L. Oberley, D. Spitz, C. Weydert, 2013 .

Cancer Therapy : Preclinical Ketogenic Diets Enhance Oxidative Stress and Radio-ChemoTherapy Responses in Lung Cancer Xenografts

Brian J. Smith, J. Buatti, D. Spitz, 2013 .

Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts

Brian J. Smith, J. Buatti, D. Spitz, 2013, Clinical Cancer Research.

Combination therapy with radiation and PARP inhibition enhances responsiveness to anti-PD-1 therapy in colorectal tumor models.

D. Spitz, S. Mott, B. Allen, 2020, International journal of radiation oncology, biology, physics.

2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism.

R. Aft, D. Spitz, D. Gius, 2003, Cancer research.

Enhancement of Carboplatin-Mediated Lung Cancer Cell Killing by Simultaneous Disruption of Glutathione and Thioredoxin Metabolism

D. Spitz, M. Fath, I. Ahmad, 2011, Clinical Cancer Research.

Hepatitis C virus‐core and non structural proteins lead to different effects on cellular antioxidant defenses

D. Spitz, B. Britigan, W. Schmidt, 2005, Journal of medical virology.

Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co‐expressing HCV core protein and CYP2E1

A. Branch, D. Spitz, B. Britigan, 2004, Journal of medical virology.

Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity

D. Spitz, J. Cullen, G. Buettner, 2020, Cancer Research.

Triphenylphosphonium derivatives disrupt metabolism and inhibit melanoma growth in vivo when delivered via a thermosensitive hydrogel.

D. Spitz, D. Seol, G. Buettner, 2020, PloS one.

Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism

D. Spitz, Yueming Zhu, B. Allen, 2016, Radiation Research.

Stress protection by a fluorescent Hsp27 chimera that is independent of nuclear translocation or multimeric dissociation

J. Landry, D. Spitz, M. Freeman, 2002, Cell stress & chaperones.

Redox Factor-1 (Ref-1) Mediates the Activation of AP-1 in HeLa and NIH 3T3 Cells in Response to Heat Shock*

C. Hunt, D. Spitz, D. Gius, 1999, The Journal of Biological Chemistry.

Heat‐induced cytotoxicity in H2O2‐resistant Chinese hamster fibroblasts

G. Li, Gloria C. Li, D. Spitz, 1990, Journal of cellular physiology.

Understanding High-Dose, Ultra-High Dose-Rate and , Spatially Fractionated Radiotherapy.

C. N. Coleman, Sha X. Chang, S. Kalnicki, 2020, International journal of radiation oncology, biology, physics.

Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock.

C. Hunt, D. Spitz, D. Gius, 1999, The Journal of biological chemistry.

Catalase Abrogates b-Lapachone–Induced PARP1 Hyperactivation–Directed Programmed Necrosis in NQO1-Positive Breast Cancers

Melissa C. Srougi, Jinming Gao, Longshan Li, 2013 .

Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil

A. Nanji, L. Oberley, D. Spitz, 1998, Hepatology.

The mechanism of cell death induced by silver nanoparticles is distinct from silver cations

D. Spitz, Ravi Singh, C. Furdui, 2021, Particle and fibre toxicology.

Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study

D. Spitz, G. Buettner, B. Allen, 2022, Journal of radiation research.

Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism.

G. Patti, D. Spitz, A. Elhammali, 2018, Cancer research.

Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription

D. Spitz, M. McCormick, O. Koval, 2018, Redox biology.

Assay of superoxide dismutase activity in tumor tissue.

L. Oberley, D. Spitz, 1984, Methods in enzymology.

Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria.

T. Scholz, D. Spitz, J. Segar, 2009, Clinical science.

Mammalian resistance to oxidative stress: a comparative analysis.

H. Lin, D. Spitz, D. Crawford, 2002, Gene expression.

Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.

L. Marnett, D. Spitz, D. Gius, 2002, Free radical biology & medicine.

The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion

C. Knudson, D. Spitz, S. Walsh, 2006, The Journal of Immunology.

An assay for superoxide dismutase activity in mammalian tissue homogenates.

L. Oberley, D. Spitz, 1989, Analytical biochemistry.

Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid

D. Spitz, M. McCormick, K. K. Kiningham, 2015, Redox biology.

Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress.

D. Spitz, K. Kregel, S. Walsh, 2005, Journal of applied physiology.

Aging reduces responsiveness to BSO- and heat stress-induced perturbations of glutathione and antioxidant enzymes.

D. Spitz, K. Kregel, S. Walsh, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress.

C. Hunt, D. Spitz, T. Featherstone, 1998, Cancer research.

Evaluation of Parameters of Oxidative Stress after In Vitro Exposure to FMCW- and CDMA-Modulated Radiofrequency Radiation Fields

E. Moros, J. Baty, R. Higashikubo, 2004, Radiation research.

All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB.

M. P. Cole, D. Spitz, Carla R. Cook, 2008, Free radical biology & medicine.

The generation of stable oxidative stress-resistant phenotypes in Chinese hamster fibroblasts chronically exposed to hydrogen peroxide or hyperoxia.

D. Spitz, S. Sullivan, 2010, Methods in molecular biology.

Stable H2O2-resistant variants of Chinese hamster fibroblasts demonstrate increases in catalase activity.

Y. Sun, L. Oberley, G. Li, 1988, Radiation research.

Contribution of increased glutathione content to mechanisms of oxidative stress resistance in hydrogen peroxide resistant hamster fibroblasts

R. Roberts, D. Spitz, M. Kinter, 1995, Journal of cellular physiology.

Cellular resistance to oxidative stress is accompanied by resistance to cisplatin: The significance of increased catalase activity and total glutathione in hydrogen peroxide‐resistant fibroblasts

J. Phillips, D. Deen, Gloria C. Li, 1993, Journal of cellular physiology.

Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress

D. Spitz, D. Rutkowski, Heather M. Tyra, 2012, Molecular biology of the cell.

Mitochondrial Cu,Zn-Superoxide Dismutase Mediates Pulmonary Fibrosis by Augmenting H2O2 Generation*

A. Ryan, S. Murthy, D. Spitz, 2011, The Journal of Biological Chemistry.

Trace quantitation of 4-hydroxy-2-nonenal in biological samples as its oxime-bis-tert.-butyldimethylsilyl derivative using 3-hydroxynonanal as an internal standard.

D. Spitz, M. Kinter, R. J. Roberts, 1992, Journal of chromatography.

Glutathione dependent metabolism and detoxification of 4-hydroxy-2-nonenal.

R. Roberts, D. Spitz, S. Sullivan, 1991, Free radical biology & medicine.

Increased activator protein 1 activity as well as resistance to heat-induced radiosensitization, hydrogen peroxide, and cisplatin are inhibited by indomethacin in oxidative stress-resistant cells.

C. Hunt, D. Spitz, D. Gius, 2001, Cancer research.

Treatment of Pancreatic Cancer Cells with Dicumarol Induces Cytotoxicity and Oxidative Stress

D. Spitz, J. Cullen, M. Hinkhouse, 2004, Clinical Cancer Research.

In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine.

D. Spitz, N. Ercal, T. C. Hammond, 1996, Free radical biology & medicine.

Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.

D. Spitz, P. Dennery, K. Poss, 1998, The Journal of clinical investigation.

Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

J. Yodoi, K. Hirota, D. Spitz, 2000, Cancer research.

Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism.

D. Spitz, N. Aykin-Burns, Ling-Hao Li, 2009, Free radical biology & medicine.

Increased hepatic telomerase activity in a rat model of iron overload: a role for altered thiol redox state?

L. Ridnour, D. Spitz, W. Schmidt, 2007, Free radical biology & medicine.

Hypoxia and resistance to hydrogen peroxide confer resistance to tumor necrosis factor in murine L929 cells.

G. Hahn, D. Spitz, R. Anderson, 1992, Radiation research.

Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle.

R. Higashikubo, D. Spitz, Hannah J. Zhang, 2003, Cancer research.

Differential susceptibility of nonmalignant human breast epithelial cells and breast cancer cells to thiol antioxidant-induced G(1)-delay.

D. Spitz, P. Goswami, S. Walsh, 2005, Antioxidants & redox signaling.

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells

F. Zhan, D. Spitz, D. Berg, 2017, Redox biology.

Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population

F. Domann, D. Spitz, Yueming Zhu, 2014, Redox biology.

Manipulations of Redox Metabolism for Enhancing Radiation Therapy Responses: A Historical Perspective and Novel Hypothesis.

D. Spitz, 2019, Seminars in radiation oncology.

Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine.

D. Spitz, M. Hauer-Jensen, 2014, Antioxidants & redox signaling.

Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes.

D. Spitz, Wusheng Xiao, Yueming Zhu, 2013, Free radical biology & medicine.

Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer

L. Oberley, Yuping Zhang, D. Spitz, 2010, Cancers.

Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen.

L. Oberley, Yuping Zhang, F. Domann, 2006, Antioxidants & redox signaling.

Growth of Pancreatic Adenocarcinoma The Role of Manganese Superoxide Dismutase in the Updated

L. Oberley, F. Domann, D. Spitz, 2003 .

Measurement of MnSOD and CuZnSOD Activity in Mammalian Tissue Homogenates

L. Oberley, D. Spitz, 2001, Current protocols in toxicology.

Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas

D. Spitz, Xingshen Sun, Yaling Yi, 2022, Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe.

Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models☆

D. Spitz, M. Milhem, G. Buettner, 2017, Redox biology.

Does heat shock enhance oxidative stress? Studies with ferrous and ferric iron.

D. Spitz, M. Freeman, M. Meredith, 1990, Radiation research.

The isolation and partial characterization of stable H2O2-resistant variants of Chinese hamster fibroblasts.

Y. Sun, L. Oberley, G. Li, 1988, Basic life sciences.

The superoxide dismutase mimetic GC4419 enhances tumor killing when combined with stereotactic ablative radiation

M. Story, L. Ding, D. Spitz, 2020, bioRxiv.

Counterpoint regarding an alternative hypothesis for why exposure to static magnetic and electric fields treat type 2 diabetes.

Ted B. Piorczynski, V. Sheffield, R. Weiss, 2021, American journal of physiology. Endocrinology and metabolism.

Response to: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes.

Ted B. Piorczynski, V. Sheffield, R. Weiss, 2021, American journal of physiology. Endocrinology and metabolism.

Inactivation of anthracyclines by cellular peroxidase.

D. Spitz, K. Reszka, B. Britigan, 2005, Cancer research.

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor

S. Flanagan, L. Oberley, F. Domann, 2005, Oncogene.

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor.

S. Flanagan, L. Oberley, F. Domann, 2005, Oncogene.

Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis*

A. Ryan, S. Murthy, D. Spitz, 2011, The Journal of Biological Chemistry.

Dominant-negative Jun N-terminal protein kinase (JNK-1) inhibits metabolic oxidative stress during glucose deprivation in a human breast carcinoma cell line.

H. Forman, Y. Lee, L. Ridnour, 2000, Free radical biology & medicine.

Serial changes in tumor oxygenation during the early phase of radiation therapy in cervical cancer-are we quantitating hypoxia change? Re: Lying et al., IJROBP 2000; 46:935-946.

W. Yuh, J. Buatti, N. Mayr, 2001, International journal of radiation oncology, biology, physics.

A common variant alters SCN5A–miR-24 interaction and associates with heart failure mortality

Anne L. Taylor, P. Ellinor, C. Yancy, 2018, The Journal of clinical investigation.

Expression of Glutathione and γ-Glutamylcysteine Synthetase mRNA Is Jun Dependent

D. Spitz, M. Freeman, K. Sekhar, 1997 .

Reconstitution of galectin-3 alters glutathione content and potentiates TRAIL-induced cytotoxicity by dephosphorylation of Akt.

Yong J. Lee, Jae-Joon Song, H. Kim, 2003, Experimental cell research.

Heme Oxygenase-mediated Resistance to Oxygen Toxicity in Hamster Fibroblasts*

D. Spitz, P. Dennery, K. Sridhar, 1997, The Journal of Biological Chemistry.

Delivery of therapeutic carbon monoxide by gas-entrapping materials

Sarah L. Becker, W. Jeck, G. Traverso, 2022, Science Translational Medicine.

Differences in basal and hyperoxia-associated HO expression in oxidant-resistant hamster fibroblasts.

D. Spitz, P. Dennery, H. E. Wong, 1996, The American journal of physiology.

Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle.

D. Spitz, E. Sarsour, P. Goswami, 2010, Free radical biology & medicine.

Hyperbilirubinemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia.

D. Stevenson, D. Spitz, P. Dennery, 1995, Free radical biology & medicine.

Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma.

Brian J. Smith, C. Knudson, D. Spitz, 2008, Free radical biology & medicine.

Assessment of Gadobutrol Safety in Combination with Ionizing Radiation Using a Preclinical MRI-Guided Radiotherapy Model

J. Buatti, V. Magnotta, D. Spitz, 2020, Radiation Research.

The Role of Low Molecular Weight Thiols in T Lymphocyte Proliferation and IL-2 Secretion1

C. Knudson, D. Spitz, S. Walsh, 2005, The Journal of Immunology.

Abstracts Presented at the 4th Annual Meeting of the North American NeuroEndocrine Tumor Society, October 21, 2011, Minneapolis, Minnesota

A. Cyr, M. Vatn, T. Edvardsen, 2012 .

Role of Glutaredoxin in Metabolic Oxidative Stress GLUTAREDOXIN AS A SENSOR OF OXIDATIVE STRESS MEDIATED BY H 2 O 2 *

M. Suntharalingam, Jae-Joon Song, J. Rhee, 2002 .

Assessment of the Stability of Supraphysiological Ascorbate in Human Blood: Appropriate Handling of Samples from Clinical Trials for Measurements of Pharmacological Ascorbate

D. Spitz, J. Cullen, Nancy J. Hollenbeck, 2019, Radiation Research.

HER2-associated radiation resistance of breast cancer stem cells isolated from HER2-negative breast cancer cells

Shiyong Li, M. Wicha, B. Chromy, 2012 .

Calcium-dependent Modulation of Poly(ADP-ribose) Polymerase-1 Alters Cellular Metabolism and DNA Repair*

D. Boothman, D. Spitz, Kathryn E. Reinicke, 2006, Journal of Biological Chemistry.

Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice.

L. Oberley, S. Toyokuni, T. Miyata, 2003, Free radical biology & medicine.

Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma

S. Altekruse, A. Bellizzi, J. Mezhir, 2015, Clinical Cancer Research.

Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy

J. Houtman, Zeb R. Zacharias, Ann M. Miller, 2022, Frontiers in Immunology.

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway

T. Ouchi, E. So, D. Spitz, 2012, Cell Death and Disease.

The Absence of CpG in Plasmid DNA–Chitosan Polyplexes Enhances Transfection Efficiencies and Reduces Inflammatory Responses in Murine Lungs

S. Geary, D. Spitz, A. Salem, 2014, Molecular pharmaceutics.

Intracellular Thiols Contribute to Th2 Function via a Positive Role in IL-4 Production 1

G. Hunninghake, M. Monick, T. Yarovinsky, 2003, The Journal of Immunology.

This information is current as Production Function via a Positive Role in IL-4 Intracellular Thiols Contribute to Th 2

G. Hunninghake, M. Monick, T. Yarovinsky, 2003 .

Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells

D. Spitz, N. Aykin-Burns, M. Fath, 2009, Cancer biology & therapy.

Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy

Brian J. Smith, J. Buatti, J. Greenlee, 2020, Redox biology.

Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease

D. Holanda, M. Attanasio, D. Spitz, 2018, Redox biology.

Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance

D. Spitz, S. Ledoux, G. Wilson, 2005, Nucleic acids research.

Comment on "Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer," i.e., all we are saying is, give C a chance.

D. Spitz, J. Cullen, G. Buettner, 2011, Free radical biology & medicine.

Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.

Ted B. Piorczynski, V. Sheffield, R. Weiss, 2020, Cell metabolism.

Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.

V. Sheffield, D. Spitz, G. Buettner, 2017, Free radical biology & medicine.

2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer.

Brian J. Smith, D. Spitz, J. Cullen, 2008, Free radical biology & medicine.

Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide.

D. Spitz, N. Ercal, J. Żukowski, 1995, Analytical biochemistry.

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes☆

A. Cyr, F. Domann, D. Spitz, 2013, Redox biology.

Enhanced gamma-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload.

H. Frierson, M. Freeman, L. Oberley, 1998, Free radical biology & medicine.

Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.

F. Domann, D. Spitz, N. Aykin-Burns, 2006, Cancer research.

The Role of Redox Dysregulation in the Effects of Prenatal Stress on Embryonic Interneuron Migration.

D. Spitz, H. Stevens, M. McCormick, 2019, Cerebral cortex.

Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesis.

A. Dispenzieri, S. Russell, S. Bera, 2010, Neoplasia.

Oxidative Stress Enhances Myeloma Cell Radiosensitization While Sparing Normal Bone Marrow Hematopoiesis 1

A. Dispenzieri, S. Russell, S. Bera, 2010 .

Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.

K. Legge, F. Domann, T. Shirasawa, 2011, Free radical biology & medicine.

A polymerase chain reaction assay for simultaneous detection and quantitation of proto‐oncogene and GAPD mRNAs in different cell growth rates

L. Albee, L. Ridnour, D. Spitz, 1997, Cell proliferation.

D‐penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2‐mediated oxidative stress

D. Spitz, M. Fath, S. Rodman, 2017, Free radical biology & medicine.

Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure.

D. Spitz, H. Lehmler, L. Robertson, 2009, Free radical biology & medicine.

POLYCHLORINATED BIPHENYL ( PCB )-INDUCED OXIDATIVE STRESS AND CYTOTOXICITY CAN BE MITIGATED BY ANTIOXIDANTS FOLLOWING EXPOSURE

Prabhat, D. Spitz, H. Lehmler, 2009 .

Mitochondrial Production of Reactive Oxygen Species Mediate Dicumarol-induced Cytotoxicity in Cancer Cells*

L. Oberley, D. Spitz, J. Cullen, 2006, Journal of Biological Chemistry.

Redox Control of Cell Cycle-Coupled Topoisomerase IIα Gene Expression

R. Higashikubo, D. Spitz, P. Goswami, 2002 .

Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response.

D. Spitz, Y. Kataoka, J. Murley, 2009, International journal of radiation oncology, biology, physics.

A spectrophotometric method for the direct detection and quantitation of nitric oxide, nitrite, and nitrate in cell culture media.

D. Wink, L. Ridnour, D. Spitz, 2000, Analytical biochemistry.

Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.

D. Spitz, Yueming Zhu, N. Aykin-Burns, 2010, Free radical biology & medicine.

Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress?

R. Roberts, D. Spitz, R. R. Malcolm, 1990, The Biochemical journal.

2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells

D. Shutt, D. Spitz, M. O'dorisio, 2010, Cancer biology & therapy.

2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress.

L. Oberley, F. Domann, D. Spitz, 2008, Free radical biology & medicine.

Contribution of Mitochondrial DNA Repair to Cell Resistance from Oxidative Stress*

D. Spitz, S. Ledoux, G. Wilson, 2005, Journal of Biological Chemistry.

A Role for Oxidative Stress in Suppressing Serum Immunoglobulin Levels in Lead-Exposed Fisher 344 Rats

D. Spitz, P. Dennery, N. Ercal, 2000, Archives of environmental contamination and toxicology.

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

Mark E. Anderson, F. Zhan, Liping Yu, 2015, Proceedings of the National Academy of Sciences.

Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells.

C. Limoli, D. Spitz, D. Dayal, 2008, The Biochemical journal.

A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11).

Rachel F. Marek, D. Spitz, H. Lehmler, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Cardiac Adverse Events Associated With Chemo‐Radiation Versus Chemotherapy for Resectable Stage III Non‐Small‐Cell Lung Cancer: A Surveillance, Epidemiology and End Results‐Medicare Study

Brian J. Smith, D. Spitz, R. Carnahan, 2022, Journal of the American Heart Association.

Glutathione peroxidase-1 inhibits UVA-induced AP-2alpha expression in human keratinocytes.

P. Wertz, F. Domann, D. Spitz, 2006, Biochemical and biophysical research communications.

Erratum: O2 ⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate (Cancer Cell (2017) 32 (2)(268) (S1535610817300624) (10.1016/j.ccell.2017.02.018))

Brian J. Smith, J. Buatti, J. Greenlee, 2017 .

Assessment of the Mitigative Capacity of Dietary Zinc on PCB126 Hepatotoxicity and the Contribution of Zinc to Toxicity.

D. Spitz, K. Gibson-Corley, L. Robertson, 2016, Chemical research in toxicology.

Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment

J. Ippolito, Kelsey L. Tinkum, Kevin Cho, 2021, bioRxiv.

This student paper was written as an assignment in the graduate course Free Radicals in Biology and Medicine ( 77 : 222 , Spring 2003 ) offered by the Free Radical and Radiation Biology Program

L. Oberley, F. Domann, D. Spitz, 2003 .

Radiation-Induced Adaptive Responses Dismutase-Mediated Gene Expression in Manganese Superoxide

L. Oberley, Zhongkui Li, A. Khaletskiy, 2002 .

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

Mark E. Anderson, Peter J. Mohler, Amy-Joan L. Ham, 2008, Cell.

Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer

D. Spitz, B. Allen, M. Petronek, 2021, Antioxidants.

α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II

F. Domann, P. Witting, J. Neuzil, 2008, Oncogene.

Oxidative Stress in Cancer Biology and Therapy

D. Spitz, D. Gius, K. Krishnan, 2012, Oxidative Stress in Applied Basic Research and Clinical Practice.

Mechanisms of H2O2-induced oxidative stress in endothelial cells.

D. Spitz, N. Weintraub, K. N. Kader, 2006, Free radical biology & medicine.

Glucose Deprivation-induced Cytotoxicity and Alterations in Mitogen-activated Protein Kinase Activation Are Mediated by Oxidative Stress in Multidrug-resistant Human Breast Carcinoma Cells*

D. Spitz, B. Davis, P. Corry, 1998, The Journal of Biological Chemistry.

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology

E. Azzam, D. Spitz, D. Gius, 2004, Cancer and Metastasis Reviews.

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H2O2-Dependent Manner

D. Spitz, D. Riley, G. Buettner, 2018, Antioxidants.

Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells

F. Zhan, D. Spitz, A. Goel, 2016, PloS one.

Detection of pro angiogenic and inflammatory biomarkers in patients with CKD

P. T. Ten Eyck, J. Thurman, M. Attanasio, 2021, Scientific Reports.

An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses.

T. Waldron, C. Limoli, D. Spitz, 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl)maleimide derivatives.

L. Ridnour, D. Spitz, N. Ercal, 1999, Methods in enzymology.

High-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrenyl)maleimide.

D. Spitz, N. Ercal, R. Matthews, 1996, Journal of chromatography. B, Biomedical applications.

Evidence that protein disulfide isomerase (PDI) is involved in DNA–nuclear matrix anchoring

R. Higashikubo, D. Spitz, R. Vanderwaal, 2002, Journal of cellular biochemistry.

H3.1Cys96 oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance

Jeanne M. Danes, V. Backman, M. Bonini, 2022, bioRxiv.

2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells.

D. Spitz, Douglas R Spitz, A. Simons, 2007, Cancer research.

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.

S. Flanagan, L. Oberley, M. Mackey, 2005, The Journal of biological chemistry.

Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells.

Y. Lee, L. Ridnour, D. Spitz, 1999, Free radical biology & medicine.

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

Brian J. Smith, J. Buatti, J. Greenlee, 2017, Cancer cell.

Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

M. Story, L. Ding, D. Spitz, 2021, Science Translational Medicine.

Response to letter regarding "An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses".

C. Limoli, D. Spitz, G. Buettner, 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism

D. Spitz, G. Buettner, B. Allen, 2019, Cancers.

Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

C. Knudson, D. Spitz, L. Love-Homan, 2012, PLoS ONE.

Thioredoxin reductase as a novel molecular target for cancer therapy.

P. Nguyen, R. Awwad, D. Spitz, 2006, Cancer letters.

Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.

Sean M Geary, Aliasger K Salem, S. Geary, 2016, Environmental science. Nano.

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

C. Deng, Hyun-Seok Kim, P. Nguyen, 2008, International journal of biological sciences.

Reactive oxygen species in normal and tumor stem cells.

Daohong Zhou, D. Spitz, Lijian Shao, 2014, Advances in cancer research.

Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3.

D. Spitz, D. Gius, D. Riley, 2014, Antioxidants & redox signaling.

Cell cycle-coupled variation in topoisomerase IIalpha mRNA is regulated by the 3'-untranslated region. Possible role of redox-sensitive protein binding in mRNA accumulation.

C. Hunt, L. Albee, R. Higashikubo, 2000, The Journal of biological chemistry.

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy

N. Horikoshi, D. Spitz, D. Gius, 2018, The Journal of clinical investigation.

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

J. Buatti, D. Spitz, C. Anderson, 2014, Redox biology.

Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials

Brian J. Smith, J. Buatti, D. Spitz, 2017, Radiation Research.

Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation.

L. Oberley, D. Spitz, Yueming Zhu, 2009, The Biochemical journal.

Aging augments mitochondrial susceptibility to heat stress.

D. Spitz, G. Buettner, K. Kregel, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Protective role of Bcl2 in metabolic oxidative stress-induced cell death.

M. Suntharalingam, Y. Lee, J. Rhee, 2001, Journal of cell science.

Glial cell type-specific responses to menadione-induced oxidative stress.

D. Spitz, S. Ledoux, G. Wilson, 2000, Free radical biology & medicine.

Glucose Deprivation‐Induced Oxidative Stress in Human Tumor Cells: A Fundamental Defect in Metabolism?

L. Ridnour, D. Spitz, J. E. Sim, 2000, Annals of the New York Academy of Sciences.

Bcl-2 and Bcl-xL in peroxide-resistant A549 and U87MG cells.

D. Spitz, H. K. Bojes, J. E. Sim, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA.

D. Spitz, A. Krieg, A. Yi, 2002, Antisense & nucleic acid drug development.

Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy

D. Spitz, Y. Zakharia, G. Buettner, 2021, Redox biology.

Mouse Embryo Fibroblast Cell Cycle to S Phase Transition in the 1 Redox Regulation of the G Updated

R. Higashikubo, D. Spitz, Hannah J. Zhang, 2003 .

Redox Regulation of the G 1 to S Phase Transition in the Mouse Embryo Fibroblast Cell Cycle 1

R. Higashikubo, D. Spitz, Hannah J. Zhang, 2003 .

WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.

J. Baulch, W. Morgan, D. Spitz, 2008, Free radical biology & medicine.

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling.

Michael D. Brooks, S. Merajver, M. Wicha, 2018, Cell metabolism.

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

E. Taylor, D. Spitz, A. Dupuy, 2019, Cell reports.

Redox signaling in cancer biology.

D. Spitz, D. Gius, Douglas R Spitz, 2006, Antioxidants & redox signaling.

All- Trans -Retinoic Acid Induces Manganese Superoxide Dismutase in Human Neuroblastoma Through NF κ B

D. Spitz, Carla R. Cook, M. Coleman, 2008 .

Lymph protects metastasizing melanoma cells from ferroptosis

S. Morrison, D. Spitz, Thomas P Mathews, 2020, Nature.

Expression of stress response genes GADD153, c-jun, and heme oxygenase-1 in H2O2- and O2-resistant fibroblasts.

K. Guyton, N. Holbrook, D. Spitz, 1996, Free radical biology & medicine.

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.

Brian J. Smith, J. Mezhir, D. Spitz, 2015, Cancer research.

Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells

D. Spitz, K. Foster, M. Fath, 2009, Journal of oncology.

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.

C. Deng, S. Abdulkadir, Keshav K. Singh, 2010, Cancer cell.

Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation.

D. Spitz, B. Allen, S. Sebag, 2019, Free radical biology & medicine.

Breast Cancer Stem Cell-Like Cells Are More Sensitive to Ionizing Radiation than Non-Stem Cells: Role of ATM

E. Prochownik, Yong J. Lee, J. Rhee, 2012, PloS one.

HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress.

J. Landry, J. Huot, F. Houle, 1996, Cancer research.

Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis

S. Park, Hyun-Seok Kim, D. Spitz, 2011, International journal of molecular sciences.

Elucidating the neurological mechanism of the FLASH effect in juvenile mice exposed to hypofractionated radiotherapy.

J. Baulch, C. Limoli, D. Spitz, 2022, Neuro-oncology.

Low-Dose Radiation-Induced Enhancement of Thymic Lymphomagenesis in Lck-Bax Mice is Dependent on LET and Gender

Brian J. Smith, P. Guida, C. Knudson, 2013, Radiation research.

Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways.

S. Goldberg, S. Signoretti, V. Torchilin, 2010, Radiology.

A stable O2-resistant cell line: role of lipid peroxidation byproducts in O2-mediated injury.

R. Roberts, D. Spitz, T. Oberley, 1992, The American journal of physiology.

The Role of Akt Pathway Signaling in Glucose Metabolism and Metabolic Oxidative Stress

Peter M. Scarbrough, D. Spitz, K. P. Orcutt, 2012 .

Manipulation of cellular redox parameters for improving therapeutic responses in B‐cell lymphoma and multiple myeloma

D. Spitz, G. Weiner, A. Goel, 2012, Journal of cellular biochemistry.

Cancer Therapeutics Insights Catalase Abrogates b-Lapachone – Induced PARP 1 Hyperactivation – Directed Programmed Necrosis in NQO 1-Positive Breast Cancers

Melissa C. Srougi, Jinming Gao, Longshan Li, 2013 .

Catalase Abrogates β-Lapachone–Induced PARP1 Hyperactivation–Directed Programmed Necrosis in NQO1-Positive Breast Cancers

Melissa C. Srougi, Jinming Gao, Longshan Li, 2013, Molecular Cancer Therapeutics.

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy

J. Buatti, D. Spitz, J. Cullen, 2021, International journal of molecular sciences.

Sensitivity to Low-Dose/Low-LET Ionizing Radiation in Mammalian Cells Harboring Mutations in Succinate Dehydrogenase Subunit C is Governed by Mitochondria-Derived Reactive Oxygen Species

Brian J. Smith, F. Domann, D. Spitz, 2011, Radiation research.

Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells.

D. Spitz, M. Fan, Jian Jian Li, 2007, Cancer research.

Physiologic and Pathologic Functions of Mitochondrial ROS

D. Spitz, B. Allen, 2016 .

Enhancement of Cancer Therapy Using Ketogenic Diet

D. Spitz, Jeffrey R. Erickson, M. Fath, 2012 .

Metabolic Production of H 2 O 2 in Carcinogenesis and Cancer Treatment

D. Spitz, B. Allen, 2016 .

Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth.

Brian J. Smith, L. Oberley, Yuping Zhang, 2008, Free radical biology & medicine.

Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth.

L. Oberley, D. Spitz, C. Weydert, 2006, Free radical biology & medicine.

Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats

L. Ridnour, D. Spitz, R. Kladney, 2003, Liver international : official journal of the International Association for the Study of the Liver.

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

S. Park, Hyun-Seok Kim, D. Spitz, 2010, Molecular cell.

Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues.

I. Batinic-Haberle, D. Spitz, C. Anderson, 2019, Seminars in radiation oncology.

Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats

Qian Wu, Jamie Weydert, Hans-Joachim Lehmler, 2009, Archives of Toxicology.

Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress.

D. Spitz, Weiling Zhao, M. Robbins, 2007, Free radical biology & medicine.

Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts

L. Oberley, D. Spitz, J. Cullen, 2009, Cancer biology & therapy.

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress

S. Park, Hyun-Seok Kim, D. Spitz, 2011, Aging.

Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation: possible role in radiosensitization

D. Spitz, D. Gius, C. M. Bradbury, 2004, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging.

Brian J. Smith, R. Hichwa, J. Buatti, 2007, International journal of radiation oncology, biology, physics.

HSP70 expression with aging differentially modulates hyperthermia-induced liver Chronic antioxidant enzyme mimetic treatment

L. Oberley, D. Spitz, Hannah J. Zhang, 2015 .

Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.

Ted B. Piorczynski, V. Sheffield, R. Weiss, 2020, Cell metabolism.

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

Brian J. Smith, J. Buatti, J. Greenlee, 2017, Cancer cell.

Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung

D. Spitz, V. Grassian, A. Salem, 2013, Nanotechnology.

Free Radicals and Cataract

L. Oberley, F. Domann, D. Spitz, 2022 .

Evidence that hydrogen peroxide generated by 365-nm UVA radiation is not important in mammalian cell killing.

D. Spitz, M. Peak, J. G. Peak, 1990, Radiation research.

Relationship between changes in ploidy and stable cellular resistance to hydrogen peroxide

L. Oberley, M. Mackey, Gloria C. Li, 1989, Journal of cellular physiology.

Glucose as a prognostic factor in ovarian carcinoma

A. Sood, D. Spitz, S. Lutgendorf, 2009, Cancer.

HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells

K. Lam, Shiyong Li, M. Wicha, 2012, Clinical Cancer Research.

The Effect of Monosaturated and Polyunsaturated Fatty Acids on Oxygen Toxicity in Cultured Cells

R. Roberts, D. Spitz, M. Kinter, 1992, Pediatric Research.

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

W. Watson, Peter M. Scarbrough, D. Spitz, 2014, Redox biology.

First-in-Human Phase I Clinical Trial of Pharmacologic Ascorbate Combined with Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Karra A. Jones, Brian J. Smith, J. Buatti, 2019, Clinical Cancer Research.

Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers

Kevin Cho, G. Patti, V. Menon, 2020, Molecular Cancer Therapeutics.

Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.

W. Watson, Peter M. Scarbrough, D. Spitz, 2012, Free radical biology & medicine.

Cytometric methods to analyze thermal effects.

R. Higashikubo, J. L. Roti, D. Spitz, 2001, Methods in cell biology.

Nitric Oxide-Induced Cytotoxicity: Involvement of Cellular Resistance to Oxidative Stress and the Role of Glutathione in Protection

R. Roberts, D. Spitz, M. Kinter, 1995, Pediatric Research.

High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages.

G. Hunninghake, L. Oberley, Yuping Zhang, 2004, American journal of respiratory cell and molecular biology.

Glucose deprivation-induced metabolic oxidative stress and cancer therapy.

D. Spitz, A. Simons, K. Dornfeld, 2009, Journal of cancer research and therapeutics.

Cells Isolated from HER 2-Negative Breast Cancer Cells HER 2-Associated Radioresistance of Breast Cancer Stem

K. Lam, Shiyong Li, M. Wicha, 2012 .

Cancer Therapy : Preclinical HER 2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER 2-Negative Breast Cancer Cells

K. Lam, Shiyong Li, M. Wicha, 2012 .

Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT.

J. Buatti, H. Quon, A. Maity, 2009, International journal of radiation oncology, biology, physics.

Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging

J. Houtman, D. Spitz, E. Abel, 2022, Arteriosclerosis, thrombosis, and vascular biology.

An inhibitor of K+ channels modulates human endometrial tumor-initiating cells

K. Leslie, D. Spitz, V. Korovkina, 2011, Cancer Cell International.

Response of cyclin B1 to ionizing radiation: regulation by NF-kappaB and mitochondrial antioxidant enzyme MnSOD.

D. Hou, D. Spitz, Jian Jian Li, 2004, Anticancer research.

Oxygen toxicity in control and H2O2-resistant Chinese hamster fibroblast cell lines.

R. Roberts, Y. Sun, L. Oberley, 1990, Archives of biochemistry and biophysics.

Ketogenic Diet with Concurrent Chemoradiation in Head and Neck Squamous Cell Carcinoma: Preclinical and Phase 1 Trial Results

Wenqing Sun, D. Spitz, C. Anderson, 2021, Radiation Research.

Constitutive ERK MAPK Activity Regulates Macrophage ATP Production and Mitochondrial Integrity1

G. Hunninghake, M. Monick, L. Powers, 2008, The Journal of Immunology.

Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma

A. Sood, D. Spitz, S. Lutgendorf, 2015, Brain, Behavior, and Immunity.

Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).

D. Spitz, Weiling Zhao, L. Poole, 2008, Free radical biology & medicine.

Avasopasem manganese (GC4419) protects against cisplatin-induced chronic kidney disease: An exploratory analysis of renal metrics from a randomized phase 2b clinical trial in head and neck cancer patients

J. Buatti, J. Holmlund, D. Spitz, 2023, Redox biology.

Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy.

J. Buatti, F. Domann, D. Spitz, 2017, Cancer research.

Myeloperoxidase-Generated Oxidants Modulate Left Ventricular Remodeling but Not Infarct Size After Myocardial Infarction

E. Topol, N. Vasilyev, S. Hazen, 2005, Circulation.

The Radioprotector GC4419 Ameliorates Radiation Induced Lung Fibrosis While Enhancing the Response of Non-Small Cell Lung Cancer Tumors to High Dose per Fraction Radiation Exposures

M. Story, D. Spitz, D. Saha, 2018, International Journal of Radiation Oncology*Biology*Physics.

Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury

E. Taylor, D. Spitz, B. Allen, 2023, bioRxiv.

Once Daily High-dose Radiation (≥60 Gy) Treatment in Limited Stage Small Cell Lung Cancer.

J. Buatti, D. Spitz, Tangel Chang, 2016, Journal of oncology translational research.

Radiofrequency electromagnetic fields have no effect on the in vivo proliferation of the 9L brain tumor.

W F Pickard, E. Moros, W. Pickard, 1999, Radiation research.

Adaptive Responses to Low-Dose/Low-Dose-Rate γ Rays in Normal Human Fibroblasts: The Role of Growth Architecture and Oxidative Metabolism

E. Azzam, S. M. de Toledo, D. Spitz, 2006, Radiation research.

Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth in vivo

A. Sadanandam, D. Quelle, D. Spitz, 2023, bioRxiv.

Essential Components of Cancer Education.

H. Nakshatri, R. Jensen, A. Riegel, 2015, Cancer Research.

Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status.

D. Spitz, W. Haschek, L. Robertson, 2010, Environment international.

2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines

T. Kuwana, C. Knudson, D. Spitz, 2011, Oncogene.

Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.

Yi Sun, M. Tan, Z. Pan, 2010, Free radical biology & medicine.

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity.

S. Park, Hyun-Seok Kim, D. Spitz, 2012, Free radical biology & medicine.

Abstract 2929: GC4419 enhances the response of non-small cell lung carcinoma cell lines to cisplatin and cisplatin plus radiation through a ROS-mediated pathway

M. Story, D. Spitz, Kelly C. Falls, 2018, Experimental and Molecular Therapeutics.

Metabolism Simultaneous Disruption of Glutathione and Thioredoxin Enhancement of Carboplatin-Mediated Lung Cancer Cell Killing

D. Spitz, I. Ahmad, Carmen J. Smith, 2011 .

Heat shock and the activation of AP-1 and inhibition of NF-κB DNA-binding activity: possible role of intracellular redox status

D. Spitz, D. Gius, C. M. Bradbury, 2004, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Metadherin enhances vulnerability of cancer cells to ferroptosis

Jianling Bi, K. Leslie, Xiangbing Meng, 2019, Cell Death & Disease.

Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: the significance of increased catalase activity in H2O2-resistant fibroblasts.

R. Roberts, D. Spitz, D. T. Adams, 1992, Archives of biochemistry and biophysics.

SIRT 3 interacts with the daf-16 homolog FOXO 3 a in the Mitochondria , as well as increases FOXO 3 a Dependent Gene expression

C. Deng, Hyun-Seok Kim, P. Nguyen, 2008 .

Regulation of normal cell cycle progression by flavin-containing oxidases

J. Little, S. Toledo, E. Azzam, 2008, Oncogene.

SOD1 deficiency: a novel syndrome distinct from amyotrophic lateral sclerosis.

E. Boltshauser, D. Spitz, T. Marquardt, 2019, Brain : a journal of neurology.

Lymph protects metastasizing melanoma cells from ferroptosis

S. Morrison, D. Spitz, Thomas P Mathews, 2020, Nature.