C. Maenhaut

发表

Cross signaling, cell specificity, and physiology.

J. Dumont, S. Dremier, I. Pirson, 2002, American journal of physiology. Cell physiology.

Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and “swarm intelligence”

V. Detours, J. Dumont, C. Maenhaut, 2013, Cancer and Metastasis Reviews.

The visual display of regulatory information and networks.

J. Dumont, S. Dremier, I. Pirson, 2000, Trends in cell biology.

Roles of hydrogen peroxide in thyroid physiology and disease.

V. Detours, J. Dumont, F. Miot, 2007, The Journal of clinical endocrinology and metabolism.

REVIEW : Roles of Hydrogen Peroxide in Thyroid Physiology and Disease

V. Detours, J. Dumont, F. Miot, 2007 .

Hallmarks of cancer: of all cancer cells, all the time?

Carine Maenhaut, Jacques E Dumont, J. Dumont, 2012, Trends in molecular medicine.

miRNA expression and function in thyroid carcinomas: a comparative and critical analysis and a model for other cancers

V. Detours, J. Dumont, C. Maenhaut, 2016, Oncotarget.

Thyrotropin activates both the cyclic AMP and the PIP2casades in CHO cells expressing the human cDNA of TSH receptor

J. Dumont, C. Maenhaut, E. Raspé, 1990, Molecular and Cellular Endocrinology.

An efficient screening morphological test for the identification and characterization of cyclic AMP-coupled hormone receptors.

C. Maenhaut, F. Libert, 1990, Experimental cell research.

Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells.

J. Dumont, C. Maenhaut, F. Libert, 1997, European journal of biochemistry.

Gene expression in thyroid autonomous adenomas provides insight into their physiopathology

V. Detours, P. Rocmans, J. Dumont, 2005, Oncogene.

Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors.

J. Dumont, F. Lamy, C. Maenhaut, 1992, Physiological reviews.

Absence of a specific radiation signature in post-Chernobyl thyroid cancers

V. Detours, J. Dumont, B. Franc, 2005, British Journal of Cancer.

Reprogramming of Energy Metabolism: Increased Expression and Roles of Pyruvate Carboxylase in Papillary Thyroid Cancer.

D. Larsimont, O. Feron, J. Dumont, 2019, Thyroid : official journal of the American Thyroid Association.

microRNA expression in autonomous thyroid adenomas: Correlation with mRNA regulation

A. Desbuleux, C. Maenhaut, G. Andry, 2015, Molecular and Cellular Endocrinology.

Gene expression and the biological phenotype of papillary thyroid carcinomas

V. Detours, J. Dumont, B. Franc, 2007, Oncogene.

MiRNA Expression May Account for Chronic but Not for Acute Regulation of mRNA Expression in Human Thyroid Tumor Models

J. Dumont, C. Maenhaut, J. M. Pita, 2014, PloS one.

Activation of the cyclic AMP cascade as an oncogenic mechanism: the thyroid example.

J. Dumont, C. Maenhaut, P. Roger, 1991, Biochimie.

Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers

V. Detours, J. Dumont, B. Franc, 2007, British Journal of Cancer.

Dissecting the role of thyrotropin in the DNA damage response in human thyrocytes after 131I, γ radiation and H2O2.

V. Detours, D. Gacquer, J. Dumont, 2019, The Journal of clinical endocrinology and metabolism.

Gene expression profiles of post-Chernobyl thyroid cancers

V. Detours, J. Dumont, C. Maenhaut, 2008, Current opinion in endocrinology, diabetes, and obesity.

Ontogeny, Anatomy, Metabolism and Physiology of the Thyroid

G. Chrousos, R. Opitz, J. Dumont, 2015 .

Study of gene expression in thyrotropin-stimulated thyroid cells by cDNA expression array: ID3 transcription modulating factor as an early response protein and tumor marker in thyroid carcinomas.

J. Dumont, C. Maenhaut, S. Deleu, 2002, Experimental cell research.

Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli

T. Nakamura, J. Dumont, I. Pirson, 1999, Journal of cellular physiology.

Identification and Characterization of Novel Genes Modulated in the Thyroid of Dogs Treated with Methimazole and Propylthiouracil*

J. Dumont, C. Maenhaut, F. Wilkin, 1996, The Journal of Biological Chemistry.

Regulation of the cell-cell adhesion protein, E-cadherin, in dog and human thyrocytes in vitro.

G. Brabant, J. Dumont, C. Maenhaut, 1995, Endocrinology.

Thyroid cancer cell lines: an overview

C. Maenhaut, M. Tarabichi, M. Saiselet, 2012, Front. Endocrin..

Gene expression of differentiation- and dedifferentiation markers in normal and malignant human thyroid tissues.

G. Brabant, C. Maenhaut, H. Dralle, 2009, Experimental and clinical endocrinology.

The orphan receptor cDNA RDC4 encodes a 5-HT1D serotonin receptor.

H. Ladinsky, J. Dumont, C. Maenhaut, 1991, Biochemical and biophysical research communications.

Characterization of autonomous thyroid adenoma: metabolism, gene expression, and pathology.

Y. Allory, I. Salmon, J. Dumont, 2000, Thyroid : official journal of the American Thyroid Association.

Chap 75. Thyroid regulatory factors

J. Dumont, J. Jameson, C. Maenhaut, 2015 .

Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations.

J. Dumont, C. Maenhaut, J. Leclère, 2011, European journal of endocrinology.

Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis

P. Courtoy, B. Vanhaesebroeck, C. Maenhaut, 2020 .

Vps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis.

P. Courtoy, B. Vanhaesebroeck, C. Maenhaut, 2020, Thyroid : official journal of the American Thyroid Association.

Regulation of protooncogenes c-fos and c-myc expressions by protein tyrosine kinase, protein kinase C, and cyclic AMP mitogenic pathways in dog primary thyrocytes: a positive and negative control by cyclic AMP on c-myc expression.

J. Dumont, C. Maenhaut, S. Reuse, 1990, Experimental cell research.

Growth factors controlling the thyroid gland.

J. Dumont, I. Pirson, C. Maenhaut, 1991, Bailliere's clinical endocrinology and metabolism.

Vps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis

P. Courtoy, B. Vanhaesebroeck, C. Maenhaut, 2019, bioRxiv.

Vps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis

P. Courtoy, B. Vanhaesebroeck, C. Maenhaut, 2019, bioRxiv.

Cyclic adenosine 3',5'-monophosphate (cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells.

S. Døskeland, J. Dumont, S. Dremier, 2007, Endocrinology.

The Role of Cyclic AMP and Its Effect on Protein Kinase A in the Mitogenic Action of Thyrotropin on the Thyroid Cell

S. Schurmans, C. Ledent, J. Dumont, 2002, Annals of the New York Academy of Sciences.

Transcriptional output, cell-type densities, and normalization in spatial transcriptomics

D. Larsimont, V. Detours, J. Lundeberg, 2018, bioRxiv.

Thyroid cancer under the scope of emerging technologies

V. Detours, C. Maenhaut, L. Craciun, 2021, Molecular and Cellular Endocrinology.

Selective amplification and cloning of four new members of the G protein-coupled receptor family.

G Vassart, F Libert, M. Parmentier, 1989, Science.

Differential involvement of the actin cytoskeleton in differentiation and mitogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesis.

J. Dumont, S. Dremier, C. Maenhaut, 2005, Endocrinology.

Large goitre as a maladaptation to iodine deficiency

C. Maenhaut, F. Coppée, J. Dumont, 1995, Clinical endocrinology.

Thyroid gene expression in familial nonautoimmune hyperthyroidism shows common characteristics with hyperfunctioning autonomous adenomas.

J. Dumont, C. Maenhaut, P. Roger, 2009, The Journal of clinical endocrinology and metabolism.

Thyroid follicular adenomas and carcinomas: molecular profiling provides evidence for a continuous evolution

S. Majjaj, E. Marbaix, J. Dumont, 2017, Oncotarget.

Multiple facets of the modulation of growth by cAMP.

J. Dumont, C. Maenhaut, P. Roger, 1995, Vitamins and hormones.

Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?

V. Detours, J. Dumont, C. Maenhaut, 2009, Biochimica et biophysica acta.

Molecular cloning of the thyrotropin receptor.

M. Parmentier, J. Dumont, C. Maenhaut, 1989, Science.

Crosstalk and specificity in signalling. Are we crosstalking ourselves into general confusion?

J. Dumont, C. Maenhaut, J E Dumont, 2001, Cellular signalling.

cAMP Analog Mapping of Epac1 and cAMP Kinase

S. Døskeland, J. Bos, J. de Rooij, 2003, Journal of Biological Chemistry.

Long-term EGF/serum-treated human thyrocytes mimic papillary thyroid carcinomas with regard to gene expression.

J. Dumont, C. Maenhaut, P. Roger, 2007, Experimental cell research.

Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.

V. Detours, J. Dumont, B. Franc, 2007, Cancer research.

Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP.

J. Dumont, I. Pirson, C. Maenhaut, 2002, European journal of biochemistry.

Study of Thyroid Gene Expression and Regulation by DNA Array Technology: Pitfalls and Necessary Controls in the Use of Commercial Filters

J. Dumont, C. Maenhaut, D. Venet, 2001, Archives of physiology and biochemistry.

Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations

D. Larsimont, J. Dumont, C. Maenhaut, 2011, Oncogene.

Cancer stem cells, a fuzzy evolving concept

J. Dumont, C. Maenhaut, A. Antoniou, 2013, Cell cycle.

Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis.

J. Dumont, C. Maenhaut, P. Roger, 2010, Carcinogenesis.

RDC8 codes for an adenosine A2 receptor with physiological constitutive activity.

S Schiffmann, G Vassart, F Libert, 1990, Biochemical and biophysical research communications.

Separation of samples into their constituents using gene expression data

Hugues Bersini, David Venet, F. Pecasse, 2001, ISMB.

Differential regulation of thyrotropin receptor and thyroglobulin mRNA accumulation at the cellular level: an in situ hybridization study.

J. Dumont, C. Maenhaut, G. Vassart, 1992, Experimental Cell Research.

Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional Maturation

M. Lambot, D. Glinoer, J. Dumont, 2021, Frontiers in Cell and Developmental Biology.

Signal transduction in the human thyrocyte and its perversion in thyroid tumors

J. Dumont, K. Coulonval, C. Maenhaut, 2010, Molecular and Cellular Endocrinology.

mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch

M. Dewaele, J. Dumont, C. Maenhaut, 2012, PloS one.

Positive control of proliferation by the cyclic AMP cascade: An oncogenic mechnism of hyper-functional adenoma

M. Parmentier, C. Ledent, J. Parma, 1995, Journal of endocrinological investigation.

Expression of thyrotropin receptor (TSH-R), thyroglobulin, thyroperoxidase, and calcitonin messenger ribonucleic acids in thyroid carcinomas: evidence of TSH-R gene transcript in medullary histotype.

A. Pinchera, C. Maenhaut, R. Elisei, 1994, The Journal of clinical endocrinology and metabolism.

Nucleotide sequence of the dog thyrotropin receptor cDNA.

M. Parmentier, J. Dumont, C. Maenhaut, 1989, Nucleic acids research.

Gene signature of the post-Chernobyl papillary thyroid cancer

A. Świerniak, V. Detours, E. Chmielik, 2016, European Journal of Nuclear Medicine and Molecular Imaging.

5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro.

J. Dumont, C. Maenhaut, E. Leteurtre, 2013, Thyroid : official journal of the American Thyroid Association.

A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas

V. Detours, K. Unger, J. Dumont, 2012, British Journal of Cancer.

Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na+/I− symporter mRNAs in dog thyroid

J. Dumont, F. Miot, C. Maenhaut, 1997, Molecular and Cellular Endocrinology.

Activation of the small G protein Rap1 in dog thyroid cells by both cAMP-dependent and -independent pathways.

J. Bos, J. Dumont, F. Vandeput, 2000, Biochemical and biophysical research communications.

A general method to derive robust organ-specific gene expression-based differentiation indices: application to thyroid cancer diagnostic

V. Detours, D. Gacquer, J. Dumont, 2012, Oncogene.

The human and dog 5-HT1D receptors can both activate and inhibit adenylate cyclase in transfected cells.

A. Allgeier, J. Dumont, C. Maenhaut, 1993, European journal of pharmacology.

Identification and characterization of mRNAs differentially expressed in thyroid cells stimulated by a mitogenic treatment.

S. Schurmans, J. Dumont, I. Pirson, 1999, Biochimie.

Gene expression profiles for radiation-induced thyroid cancer.

V. Detours, C. Maenhaut, B. Jarzab, 2011, Clinical oncology (Royal College of Radiologists (Great Britain)).

Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis.

Carine Maenhaut, Vincent Detours, Jacques E Dumont, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Human thyrotropin receptor gene: Expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation

G. Brabant, J. Köhrle, J. Dumont, 1991, Molecular and Cellular Endocrinology.

Pitfalls in the use of several "housekeeping" genes as standards for quantitation of mRNA: the example of thyroid cells.

I. Pirson, C. Maenhaut, V. Savonet, 1997, Analytical biochemistry.

Control of thyroid cell proliferation and goitrogenesis

J. Dumont, F. Lamy, C. Maenhaut, 1992, Trends in Endocrinology & Metabolism.

Role of Epac and protein kinase A in thyrotropin-induced gene expression in primary thyrocytes.

Carine Maenhaut, Christophe Trésallet, Jacques E Dumont, 2012, Experimental cell research.

In vitro and in vivo regulation of thyrotropin receptor mRNA levels in dog and human thyroid cells.

G. Brabant, J. Dumont, C. Maenhaut, 1992, The Journal of biological chemistry.

Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications

V. Detours, J. Dumont, C. Maenhaut, 2022, Cancers.

15 Systems biology, cell specificity, and physiology

V. Detours, J. Dumont, C. Maenhaut, 2005 .

Integration and cross‐validation of high‐throughput gene expression data: comparing heterogeneous data sets

Hugues Bersini, Carine Maenhaut, Vincent Detours, 2003, FEBS letters.

Revisiting the transcriptional analysis of primary tumours and associated nodal metastases with enhanced biological and statistical controls: application to thyroid cancer

D. Larsimont, V. Detours, C. Maenhaut, 2015, British Journal of Cancer.

Distinctive desmoplastic 3D morphology associated with BRAFV600E in papillary thyroid cancers

V. Detours, D. Gacquer, J. Dumont, 2017, bioRxiv.

New global analysis of the microRNA transcriptome of primary tumors and lymph node metastases of papillary thyroid cancer

V. Detours, D. Gacquer, C. Maenhaut, 2015, BMC Genomics.

IGF-1 or insulin, and the TSH cyclic AMP cascade separately control dog and human thyroid cell growth and DNA synthesis, and complement each other in inducing mitogenesis

T. Nakamura, K. Coulonval, I. Pirson, 1999, Molecular and Cellular Endocrinology.

Activation by thyroid stimulating hormone of nerve growth factor-induced gene-B expression in thyrocytes in culture: relation with proliferation and specific gene expression.

J. Dumont, C. Maenhaut, B. Pichon, 1998, Biochimica et biophysica acta.

Induction of nerve growth factor-induced gene-B (NGFI-B) as an early event in the cyclic adenosine monophosphate response of dog thyrocytes in primary culture.

I. Pirson, C. Maenhaut, B. Pichon, 1996, Endocrinology.

376: Cancer stem cells, a fuzzy evolving concept: A cell population or a cell property?

J. Dumont, C. Maenhaut, A. Antoniou, 2014 .

ApolipoproteinL1 is expressed in papillary thyroid carcinomas.

C. Maenhaut, P. Delrée, L. Vanhamme, 2016, Pathology, research and practice.

Cancer heterogeneity is not compatible with one unique cancer cell metabolic map

J. Dumont, C. Maenhaut, M. Saiselet, 2016, Oncogene.

Search for new cyclic AMP‐binding proteins

S. Døskeland, J. Dumont, S. Dremier, 2003, FEBS letters.

Growth and proliferation of the thyroid cell in normal physiology and in disease.

J. Dumont, F. Lamy, I. Pirson, 2003, Annales d'endocrinologie.

CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas

J. Dumont, L. Marlow, K. Coulonval, 2023, bioRxiv.

Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and “swarm intelligence”

V. Detours, J. Dumont, C. Maenhaut, 2013, Cancer and Metastasis Reviews.

Intratumor heterogeneity and clonal evolution in an aggressive papillary thyroid cancer and matched metastases.

D. Larsimont, V. Detours, D. Gacquer, 2015, Endocrine-related cancer.

Activation of cyclic AMP-dependent kinase is required but may not be sufficient to mimic cyclic AMP-dependent DNA synthesis and thyroglobulin expression in dog thyroid cells

S. Døskeland, J. Dumont, J. Corbin, 1997, Molecular and cellular biology.

miRNA Expression in Anaplastic Thyroid Carcinomas

A. Desbuleux, C. Maenhaut, E. Leteurtre, 2014, PloS one.

Identification of differentially expressed genes in thyrotropin stimulated dog thyroid cells by the cDNA-AFLP technique

F. Vandeput, C. Maenhaut, M. Zabeau, 2005, Molecular and Cellular Endocrinology.

Unraveling the Roles of miR-204-5p and HMGA2 in Papillary Thyroid Cancer Tumorigenesis

C. Maenhaut, L. Craciun, P. Demetter, 2023, International journal of molecular sciences.

Phosphorylation of the three Rb protein family members is a common step of the cAMP-, the growth factor, and the phorbol ester-mitogenic cascades but is not necessary for the hypertrophy induced by insulin.

J. Dumont, K. Coulonval, F. Lamy, 1997, Experimental cell research.

11 The cAMP in thyroid

A. Allgeier, M. Parmentier, C. Ledent, 1997 .

Cloning of cDNA specifically involved in the thyroid cAMP mitogenic pathway.

J. Dumont, F. Miot, F. Lamy, 1994, Hormone research.

The phylogeny, ontogeny, anatomy and regulation of the iodine metabolizing thyroid

Carine Maenhaut, Jacques Emile Dumont, J. Dumont, 2005 .

The Control of Human Thyroid Cell Function, Proliferation and Differentiation

M. Parmentier, J. Mockel, E. Laurent, 1990 .

Transducing systems in the control of human thyroid cell function, proliferation and differentiation.

M. Parmentier, E. Laurent, J. Dumont, 1989, Advances in experimental medicine and biology.

MiR-7-5p inhibits thyroid cell proliferation by targeting the EGFR/MAPK and IRS2/PI3K signaling pathways

J. Dumont, C. Maenhaut, M. Saiselet, 2021, Oncotarget.

Function, proliferation and differentiation of the dog and human thyrocyte.

M. Parmentier, J. Mockel, E. Laurent, 1990, Hormone and metabolic research. Supplement series.

Normal Thyroid Structure and Function in Rhophilin 2-Deficient Mice

S. Schurmans, J. Dumont, C. Maenhaut, 2005, Molecular and Cellular Biology.

Signal transduction in the human thyrocyte and its perversion in thyroid tumors

J. Dumont, K. Coulonval, C. Maenhaut, 2010, Molecular and Cellular Endocrinology.

Hallmarks of cancer: of all cancer cells, all the time?

J. Dumont, C. Maenhaut, E. Raspé, 2012, Trends in molecular medicine.

The TSH cyclic AMP cascade in the control of thyroid cell proliferation: the story of a concept.

C. Maenhaut, M. Taton, Marc Parmentier, 1991, Thyroidology.

5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro.

J. Dumont, C. Maenhaut, E. Leteurtre, 2013, Thyroid.