J. Ledbetter

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The Raf-1 serine-threonine kinase is a substrate for the p56lck protein tyrosine kinase in human T-cells.

P. Thompson, U. Rapp, J. Ledbetter, 1991, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

P. Linsley, J. Bradshaw, J. Ledbetter, 1992, The Journal of experimental medicine.

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors.

P. Linsley, J. Bajorath, R. Peach, 1994, Immunity.

The role of the CD28 receptor during T cell responses to antigen.

P. Linsley, J. Ledbetter, 1993, Annual review of immunology.

Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway.

C. Thompson, C. June, J. Ledbetter, 1989, Science.

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

K. Elkon, J. Ledbetter, L. Blanco, 2015, Nature Medicine.

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

C. Thompson, C. June, J. Ledbetter, 1987, Molecular and cellular biology.

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.

C. Thompson, C. June, K. Lee, 1990, Journal of immunology.

Engagement of interleukin-7 receptor stimulates tyrosine phosphorylation, phosphoinositide turnover, and clonal proliferation of human T-lineage acute lymphoblastic leukemia cells.

G. Schieven, J. Ledbetter, L. Tuel-ahlgren, 1991, Blood.

Interleukin 3 Stimulation Enhances Tyrosine Phosphorylation and Proliferative Activity of Human Fetal Thymocytes and Leukemic T-cell Precursors at Multiple Developmental Stages of T-cell Ontogeny

G. Schieven, J. Ledbetter, F. Uckun, 1992 .

Use of colony assays and anti-T cell immunotoxins to elucidate the immunobiologic features of leukemic progenitor cells in T-lineage acute lymphoblastic leukemia.

J. Ledbetter, D. Vallera, D. E. Myers, 1988, Journal of immunology.

Antigen-independent regulation of cytoplasmic calcium in B cells with a 12-kDa B-cell growth factor and anti-CD19.

P. Rabinovitch, C. June, C. Song, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Accessory receptors regulate coupling of the T-cell receptor complex to tyrosine kinase activation and mobilization of cytoplasmic calcium in T-lineage acute lymphoblastic leukemia.

G. Schieven, J. Ledbetter, F. Uckun, 1991, Blood.

Developmental regulation of pp44/46, tyrosine-phosphorylated proteins associated with tyrosine/serine kinase activity in Trypanosoma brucei.

S. Kanner, G. Schieven, M. Parsons, 1994, Molecular and biochemical parasitology.

The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma.

Michèl Schummer, Nicole Urban, M. Schummer, 2003, Cancer research.

CD28 ligation in T-cell activation: evidence for two signal transduction pathways.

P. Rabinovitch, G. Schieven, C. Thompson, 1990, Blood.

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co‐stimulatory activity.

I. Stamenkovic, A. Aruffo, J. Ledbetter, 1992, The EMBO journal.

Co-ligation of the Antigen and Fc Receptors Gives Rise to the Selective Modulation of Intracellular Signaling in B Cells

P. Kiener, J. Ledbetter, S. Nadler, 1997, The Journal of Biological Chemistry.

T Cell Activation Inhibitors Reduce CD8+ T Cell and Pro-Inflammatory Macrophage Accumulation in Adipose Tissue of Obese Mice

S. Subramanian, A. Chait, J. Ledbetter, 2013, PloS one.

Signal transduction in Sjögren's syndrome T cells. Abnormalities associated with a newly described human A-type retrovirus.

E. Flescher, J. Ledbetter, N. Talal, 1992, Arthritis and rheumatism.

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

M. Barbacid, X. Bustelo, J. Ledbetter, 1992, Nature.

Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies

D. Richman, C. Spina, J. Ledbetter, 1990, Nature.

Effects of Anti-gpl 20 Monoclonal Antibodies on CD 4 Receptor Binding by the env Protein of Human Immunodeficiency Virus Type 1

P. Linsley, J. Ledbetter, E. Kinney-Thomas, 2022 .

Effects of Anti-gpl20 Monoclonal Antibodies

P. Linsley, J. Ledbetter, E. Kinney-Thomas, 2022 .

CD4, CD8 and the role of CD45 in T-cell activation.

S. Kanner, G. Schieven, A. Aruffo, 1993, Current opinion in immunology.

B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells

H. Ochs, A. Aruffo, J. Ledbetter, 1993, The Journal of experimental medicine.

CD22 associates with the human surface IgM-B-cell antigen receptor complex.

R. Geahlen, E. Clark, C. Leprince, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains.

J. Brown, E. Clark, J. Ledbetter, 1988, The EMBO journal.

T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views

L. Herzenberg, R. Rouse, J. Ledbetter, 1980, The Journal of experimental medicine.

CD45 ligation in T cells regulates signal transduction through both the interleukin-2 receptor and the CD3/Ti T-cell receptor complex.

G. Schieven, J. Ledbetter, N. Damle, 1990, Tissue antigens.

Phosphatidyl inositol hydrolysis after CD3 binding in human peripheral blood T cells: inhibition by prostaglandin E2.

J. Ledbetter, J. Goodwin, S. Liang, 1989, International journal of immunopharmacology.

Enhanced transmembrane signalling activity of monoclonal antibody heteroconjugates suggests molecular interactions between receptors on the T cell surface.

P. Rabinovitch, C. June, J. Ledbetter, 1989, Molecular immunology.

Detailed Studies on Expression and Function of CD19 Surface Determinant by Using B43 Monoclonal Antibody and the Clinical Potential of Anti-CD19 Immunotoxins

M. Wick, J. Ledbetter, F. Uckun, 1988 .

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

P. Rabinovitch, C. June, J. Imboden, 1988, European journal of immunology.

Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway

P. Rabinovitch, C. June, J. Ledbetter, 1987 .

Role of the CD28 receptor in T-cell activation.

P. Linsley, C. Thompson, C. June, 1990, Immunology today.

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

P. Linsley, Lieping Chen, J. Ledbetter, 1992, Cell.

Effects of mutations in glycosylation sites and disulphide bonds on processing, CD4-binding and fusion activity of human immunodeficiency virus envelope glycoproteins.

J. Ledbetter, H. Wigzell, P. Flodby, 1991, The Journal of general virology.

A role for CD5 in TCR-mediated signal transduction and thymocyte selection.

K. Rajewsky, A. Tarakhovsky, S. Kanner, 1995, Science.

Cross‐linking of CD18 primes human neutrophils for activation of the respiratory burst in response to specific stimuli: Implications for adhesion‐dependent physiological responses in neutrophils

J. Ledbetter, W. Liles, S. Klebanoff, 1995, Journal of Leukocyte Biology.

CD28 ligation in T-cell activation: evidence for two signal transduction pathways.

P. Rabinovitch, G. Schieven, C. Thompson, 1990, Blood.

Activation of murine T-cells via phospholipase-C gamma 1-associated protein tyrosine phosphorylation is reduced with aging.

P. Rabinovitch, S. Kanner, T. Kavanagh, 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA

K. Elkon, J. Ledbetter, C. Lood, 2017, The Journal of experimental medicine.

CD 22-mediated stimulation of T cells regulates T-cell receptor / CD 3-induced signaling ( CD 22 / CD 45 / sialic acid / carbohydrate / adheslon )

S. Kanner, A. Aruffo, J. Ledbetter, 2022 .

CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling.

D. Sgroi, I. Stamenkovic, S. Kanner, 1992, Proceedings of the National Academy of Sciences of the United States of America.

T-cell activation molecule 4-1BB binds to extracellular matrix proteins.

R. Peach, A. Aruffo, J. Ledbetter, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

G. Schieven, C. June, L. Samelson, 1990, Proceedings of the National Academy of Sciences of the United States of America.

CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation.

B. Dörken, P. Rabinovitch, E. Clark, 1987, Journal of immunology.

Immunobiologic differences between normal and leukemic human B-cell precursors.

J. Ledbetter, F. Uckun, 1988, Proceedings of the National Academy of Sciences of the United States of America.

In vivo efficacy and toxicity of a single-chain immunotoxin targeted to CD40.

G. Schreiber, J. Ledbetter, J. A. Francisco, 1997, Blood.

Homotypic aggregation of human cell lines by HLA class II‐, class Ia‐ and HLA‐G‐specific monoclonal antibodies

J. Ledbetter, D. Geraghty, J. Hansen, 1991, European journal of immunology.

Production of a mouse-human chimeric monoclonal antibody to CD20 with potent Fc-dependent biologic activity.

R. R. Robinson, J. Ledbetter, K. Hellstrom, 1987, Journal of immunology.

Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40.

A. Aruffo, J. Ledbetter, R. Noelle, 1993, Science.

Soluble CD23 is released by B lymphocytes cycling in response to interleukin 4 and anti‐Bp50 (CDw40)

G. Guy, J. Ledbetter, J. Cairns, 1988, European journal of immunology.

Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells

J. Ledbetter, O. Press, Daming Shan, 2000, Cancer Immunology, Immunotherapy.

T cell ontogeny. Organ location of maturing populations as defined by surface antigen markers is similar in neonates and adults

J. Dangl, L. Herzenberg, J. Ledbetter, 1981, The Journal of experimental medicine.

A rapid method for the detection of antibodies to cell surface antigens: a solid phase radioimmunoassay using cell membranes.

L. Herzenberg, J. Ledbetter, F. D. Howard, 1980, Journal of immunological methods.

In Vivo CD 40-gp 39 Interactions Are Essential for Thymus-dependent Humoral Immunity . I . In Vivo Expression of CD 40 Ligand , Cytokines , and Antibody Production Delineates Sites of Cognate TB Cell Interactions By

J. Ledbetter, R. Noelle, E. Claassen, 2003 .

Apoptosis in hematopoietic cells is associated with an extensive decrease in cellular phosphotyrosine content that can be inhibited by the tyrosine phosphatase antagonist pervanadate.

P. Thompson, J. Ledbetter, F. Lund-Johansen, 1996, Cytometry.

A new mouse lymphoid alloantigen (Lgp100) recognized by a monoclonal rat antibody

L. Herzenberg, J. Ledbetter, J. Goding, 1979, Immunogenetics.

Rapid and reliable cloning of antibody variable regions and generation of recombinant single chain antibody fragments.

J. Ledbetter, H. Marquardt, R. Mittler, 1996, Tissue antigens.

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

G. Schieven, J. Ledbetter, F. Uckun, 1993 .

A d-Amino Acid Peptide Inhibitor of NF-κB Nuclear Localization Is Efficacious in Models of Inflammatory Disease

J. Ledbetter, S. Nadler, K. A. Kennedy, 2000, The Journal of Immunology.

Differential Induction of Apoptosis by Fas–Fas Ligand Interactions in Human Monocytes and Macrophages

P. M. Davis, P. Kiener, J. Ledbetter, 1997, The Journal of experimental medicine.

Bindungsdomäne-immunglobulin-fusionsproteine

J. Ledbetter, Martha Hayden-Ledbetter, 2002 .

p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals.

G. Schieven, R. Geahlen, J. Ledbetter, 1993, The Journal of biological chemistry.

Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes.

J. Ledbetter, F. Uckun, L. Tuel-ahlgren, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors.

G. Schieven, J. Ledbetter, F. Uckun, 1991, Proceedings of the National Academy of Sciences of the United States of America.

CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells.

G. Schieven, J. Imboden, J. Ledbetter, 1991, Journal of immunology.

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.

G. Schieven, J. Ledbetter, F. Uckun, 1991, The Journal of biological chemistry.

The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release.

G. Schieven, E. Clark, J. Ledbetter, 1991, Journal of immunology.

The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation.

G. Schieven, E. Clark, J. Ledbetter, 1990, Journal of immunology.

Signal transduction via CD4, CD8, and CD28 in mature and immature thymocytes. Implications for thymic selection.

P. Linsley, G. Schieven, L. Turka, 1991, Journal of immunology.

Rapid Antibody to the Ligand of CD40, gp39, Blocks the Occurrence of the Acute and Chronic Forms of Graft-vs-Host Disease

A. Aruffo, J. Ledbetter, R. Noelle, 2022 .

Differential Expression o f Fas ( CD 95 ) and Fas Ligand on Normal Human Phagocytes : Implications for the Regulation o f Apoptosis in Neutrophils

P. Kiener, A. Aruffo, J. Ledbetter, 2003 .

CD3-mediated activation of tumor-reactive lymphocytes from patients with advanced cancer

Z. Ye, G. Goodman, J. Ledbetter, 2001, Proceedings of the National Academy of Sciences of the United States of America.

An essential role for gp39, the ligand for CD40, in thymic selection

R. Flavell, A. Aruffo, S. Hedrick, 1995, The Journal of experimental medicine.

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

A. Aruffo, J. Ledbetter, R. Noelle, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB

A. Dahlin, Z. Ye, J. Ledbetter, 2002, Nature Medicine.

Thymic Influences on Autoimmunity in MRL‐1pr Mice

W. Seaman, J. Ledbetter, D. Wofsy, 1982, Scandinavian journal of immunology.

In the absence of a CD40 signal, B cells are tolerogenic.

R. Flavell, A. Aruffo, J. Ledbetter, 1995, Immunity.

The Role of CD40 and its Ligand in the Regulation of the Immune Response

H. Ochs, A. Aruffo, J. Ledbetter, 1994, Immunological Reviews.

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

A. Aruffo, J. Ledbetter, R. Noelle, 1994, The Journal of clinical investigation.

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

A. Aruffo, J. Ledbetter, R. Noelle, 1993, Journal of immunology.

Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses

P. Linsley, A. Aruffo, J. Ledbetter, 1995, European journal of immunology.

Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity

W. Seaman, L. Herzenberg, J. Ledbetter, 1981, The Journal of experimental medicine.

Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-gamma 1 and PLC phospholipase C-gamma 2.

G. Schieven, A. Aruffo, E. Clark, 1993, Journal of immunology.

ICOS ligand costimulation is required for T-cell encephalitogenicity.

J. Ledbetter, P. Perrin, M. Hayden-Ledbetter, 2001, Clinical immunology.

Tumor Necrosis Factor-α Regulates the Expression of Inducible Costimulator Receptor Ligand on CD34+ Progenitor Cells during Differentiation into Antigen Presenting Cells*

E. Clark, J. Ledbetter, A. Aicher, 2001, The Journal of Biological Chemistry.

Direct helper T cell‐induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7

P. Linsley, J. Ledbetter, N. Damle, 1991, European journal of immunology.

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells

G. Freeman, C. Thompson, C. June, 1992, The Journal of experimental medicine.

Definition of a common leukocyte cell-surface antigen (Lp95-150) associated with diverse cell-mediated immune functions.

J. Ledbetter, J. Hansen, P. Beatty, 1983, Journal of immunology.

Identification of distinct populations of PI-3 kinase activity following T-cell activation.

P. Thompson, K. Robbins, J. Gutkind, 1992, Oncogene.

The lateral mobility and surface distribution of Lyt-1, Lyt-2 and Lyt-3 on mouse thymocytes.

J. Ledbetter, L. M. Smith, H. Mcconnell, 1982, Molecular immunology.

Structure, function, and genetics of human B cell-associated surface molecules.

E. Clark, J. Ledbetter, 1989, Advances in cancer research.

Therapeutic uses of agonistic monoclonal antibodies to human lymphocyte cell-surface molecules

E. Clark, J. Ledbetter, 1988 .

CD5 antibodies increase intracellular ionized calcium concentration in T cells.

P. Rabinovitch, C. June, J. Ledbetter, 1987, Journal of immunology.

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.

P. Rabinovitch, C. June, J. Ledbetter, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression.

P. Rabinovitch, M. Parsons, C. June, 1986, Journal of immunology.

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

P. Rabinovitch, C. June, J. Ledbetter, 1986, Journal of immunology.

Anti-Ly-1 antibody induces interleukin 2 release from T cells.

J. Ledbetter, D. Wofsy, T. L. Stevens, 1986, Journal of immunology.

Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells.

J. Ledbetter, D. Wofsy, P. Beatty, 1985, Journal of immunology.

Functional roles of the V3 hypervariable region of HIV-1 gp160 in the processing of gp160 and in the formation of syncytia in CD4+ cells.

J. Ledbetter, J. B. Lewis, S. Hu, 1992, Virology.

Role of the Bp35 cell surface polypeptide in human B-cell activation.

E. Clark, J. Ledbetter, G. Shu, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Induction of calcium flux and enhancement of cytolytic activity in natural killer cells by cross-linking of the sheep erythrocyte binding protein (CD2) and the Fc-receptor (CD16).

P. Rabinovitch, C. June, J. Ledbetter, 1987, Journal of immunology.

Abnormalities in lymphocyte profile and specificity repertoire of patients with Waldenstrom's macroglobulinemia, multiple myeloma, and IgM monoclonal gammopathy of undetermined significance

L. Pilarski, M. Mant, J. Ledbetter, 1989, American journal of hematology.

Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice

C. Alpers, D. Liggitt, K. Elkon, 2013, The Journal of Immunology.

Increased RNase Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice

C. Alpers, D. Liggitt, K. Elkon, 2013 .

Inflammation and Prolongs Survival in Increased Ribonuclease Expression Reduces

C. Alpers, D. Liggitt, K. Elkon, 2013 .

Transgenic TLR7 Inflammation and Prolongs Survival in Increased RNase Expression Reduces

C. Alpers, D. Liggitt, K. Elkon, 2013 .

Ultraviolet radiation rapidly induces tyrosine phosphorylation and calcium signaling in lymphocytes.

G. Schieven, J. Ledbetter, F. Uckun, 1993, Molecular biology of the cell.

Developmental hierarchy during early human B-cell ontogeny after autologous bone marrow transplantation using autografts depleted of CD19+ B-cell precursors by an anti-CD19 pan-B-cell immunotoxin containing pokeweed antiviral protein.

J. Ledbetter, D. Weisdorf, J. Kersey, 1992, Blood.

Association of 75/80-kDa Phosphoproteins and the Tyrosine Kinases Lyn, Fyn, and Lck with the B Cell Molecule CD20

G. Schieven, J. Ledbetter, J. Bolen, 1995, The Journal of Biological Chemistry.

7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium.

G. Schieven, S. Burchiel, G. G. Deanin, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells

P. Linsley, K. Tung, J. Ledbetter, 1996, Journal of Experimental Medicine.

A human T lymphocyte differentiation marker defined by monoclonal antibodies that block E-rosette formation.

L. Herzenberg, J. Ledbetter, E. Stinson, 1981, Journal of immunology.

A role for tumour necrosis factor‐α, Fas and Fas‐Ligand in marrow failure associated with myelodysplastic syndrome

P. Kiener, M. Loken, J. Ledbetter, 1998, British journal of haematology.

P. Rabinovitch, J. Ledbetter, A. Grossmann, 1990, Journal of gerontology.

Reduced proliferation in T lymphocytes in aged humans is predominantly in the CD8+ subset, and is unrelated to defects in transmembrane signaling which are predominantly in the CD4+ subset.

P. Rabinovitch, J. Ledbetter, A. Grossmann, 1989, Experimental cell research.

The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGM1.

H. Ochs, A. Aruffo, J. Ledbetter, 1994, The Journal of clinical investigation.

Granulocytes and cultured human fibroblasts express common acute lymphoblastic leukemia-associated antigens.

J. Ledbetter, J. Hansen, P. Martin, 1983, Blood.

IL-2 and IL-15 Regulate CD154 Expression on Activated CD4 T Cells1

J. Ledbetter, S. Skov, N. Ødum, 2000, The Journal of Immunology.

CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation.

G. Schieven, J. Ledbetter, F. Uckun, 1991, Journal of immunology.

Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation.

S. Kanner, J. Ledbetter, N. Damle, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway

P. Rabinovitch, C. June, J. Ledbetter, 1987, Molecular and cellular biology.

Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation.

C. June, J. Ledbetter, J. Hansen, 1986, Journal of immunology.

A n Essential R o l e for gp 39 , the Ligand for C D 4 0 , in Thymic Selection

A. Aruffo, S. Hedrick, J. Ledbetter, 2003 .

Differential regulatory effects of intercellular adhesion molecule-1 on costimulation by the CD28 counter-receptor B7.

P. Linsley, A. Aruffo, J. Ledbetter, 1992, Journal of immunology.

Anti-CD180 (RP105) Activates B Cells To Rapidly Produce Polyclonal Ig via a T Cell and MyD88-Independent Pathway

E. Clark, J. Ledbetter, S. Kasahara, 2011, The Journal of Immunology.

and MyD88-Independent Pathway Rapidly Produce Polyclonal Ig via a T Cell Anti-CD180 (RP105) Activates B Cells To

E. Clark, J. Ledbetter, Jay W. Chaplin, 2011 .

MyD 88-Independent Pathway Rapidly Produce Polyclonal Ig via a T Cell Anti-CD 180 ( RP 105 ) Activates B Cells To

E. Clark, J. Ledbetter, S. Kasahara, 2011 .

Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLC gamma 1 SH2 domains.

S. Kanner, G. Schieven, A. Aruffo, 1992, The Journal of biological chemistry.

CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.

N. Tonks, E. Fischer, E. Clark, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

C. Thompson, C. June, J. Ledbetter, 1989, Journal of immunology.

Studies of T Cell Proliferation Induced by Monoclonal Antibodies of the Second International Workshop

E. Clark, J. Ledbetter, J. Hansen, 1986 .

Effects of anti-gp120 monoclonal antibodies on CD4 receptor binding by the env protein of human immunodeficiency virus type 1

P. Linsley, J. Ledbetter, S. Hu, 1988, Journal of virology.

Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction.

G. Schieven, E. Flescher, J. Ledbetter, 1994, Journal of immunology.

ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.

S. Kanner, G. Schieven, J. Ledbetter, 1994, The Journal of biological chemistry.

Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34(+) progenitor cells during differentiation into antigen presenting cells.

E. Clark, J. Ledbetter, A. Aicher, 2001, The Journal of biological chemistry.

Ligation of the T-cell Antigen Receptor (TCR) Induces Association of hSos1, ZAP-70, Phospolipase C-γ1, and Other Phosphoproteins with Grb2 and the ζ-Chain of the TCR (*)

S. Kanner, A. Nel, Shalini Gupta, 1995, The Journal of Biological Chemistry.

Major histocompatibility complex class II-mediated inhibition of hematopoiesis in long-term marrow cultures involves apoptosis and is prevented by c-kit ligand.

H. Deeg, J. Ledbetter, D. Hockenbery, 1995, Blood.

CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.

H. Ochs, A. Aruffo, J. Ledbetter, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Synergistic interaction between interleukin 4 and anti‐Bp50 (CDw40) revealed in a novel B cell restimulation assay

G. Guy, J. Ledbetter, J. Gordon, 1987, European journal of immunology.

Activity of a single-chain immunotoxin that selectively kills lymphoma and other B-lineage cells expressing the CD40 antigen.

J. Ledbetter, J. A. Francisco, C. Siegall, 1995, Cancer research.

Autologous bone marrow transplantation in high-risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4-hydroperoxycyclophosphamide for marrow purging.

J. Ledbetter, F. Uckun, D. Weisdorf, 1990, Blood.

Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors

G. Schieven, C. Song, J. Ledbetter, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Two-dimensional analysis of murine leukemia virus gag-gene polyproteins.

J. Ledbetter, 1979, Virology.

Evolution of epitopes on human and nonhuman primate lymphocyte cell surface antigens

E. Clark, J. Ledbetter, J. Hansen, 2004, Immunogenetics.

Human T Lymphocyte Cell Surface Molecules Defined by the Workshop Monoclonal Antibodies (“T Cell Protocol”)

E. Clark, J. Ledbetter, J. Hansen, 1984 .

Interleukio 2 stimulates serine phosphorylation of CD45 in CTLL‐2.4 cells

E. Clark, J. Ledbetter, D. Brautigan, 1991, European journal of immunology.

Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase.

P. Linsley, G. Schieven, J. Ledbetter, 1992, Journal of immunology.

ZAP-70 and p72syk are signaling response elements through MHC class II molecules.

S. Kanner, G. Schieven, J. Ledbetter, 1995, Tissue antigens.

Activation with superantigens induces programmed death in antigen‐primed CD4+ class II+ major histocompatibility complex T lymphocytes via a CD11a/CD18‐dependent mechanism

J. Ledbetter, N. Damle, G. Leytze, 1993, European journal of immunology.

Regulation of HIV production by blood mononuclear cells from HIV-infected donors: II. HIV-1 production depends on T cell-monocyte interaction.

J. Ledbetter, N. Damle, M. Diegel, 1993, AIDS research and human retroviruses.

Evidence for LFA‐1/ICAM‐1 dependent stimulation of protein tyrosine phosphorylation in human B lymphoid cell lines during homotypic adhesion

S. Kanner, A. Nel, S. Gupta, 1995, Journal of leukocyte biology.

Coengagement of CD2 with LFA‐1 or VLA‐4 by bispecific ligand fusion proteins primes T cells to respond more effectively to T cell receptor‐dependent signals

P. Linsley, S. Kanner, A. Aruffo, 1994, Journal of leukocyte biology.

A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes.

C. June, J. Ledbetter, J. Hansen, 1986, Journal of immunology.

Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors

G. Schieven, A. Aruffo, J. Ledbetter, 1993, The Journal of experimental medicine.

CD83 Is a Sialic Acid-Binding Ig-Like Lectin (Siglec) Adhesion Receptor that Binds Monocytes and a Subset of Activated CD8+ T Cells1

J. Ledbetter, K. Hellström, I. Hellström, 2001, The Journal of Immunology.

Monocytes and a Subset of Activated CD 8 ( Siglec ) Adhesion Receptor that Binds CD 83 Is a Sialic Acid-Binding Ig-Like Lectin Hellström

J. Ledbetter, K. Hellström, I. Hellström, 2001 .

Costimulation with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of antigen-specific CD4+ T lymphocytes.

P. Linsley, A. Aruffo, J. Ledbetter, 1993, Journal of immunology.

Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7.

P. Linsley, A. Aruffo, J. Ledbetter, 1994, Journal of immunology.

CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling.

P. Linsley, J. Bradshaw, J. Ledbetter, 1993, Journal of immunology.

Construction, expression, and characterization of anticarcinoma sFv fused to IL-2 or GM-CSF.

H. P. Fell, J. Ledbetter, L. Zhao, 1999, Journal of hematotherapy & stem cell research.

Costimulation by CD28 sFv expressed on the tumor cell surface or as a soluble bispecific molecule targeted to the L6 carcinoma antigen.

H. P. Fell, P. Linsley, G. Winberg, 1996, Tissue antigens.

Surface Expression of CD28 Single Chain Fv for Costimulation by Tumor Cells

H. P. Fell, G. Winberg, J. Ledbetter, 1996, Immunological reviews.

T cell long‐term hyporesponsiveness follows antigen receptor engagement and results from defective signal transduction

M. Kaufman, F. Andris, O. Leo, 1994, European journal of immunology.

Quantitative immunofluorescent analysis of surface phenotypes of murine B cell lymphomas and plasmacytomas with monoclonal antibodies.

L. Lanier, L. Herzenberg, J. Ledbetter, 1981, Journal of immunology.

A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5.

A. Aruffo, J. Ledbetter, S. Bondada, 1998, International immunology.

Induction of transcription factors in human T lymphocytes by aspirin-like drugs.

E. Flescher, J. Ledbetter, N. Ogawa, 1995, Cellular immunology.

Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase.

C. June, L. Samelson, J. Ledbetter, 1990, Journal of immunology.

Expression and characterization of recombinant soluble human CD3 molecules: presentation of antigenic epitopes defined on the native TCR-CD3 complex.

J. Ledbetter, R. Dua, C. Law, 2002, International immunology.

CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.

S. Kanner, A. Aruffo, J. Ledbetter, 1992, Journal of immunology.

Amplification of the immune response by agonistic antibodies.

E. Clark, J. Ledbetter, 1986, Immunology today.

HLA-DR molecules enhance signal transduction through the CD3/Ti complex in activated T cells.

G. Schieven, J. Ledbetter, J. Hansen, 1991, Tissue antigens.

Triggering of neoplastic B cells via surface IgM and the cell surface antigens CD20 and CDw40. Responses differ from normal blood B cells and are restricted to certain morphologic subsets

E. Smeland, H. Holte, K. Beiske, 1988, International journal of cancer.

Interaction of CD4:lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase

S. Kanner, R. Torres, J. Ledbetter, 1992, European journal of immunology.

Surface antigens on mouse natural killer cells: use of monoclonal antibodies to inhibit or to enrich cytotoxic activity.

W. Seaman, L. Herzenberg, J. Ledbetter, 1981, Journal of immunology.

Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes.

J. Ledbetter, N. Damle, L. Grosmaire, 1988, Journal of immunology.

Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals.

J. Banchereau, E. Clark, J. Ledbetter, 1989, Journal of immunology.

Tyrosine phosphorylation of CD19 in pre‐B and mature B cells.

S. Kanner, G. Schieven, A. Aruffo, 1993, The EMBO journal.

The interaction of CD4 with CD3/Ti regulates tyrosine phosphorylation of substrates during T cell activation.

G. Schieven, J. Ledbetter, L. Gilliland, 1990, Seminars in immunology.

Regulation of HIV production by blood mononuclear cells from HIV-infected donors: I. Lack of correlation between HIV-1 production and T cell activation.

J. Ledbetter, J. Sias, M. Diegel, 1993, AIDS research and human retroviruses.

Expression of Lyt-1 antigen on certain murine B cell lymphomas

L. Lanier, L. Herzenberg, J. Ledbetter, 1981, The Journal of experimental medicine.

Ultraviolet radiation induces differential calcium signals in human peripheral blood lymphocyte subsets.

G. Schieven, J. Ledbetter, 1993, Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy.

Phorbol-12-myristate-13-acetate-treated human keratinocytes express B7-like molecules that serve a costimulatory role in T-cell activation.

P. Linsley, J. Simon, J. Ledbetter, 1993, The Journal of investigative dermatology.

Selective loss of a subset of T helper cells in active multiple sclerosis.

E. Clark, J. Ledbetter, T. Rothstein, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of molecular components associated with surface immunoglobulin M in human B lymphocytes: Presence of tyrosine and serine/threonine protein kinases

E. Clark, C. Leprince, R. Torres, 1992, European journal of immunology.

Tyrosine Phosphorylation of CD 6 by Stimulation of CD 3 : Augmentation by the CD 4 and CD 2 Coreceptors

G. Schieven, A. Aruffo, J. Ledbetter, 2003 .

Murine T-Cell Differentiation Antigens Detected by Monoclonal Antibodies

L. Herzenberg, T. Tokuhisa, J. Ledbetter, 1980 .

Cytokine activation sensitizes human monocytic and endothelial cells to the cytotoxic effects of an anti-CD40 immunotoxin.

P. Kiener, J. Ledbetter, J. A. Francisco, 1996, Journal of immunology.

Cutting Edge: CD83 Regulates the Development of Cellular Immunity1

A. Dahlin, J. Ledbetter, K. Hellström, 2002, The Journal of Immunology.

Mantle Zone and Germinal Center B cells Respond to Different Activation Signals

E. Clark, J. Ledbetter, Paul J. Martin, 1985 .

Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.

L. Pilarski, J. Krowka, J. Ledbetter, 1988, Journal of immunology.

Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR.

S. Kanner, A. Nel, S. Gupta, 1995, The Journal of biological chemistry.

Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40).

E. Clark, J. Ledbetter, G. Shu, 1987, Journal of immunology.

Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.

W. Seaman, J. Ledbetter, D. Wofsy, 1983, Journal of immunology.

Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1.

P. Rabinovitch, S. Kanner, T. Kavanagh, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Surface phenotype and function of tonsillar germinal center and mantle zone B cell subsets.

E. Clark, J. Ledbetter, 1986, Human Immunology.

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

Lieping Chen, I. Melero, A. Aruffo, 1997, Nature Medicine.

J. Ledbetter, F. Uckun, D. Weisdorf, 1992 .

Early signal transduction by the receptor to the chemokine monocyte chemotactic protein-1 in a murine T cell hybrid.

M. Webb, J. Ledbetter, R. Shapiro, 1996, Journal of immunology.

Signal transduction by HLA class II antigens expressed on activated T cells

G. Schieven, J. Ledbetter, J. Hansen, 1991, European journal of immunology.

Inhibition of HIV-1 replication in seropositive patients' CD4+ T-cells by pokeweed antiviral protein-monoclonal antibody conjugates.

J. Ledbetter, O. Haffar, D. E. Myers, 1991, International journal of immunopharmacology.

An immunoglobulin light chain dimer with CD4 antigen specificity.

H. P. Fell, J. Ledbetter, L. Grosmaire, 1987, Molecular immunology.

Identification and functional characterization of two distinct epitopes on the human T cell surface protein Tp50.

G. Longton, J. Ledbetter, J. Hansen, 1983, Journal of immunology.

Apoptosis following interleukin-2 withdrawal from T cells: evidence for a regulatory role of CD18 (beta 2-integrin) molecules.

J. Ledbetter, A. Svejgaard, N. Odum, 1996, Tissue antigens.

Distinct patterns of tyrosine phosphorylation during the life cycle of Trypanosoma brucei.

G. Schieven, M. Parsons, J. Ledbetter, 1991, Molecular and biochemical parasitology.

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes.

G. Schieven, J. Ledbetter, F. Uckun, 1993, Blood.

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens *

L. Herzenberg, J. Ledbetter, 1979, Immunological reviews.

Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule.

P. Linsley, J. Ledbetter, J. Greene, 1992, Science.

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

J. Bajorath, U. Francke, H. Ochs, 1993, Cell.

Selective loss of CD4+ CD45R+ T cells in peripheral blood of multiple myeloma patients

L. Pilarski, M. Mant, J. Ledbetter, 1988, Journal of Clinical Immunology.

HIV-infected humans, but not chimpanzees, have circulating cytotoxic T lymphocytes that lyse uninfected CD4+ cells.

P. Fultz, J. Ledbetter, J. Sias, 1990, Journal of immunology.

Identification of an FMR cell surface antigen associated with murine leukemia virus-infected cells

J. Ledbetter, R. Nowinski, S. Emery, 1978, Journal of virology.

Role of Oxidative Stress in the Action of Vanadium Phosphotyrosine Phosphatase Inhibitors

G. Schieven, T. Kavanagh, C. Krejsa, 1997, The Journal of Biological Chemistry.

Leukocyte cell surface enzymology: CD45 (LCA, T200) is a protein tyrosine phosphatase.

E. Clark, J. Ledbetter, 1989, Immunology today.

Viral proteins expressed on the surface of murine leukemia cells

J. Ledbetter, R. Nowinski, S. Emery, 1977, Journal of virology.

Signal transduction by HLA-DR is mediated by tyrosine kinase(s) and regulated by CD45 in activated T cells.

G. Schieven, J. Ledbetter, J. Hansen, 1991, Human immunology.

HIV-1-infected T cells show a selective signaling defect after perturbation of CD3/antigen receptor.

G. Linette, C. June, J. Ledbetter, 1988, Science.

Antibodies to common leukocyte antigen p220 influence human T cell proliferation by modifying IL 2 receptor expression.

E. Clark, J. Ledbetter, P. Beatty, 1985, Journal of immunology.

Biosynthesis and metabolism of viral proteins expressed on the surface of murine leukemia virus-infected cells.

R. Eisenman, J. Ledbetter, R. Nowinski, 1978, Virology.

Identification of the Gross cell surface antigen associated with murine leukemia virus-infected cells

J. Ledbetter, R. Nowinski, Jeffrey A. Ledbetter, 1977, Journal of virology.

CTLA-4 is a second receptor for the B cell activation antigen B7

P. Linsley, J. Ledbetter, N. Damle, 1991, The Journal of experimental medicine.

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation

P. Linsley, A. Aruffo, J. Ledbetter, 1991, The Journal of experimental medicine.

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

P. Linsley, E. Clark, J. Ledbetter, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Molecular mechanisms of toxicant-induced immunosuppression: role of second messengers.

G. Schieven, S. Burchiel, J. Karras, 1996, Annual review of pharmacology and toxicology.

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions

A. Aruffo, J. Ledbetter, R. Noelle, 1993, The Journal of experimental medicine.

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

I. Stamenkovic, A. Aruffo, J. Ledbetter, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies.

J. Ledbetter, O. Press, Daming Shan, 1998, Blood.

CD83 is an I-type lectin adhesion receptor that binds monocytes and a subset of activated CD8+ T cells [corrected].

J. Ledbetter, K. Hellström, I. Hellström, 2001, Journal of immunology.

CD28/CTLA-4 receptor structure, binding stoichiometry and aggregation during T-cell activation.

P. Linsley, J. Bajorath, R. Peach, 1995, Research in immunology.

Monoclonal antibody 1F5 (anti-CD20) serotherapy of human B cell lymphomas.

F. Appelbaum, J. Ledbetter, O. Press, 1987, Blood.

Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins.

A. Fauci, M. Wick, C. Song, 1988, Blood.

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

G. Schieven, C. Song, J. Ledbetter, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The molecular basis for T cell help in humoral immunity: CD40 and its ligand, gp39

A. Aruffo, J. Ledbetter, R. Noelle, 1993, Journal of Clinical Immunology.

Influence of antibody isotype on passive serotherapy of lymphoma.

I. Bernstein, E. Denkers, J. Ledbetter, 1985, Journal of immunology.

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

A. Aruffo, J. Ledbetter, C. Larsen, 1997, The Journal of experimental medicine.

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

E. Clark, J. Ledbetter, 1986, Proceedings of the National Academy of Sciences of the United States of America.

CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses.

P. Linsley, S. Kanner, J. Ledbetter, 1995, Journal of immunology.

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

C. Thompson, C. June, H. Young, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Specific binding of Fyn and phosphatidylinositol 3‐kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains

J. Bajorath, A. Aruffo, J. Ledbetter, 1995, European journal of immunology.

Lymphocyte Adhesion Coreceptors and their Roles in HIV-1 Replication

J. Ledbetter, 1996 .

How B and T cells talk to each other

Jeffrey A. Ledbetter, E. Clark, J. Ledbetter, 1994, Nature.

Polypeptides on human B lymphocytes associated with cell activation.

E. Clark, J. Ledbetter, P. Dinndorf, 1986, Human immunology.

Association of CD8 with p56lck is required for early T cell signalling events.

P. Kavathas, J. Ledbetter, N. J. Chalupny, 1991, The EMBO journal.

Ligands AND METHODS TO INCREASE THE PROLIFERATION OF CELLS B.

E. Clark, J. Ledbetter, 1987 .

Epitope mapping of the human surface suppressor/cytotoxic T cell molecule Tp32.

E. Clark, J. Ledbetter, J. Hansen, 1984, Journal of immunology.

Covalent association between human thymus leukemia-like antigens and CD8(Tp32) molecules.

E. Clark, J. Ledbetter, T. Tsu, 1985, Journal of immunology.

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39

A. Aruffo, J. Ledbetter, R. Noelle, 1993, The Journal of experimental medicine.

Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells.

J. Ledbetter, F. Uckun, D. E. Myers, 1990, Blood.

THE BEIGE (bg) GENE INFLUENCES THE DEVELOPMENT OF AUTOIMMUNE DISEASE IN SB/Le MALE MICE

E. Clark, J. Ledbetter, J. Roths, 1982 .

Cell-type-specific cytotoxicity of anti-CD4 and anti-CD8 ricin immunotoxins against human alloreactive T-cell clones.

J. Ledbetter, F. Uckun, D. Vallera, 1989, Blood.

Genetic construction and characterization of a fusion protein consisting of a chimeric F(ab') with specificity for carcinomas and human IL-2.

H. P. Fell, M. Gayle, J. Ledbetter, 1991, Journal of immunology.

Characterization of Human Inducible Costimulator Ligand Expression and Function1

E. Clark, J. Ledbetter, W. Brady, 2000, The Journal of Immunology.

Signal transduction in lymphocyte activation through crosslinking of HLA class I molecules.

S. Ferrone, J. Ledbetter, L. Grosmaire, 1989, Human immunology.

CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation.

A. Aruffo, J. Ledbetter, R. Noelle, 1992, Immunology today.

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory

A. Aruffo, J. Ledbetter, T. Foy, 1994, The Journal of experimental medicine.

Signaling events during helper T cell-dependent B cell activation. I. Analysis of the signal transduction pathways triggered by activated helper T cell in resting B cells.

A. Aruffo, J. Ledbetter, R. Noelle, 1994, Journal of immunology.

B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes.

P. Linsley, J. Ledbetter, H. Teh, 1992, Journal of immunology.

CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1

P. Linsley, J. Ledbetter, 1992 .

A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.

P. Kavathas, J. Ledbetter, P. Giblin, 1989, Proceedings of the National Academy of Sciences of the United States of America.

CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T cells

J. Ledbetter, K. Hellström, I. Hellström, 2009, The Journal of Immunology.

CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.

S. Kanner, J. Ledbetter, C. Terhorst, 1992, The Journal of biological chemistry.

Activation of MAP-2 kinase activity by the CD2 receptor in Jurkat T cells can be reversed by CD45 phosphatase.

A. Nel, J. Ledbetter, B. Akerley, 1991, Immunology.

CD-3-mediated activation of MAP-2 kinase can be modified by ligation of the CD4 receptor. Evidence for tyrosine phosphorylation during activation of this kinase.

A E Nel, A. Nel, G. Landreth, 1990, Journal of immunology.

Mitogenic properties of a bispecific single-chain Fv-Ig fusion generated from CD2-specific mAb to distinct epitopes.

S. Kanner, J. Ledbetter, R. Connelly, 1998, International immunology.

CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL- 3 fusion protein, and mast cell growth factor (a c-kit ligand)

D. Williams, H. Broxmeyer, J. Ledbetter, 1991, The Journal of experimental medicine.

Stimulation of CD5 enhances signal transduction by the T cell antigen receptor.

C. June, J. Imboden, J. Ledbetter, 1990, The Journal of clinical investigation.

Stimulation of CD 5 Enhances Signal Transduction by the T Cell Antigen Receptor

C. June, J. Ledbetter, M. Mccutcheon, 2022 .

Single-chain mono- and bispecific antibody derivatives with novel biological properties and antitumour activity from a COS cell transient expression system.

H. P. Fell, J Bajorath, M. Gayle, 1994, Therapeutic immunology.

Regulation of CD3-induced phospholipase C-gamma 1 (PLC gamma 1) tyrosine phosphorylation by CD4 and CD45 receptors.

S. Kanner, J. Ledbetter, J. Deans, 1992, Immunology.

CD45 modulates T cell receptor/CD3‐induced activation of human thymocytes via regulation of tyrosine phosphorylation

S. Kanner, G. Schieven, C. Thompson, 1992, European journal of immunology.

Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

C H June, P. Rabinovitch, C. June, 1986, The Journal of clinical investigation.

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

C. June, L. Samelson, J. Ledbetter, 1990, Journal of immunology.

Transitions in CD45 isoform expression indicate continuous differentiation of a monoclonal CD5+ CD11b+ B lineage in Waldenstrom's macroglobulinemia

L. Pilarski, M. Mant, J. Ledbetter, 1991, American journal of hematology.

How does B cell depletion therapy work, and how can it be improved?

E. Clark, J. Ledbetter, Ledbetter, 2005, Annals of the rheumatic diseases.

CD20-Directed Small Modular Immunopharmaceutical, TRU-015, Depletes Normal and Malignant B Cells

P. Thompson, A. Wahl, J. Ledbetter, 2009, Clinical Cancer Research.

Treatment of murine lupus with monoclonal anti-T cell antibody.

W. Seaman, P. Hendler, J. Ledbetter, 1985, Journal of immunology.

HLA-DR-triggered inhibition of hemopoiesis involves Fas/Fas ligand interactions and is prevented by c-kit ligand.

H. Deeg, P. Kiener, J. Ledbetter, 1997, Journal of immunology.

Identification of Amino Acid Residues Important for Ligand Binding to Fas

Jürgen Bajorath, Jeffrey A. Ledbetter, Alejandro Aruffo, 1997, The Journal of experimental medicine.

Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress*

G. Schieven, T. Kavanagh, C. Krejsa, 2010, The Journal of Biological Chemistry.

Tumor Necrosis Factor-Regulates the Expression of Inducible Costimulator Receptor Ligand on CD 34 Progenitor Cells during Differentiation into Antigen Presenting Cells *

E. Clark, J. Ledbetter, A. Aicher, 2001 .

The Lyt‐2, Lyt‐3 Macromolecules: Structural and Functional Studies

W. Seaman, J. Ledbetter, 1982, Immunological reviews.

Characterization of scFv-Ig constructs generated from the anti-CD20 mAb 1F5 using linker peptides of varying lengths.

J. Ledbetter, O. Press, T. Tsu, 1999, Journal of immunology.

Using Linker Peptides of Varying Lengths Generated from the Anti-CD 20 mAb 1 F 5 Characterization of scFv-Ig Constructs

J. Ledbetter, O. Press, T. Tsu, 1999 .

Lysis of cells infected with HIV-1 by human lymphocytes targeted with monoclonal antibody heteroconjugates.

J. Ledbetter, L. Grosmaire, J. Mcclure, 1988, Journal of immunology.

Bispecific receptor globulins, novel tools for the study of cellular interactions. Preparation and characterization of an E-selectin/P-selectin bispecific receptor globulin.

P. Linsley, A. Aruffo, J. Ledbetter, 1993, Journal of immunological methods.

Treatment with monoclonal antibodies (mAbs) against the 4-1BB T-cell activation molecule eradicate established tumors

Lieping Chen, I. Melero, A. Aruffo, 1997 .

Apparent loss of 2H4+ T cells in peripheral blood lymphocytes of normal donors: a 2H4-specific artefact unique to T cells.

L. Pilarski, J. Ledbetter, H. Serra, 1988, Human immunology.

Suppressor-inducer T-cells in multiple sclerosis.

E. Clark, J. Ledbetter, T. Rothstein, 1987, The New England journal of medicine.

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

G. Schieven, P. Kiener, A. Burkhardt, 1993, The Journal of biological chemistry.

Diagnostic de carcinomes

M. Schummer, J. Ledbetter, I. Hellstrom, 2002 .

Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase Cyl

P. Rabinovitch, S. Kanner, J. Ledbetter, 2004 .

Antibody to a novel 95-kDa surface glycoprotein on human B cells induces calcium mobilization and B cell activation.

E. Clark, J. Ledbetter, G. Shu, 1988, Journal of immunology.

Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF-kappaB.

G. Schieven, T. Kavanagh, C. Krejsa, 1997, The Journal of biological chemistry.

Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. A comparison with IL-4-mediated signaling.

G. Guy, J. Ledbetter, J. Gordon, 1988, Journal of immunology.

CD4 and CD8 T cells from SIV-infected macaques have defective signaling responses after perturbation of either CD3 or CD2 receptors.

G. Schieven, M. Gale, E. Clark, 1990, Disease markers.

CD28 receptor crosslinking induces tyrosine phosphorylation of PLC gamma 1.

P. Linsley, J. Ledbetter, 1992, Advances in experimental medicine and biology.

Analysis of Lymphocyte Subpopulations with Monoclonal Antibodies to Thy-1, Lyt-1, Lyt-2, and ThB Antigens

L. Herzenberg, J. Ledbetter, L. Eckhardt, 1980 .

Activation of tyrosine kinase signal pathways by radiation and oxidative stress

G. Schieven, J. Ledbetter, 1994, Trends in Endocrinology & Metabolism.

MHC class II molecules deliver costimulatory signals in human T cells through a functional linkage with IL-2-receptors.

S. Kanner, J. Ledbetter, N. Odum, 1993, Journal of immunology.

Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking.

J. Fargnoli, J. Ledbetter, J. Bolen, 1992, The Journal of biological chemistry.

Identification of an alternatively spliced form of the murine homologue of B7.

P. Linsley, J. Ledbetter, M. Inobe, 1994, Biochemical and Biophysical Research Communications - BBRC.

Fluctuations of CD4+ T‐cell subsets in remitting‐relapsing multiple sclerosis

E. Clark, J. Ledbetter, T. Rothstein, 1988, Annals of neurology.

CD4 and CD8 T cells from SIV-infected macaques have defective signaling responses after perturbation of either CD3 or CD2 receptors.

G. Schieven, M. Gale, E. Clark, 1990, International Immunology.

Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes.

C. Thompson, C. June, J. Ledbetter, 1989, Journal of autoimmunity.

Antibody and B 7 / BBl-mediated Ligation of the CD 28 Receptor Induces Tyrosine Phosphorylation in Human T Cells

G. Freeman, C. Thompson, C. June, 2003 .

Inhibition of virus production in peripheral blood mononuclear cells from human immunodeficiency virus (HIV) type 1-seropositive donors by treatment with recombinant HIV-like particles

J. Ledbetter, O. Haffar, M. Smithgall, 1992, Journal of virology.

Costimulation via vascular cell adhesion molecule-1 induces in T cells increased responsiveness to the CD28 counter-receptor B7.

P. Linsley, H. Ochs, A. Aruffo, 1993, Cellular immunology.

Expression and Characterization of Leucocyte Antigens

P. Gregersen, K. Lennert, B. Dörken, 1984 .

TRU-015, a novel CD20-directed biologic therapy, demonstrates significant anti-tumor activity in human tumor xenograft models

J. Ledbetter, K. Mohler, M. Hayden-Ledbetter, 2005 .

Quantitative expression and function of differentiation antigens on normal and malignant lymphoid cells.

I. Bernstein, E. Clark, J. Ledbetter, 1985, Haematology and blood transfusion.

Role of the Bp 35 cell surface polypeptide in human B-cell activation ( B lymphocytes / proliferation / monoclonal antibodies )

E. Clark, J. Ledbetter, G. Shu, 2022 .

Superantigen and HLA-DR ligation induce phospholipase-C gamma 1 activation in class II+ T cells.

S. Kanner, J. Ledbetter, A. Svejgaard, 1992, Journal of Immunology.

Biphenotypic leukemic lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues.

B. Koller, J. Ledbetter, A. Muraguchi, 1989, Blood.

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1

C Anasetti, P. Linsley, J. Bradshaw, 1993, The Journal of experimental medicine.

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils

P. Kiener, A. Aruffo, W. Liles, 1996, The Journal of experimental medicine.

Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28.

P. Linsley, G. Mize, D. Morris, 1994, Journal of immunology.

CTLA-4 is a second receptor for the B cell activation antigen B7

P. Linsley, J. Ledbetter, N. Damle, 1991, The Journal of experimental medicine.

Lineage-specific Induction of B Cell Apoptosis and Altered Signal Transduction by the Phosphotyrosine Phosphatase Inhibitor Bis(maltolato)oxovanadium(IV) (*)

G. Schieven, J. Ledbetter, S. Myrdal, 1995, The Journal of Biological Chemistry.

Human monocytic cells contain high levels of intracellular Fas ligand: rapid release following cellular activation.

P. M. Davis, P. Kiener, J. Ledbetter, 1997, Journal of immunology.

Molecular weight determination of two genetically linked cell surface murine antigens: ThB and Ly-6

L. Herzenberg, J. Ledbetter, P. Rogers, 1982, Immunogenetics.

Differential Induction of Apoptosis by Fas–Fas Ligand Interactions in Human Monocytes and Macrophages

P. M. Davis, P. Kiener, J. Ledbetter, 1997, The Journal of experimental medicine.

Transitions in CD45 lsoform Expression Indicate Continuous Differentiation of a Monoclonal CD5-t

L. Pilarski, M. Mant, J. Ledbetter, 2006 .

Role of CD2 cross‐linking in cytoplasmic calcium responses and T cell activation

P. Rabinovitch, C. June, J. Ledbetter, 1988, European journal of immunology.

Inhibition of allostimulated HLA-DQ and DP-specific T cells by staphylococcal enterotoxin A.

J. Ledbetter, J. Hansen, N. Odum, 1993, Human immunology.