H. Toyoshima

发表

Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.

Y. Yazaki, H. Hirai, H. Kozutsumi, 1994, Oncogene.

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

Tony Hunter, T. Hunter, H. Toyoshima, 1994, Cell.

Protein Kinase A Suppresses Sterol Regulatory Element-binding Protein-1C Expression via Phosphorylation of Liver X Receptor in the Liver*

Hitoshi Shimano, Takashi Matsuzaka, Hirohito Sone, 2007, Journal of Biological Chemistry.

Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.

H. Sone, H. Shimano, N. Yamada, 2004, Biochemical and biophysical research communications.

Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue.

H. Shimano, N. Yamada, H. Toyoshima, 2007, Journal of atherosclerosis and thrombosis.

Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.

Y. Ouchi, S. Inoue, H. Toyoshima, 1993, Proceedings of the National Academy of Sciences of the United States of America.

SREBPs suppress IRS-2-mediated insulin signalling in the liver

A. Fukamizu, H. Sone, H. Shimano, 2004, Nature Cell Biology.

Suppression of centrosome amplification after DNA damage depends on p27 accumulation.

M. Schwab, H. Saya, K. Nakayama, 2006, Cancer research.

Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFβ-treated cells

T. Hunter, R. Poon, P. Howe, 1996, Nature.

Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes.

H. Sone, H. Shimano, N. Yamada, 2005, Biochimica et biophysica acta.

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.

H. Sone, H. Shimano, N. Yahagi, 2004, Diabetes.

Lipid Synthetic Transcription Factor SREBP-1a Activates p21 WAF1/CIP1 , a Universal Cyclin-Dependent

H. Sone, H. Shimano, N. Yahagi, 2005 .

Lipid Synthetic Transcription Factor SREBP-1a Activates p21WAF1/CIP1, a Universal Cyclin-Dependent Kinase Inhibitor

H. Sone, H. Shimano, N. Yahagi, 2005, Molecular and Cellular Biology.

Possible involvement of the p57(Kip2) gene in bone metabolism.

Y. Ouchi, S. Inoue, H. Toyoshima, 2000, Biochemical and biophysical research communications.

Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.

Koichi Sugimoto, Y. Yazaki, H. Mano, 1993, Blood.

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status.

A. Iwama, H. Sone, H. Shimano, 2002, American journal of physiology. Endocrinology and metabolism.

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.

H. Gomi, Satoru Takahashi, H. Sone, 2006, Cell metabolism.

Frequent mutations in the p53 gene in human myeloid leukemia cell lines.

Koichi Sugimoto, Y. Yazaki, K. Miyagawa, 1992, Blood.

Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis.

H. Sone, H. Shimano, N. Yamada, 2001, Biochemical and Biophysical Research Communications - BBRC.

Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis correlation with disease activity.

H. Shimano, H. Toyoshima, A. Takahashi, 2001, Life sciences.

Transgenic Mice Overexpressing Nuclear SREBP-1 c in Pancreatic-Cells

H. Sone, H. Shimano, N. Yahagi, 2005 .

Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-Cells

H. Sone, H. Shimano, N. Yahagi, 2005 .

A transcription factor of lipid synthesis, sterol regulatory element‐binding protein (SREBP)‐1a causes G1 cell‐cycle arrest after accumulation of cyclin‐dependent kinase (cdk) inhibitors

H. Shimano, N. Yahagi, N. Yamada, 2007, The FEBS journal.

SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes*

H. Sone, H. Shimano, N. Yahagi, 2004, Journal of Biological Chemistry.

Plasma chloride concentration as a new diagnostic indicator of insulin insufficiency.

H. Sone, H. Shimano, N. Yamada, 2005, Diabetes research and clinical practice.

Frequent Mutations in the p 53 Gene in Human Myeloid Leukemia Cell Lines

Y. Yazaki, K. Miyagawa, K. Sugimoto, 2003 .

Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.

Y. Yazaki, H. Hirai, H. Kozutsumi, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy

H. Sone, H. Shimano, N. Yamada, 2006, Diabetes/metabolism research and reviews.

p57(Kip2) is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor beta1.

Y. Ouchi, S. Inoue, H. Toyoshima, 1999, The Journal of biological chemistry.

Cyclin-dependent Kinase Inhibitor, p21 WAF1/CIP1 , Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Cyclin-dependent Kinase Inhibitor , p 21 WAF 1 / CIP 1 , Is Involved in Adipocyte Differentiation and Hypertrophy , Linking to Obesity , and Insulin Resistance *

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

H. Sone, H. Shimano, N. Yahagi, 2005, Diabetes.

The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells.

Y. Yazaki, H. Mano, T. Tanaka, 1994, Oncogene.

Targeted Deletion of Both Thymidine Phosphorylase and Uridine Phosphorylase and Consequent Disorders in Mice

M. Fukushima, T. Noda, K. Miyazono, 2002, Molecular and Cellular Biology.

Detection of the PML/RAR alpha fusion gene in acute promyelocytic leukemia with a complex translocation involving chromosomes 15, 17, and 18.

Y. Yazaki, H. Mano, K. Sugimoto, 1993, Cancer genetics and cytogenetics.

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

H. Sone, H. Shimano, N. Yahagi, 2006, Nature Medicine.

Cyclin-dependent Kinases Are Inactivated by a Combination of p21 and Thr-14/Tyr-15 Phosphorylation after UV-induced DNA Damage*

T. Hunter, W. Jiang, R. Poon, 1996, The Journal of Biological Chemistry.

Smad-mediated Transcription Is Required for Transforming Growth Factor-β1-induced p57Kip2 Proteolysis in Osteoblastic Cells*

K. Miyazono, Keiji Tanaka, T. Imamura, 2001, The Journal of Biological Chemistry.

Insulin Inhibits Apoptosis of Macrophage Cell Line, THP-1 Cells, via Phosphatidylinositol-3-Kinase–Dependent Pathway

T. Asano, H. Sone, H. Shimano, 2002, Arteriosclerosis, thrombosis, and vascular biology.

p57Kip2 Regulates Actin Dynamics by Binding and Translocating LIM-kinase 1 to the Nucleus*

Keiji Tanaka, H. Sone, H. Shimano, 2003, Journal of Biological Chemistry.

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

K. Miyazono, C. Heldin, H. Ichijo, 1993, Oncogene.

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2007, Nature Medicine.

Mutations of the p53 gene in lymphoid leukemia.

Koichi Sugimoto, K. Miyagawa, K. Sugimoto, 1991, Blood.

Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance*

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2008, Journal of Biological Chemistry.

Cerebral hemorrhagic infarction after radiation for pituitary adenoma.

H. Sone, H. Shimano, N. Yamada, 2002, Internal medicine.

Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats.

K. Shimada, H. Sone, H. Shimano, 2003, American journal of physiology. Endocrinology and metabolism.

p57Kip2 Is Degraded through the Proteasome in Osteoblasts Stimulated to Proliferation by Transforming Growth Factor β1*

Y. Ouchi, S. Inoue, H. Toyoshima, 1999, The Journal of Biological Chemistry.

WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.

H. Sone, H. Shimano, N. Yamada, 2004, Biochemical and biophysical research communications.

PPARγ ligands, troglitazone and pioglitazone, up‐regulate expression of HMG‐CoA synthase and HMG‐CoA reductase gene in THP‐1 macrophages

H. Sone, H. Shimano, N. Yamada, 2002 .

Insulin Up-regulates Tumor Necrosis Factor-α Production in Macrophages through an Extracellular-regulated Kinase-dependent Pathway*

T. Asano, H. Shimano, H. Toyoshima, 2001, The Journal of Biological Chemistry.

Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects.

Hitoshi Shimano, Yuichi Noguchi, Hirohito Sone, 2003, Metabolism: clinical and experimental.

Identification of the human ltk gene product in placenta and hematopoietic cell lines.

Y. Yazaki, H. Hirai, H. Kozutsumi, 1993, Biochemical and biophysical research communications.

SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy.

H. Shimano, N. Yamada, H. Toyoshima, 2009, Journal of atherosclerosis and thrombosis.

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.

T. Hunter, R. Poon, H. Toyoshima, 1995, Molecular biology of the cell.

The presence of platelet-derived endothelial cell growth factor in human endometrium and its characteristic expression during the menstrual cycle and early gestational period.

H. Toyoshima, N. Mitsuhashi, Yutaka Osuga, 1995, Human reproduction.

Transgenic mice expressing an intestine-specific secretory protein, IBCAP, demonstrates pancreatic beta cell augmenting activity

T. Yokoo, H. Shimano, N. Yamada, 2010 .