J. Chambers

发表

Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

Eleanor C. Saunders, M. Ng, E. Saunders, 2014, PLoS pathogens.

Multivalent Small-Molecule Pan-RAS Inhibitors

Matthew E. Welsch, A. Ferrando, B. Stockwell, 2017, Cell.

Protein-Ligand Binding Free Energy Calculations with FEP.

Robert Abel, Lingle Wang, J. Chambers, 2019, Methods in molecular biology.

Isotopomer Profiling of Leishmania mexicana Promastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tricarboxylic Acid Cycle (TCA) Anaplerosis, Glutamate Synthesis, and Growth*

Eleanor C. Saunders, J. Krömer, M. Ng, 2011, The Journal of Biological Chemistry.

Use of (13)C stable isotope labelling for pathway and metabolic flux analysis in Leishmania parasites.

Eleanor C. Saunders, M. Ng, E. Saunders, 2015, Methods in molecular biology.

Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs.

G. Leonard, T. Brown, J. Chambers, 1989, Journal of molecular biology.

K-RasG12D has an allosteric small molecule binding site

B. Stockwell, J. Chambers, Huizhong Feng, 2021 .

Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II.

D. Christianson, J. Chambers, I. Dmochowski, 2008, Journal of the American Chemical Society.

Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity

A. Bobkov, J. Chambers, C. Sohl, 2021 .

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

K. J. Henley, A. Strasser, R. Johnstone, 2012, Cell Death and Disease.

Total synthesis of a biotinylated rocaglate: Selective targeting of the translation factors eIF4AI/II.

J. Chambers, G. P. Savage, M. Rizzacasa, 2016, Bioorganic & medicinal chemistry letters.

Simplified Silvestrol Analogues with Potent Cytotoxic Activity

David C. S. Huang, J. Chambers, J. White, 2014, ChemMedChem.

Synthesis of biotinylated episilvestrol: highly selective targeting of the translation factors eIF4AI/II.

D. Huang, J. Chambers, G. P. Savage, 2013, Organic letters.

Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase.

D. Christianson, J. Chambers, I. Dmochowski, 2009, Journal of the American Chemical Society.

Total synthesis of 2''',5'''-diepisilvestrol and its C1''' epimer: key structure activity relationships at C1''' and C2'''.

D. Huang, J. Chambers, G. P. Savage, 2012, Journal of natural products.

Multivalent Small-Molecule Pan-RAS Inhibitors Graphical

Matthew E. Welsch, A. Ferrando, B. Stockwell, 2017 .

K-RasG12D Has a Potential Allosteric Small Molecule Binding Site.

B. Stockwell, J. Chambers, Huizhong Feng, 2019, Biochemistry.

K‐Ras Has a Potential Allosteric Small Molecule Binding Site

B. Stockwell, J. Chambers, Huizhong Feng, 2019 .

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

L. Tilley, J. Chambers, M. McConville, 2013, BMC Biology.

Water networks and correlated motions in mutant IDH1 are critical for allosteric inhibitor binding and activity.

A. Bobkov, J. Chambers, C. Sohl, 2019, Biochemistry.

Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE.

K. Austen, J. Chambers, É. Vivier, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Benchmarking Refined and Unrefined AlphaFold2 Structures for Hit Discovery

Matthew P. Repasky, C. Higgs, J. Chambers, 2023, J. Chem. Inf. Model..