Siliang Zhang

发表

Time-Resolved Transcriptome Analysis of Bacillus subtilis Responding to Valine, Glutamate, and Glutamine

Yuanyuan Li, B. Ye, J. Chu, 2009, PloS one.

Multi-scale data-driven engineering for biosynthetic titer improvement.

Jiaming Yu, Siliang Zhang, Zhixing Cao, 2020, Current opinion in biotechnology.

Purification and bioactivity of exendin-4, a peptide analogue of GLP-1, expressed in Pichia pastoris

Hui Wang, Y. Zhuang, J. Chu, 2007, Biotechnology Letters.

Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway.

Y. Zhuang, J. Chu, M. Guo, 2011, Enzyme and microbial technology.

Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glucose, metabolite, and transcript levels

H. Noorman, J. Heijnen, W. V. van Gulik, 2018, Biotechnology and bioengineering.

Combined 13C-assisted metabolomics and metabolic flux analysis reveals the impacts of glutamate on the central metabolism of high β-galactosidase-producing Pichia pastoris

Mingzhi Huang, Y. Zhuang, J. Chu, 2016, Bioresources and Bioprocessing.

Influence of High Solid Concentration on Enzymatic Hydrolysis and Fermentation of Steam-Exploded Corn Stover Biomass

Y. Zhuang, J. Chu, Siliang Zhang, 2010, Applied biochemistry and biotechnology.

On structural identifiability analysis of the cascaded linear dynamic systems in isotopically non-stationary 13C labelling experiments.

Mingzhi Huang, Y. Zhuang, Siliang Zhang, 2018, Mathematical biosciences.

Impacts of high β-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via (13)C metabolic flux analysis.

Mingzhi Huang, Y. Zhuang, J. Chu, 2014, Journal of biotechnology.

Comprehensive reconstruction and in silico analysis of Aspergillus niger genome‐scale metabolic network model that accounts for 1210 ORFs

Mingzhi Huang, H. Noorman, Y. Zhuang, 2017, Biotechnology and bioengineering.

Bioreactors and bioseparation.

Y. Zhuang, J. Chu, Siliang Zhang, 2010, Advances in biochemical engineering/biotechnology.

Evaluate the number of clusters in finite mixture models with the penalized histogram difference criterion

Yingping Zhuang, Siliang Zhang, Weilu Lin, 2013 .

On estimation of multivariate prediction regions in partial least squares regression

E. Martin, Y. Zhuang, Siliang Zhang, 2013 .

Incomplete protein disulphide bond conformation and decreased protein expression result from high cell growth during heterologous protein expression in Pichia pastoris.

Y. Zhuang, J. Chu, Siliang Zhang, 2012, Journal of biotechnology.

High efficient production of recombinant human consensus interferon mutant in high cell density culture of Pichia pastoris using two phases methanol control

Y. Zhuang, J. Chu, Siliang Zhang, 2011 .

Incomplete formation of intramolecular disulfide bond triggers degradation and aggregation of human consensus interferon-α mutant by Pichia pastoris

Dan Wu, Y. Zhuang, J. Chu, 2010, Applied Microbiology and Biotechnology.

Purification and properties of Saccharomyces cerevisiaeS-adenosylmethionine synthetase expressed in recombinant Pichia pastoris

Y. Zhuang, J. Chu, Siliang Zhang, 2008 .

The inhibition of aggregation of recombinant human consensus interferon-α mutant during Pichia pastoris fermentation

Y. Zhuang, J. Chu, Siliang Zhang, 2007, Applied Microbiology and Biotechnology.

Transcriptional investigation of the effect of mixed feeding to identify the main cellular stresses on recombinant Pichia pastoris

H. Hang, Y. Zhuang, J. Chu, 2013, Journal of Industrial Microbiology & Biotechnology.

Understanding the effect of foreign gene dosage on the physiology of Pichia pastoris by transcriptional analysis of key genes

Y. Zhuang, J. Chu, M. Guo, 2011, Applied Microbiology and Biotechnology.

A NIR luminescent copolymer based on platinum porphyrin as high permeable dissolved oxygen sensor for microbioreactors

Weihong Zhu, Siliang Zhang, Pengwei Jin, 2013 .

An assessment of seed quality on erythromycin production by recombinant Saccharopolyspora erythraea strain.

Y. Zhuang, J. Chu, Siliang Zhang, 2011, Bioresource technology.

Efficient extraction of intracellular reduced glutathione from fermentation broth of Saccharomyces cerevisiae by ethanol.

Y. Zhuang, J. Chu, M. Guo, 2009, Bioresource technology.

Enhancement of Gluconobacter oxydans catalyzing D‐lactic acid production by coupling of synthesis and separation

Siliang Zhang, D. Wei, Keliang Gao, 2009 .

Development of a continuous cell-recycle fermentation system for production of lactic acid by Lactobacillus paracasei

Y. Zhuang, J. Chu, Siliang Zhang, 2006 .

Effects of light/dark cycle, mixing pattern and partial pressure of H2 on biohydrogen production by Rhodobacter sphaeroides ZX-5.

Mingzhi Huang, Xu Li, Y. Zhuang, 2011, Bioresource technology.

Effect of Mycelial Morphology on Bioreactor Performance and Avermectin Production of Streptomyces avermitilis in Submerged Cultivations

N. Chen, Y. Zhuang, J. Chu, 2008 .

High-throughput system for screening of Monascus purpureus high-yield strain in pigment production

Y. Zhuang, J. Chu, Siliang Zhang, 2014, Bioresources and Bioprocessing.

Power consumption, local and average volumetric mass transfer coefficient in multiple-impeller stirred bioreactors for xanthan gum solutions

H. Noorman, Y. Zhuang, J. Chu, 2014 .

Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter

Y. Zhuang, J. Chu, Siliang Zhang, 2012, Bioprocess and Biosystems Engineering.

Novel scale-up strategy based on three-dimensional shear space for animal cell culture

Y. Zhuang, Siliang Zhang, Jianye Xia, 2020 .

Genetic Modulation of the Overexpression of Tailoring Genes eryK and eryG Leading to the Improvement of Erythromycin A Purity and Production in Saccharopolyspora erythraea Fermentation

Y. Zhuang, J. Chu, Siliang Zhang, 2008, Applied and Environmental Microbiology.

Impacts of proline on the central metabolism of an industrial erythromycin-producing strain Saccharopolyspora erythraea via (13)C labeling experiments.

Mingzhi Huang, Y. Zhuang, J. Chu, 2016, Journal of biotechnology.

The dynamic regulation of nitrogen and phosphorus in the early phase of fermentation improves the erythromycin production by recombinant Saccharopolyspora erythraea strain

Y. Zhuang, J. Chu, Siliang Zhang, 2014, Bioresources and Bioprocessing.

Significant decrease of broth viscosity and glucose consumption in erythromycin fermentation by dynamic regulation of ammonium sulfate and phosphate.

Y. Zhuang, J. Chu, Siliang Zhang, 2013, Bioresource technology.

Controlling the feed rate of glucose and propanol for the enhancement of erythromycin production and exploration of propanol metabolism fate by quantitative metabolic flux analysis

Mingzhi Huang, Y. Zhuang, J. Chu, 2013, Bioprocess and Biosystems Engineering.

Toward Improvement of Erythromycin A Production in an Industrial Saccharopolyspora erythraea Strain via Facilitation of Genetic Manipulation with an Artificial attB Site for Specific Recombination

Siliang Zhang, J. Qian, Qinglin Zhang, 2011, Applied and Environmental Microbiology.

Fermentation optimization and industrialization of recombinant Saccharopolyspora erythraea strains for improved erythromycin a production

Y. Zhuang, J. Chu, Siliang Zhang, 2010 .

Enhancement of erythromycin A production with feeding available nitrogen sources in erythromycin biosynthesis phase.

H. Hang, Y. Zhuang, J. Chu, 2009, Bioresource technology.

Improvement of Erythromycin a purity and production at the fermentation stage of Saccharopolyspora erytharea by metabolic engineering

Siliang Zhang, Y. Chen, Wei Deng, 2008 .

Improved production of erythromycin A by expression of a heterologous gene encoding S-adenosylmethionine synthetase

Y. Zhuang, J. Chu, Siliang Zhang, 2007, Applied Microbiology and Biotechnology.

Hydrodynamics Characterization of an Ellipse Gate Impeller by Experimental and Numerical Studies

Siliang Zhang, Jianye Xia, Minghui Xie, 2013 .

Comparison of Power Number for Paddle-Type Impellers by Three Methods

Siliang Zhang, Jianye Xia, Minghui Xie, 2011 .

Oxygen Uptake Rate Controlling Strategy Balanced with Oxygen Supply for Improving Coenzyme Q10 Production by Rhodobacter sphaeroides

Ping Wang, Y. Zhuang, M. Guo, 2020, Biotechnology and Bioprocess Engineering.

A high-throughput screening strategy for accurate quantification of erythromycin

Y. Zhuang, J. Chu, Siliang Zhang, 2013 .

The effect of redox environment on l-lactic acid production by Lactobacillus paracasei—A proof by genetically encoded in vivo NADH biosensor

Y. Zhuang, J. Chu, Siliang Zhang, 2015 .

Isolation of soluble proteins from an industrial strain Streptomyces avermitilis in complex culture medium for two-dimensional gel electrophoresis.

Y. Zhuang, J. Chu, Siliang Zhang, 2008, Journal of microbiological methods.

Improvement in the suspension‐culture production of recombinant adeno‐associated virus–LacZ in HEK‐293 cells using polyethyleneimine–DNA complexes in combination with hypothermic treatment

Y. Zhuang, J. Chu, M. Guo, 2008, Biotechnology and applied biochemistry.

Optimization of cellulase mixture for efficient hydrolysis of steam-exploded corn stover by statistically designed experiments.

Y. Zhuang, J. Chu, Siliang Zhang, 2009, Bioresource technology.

Quantitative metabolomics and metabolic flux analysis reveal impact of altered trehalose metabolism on metabolic phenotypes of Penicillium chrysogenum in aerobic glucose-limited chemostats

H. Noorman, Y. Zhuang, J. Chu, 2019, Biochemical Engineering Journal.

Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer

H. Noorman, Y. Zhuang, J. Chu, 2015 .

[Development and application of morphological analysis method in Aspergillus niger fermentation].

Y. Zhuang, J. Chu, Siliang Zhang, 2015, Sheng wu gong cheng xue bao = Chinese journal of biotechnology.

13C-assisted Ultra-High Performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry Method for Precise Determination of Intracellular Metabolites in Pichia pastoris

Y. Zhuang, J. Chu, Siliang Zhang, 2016 .

An alkaline pH control strategy for methionine adenosyltransferase production in Pichia pastoris fermentation

Y. Zhuang, J. Chu, Siliang Zhang, 2014, Biotechnology and Bioprocess Engineering.

A simple fermentation strategy for high-level production of recombinant phytase by Pichia pastoris using glucose as the growth substrate

Xinhao Ye, H. Hang, Y. Zhuang, 2009 .

Medium optimization for meilingmycin production by Streptomyces nanchangensis using response surface methodology

Bin Chen, Ju Chu, Siliang Zhang, 2006 .

Regulation of meilingmycin in Streptomyces nanchangensis: Effect of ammonium ion

Ping Wang, Y. Zhuang, J. Chu, 2010 .

Application of oxygen uptake rate and response surface methodology for erythromycin production by Saccharopolyspora erythraea

H. Hang, Y. Zhuang, J. Chu, 2008, Journal of Industrial Microbiology & Biotechnology.

Effects of vitamins on the lactic acid biosynthesis of Lactobacillus paracasei NERCB 0401

Y. Zhuang, J. Chu, Siliang Zhang, 2008 .

Variable selection in partial least squares with the weighted variable contribution to the first singular value of the covariance matrix

H. Hang, Y. Zhuang, Siliang Zhang, 2018, Chemometrics and Intelligent Laboratory Systems.

Screen-Printed Red Luminescent Copolymer Film Containing Cyclometalated Iridium(III) Complex as a High-Permeability Dissolved-Oxygen Sensor for Fermentation Bioprocess

Zhiqian Guo, Weihong Zhu, Siliang Zhang, 2013 .

Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition

Mingzhi Huang, H. Noorman, Y. Zhuang, 2018, Scientific Reports.

Effect of glycosylation on biochemical characterization of recombinant phytase expressed in Pichia pastoris

H. Hang, Y. Zhuang, J. Chu, 2008 .

Accurate Determination of Isotopic Abundance of Intracellular Metabolites of Saccharopolysporaerythraea Based on Ultra Performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry

Y. Zhuang, J. Chu, Siliang Zhang, 2017 .

Global transcriptional response of Aspergillus niger in the process of glucoamylase fermentation

Y. Zhuang, J. Chu, Siliang Zhang, 2017, Bioresources and Bioprocessing.

Enhance Vitamin B 12 Production by Online CO 2 Concentration Control Optimization in 120 m 3 Fermentation

Ping Wang, Y. Zhuang, J. Chu, 2014 .

A combined strategy to simultaneously improve the component of isovalerylspiramycin in a bitespiramycin (4″-O-acylspiramycins) complex and its biological titre

Siliang Zhang, Yuyou Hao, Mingzhi Huang, 2008 .

Progress in the research of S-adenosyl-l-methionine production

Y. Zhuang, J. Chu, Siliang Zhang, 2012, Applied Microbiology and Biotechnology.

Dynamic metabolic response of Aspergillus niger to glucose perturbation: evidence of regulatory mechanism for reduced glucoamylase production.

C. Li, Siliang Zhang, P. Liu, 2018, Journal of biotechnology.

and 13C metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger

H. Noorman, Y. Zhuang, J. Chu, 2018 .

Phosphate limitation increases coenzyme Q10 production in industrial Rhodobacter sphaeroides HY01

Siliang Zhang, Weishan Wang, Hui Xu, 2019, Synthetic and systems biotechnology.

Regulation of branched-chain amino acid catabolism: glucose limitation enhances the component of isovalerylspiramycin for the bitespiramycin production

Y. Zhuang, J. Chu, Siliang Zhang, 2010, Bioprocess and biosystems engineering.

Leucine improves the component of isovalerylspiramycins for the production of bitespiramycin

Y. Zhuang, J. Chu, Siliang Zhang, 2009, Bioprocess and biosystems engineering.

Simultaneous Quantitative Analysis of Sorbitol and Sorbose in the Fermentation Broth with Fourier Transform Infrared Spectroscopy

Q. Ye, H. Hang, Siliang Zhang, 2001 .

Numerical and experimental assessment of a miniature bioreactor equipped with a mechanical agitator and non‐invasive biosensors

H. Hang, Siliang Zhang, Weifei Wang, 2019, Journal of Chemical Technology & Biotechnology.

Effects of vitamins (nicotinic acid, vitamin B1 and biotin) on phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5

Mingzhi Huang, Xu Li, Y. Zhuang, 2011 .

Human Papillomavirus 16 L1 Protein Expression and Self-Assembly in Recombinant Pichia pastoris

H. Hang, Y. Zhuang, J. Chu, 2015 .

Characteristics of mixotrophic growth of Synechocystis sp. in an enclosed photobioreactor

Siliang Zhang, Yuan-guang Li, G. Shen, 2002, Biotechnology Letters.

Genetic Modulation of the Overexpression of Tailoring Genes eryK and eryG Leading to the Improvement of Erythromycin A Purity and Production in Saccharopolyspora erythraea Fermentation

Y. Zhuang, J. Chu, Siliang Zhang, 2008, Applied and Environmental Microbiology.

Genetic Modulation of the Overexpression of Tailoring Genes eryK and eryG Leading to the Improvement of Erythromycin A Purity and Production in Saccharopolyspora erythraea Fermentation

Y. Zhuang, J. Chu, Siliang Zhang, 2008, Applied and Environmental Microbiology.

Production and purification of a novel thermostable phytase by Pichia pastoris FPHY34

A. Xiong, R. Peng, Q. Yao, 2007 .

Production and distribution of beta-glucosidase in a mutant strain Trichoderma viride T 100-14.

Y. Zhuang, J. Chu, Siliang Zhang, 2009, New biotechnology.

A qualitative and quantitative high-throughput assay for screening of gluconate high-yield strains by Aspergillus niger.

Y. Zhuang, J. Chu, Siliang Zhang, 2015, Journal of microbiological methods.

Identification and purification of the main components of cellulases from a mutant strain of Trichoderma viride T 100-14.

Y. Zhuang, J. Chu, Siliang Zhang, 2008, Bioresource technology.

[Construction and application of black-box model for glucoamylase production by Aspergillus niger].

Y. Zhuang, J. Chu, Siliang Zhang, 2015, Sheng wu gong cheng xue bao = Chinese journal of biotechnology.

Application of EulerLagrange CFD for quantitative evaluating the effect of shear force on Carthamus tinctorius L. cell in a stirred tank bioreactor

Ju Chu, Yingping Zhuang, Cees Haringa, 2016 .

Dependence of fungal characteristics on seed morphology and shear stress in bioreactors

H. Noorman, C. Li, Y. Zhuang, 2015, Bioprocess and Biosystems Engineering.

Comparative fluxome and metabolome analysis of formate as an auxiliary substrate for penicillin production under glucose-limited cultivation of Penicillium chrysogenum.

H. Noorman, W. V. van Gulik, Y. Zhuang, 2019, Biotechnology journal.

Molecular cloning and characterization of two novel cellulase genes from the mollusc Ampullaria crossean

Siliang Zhang, Gen‐jun Xu, F. Zhao, 2008, Journal of Comparative Physiology B.

Advances and Practices of Bioprocess Scale-up.

Guan Wang, Yonghong Wang, Ju Chu, 2016, Advances in biochemical engineering/biotechnology.

Prelude to rational scale-up of penicillin production: a scale-down study

Guan Wang, Ju Chu, Yingping Zhuang, 2014, Applied Microbiology and Biotechnology.

Optimization of nutritional requirements and ammonium feeding strategies for improving vitamin B 12 production by Pseudomonas denitrificans

Ping Wang, J. Chu, Siliang Zhang, 2011 .

Insight into microevolution of Streptomyces rimosus based on analysis of zwf and rex genes

M. Guo, Siliang Zhang, Zhenyu Tang, 2012 .

Intracellular expression of Vitreoscilla hemoglobin improves S-adenosylmethionine production in a recombinant Pichia pastoris

Ju Chu, Yingping Zhuang, Siliang Zhang, 2007, Applied Microbiology and Biotechnology.

Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis

Siliang Zhang, Bang-Ce Ye, Mei Liu, 2010, Proceedings of the National Academy of Sciences.

Effect of branched-chain amino acids, valine, isoleucine and leucine on the biosythesis of bitespiramycin 4"-O-acylspiramycins

Y. Zhuang, J. Chu, Siliang Zhang, 2009, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].

Molecular cloning and functional characterization of an ATP-binding cassette transporter OtrC from Streptomyces rimosus

Y. Zhuang, J. Chu, M. Guo, 2012, BMC Biotechnology.

Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes.

Y. Zhuang, J. Chu, M. Guo, 2012, Enzyme and microbial technology.

Down-Regulation of Pm4CL1 Gene Expression in E. coli Model by Antisense mRNA

Siliang Zhang, Yong Wang, H. Huân, 2012, Biochemical Genetics.

Overexpression and the enzymatic properties of the recombinant 4-coumarate: coenzyme A ligase, a key enzyme in lignin biosynthesis pathway

Siliang Zhang, Yong Wang, H. Huân, 2011, Journal of the Indian Academy of Wood Science.

Identification and functional analysis of the Pm4CL1 gene in transgenic tobacco plant as the basis for regulating lignin biosynthesis in forest trees

Siliang Zhang, Yong Wang, N. V. Thanh, 2010, Molecular Breeding.

Effects of different glycerol feeding strategies on S-adenosyl-l-methionine biosynthesis by P(GAP)-driven Pichia pastoris overexpressing methionine adenosyltransferase.

Y. Zhuang, J. Chu, M. Guo, 2008, Journal of biotechnology.

Oxygen transfer efficiency and environmental osmolarity response to neutralizing agents on l-lactic acid production efficiency by Lactobacillus paracasei

Y. Zhuang, J. Chu, Siliang Zhang, 2014 .

Limitations in the process of transcription and translation inhibit recombinant human chorionic gonadotropin expression in CHO cells.

Y. Zhuang, Siliang Zhang, X. Yi, 2015, Journal of biotechnology.

Correlation between key enzyme activities in the inosine synthetic pathway and inosine production

Y. Zhuang, J. Chu, Siliang Zhang, 2004 .

Effective utilization of wastewater for valuable validamycin A biosynthesis by Streptomyces hygroscopicus K2509 in plant-scale bioreactor

Ali Mohsin, Y. Zhuang, M. Guo, 2018, Bioresources and Bioprocessing.

Flow Pattern, Mixing, Gas Hold-Up and Mass Transfer Coefficient of Triple-Impeller Configurations in Stirred Tank Bioreactors

Ju Chu, Yingping Zhuang, Siliang Zhang, 2014 .

Structural Elucidation and Antioxidant Activity of a Polysaccharide from Mycelia Fermentation of Hirsutella sinensis Isolated from Ophiocordyceps sinensis

Y. Zhuang, J. Chu, Siliang Zhang, 2014 .

Expression and Aggregation of Recombinant Human Consensus Interferon-α Mutant by Pichia pastoris

Y. Zhuang, J. Chu, Siliang Zhang, 2006, Biotechnology Letters.

Effect of metal ions on the binding of gentamicin to the peptidoglycan of Micromonospora echinospora

Y. Zhuang, J. Chu, Siliang Zhang, 2004 .

Metabolite profiling coupled with metabolic flux analysis reveals physiological and metabolic impacts on Lactobacillus paracasei oxygen metabolism

Y. Zhuang, J. Chu, Siliang Zhang, 2017 .

Improvement of L‐lactic acid production with a two‐step OUR control strategy

Y. Zhuang, J. Chu, Siliang Zhang, 2016 .

In silico analysis and experimental improvement of taxadiene heterologous biosynthesis in Escherichia coli

Yong Wang, Siliang Zhang, Qiang Hua, 2011 .

CFD analysis of the turbulent flow in baffled shake flasks

Y. Zhuang, J. Chu, Siliang Zhang, 2013 .

High-throughput screening strategy used for enhanced production of pigment by Monascus purpureus D39-4

T. Imanaka, Y. Zhuang, J. Chu, 2012, Food Science and Biotechnology.

Production and properties of a cellobiose-oxidizing enzyme from a newly isolatedcellulolytic bacterium Cytophaga sp. LX-7

P. Gao, Siliang Zhang, F. Jin, 1997 .

Screening endogenous signal peptides and protein folding factors to promote the secretory expression of heterologous proteins in Pichia pastoris.

J. Chu, Siliang Zhang, J. Qian, 2019, Journal of biotechnology.

Comprehensive reconstruction and evaluation of Pichia pastoris genome-scale metabolic model that accounts for 1243 ORFs

Y. Zhuang, J. Chu, Siliang Zhang, 2017, Bioresources and Bioprocessing.

GAP Promoter Library for Fine-Tuning of Gene Expression in Pichia pastoris

Ju Chu, Yingping Zhuang, Siliang Zhang, 2011, Applied and Environmental Microbiology.

Enhanced proliferation of bone marrow mesenchymal stem cells by co-culture with TM4 mouse Sertoli cells: involvement of the EGF/PI3K/AKT pathway

Y. Zhuang, J. Chu, M. Guo, 2014, Molecular and Cellular Biochemistry.

Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition

H. Noorman, Y. Zhuang, J. Chu, 2018, Scientific Reports.

Optimization of transfection mediated by calcium phosphate for plasmid rAAV‐LacZ (recombinant adeno‐associated virus–β‐galactosidase reporter gene) production in suspension‐cultured HEK‐293 (human embryonic kidney 293) cells

Y. Zhuang, J. Chu, M. Guo, 2007, Biotechnology and applied biochemistry.

[The influence of controlling redox potential on ethanol production by Saccharomyces cerevisiae].

Y. Zhuang, J. Chu, Siliang Zhang, 2007, Sheng wu gong cheng xue bao = Chinese journal of biotechnology.

Direct proteomic mapping of Streptomyces avermitilis wild and industrial strain and insights into avermectin production.

B. Ye, Siliang Zhang, Jin Zhou, 2013, Journal of proteomics.

An effective and simplified pH-stat control strategy for the industrial fermentation of vitamin B12 by Pseudomonas denitrificans

Y. Zhuang, J. Chu, Siliang Zhang, 2008, Bioprocess and biosystems engineering.

Metabolic flux analysis of the central carbon metabolism of the industrial vitamin B12 producing strain Pseudomonas denitrificans using 13C-labeled glucose

Ping Wang, Ju Chu, Yi Ming Zhang, 2012 .

Improved vitamin B(12) production by step-wise reduction of oxygen uptake rate under dissolved oxygen limiting level during fermentation process.

Ju Chu, Y. Zhuang, J. Chu, 2010, Bioresource technology.

Structural Elucidation and Antioxidant Activity of a Polysaccharide from Mycelia Fermentation of Hirsutella sinensis Isolated from Ophiocordycepssinensis

Siliang Zhang, Jin-hua Liu, Zebin Wang, 2014 .

Improved large-scale production of vitamin B12 by Pseudomonas denitrificans with betaine feeding.

Y. Zhuang, J. Chu, Siliang Zhang, 2008, Bioresource technology.

Influence of Zn2+, Co2+ and dimethylbenzimidazole on vitamin B12 biosynthesis by Pseudomonas denitrificans

Y. Zhuang, J. Chu, Siliang Zhang, 2008 .

Oxygen uptake rate optimization with nitrogen regulation for erythromycin production and scale-up from 50 L to 372 m3 scale.

H. Hang, Y. Zhuang, J. Chu, 2009, Bioresource technology.

A multi-scale study of industrial fermentation processes and their optimization.

Ju Chu, Yingping Zhuang, Siliang Zhang, 2004, Advances in biochemical engineering/biotechnology.

Application of 8-parallel micro-bioreactor system with non-invasive optical pH and DO biosensor in high-throughput screening of l-lactic acid producing strain

Ali Mohsin, H. Hang, Y. Zhuang, 2018, Bioresources and Bioprocessing.

Optimization of polyhydroxyalkanoates fermentations with on-line capacitance measurement.

Ju Chu, Y. Zhuang, J. Chu, 2014, Bioresource technology.

Production of penicillin G amidase from Alcaligenes faecalis in a recombinant Escherichia coli

Y. Zhuang, J. Chu, Siliang Zhang, 2009 .

Expression and characterization of two secreted His6-tagged endo-beta-1,4-glucanases from the mollusc Ampullaria crossean in Pichia pastoris.

Siliang Zhang, F. Zhao, M. Ding, 2008, Acta biochimica et biophysica Sinica.

Purification and characterization of two endo-beta-1,4-glucanases from mollusca, Ampullaria crossean.

Siliang Zhang, Gen‐jun Xu, F. Zhao, 2005, Acta biochimica et biophysica Sinica.

Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces

G. Alterovitz, K. Fan, Siliang Zhang, 2019, Nature Biotechnology.

Coupled metabolic‐hydrodynamic modeling enabling rational scale‐up of industrial bioprocesses

Guan Wang, Ju Chu, Cees Haringa, 2019, Biotechnology and bioengineering.

Enhanced l-lactic acid production in Lactobacillus paracasei by exogenous proline addition based on comparative metabolite profiling analysis

Y. Zhuang, J. Chu, Siliang Zhang, 2016, Applied Microbiology and Biotechnology.

Bioprocess development for the production of mouse-human chimeric anti-epidermal growth factor receptor vIII antibody C12 by suspension culture of recombinant Chinese hamster ovary cells

Y. Zhuang, J. Chu, M. Guo, 2011, Cytotechnology.

Multiple Propionyl Coenzyme A-Supplying Pathways for Production of the Bioplastic Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) in Haloferax mediterranei

H. Xiang, Siliang Zhang, L. Cai, 2013, Applied and Environmental Microbiology.

Multiple Propionyl-CoA Supplying Pathways for Production of

H. Xiang, Siliang Zhang, L. Cai, 2013 .

Study on production enhancement of validamycin A using online capacitance measurement coupled with 1H NMR spectroscopy analysis in a plant-scale bioreactor

Ali Mohsin, Y. Zhuang, M. Guo, 2017 .

Enhancement of inosine production by Bacillus subtilis through suppression of carbon overflow by sodium citrate

Y. Zhuang, J. Chu, Siliang Zhang, 2005, Biotechnology Letters.

Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment

Ning Chen, Ju Chu, Yingping Zhuang, 2009 .

GAP promoter library for fine-tuning 1 gene expression in Pichia pastoris 2 3 Running title : GAP promoter library for fine-tuning gene expression 4 5

Y. Zhuang, Siliang Zhang, J. Qian, 2011 .

Optimization of Enzymatic Hydrolysis of Channel Catfish Bones for Preparing Antimicrobial Agents

Hongshun Yang, Y. Zhuang, J. Chu, 2012 .

A molecular redox sensor from streptomyces rimosus M4018 for escherichia coli

Y. Zhuang, J. Chu, M. Guo, 2011 .

On-line ultrasound stimulates the secretion and production of gentamicin by Micromonospora echinospora

J. Chu, Siliang Zhang, Yourong Li, 2000 .

[The effect of induction temperature on aggregation of consensus interferon-alpha expressed by Pichia pastoris].

Y. Zhuang, J. Chu, Siliang Zhang, 2006, Sheng wu gong cheng xue bao = Chinese journal of biotechnology.

Enhancement of phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5 using fed-batch oper

Xu Li, Siliang Zhang, Yonghong Wang, 2011 .

Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains

Yixue Li, B. Ye, Yan Zhang, 2013, BMC Genomics.

Quantitative metabolic flux analysis revealed uneconomical utilization of ATP and NADPH in Acremonium chrysogenum fed with soybean oil

Y. Zhuang, J. Chu, Siliang Zhang, 2010, Bioprocess and biosystems engineering.

A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production.

Y. Zhuang, J. Chu, Siliang Zhang, 2012, Journal of biotechnology.

A systematical investigation on the genetic stability of multi-copy Pichia pastoris strains

Ju Chu, Yingping Zhuang, Siliang Zhang, 2009, Biotechnology Letters.

DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris.

Y. Zhuang, J. Chu, Siliang Zhang, 2009, Journal of biotechnology.

Introduction of Extra Copy of Oxytetracycline Resistance Gene otrB Enhances the Biosynthesis of Oxytetracycline in Streptomyces rimosus

Y. Zhuang, J. Chu, M. Guo, 2012 .

Enhancement of phototrophic hydrogen production by Rhodobacter sphaeroides ZX-5 using a novel strategy — shaking and extra-light supplementation approach

Xu Li, Y. Zhuang, J. Chu, 2009 .

Accurate Determination of 13C Isotopic Abundance of Free Intracellular Amino acids with Low Concentration by GC-MS-Selective Ion Monitoring Method

L. Yuwei, Y. Zhuang, J. Chu, 2014 .

l-Lactic acid production benefits from reduction of environmental osmotic stress through neutralizing agent combination

Y. Zhuang, J. Chu, Siliang Zhang, 2014, Bioprocess and Biosystems Engineering.

Real-time viable-cell mass monitoring in high-cell-density fed-batch glutathione fermentation by Saccharomyces cerevisiae T65 in industrial complex medium.

Ju Chu, Y. Zhuang, J. Chu, 2008, Journal of bioscience and bioengineering.

Fermentation process optimization of recombinant Saccharomyces cerevisiae for the production of human interferon-α2a

Y. Zhuang, J. Chu, Siliang Zhang, 2003, Applied Biochemistry and Biotechnology.

A simple unstructured model-based control for efficient expression of recombinant porcine insulin precursor by Pichia pastoris

H. Hang, Y. Zhuang, J. Chu, 2008 .

In silico improvement of heterologous biosynthesis of erythromycin precursor 6-deoxyerythronolide B in Escherichia coli

Yong Wang, Siliang Zhang, Hailin Meng, 2011 .

High efficiency cell-recycle continuous sodium gluconate production by Aspergillus niger using on-line physiological parameters association analysis to regulate feed rate rationally.

C. Li, Y. Zhuang, J. Chu, 2016, Bioresource technology.

Performance and Mechanism of Neuroleukin in the Growth and Survival of Sertoli Cell-Induced Neurons in a Coculture System

Y. Zhuang, J. Chu, M. Guo, 2014, Cell transplantation.

Progress in the research of S-adenosyl-l-methionine production

Y. Zhuang, J. Chu, Siliang Zhang, 2012, Applied Microbiology and Biotechnology.

A novel feeding strategy during the production phase for enhancing the enzymatic synthesis of S-adenosyl-l-methionine by methylotrophic Pichia pastoris

Y. Zhuang, J. Chu, Siliang Zhang, 2007 .

Prelude to rational scale-up of penicillin production: a scale-down study

H. Noorman, Y. Zhuang, J. Chu, 2014, Applied Microbiology and Biotechnology.

Optimization of l-methionine feeding strategy for improving S-adenosyl-l-methionine production by methionine adenosyltransferase overexpressed Pichia pastoris

Y. Zhuang, J. Chu, Siliang Zhang, 2009, Applied Microbiology and Biotechnology.

[Over-expression in Escherichia coli and characterization of apolipoprotein AI].

Y. Zhuang, J. Chu, M. Guo, 2005, Sheng wu gong cheng xue bao = Chinese journal of biotechnology.

Identification of novel knockout and up-regulated targets for improving isoprenoid production in E. coli

Siliang Zhang, Zhi-qiang Xiong, Jian-Feng Wang, 2014, Biotechnology Letters.

1,1′-Dimethylferrocene Mediated L-Glutamate Electrodes Modified With Electropolymerized 1,3-Diaminobenzene Film

Siliang Zhang, Juntang Yu, Qingshan Li, 1995 .

High-Throughput System for Screening of Cephalosporin C High-Yield Strain by 48-Deep-Well Microtiter Plates

Y. Zhuang, J. Chu, Siliang Zhang, 2013, Applied Biochemistry and Biotechnology.

Inhibition of degradation and aggregation of recombinant human consensus interferon-α mutant expressed in Pichia pastoris with complex medium in bioreactor

Dan Wu, Y. Zhuang, J. Chu, 2008, Applied Microbiology and Biotechnology.

Oxygen uptake rate regulation during cell growth phase for improving avermectin B1a batch fermentation on a pilot scale (2 m3)

Y. Zhuang, J. Chu, Siliang Zhang, 2011 .

Ethanol evolution rate: a new parameter to determine the feeding rate for the production of avermectins by Streptomyces avermitilis

Y. Zhuang, J. Chu, Siliang Zhang, 2004, Biotechnology Letters.

Modelling steady state intercellular isotopic distributions with isotopomer decomposition units

Zejian Wang, Yingping Zhuang, Siliang Zhang, 2019, Comput. Chem. Eng..

Ex vivo expansion of bone marrow mesenchymal stem cells using microcarrier beads in a stirred bioreactor

Y. Zhuang, J. Chu, M. Guo, 2013, Biotechnology and Bioprocess Engineering.

Industrial bioprocess control and optimization in the context of systems biotechnology.

Yonghong Wang, Ju Chu, Yingping Zhuang, 2009, Biotechnology advances.

[Progress in omics research of Aspergillus niger].

Y. Zhuang, Siliang Zhang, L. Ouyang, 2016, Sheng wu gong cheng xue bao = Chinese journal of biotechnology.

Comparative performance of different scale‐down simulators of substrate gradients in Penicillium chrysogenum cultures: the need of a biological systems response analysis

Guan Wang, Ju Chu, Yingping Zhuang, 2018, Microbial biotechnology.

From multi-scale methodology to systems biology: to integrate strain improvement and fermentation optimization

Ju Chu, Yingping Zhuang, Siliang Zhang, 2006 .

Quantitative evaluation of the shear threshold on Carthamus tinctorius L. cell growth with computational fluid dynamics in shaken flask bioreactors

Y. Zhuang, J. Chu, Siliang Zhang, 2016 .

Penicillin G acylase purification with the aid of high-throughput screening approach

Y. Zhuang, J. Chu, Siliang Zhang, 2008 .

On stability analysis of cascaded linear time varying systems in dynamic isotope experiments

Y. Zhuang, J. Chu, Siliang Zhang, 2020 .

Integrated isotope-assisted metabolomics and 13C metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger

H. Noorman, Y. Zhuang, J. Chu, 2015, Microbial Cell Factories.

Comprehensive reconstruction and in silico analysis of Aspergillus niger genome‐scale metabolic network model that accounts for 1210 ORFs

H. Noorman, Y. Zhuang, J. Chu, 2017, Biotechnology and bioengineering.

Oxygen uptake rate (OUR) control strategy for improving avermectin B 1a production during fed-batch fermentation on industrial scale (150 m 3 )

Y. Zhuang, J. Chu, Siliang Zhang, 2010 .

Immobilization of L-glutamate oxidase and peroxidase for glutamate determination in flow injection analysis system

Siliang Zhang, Ju‐hyun Yu, Qingshan Li, 1996 .

Efficient generation of multi‐copy strains for optimizing secretory expression of porcine insulin precursor in yeast Pichia pastoris

Y. Zhuang, J. Chu, Siliang Zhang, 2009, Journal of applied microbiology.

Reliable high‐throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris

Y. Zhuang, J. Chu, Siliang Zhang, 2011, Letters in applied microbiology.

Comparative performance of S-adenosyl-L-methionine biosynthesis and degradation in Pichia pastoris using different promoters and novel consumption inhibitors.

Y. Zhuang, J. Chu, Siliang Zhang, 2014, Enzyme and microbial technology.

Biotechnology and Bioengineering

H. Noorman, Y. Zhuang, J. Chu, 2020 .

Optimization of cellulase mixture for efficient hydrolysis of steam-exploded corn stover by statistically designed experiments.

Y. Zhuang, J. Chu, Siliang Zhang, 2009, Bioresource technology.

Significant decrease of broth viscosity and glucose consumption in erythromycin fermentation by dynamic regulation of ammonium sulfate and phosphate.

Y. Zhuang, J. Chu, Siliang Zhang, 2013, Bioresource technology.