C. De Virgilio

发表

The TOR signalling network from yeast to man.

Robbie Loewith, R. Loewith, C. De Virgilio, 2006, The international journal of biochemistry & cell biology.

Deciphering Protein Kinase Specificity through Large-scale Analysis of Materials Supplemental Deciphering Protein Kinase Specificity through Large-scale Analysis of Yeast Phosphorylation Site Motifs

Bruce Stillman, Hugo Y. K. Lam, Philip M. Kim, 2010 .

Mitochondrial Genomic Dysfunction Causes Dephosphorylation of Sch9 in the Yeast Saccharomyces cerevisiae

Jörg Urban, R. Loewith, C. De Virgilio, 2011, Eukaryotic Cell.

growth and for cytokinesis in budding yeast. Ste20-like protein kinases are required for normal localization of cell

K Nasmyth, K. Nasmyth, F. Cvrčková, 2007 .

Flavin adenine dinucleotide and flavin mononucleotide metabolism in rat liver--the occurrence of FAD pyrophosphatase and FMN phosphohydrolase in isolated mitochondria.

C. De Virgilio, C. D. Virgilio, S. Passarella, 1997, European journal of biochemistry.

Saccharomyces cerevisiae Ras/cAMP pathway controls post‐diauxic shift element‐dependent transcription through the zinc finger protein Gis1

I. Pedruzzi, C. De Virgilio, N. Bürckert, 2000, The EMBO journal.

Leucyl-tRNA synthetase controls TORC1 via the EGO complex.

C. De Virgilio, S. Bontron, C. Ostrowicz, 2012, Molecular cell.

Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.

G F Sprague, G. Sprague,, J. Pringle, 1995, Genes & development.

A method to study the rapid phosphorylation‐related modulation of neutral trehalase activity by temperature shifts in yeast

T. Boller, C. De Virgilio, A. Wiemken, 1991, FEBS letters.

Trehalose synthesis is important for the acquisition of thermotolerance in Schizosaccharomyces pombe

T. Boller, C. De Virgilio, A. Wiemken, 1997, Molecular microbiology.

The 70-kilodalton heat-shock proteins of the SSA subfamily negatively modulate heat-shock-induced accumulation of trehalose and promote recovery from heat stress in the yeast, Saccharomyces cerevisiae.

T. Boller, C. De Virgilio, A. Wiemken, 1992, European journal of biochemistry.

A constitutive, heat shock-activated neutral trehalase occurs in Schizosaccharomyces pombe in addition to the sporulation-specific acid trehalase.

T. Boller, C. De Virgilio, A. Wiemken, 1991, FEMS microbiology letters.

Heat shock induces enzymes of trehalose metabolism, trehalose accumulation, and thermotolerance in Schizosaccharomyces pombe, even in the presence of cycloheximide

C. De Virgilio, U. Simmen, A. Wiemken, 1990, FEBS letters.

The Thermophilic Yeast Hansenula polymorpha Does Not Require Trehalose Synthesis for Growth at High Temperatures but Does for Normal Acquisition of Thermotolerance

C. De Virgilio, A. Wiemken, A. Reinders, 1999, Journal of bacteriology.

Unsolved mysteries of Rag GTPase signaling in yeast

C. De Virgilio, Riko Hatakeyama, 2016, Small GTPases.

The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity

C. De Virgilio, Zilei Chen, F. Fröhlich, 2022, The Journal of cell biology.

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.

Robbie Loewith, Gustav Ammerer, Dorothea Anrather, 2007, Molecular cell.

Indole-3-acetic acid is a physiological inhibitor of TORC1 in yeast

C. De Virgilio, B. Kornmann, M. Jaquenoud, 2021, PLoS genetics.

TORC1 specifically inhibits microautophagy through ESCRT-0

C. De Virgilio, Riko Hatakeyama, 2019, Current Genetics.

An EGOcentric view of TORC1 signaling

C. De Virgilio, Nicolas Panchaud, M. Binda, 2010, Cell cycle.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity.

C. De Virgilio, C. Gancedo, Ó. Zaragoza, 2002, Microbiology.

Structural analysis of the subunits of the trehalose‐6‐phosphate synthase/phosphatase complex in Saccharomyces cerevisiae and their function during heat shock

Stefan Hohmann, J. Thevelein, T. Boller, 1997, Molecular microbiology.

Genetic and physical localization of the acetyl‐coenzyme A synthetase gene ACS1 on chromosome I of Saccharomyces cerevisiae

G. Barth, C. De Virgilio, H. Steensma, 1993, Yeast.

The TOR and EGO protein complexes orchestrate microautophagy in yeast.

E. Cameroni, C. De Virgilio, V. Wanke, 2005, Molecular cell.

Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation

J. Winderickx, J. Dengjel, F. Tripodi, 2022, bioRxiv.

The Vam6 GEF controls TORC1 by activating the EGO complex.

Nicolas Panchaud, Robbie Loewith, Jörg Urban, 2009, Molecular cell.

Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs

C. De Virgilio, Xu-Gang Luo, Nicolas Talarek, 2011, RNA biology.

Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor

A. Teleman, S. Vanni, C. De Virgilio, 2022, bioRxiv.

Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase.

T. Boller, C. De Virgilio, A. Wiemken, 1998, Genes & development.

Expression of a functional barley sucrose‐fructan 6‐fructosyltransferase in the methylotrophic yeast Pichia pastoris

T. Boller, C. De Virgilio, A. Wiemken, 1998, FEBS letters.

The riboflavin/FAD cycle in rat liver mitochondria.

C. De Virgilio, C. D. Virgilio, D. Valenti, 2000, European journal of biochemistry.

The role of trehalose synthesis for the acquisition of thermotolerance in yeast. II. Physiological concentrations of trehalose increase the thermal stability of proteins in vitro.

T. Boller, C. De Virgilio, A. Wiemken, 1994, European journal of biochemistry.

Disruption of TPS2, the gene encoding the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae, causes accumulation of trehalose-6-phosphate and loss of trehalose-6-phosphate phosphatase activity.

T. Boller, C. De Virgilio, A. Wiemken, 1993, European journal of biochemistry.

Manganese is a physiologically relevant TORC1 activator in yeast and mammals

C. De Virgilio, Marie-Pierre Péli-Gulli, R. V. Dúran, 2021, bioRxiv.

Bud8p and Bud9p, proteins that may mark the sites for bipolar budding in yeast.

H. Bussey, S. Shaw, L. R. Schenkman, 2001, Molecular biology of the cell.

SPR28, a sixth member of the septin gene family in Saccharomyces cerevisiae that is expressed specifically in sporulating cells.

J. Pringle, D. Demarini, C. De Virgilio, 1996, Microbiology.

The essence of yeast quiescence.

C. De Virgilio, 2012, FEMS microbiology reviews.

TORC1 controls G1–S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway

C. De Virgilio, M. Jaquenoud, M. Moreno-Torres, 2015, Nature Communications.

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

J. Dengjel, E. Cameroni, C. De Virgilio, 2019, eLife.

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

J. Dengjel, E. Cameroni, C. De Virgilio, 2019, bioRxiv.

Cell growth control: little eukaryotes make big contributions

C. De Virgilio, R. Joseph, 2022 .

PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability

Kathleen Marchal, Janick Mathys, Kristof Engelen, 2004, Molecular microbiology.

Saccharomyces cerevisiae Ccr4–Not complex contributes to the control of Msn2p‐dependent transcription by the Ras/cAMP pathway

C. De Virgilio, C De Virgilio, M. Collart, 2002, Molecular microbiology.

The role of trehalose synthesis for the acquisition of thermotolerance in yeast. I. Genetic evidence that trehalose is a thermoprotectant.

T. Boller, C. De Virgilio, A. Wiemken, 1994, European journal of biochemistry.

Quantification of mRNA stability of stress-responsive yeast genes following conditional excision of open reading frames

C. De Virgilio, S. Bontron, Nicolas Talarek, 2013, RNA biology.

Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast.

J. Dengjel, C. De Virgilio, M. Jaquenoud, 2021, Cell reports.

The nutrient-responsive CDK Pho85 primes the Sch9 kinase for its activation by TORC1

J. Winderickx, C. De Virgilio, C. Ungermann, 2023, PLoS genetics.

The Architecture of the Rag GTPase Signaling Network

C. De Virgilio, Nicolas Panchaud, R. Nicastro, 2017, Biomolecules.

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

J. Dengjel, Florian Steinberg, C. De Virgilio, 2019, The Journal of cell biology.

Caffeine extends yeast lifespan by targeting TORC1

Robbie Loewith, Jörg Urban, R. Loewith, 2008, Molecular microbiology.

Establishment of cell polarity in yeast.

J. Chant, E. Bi, J. Pringle, 1995, Cold Spring Harbor symposia on quantitative biology.

Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae

Ivo Pedruzzi, J. Winderickx, B. Smets, 2006, Cell Division.

Regulation of G0 entry by the Pho80–Pho85 cyclin–CDK complex

I. Pedruzzi, E. Cameroni, C. De Virgilio, 2005, The EMBO journal.

TORC1 Regulates Pah1 Phosphatidate Phosphatase Activity via the Nem1/Spo7 Protein Phosphatase Complex

R. Schneiter, C. De Virgilio, S. Bontron, 2014, PloS one.

Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway.

J. Broach, M. Snyder, E. Cameroni, 2010, Molecular cell.

Multilayered Control of Protein Turnover by TORC1 and Atg1.

J. Dengjel, C. De Virgilio, F. Reggiori, 2019, Cell reports.

Phosphatidylinositol 4-Phosphate Is Required for Translation Initiation in Saccharomyces cerevisiae*

E. Cameroni, C. De Virgilio, O. Deloche, 2006, Journal of Biological Chemistry.

The septins: roles in cytokinesis and other processes.

M. Longtine, J. Pringle, D. Demarini, 1996, Current opinion in cell biology.

TORC1 Determines Fab1 Lipid Kinase Function at Signaling Endosomes and Vacuoles

J. Winderickx, J. Dengjel, Taki Nishimura, 2020, Current Biology.

Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

C. De Virgilio, Katie Powis, 2016, Cell Discovery.

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2.

C. De Virgilio, Nicolas Panchaud, Marie-Pierre Péli-Gulli, 2015, Cell reports.

SEACing the GAP that nEGOCiates TORC1 activation

C. De Virgilio, Nicolas Panchaud, Marie-Pierre Péli-Gulli, 2013, Cell cycle.

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

C. De Virgilio, Nicolas Panchaud, Marie-Pierre Péli-Gulli, 2013, Science Signaling.

Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1.

Jianping Ding, C. De Virgilio, Marie-Pierre Péli-Gulli, 2012, Structure.

Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A.

Ruedi Aebersold, Bernd Bodenmiller, R. Aebersold, 2013, Cell reports.

The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis

H. Arlt, C. De Virgilio, F. Reggiori, 2015, Journal of Cell Science.

Global phosphoproteomics pinpoints uncharted Gcn2-mediated mechanisms of translational control.

J. Dengjel, C. De Virgilio, D. Kressler, 2021, Molecular cell.

Structural insights into the EGO-TC–mediated membrane tethering of the TORC1-regulatory Rag GTPases

Jianping Ding, C. De Virgilio, Marie-Pierre Péli-Gulli, 2019, Science Advances.

Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals.

J. Dengjel, C. De Virgilio, Marie-Pierre Péli-Gulli, 2017, Cell reports.

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1

C. De Virgilio, Marie-Pierre Péli-Gulli, M. Jaquenoud, 2017, Cell Discovery.

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson.

J. Winderickx, C. Delay, C. De Virgilio, 2008, Biochimica et biophysica acta.

Saccharomyces cerevisiae mitochondria can synthesise FMN and FAD from externally added riboflavin and export them to the extramitochondrial phase

A Fratianni, C. De Virgilio, S. Passarella, 1998, FEBS letters.

TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0.

Ivo Pedruzzi, J. Winderickx, I. Pedruzzi, 2003, Molecular cell.

Functional mapping of yeast genomes by saturated transposition

M. Peter, Joao Matos, C. De Virgilio, 2017, eLife.

N- and C-terminal Gln3-Tor1 interaction sites: one acting negatively and the other positively to regulate nuclear Gln3 localization.

T. Cooper, R. Rai, C. De Virgilio, 2021, Genetics.

The Impact of ESCRT on Aβ1-42 Induced Membrane Lesions in a Yeast Model for Alzheimer’s Disease

J. Winderickx, C. De Virgilio, Gernot Fruhmann, 2018, Front. Mol. Neurosci..

CNE1, a Saccharomyces cerevisiae Homologue of the Genes Encoding Mammalian Calnexin and Calreticulin

T. Boller, C. De Virgilio, J. Neuhaus, 1993, Yeast.

Cloning and disruption of a gene required for growth on acetate but not on ethanol: The acetyl‐coenzyme a synthetase gene of Saccharmoyces cerevisiae

T. Boller, G. Barth, C. De Virgilio, 1992, Yeast.

Acquisition of thermotolerance in Saccharomyces cerevisiae without heat shock protein hsp104 and in the absence of protein synthesis

P. Piper, T. Boller, C. De Virgilio, 1991, FEBS letters.

Spatially Distinct Pools of TORC1 Balance Protein Homeostasis.

J. Dengjel, C. De Virgilio, Marie-Pierre Péli-Gulli, 2019, Molecular cell.

Composition and Functional Analysis of the Saccharomyces cerevisiae Trehalose Synthase Complex*

Stefan Hohmann, Weining Sun, J. Thevelein, 1998, The Journal of Biological Chemistry.

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability

J. Winderickx, E. Cameroni, G. Smits, 2017, PLoS genetics.

The Ccr4-Not Complex Independently Controls both Msn2-Dependent Transcriptional Activation—via a Newly Identified Glc7/Bud14 Type I Protein Phosphatase Module—and TFIID Promoter Distribution

J. Winderickx, I. Pedruzzi, M. Werner, 2005, Molecular and Cellular Biology.

Control of Cellular Physiology by TM9 Proteins in Yeast and Dictyostelium*

E. Cameroni, C. De Virgilio, P. Cosson, 2008, Journal of Biological Chemistry.

RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome

A. Ballabio, F. Trepiccione, V. Meraviglia, 2023, Nature communications.

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.

Terry D. Foutz, Tuanli Yao, Jennifer E. Golden, 2012, ACS chemical biology.

Modulation of Ubc4p/Ubc5p-Mediated Stress Responses by the RING-Finger-Dependent Ubiquitin-Protein Ligase Not4p in Saccharomyces cerevisiae

K. Mulder, G. S. Winkler, H. Timmers, 2007, Genetics.

A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast

C. De Virgilio, Riko Hatakeyama, 2019, Autophagy.

The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses.

J. Winderickx, C. De Virgilio, B. Sampaio-Marques, 2023, Journal of fungi.

The Bud14p–Glc7p complex functions as a cortical regulator of dynein in budding yeast

M. Peter, I. Pedruzzi, E. Cameroni, 2005, The EMBO journal.

Cell growth control: little eukaryotes make big contributions

R. Loewith, C. D. Virgilio, C. De Virgilio, 2006, Oncogene.

Bni5p, a Septin-Interacting Protein, Is Required for Normal Septin Function and Cytokinesis in Saccharomyces cerevisiae

M. Longtine, J. Pringle, Rong Li, 2002, Molecular and Cellular Biology.

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

C. De Virgilio, Nicolas Panchaud, Marie-Pierre Péli-Gulli, 2013, Science Signaling.

Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1.

Jianping Ding, C. De Virgilio, Marie-Pierre Péli-Gulli, 2012, Structure.

Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor

A. Teleman, S. Vanni, C. De Virgilio, 2023, Nature Cell Biology.

Deciphering Protein Kinase Specificity Through Large-Scale Analysis of Yeast Phosphorylation Site Motifs

Hugo Y. K. Lam, Philip M. Kim, M. Gerstein, 2010, Science Signaling.