J. Zhen

发表

Dopamine transporter phosphorylation site threonine 53 is stimulated by amphetamines and regulates dopamine transport, efflux, and cocaine analog binding

M. Reith, Sathyavathi ChallaSivaKanaka, J. Zhen, 2017, The Journal of Biological Chemistry.

Interaction of novel hybrid compounds with the D3 dopamine receptor: Site-directed mutagenesis and homology modeling studies.

M. Reith, S. Kortagere, J. Zhen, 2011, Biochemical pharmacology.

Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter.

M. Reith, J. Zhen, Aloke K. Dutta, 2004, European journal of pharmacology.

Impact of disruption of secondary binding site S2 on dopamine transporter function

M. Reith, J. Zhen, 2016, Journal of neurochemistry.

Substrate and drug binding sites in LeuT.

M. Reith, N. Karpowich, Da-Neng Wang, 2010, Current opinion in structural biology.

Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures

M. Reith, N. Karpowich, Da-Neng Wang, 2009, Nature Structural &Molecular Biology.

Interaction of catechol and non‐catechol substrates with externally or internally facing dopamine transporters

M. Reith, J. Zhen, N. Chen, 2009, Journal of neurochemistry.

Latch and trigger role for R445 in DAT transport explains molecular basis of DTDS.

M. Reith, J. Zhen, S. Topiol, 2017, Bioorganic & medicinal chemistry letters.

Tamoxifen Directly Interacts with the Dopamine Transporter

M. Reith, J. Zhen, B. Guptaroy, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Glatiramer acetate protects against oxygen-glucose deprivation/reperfusion-induced injury by inhibiting Egr-1 in H9c2 cells.

J. Zhen, Jian Du, Si-Tong Yang, 2020, Molecular immunology.

Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters.

M. Reith, J. Zhen, Aloke K. Dutta, 2008, Bioorganic & medicinal chemistry.

Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms

J. Zhen, Jiyan Leng, L. Cai, 2019, Acta Pharmacologica Sinica.

Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats

J. Zhen, Bo Pang, Hai-tao Yu, 2015, Journal of Zhejiang University-SCIENCE B.

Neonatal murine engineered cardiac tissue toxicology model: Impact of dexrazoxane on doxorubicin induced injury.

J. Zhen, Jiyan Leng, L. Cai, 2019, Life sciences.

Rg1 protects H9C2 cells from high glucose‐/palmitate‐induced injury via activation of AKT/GSK‐3β/Nrf2 pathway

J. Zhen, Jian Du, Jiyan Leng, 2020, Journal of cellular and molecular medicine.

Use of radiolabeled antagonist assays for assessing agonism at D2 and D3 dopamine receptors: Comparison with functional GTPγS assays

K. Neve, M. Reith, J. Zhen, 2015, Journal of Neuroscience Methods.

MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia

D. Grozeva, Hiromi Hirata, R. Guerreiro, 2022, Movement disorders : official journal of the Movement Disorder Society.

Functional properties of dopamine transporter oligomers after copper linking

M. Reith, J. Zhen, 2018, Journal of neurochemistry.

Differences in interactions with the dopamine transporter as revealed by diminishment of Na+ gradient and membrane potential: Dopamine versus other substrates

M. Reith, J. Zhen, N. Chen, 2005, Neuropharmacology.

Zinc as a countermeasure for cadmium toxicity

J. Zhen, Jiyan Leng, L. Cai, 2020, Acta Pharmacologica Sinica.

Concentration of receptor and ligand revisited in a modified receptor binding protocol for high-affinity radioligands: [3H]Spiperone binding to D2 and D3 dopamine receptors

M. Reith, J. Zhen, Aloke K. Dutta, 2010, Journal of Neuroscience Methods.

Characterization of [3H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive

M. Reith, J. Zhen, Aloke K. Dutta, 2012, Journal of Neuroscience Methods.

Synthesis and Biological Characterization of (3R,4R)‐4‐(2‐(Benzhydryloxy)ethyl)‐1‐((R)‐2‐hydroxy‐2‐phenylethyl)‐piperidin‐3‐ol and Its Stereoisomers for Activity toward Monoamine Transporters

M. Reith, J. Zhen, Aloke K. Dutta, 2009, ChemMedChem.

Dexmedetomidine attenuates myocardial ischemia/reperfusion injury through regulating lactate signaling cascade in mice.

J. Zhen, Jiyan Leng, J. Du, 2019, European review for medical and pharmacological sciences.

Efficacy of Hybrid Tetrahydrobenzo[d]thiazole Based Aryl Piperazines D-264 and D-301 at D2 and D3 Receptors

D. Grandy, D. Selley, M. Reith, 2016, Neurochemical Research.

Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action.

M. Reith, J. Zhen, B. Ghosh, 2008, Journal of medicinal chemistry.

Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models.

M. Reith, J. Zhen, B. Ghosh, 2010, Journal of medicinal chemistry.

Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and nor

J. Deschamps, M. Reith, J. Zhen, 2006, Journal of medicinal chemistry.

The novel trisubstituted pyran derivative D-142 has triple monoamine reuptake inhibitory activity and exerts potent antidepressant-like activity in rodents.

M. Reith, J. Zhen, Aloke K. Dutta, 2011, European journal of pharmacology.

Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine.

M. Reith, J. Zhen, Aloke K. Dutta, 2006, Bioorganic & medicinal chemistry.

Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study

H. Christen, M. Reith, S. Heales, 2010, The Lancet Neurology.

Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia.

Paul Gissen, Shu-Yuan Cheng, M. Reith, 2009, The Journal of clinical investigation.

The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins.

M. Reith, J. Zhen, N. Chen, 2006, Handbook of experimental pharmacology.

Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters.

M. Reith, J. Zhen, Aloke K. Dutta, 2004, Bioorganic & medicinal chemistry.

Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.

M. Reith, J. Zhen, Aloke K. Dutta, 2005, Journal of medicinal chemistry.

Astragaloside IV protects cardiomyocytes from hypoxia-induced injury by down-regulation of lncRNA GAS5.

J. Zhen, Jian Du, Si-Tong Yang, 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures

I. Scheffer, Hiromi Hirata, D. Kullmann, 2015, Nature Communications.

Overexpression of seven in absentia homolog 2 protein in human breast cancer tissues is associated with the promotion of tumor cell malignant behavior in in vitro.

J. Zhen, Jie Sun, Yuan Meng, 2016, Oncology reports.

Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine

M. Reith, J. Zhen, N. Chen, 2004, Journal of neurochemistry.

Importance of cholesterol in dopamine transporter function

M. Reith, J. Zhen, K. Jones, 2012, Journal of neurochemistry.

Interaction of cocaine‐, benztropine‐, and GBR12909‐like compounds with wild‐type and mutant human dopamine transporters: molecular features that differentially determine antagonist‐binding properties

M. Reith, J. Zhen, Aloke K. Dutta, 2008, Journal of neurochemistry.

Thymidylate synthase predicts for clinical outcome in invasive breast cancer.

J. Zhen, J. Sun, Q. Zhang, 2005, Histology and histopathology.

Systematic review and meta-analysis on influence of human papillomavirus infection during pregnancy on premature rupture of membranes and premature delivery.

J. Zhen, Li-li Chen, Xia Jin, 2021, Annals of palliative medicine.

PCSK9 in cholesterol metabolism: from bench to bedside.

J. Zhen, L. Kasselman, J. Deleon, 2018, Clinical science.

A sensitive LC-MS/MS-based bioanalytical method for quantification of salviaflaside and rosmarinic acid in rat plasma and its application in a pharmacokinetic study.

J. Zhen, Dongmei Chen, T. Li, 2018, Biomedical chromatography : BMC.

Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress‐induced apoptosis in a streptozotocin‐induced diabetes rat model

J. Zhen, Yang Yang, Quan Liu, 2016, Journal of cellular and molecular medicine.

Effects of diet and insulin on dopamine transporter activity and expression in rat caudate‐putamen, nucleus accumbens, and midbrain

M. Reith, J. Zhen, Tamara Antonio, 2017, Journal of neurochemistry.

Zinc as a countermeasure for cadmium toxicity

J. Zhen, Jiyan Leng, B. Keller, 2020, Acta Pharmacologica Sinica.

Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood

E. Puffenberger, K. Strauss, M. Reith, 2014, Brain : a journal of neurology.

LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake

Da-Neng Wang, M. Reith, N. Karpowich, 2007, Science.

Dopamine transporter oligomerization: impact of combining protomers with differential cocaine analog binding affinities

M. Reith, J. Zhen, Shu-Yuan Cheng, 2015, Journal of neurochemistry.

Structural Exploration of (3S,6S)‐6‐Benzhydryl‐N‐benzyltetrahydro‐2H‐pyran‐3‐amine Analogues: Identification of Potent Triple Monoamine Reuptake Inhibitors as Potential Antidepressants

M. Reith, J. Zhen, Aloke K. Dutta, 2012, ChemMedChem.

Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.

M. Reith, J. Zhen, Aloke K. Dutta, 2011, Journal of medicinal chemistry.

Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats

J. Zhen, Hai-tao Yu, Sui-sheng Wu, 2015, Journal of Zhejiang University-SCIENCE B.

Chronic food restriction and dopamine transporter function in rat striatum

M. Reith, J. Zhen, K. Carr, 2006, Brain Research.

VKORC1 and CD-14 genetic polymorphisms associate with susceptibility to cardiovascular and cerebrovascular diseases.

J. Zhen, Jian Du, Jiyan Leng, 2015, International journal of clinical and experimental medicine.

Locus Heterogeneity in Epilepsy of Infancy with Migrating Focal Seizures

G. Carvill, M. Mackay, J. Lundeberg, 2016 .

Dihydropyrimidine dehydrogenase activity correlates with fluorouracil sensitivity in breast cancer.

J. Zhen, J. Sun, Z. Yu, 2007, Experimental oncology.

Human Lupus Plasma Pro-Atherogenic Effects on Cultured Macrophages Are Not Mitigated by Statin Therapy: A Mechanistic LAPS Substudy

M. Petri, J. Zhen, S. Carsons, 2019, Medicina.

Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms

J. Zhen, Jiyan Leng, L. Cai, 2019, Acta Pharmacologica Sinica.

Early B Cytokine 1 Improves the Proliferation, Invasion and Migration of Ovarian Cancer Cells by Transcriptional Inhibition of the Expression of Cripto-1

J. Zhen, Ying Wang, Chunhong Song, 2022, Journal of Biomaterials and Tissue Engineering.

Use of radiolabeled antagonist assays for assessing agonism at D2 and D3 dopamine receptors: Comparison with functional GTPγS assays

K. Neve, M. Reith, J. Zhen, 2015, Journal of Neuroscience Methods.

Efficacy of Hybrid Tetrahydrobenzo[d]thiazole Based Aryl Piperazines D-264 and D-301 at D2 and D3 Receptors

D. Grandy, D. Selley, M. Reith, 2015, Neurochemical Research.

O6-1 Loss-of-function mutations in the gene encoding the dopamine transporter, SLC6A3, cause Infantile Parkinsonism Dystonia (IPD)

S. Heales, J. Zhen, M. Kurian, 2009 .