D. Fazakerley

发表

Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies

Sean J. Humphrey, D. James, Pengyi Yang, 2016, PloS one.

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

Sean J. Humphrey, D. James, L. K. Nguyen, 2019, Nature Communications.

Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

R. Scalzo, L. Quek, D. James, 2020, iScience.

Re-fraction: a machine learning approach for deterministic identification of protein homologues and splice variants in large-scale MS-based proteomics.

David E James, Sean J Humphrey, Pengyi Yang, 2012, Journal of proteome research.

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

Sean J. Humphrey, Nolan J. Hoffman, D. James, 2018, eLife.

The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes

D. James, J. Yang, K. Hoehn, 2018, Scientific Reports.

Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity

D. James, Z. Modrušan, J. Yang, 2015, npj Systems Biology and Applications.

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

D. Fazakerley, S. Cushman, V. Lizunov, 2009, Journal of Cell Science.

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

D. James, M. Ruegg, P. Schjerling, 2014, Molecular metabolism.

The role of mitochondrial reactive oxygen species in insulin resistance.

D. James, R. Stocker, D. Fazakerley, 2021, Free radical biology & medicine.

Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion.

Sean J. Humphrey, D. James, E. Needham, 2019, Cell reports.

Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance

Sean J. Humphrey, David E. James, J. Burchfield, 2022, bioRxiv.

Novel Systems for Dynamically Assessing Insulin Action in Live Cells Reveals Heterogeneity in the Insulin Response

David E. James, D. James, K. Mele, 2013, Traffic.

Insulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes

D. Fazakerley, G. Holman, F. Koumanov, 2015, Diabetologia.

Muscling in on GLUT4 kinetics

D. James, A. Coster, D. Fazakerley, 2010, Communicative & integrative biology.

Kinetic Evidence for Unique Regulation of GLUT4 Trafficking by Insulin and AMP-activated Protein Kinase Activators in L6 Myotubes*

D. James, A. Coster, D. Fazakerley, 2009, The Journal of Biological Chemistry.

Highlights from the eleventh ISCB Student Council Symposium 2015-DTU Orbit (03/12/2018)

Sean J. Humphrey, D. James, K. Laukens, 2017 .

The exocyst complex is an essential component of the mammalian constitutive secretory pathway

D. Fazakerley, J. Houghton, R. Antrobus, 2022, bioRxiv.

The Role of the Niemann-Pick Disease, Type C1 Protein in Adipocyte Insulin Action

D. James, J. Burchfield, J. Krycer, 2014, PloS one.

Selective Insulin Resistance in Adipocytes*

D. James, A. Coster, D. Fazakerley, 2015, The Journal of Biological Chemistry.

The RabGAP TBC 1 D 1 Plays a Central Role in Exercise-Regulated Glucose Metabolism in Skeletal Muscle

Nolan J. Hoffman, D. James, G. Cooney, 2015 .

The RabGAP TBC1D1 Plays a Central Role in Exercise-Regulated Glucose Metabolism in Skeletal Muscle

Nolan J. Hoffman, D. James, G. Cooney, 2015, Diabetes.

Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation.

B. Kemp, S. Jørgensen, D. Fazakerley, 2009, American journal of physiology. Endocrinology and metabolism.

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

D. James, J. Burchfield, R. Stocker, 2018, The Journal of Biological Chemistry.

PFKFB3 and insulin signalling

D. James, B. Parker, J. Krycer, 2015 .

GLUT4 exocytosis

D. James, D. Fazakerley, J. Stöckli, 2011, Journal of Cell Science.

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

D. Fazakerley, S. Cushman, V. Lizunov, 2009, Journal of Cell Science.

Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction

N. van Bruggen, J. Gamble, D. James, 2014, Diabetes.

Systemic vascular endothelial growth factor-A (VEGF-A) neutralization ameliorates diet induced metabolic dysfunction

J. Gamble, D. James, N. Bruggen, 2014 .

A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology

Sean J. Humphrey, David E. James, J. Burchfield, 2022, Life Science Alliance.

Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes

D. James, G. Cooney, J. Burchfield, 2019, The Journal of Biological Chemistry.

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.

D. James, N. Turner, K. Hoehn, 2014, Molecular metabolism.

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

Sean J. Humphrey, Thomas A. Geddes, D. James, 2021, eLife.

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.

Nolan J Hoffman, David E James, Sean J Humphrey, 2015, Cell metabolism.

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity

D. James, N. Turner, D. Fazakerley, 2014, Molecular metabolism.

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

David E. James, Pengyi Yang, Sean J. Humphrey, 2013, Cell metabolism.

Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration

D. Fazakerley, D. Saunders, J. Holst, 2017, Cancer & metabolism.

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes*

Matthew J. Prior, D. James, J. Burchfield, 2015, The Journal of Biological Chemistry.

Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

R. Scalzo, L. Quek, D. James, 2020, iScience.

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes*

David E. James, Shireen Vali, Shi-Xiong Tan, 2011, The Journal of Biological Chemistry.

Terminal Galactosylation and Sialylation Switching on Membrane Glycoproteins upon TNF-Alpha-Induced Insulin Resistance in Adipocytes*

David E James, Nicolle H Packer, Benjamin L Parker, 2015, Molecular & Cellular Proteomics.

Identifying a GSK3-TRARG1 signaling axis reveals BCL9L as a novel regulator of GLUT4 trafficking

Sean J. Humphrey, D. James, F. Brodsky, 2020 .

Highlights from the 11th ISCB Student Council Symposium 2015

Giovanni Felici, Farzana Rahman, M. Michael Gromiha, 2016, BMC Bioinformatics.

Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: a comprehensive resource for in vitro studies of hepatic metabolism.

J. Krycer, D. Fazakerley, A. Hoy, 2019, American journal of physiology. Endocrinology and metabolism.

Oxygen is a critical regulator of cellular metabolism and function in cell culture

E. Petsalaki, A. Murray, L. Vallier, 2022 .

Cell Metabolism Resource Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC 2

Sean J. Humphrey, D. James, Pengyi Yang, 2014 .

Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance.

D. James, G. Cooney, Senthil Thillainadesan, 2022, Cell metabolism.

Muscle and adipose tissue insulin resistance: malady without mechanism?

D. James, J. Krycer, D. Fazakerley, 2018, Journal of Lipid Research.

Mapping Insulin/GLUT4 Circuitry

D. James, Alexander F. Rowland, D. Fazakerley, 2011, Traffic.

Investigating GLUT4 Trafficking in Muscle

D. Fazakerley, 2010 .

Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression

Thomas A. Geddes, D. James, J. Burchfield, 2021, iScience.

The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes

D. James, J. Yang, K. Hoehn, 2018, Scientific Reports.

The amino acid transporter, SLC1A3, is plasma membrane‐localised in adipocytes and its activity is insensitive to insulin

Sean J. Humphrey, David E. James, R. Vandenberg, 2017, FEBS letters.

Correction: The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action

Wellcome, D. James, J. Burchfield, 2014, PLoS ONE.

GLUT4 On the move

D. Fazakerley, G. Holman, F. Koumanov, 2022, The Biochemical journal.

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.

Westa Domanova, David E James, Sean J Humphrey, 2016, Cell reports.

Lactate production is a prioritized feature of adipocyte metabolism

L. Quek, D. James, G. Cooney, 2019, The Journal of Biological Chemistry.

A gas trapping method for high-throughput metabolic experiments.

D. James, Xiao-Yi Zeng, J. Krycer, 2018, BioTechniques.

Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q

D. James, D. Vance, J. Ho, 2021, Redox biology.

Integrating adipocyte insulin signaling and metabolism in the multi-omics era.

D. Guertin, D. Fazakerley, C. M. Calejman, 2022, Trends in biochemical sciences.

Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes

D. James, J. Burchfield, J. Krycer, 2019, The Journal of Biological Chemistry.

Metabolomic analysis of insulin resistance across different mouse strains and diets

Nolan J. Hoffman, D. James, Xiao-Yi Zeng, 2017, The Journal of Biological Chemistry.

Bicarbonate alters cellular responses in respiration assays.

D. James, J. Krycer, D. Fazakerley, 2017, Biochemical and biophysical research communications.

Exposure to solar ultraviolet radiation limits diet-induced weight gain, increases liver triglycerides and prevents the early signs of cardiovascular disease in mice.

D. Fazakerley, S. Byrne, L. Kok, 2019, Nutrition, metabolism, and cardiovascular diseases : NMCD.

High dietary fat and sucrose result in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

Nolan J. Hoffman, B. Vissel, D. James, 2018, The Journal of Biological Chemistry.

Insulin Tolerance Test under Anaesthesia to Measure Tissue-specific Insulin-stimulated Glucose Disposal.

Sean J. Humphrey, D. James, G. Cooney, 2019, Bio-protocol.

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

Nolan J. Hoffman, D. James, M. Ruegg, 2016, Molecular metabolism.

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

L. Quek, G. Reid, A. Burgess, 2019, Redox biology.

Insulin signaling requires glucose to promote lipid anabolism in adipocytes

Sean J. Humphrey, R. Scalzo, L. Quek, 2020, The Journal of Biological Chemistry.

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway*

D. James, James Lee, B. Parker, 2015, The Journal of Biological Chemistry.

Genome-wide association study and functional characterisation identifies candidate genes for insulin-stimulated glucose uptake

C. Gieger, N. Grarup, C. Lindgren, 2023, Nature Genetics.

Lactate production is a prioritized feature of adipocyte metabolism.

L. Quek, D. James, G. Cooney, 2020, The Journal of biological chemistry.

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism.

Sean J. Humphrey, R. Scalzo, L. Quek, 2017, Cell reports.

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

E. Petsalaki, A. Murray, L. Vallier, 2023, bioRxiv.

Insulin signalling and GLUT4 trafficking in insulin resistance

D. Fazakerley, A. S. Shun-Shion, Julian van Gerwen, 2023, Biochemical Society transactions.

An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction

D. James, J. Burchfield, Pengyi Yang, 2017, Journal of Cell Science.

Universitet mTORC 2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

Nolan J. Hoffman, D. James, M. Ruegg, 2016 .

Direction pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathway

Jean Yee Hwa Yang, Ellis Patrick, Christopher Gribben, 2014, Bioinform..

Highlights from the 11th ISCB Student Council Symposium 2015

Zdenka Kuncic, Westa Domanova, Dan F. DeBlasio, 2016, BMC Bioinformatics.

Highlights from the eleventh ISCB Student Council Symposium 2015

Dan F. DeBlasio, Sean J. Humphrey, P. Bertolazzi, 2016 .

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

Sean J. Humphrey, David E. James, J. Burchfield, 2020, bioRxiv.

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

D. Fazakerley, S. Cushman, V. Lizunov, 2009, Journal of Cell Science.

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

Nolan J. Hoffman, D. James, M. Ruegg, 2016, Molecular metabolism.

AMPK differentially regulate muscle triglyceride content via Perilipin 3

Nolan J. Hoffman, D. James, M. Ruegg, 2016 .

Glucose Transport: Methods for Interrogating GLUT4 Trafficking in Adipocytes.

Thomas A. Geddes, D. James, J. Burchfield, 2018, Methods in molecular biology.

Exploring alternative proteases and fragmentation methods for proteomics

Kiyoko F. Aoki-Kinoshita, Monika S. Doblin, Kristina L. Ford, 2022 .

Mapping Insulin/GLUT4 Circuitry

D. James, Alexander F. Rowland, D. Fazakerley, 2011, Traffic.

Limited oxygen in standard cell culture alters metabolism and function of differentiated cells

E. Petsalaki, J. Krycer, D. Fazakerley, 2024, The EMBO journal.

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

D. James, J. Burchfield, R. Stocker, 2018, The Journal of Biological Chemistry.